The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Nanotechnology and Cancer
Open accessAbstract
The biological picture of cancer is rapidly advancing from models built from phenomenological descriptions to network models derived from systems biology, which can capture the evolving pathophysiology of the disease at the molecular level. The translation of this (still academic) picture into a clinically relevant framework can be enabling for the war on cancer, but it is a scientific and technological challenge. In this review, we discuss emerging in vitro diagnostic technologies and therapeutic approaches that are being developed to handle this challenge. Our discussion of in vitro diagnostics is guided by the theme of making large numbers of measurements accurately, sensitively, and at very low cost. We discuss diagnostic approaches based on microfluidics and nanotechnology. We then review the current state of the art of nanoparticle-based therapeutics that have reached the clinic. The goal of the presentation is to identify nanotherapeutic strategies that are designed to increase efficacy while simultaneously minimizing the toxic side effects commonly associated with cancer chemotherapies.
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Cites
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
Systems Biology and New Technologies Enable Predictive and Preventative Medicine
Hood, L., Heath, J. R., Phelps, M. E., & Lin, B. (2004) · Science · doi:10.1126/science.1104635 · Cited by 1,108
Self-citationGene expression changes associated with progression and response in chronic myeloid leukemia
Radich, J. P., Dai, H., Mao, M., Oehler, V., Schelter, J., Druker, B., Sawyers, C., Shah, N., Stock, W., Willman, C. L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510423103 · Cited by 583
Huang, F., Reeves, K., Han, X., Fairchild, C., Platero, S., Wong, T. W., Lee, F., Shaw, P., & Clark, E. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3633 · Cited by 344 · cited 1×
“Such an analysis can potentially indicate an appropriate therapy (7, 8), the progression of the cancer (9), the potential for recurrence after therapy (10), or the potential for drug resistance (8).”
Background
Cited by
Nanotherapeutics to Overcome Conventional Cancer Chemotherapy Limitations
Chidambaram, M., Manavalan, R., & Kathiresan, K. (2011) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j30c7d · Cited by 566
More Effective Nanomedicines through Particle Design
Wang, J., Byrne, J. D., Napier, M. E., & DeSimone, J. M. (2011) · Small · doi:10.1002/smll.201100442 · Cited by 466
Receptor-targeted nanocarriers for therapeutic delivery to cancer
Yu, B., Tai, H. C., Xue, W., Lee, L. J., & Lee, R. J. (2010) · Molecular Membrane Biology · doi:10.3109/09687688.2010.521200 · Cited by 423
Metal–Organic Frameworks as Sensory Materials and Imaging Agents
Liu, D., Lu, K., Poon, C., & Lin, W. (2014) · Inorganic Chemistry · doi:10.1021/ic402194c · Cited by 386
Recent advances in green synthesized nanoparticles: from production to application
kazemi, S., Hosseingholian, A., Gohari, S. D., Feirahi, F., Moammeri, F., Mesbahian, G., Moghaddam, Z. S., & Ren, Q. (2023) · Materials Today Sustainability · doi:10.1016/j.mtsust.2023.100500 · Cited by 341
Metadata
- Authors
- Heath, J. R., & Davis, M. E.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 2008-02-01
- Volume
- 59
- Issue
- 1
- Pages
- 251-265
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2156429223
- Cited by
- 354
- References
- 4
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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