The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Nanotherapeutics to Overcome Conventional Cancer Chemotherapy Limitations
Open accessAbstract
Cancer is one of the major causes of death worldwide and chemotherapy is a major therapeutic approach for the treatment which may be used alone or combined with other forms of therapy. However, conventional chemotherapy suffers lack of aqueous solubility, lack of selectivity and multidrug resistance. Nanotherapeutics is rapidly progressing aimed to solve several limitations of conventional drug delivery systems. Nonspecific target of cancer chemotherapy leads to damage rapidly proliferating normal cells and can be significantly reduced through folate and transferrin mediated nanotherapeutics which are aimed to target cancerous cells. Multidrug resistance is challenge in cancer chemotherapy which can be significantly reversed by solid lipid nanoparticles, polymeric nanoparticles, mesoporous silica nanoparticles, nanoparticulated chemosensitizer, nanoparticluated poloxamer and magnetic nanoparticles. Hydrophobic nature of chemotherapeutics leads to poor aqueous solubility and low bioavailability which can be overcome by nanocrystals, albumin based nanoparticles, liposomal formulation, polymeric micelles, cyclodextrin and chitosan based nanoparticles. This review focuses the role of nanotherapeutics to overcome lack of selectivity, multidrug resistance and lack of aqueous solubility of conventional cancer chemotherapy.
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Therapeutic Nanoparticles and Their Targeted Delivery Applications
Yetisgin, A. A., Cetinel, S., Zuvin, M., Kosar, A., & Kutlu, O. (2020) · Molecules · doi:10.3390/molecules25092193 · Cited by 1,080
2D MoS2‐Based Nanomaterials for Therapeutic, Bioimaging, and Biosensing Applications
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Gold nanoparticles enhance 5-fluorouracil anticancer efficacy against colorectal cancer cells
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Roshani, M., Rezaian-Isfahni, A., Lotfalizadeh, M. H., Khassafi, N., Abadi, M. H. J. N., & Nejati, M. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03115-1 · Cited by 84
Metadata
- Authors
- Chidambaram, M., Manavalan, R., & Kathiresan, K.
- Venue
- Journal of Pharmacy & Pharmaceutical Sciences
- Publisher
- Frontiers Media SA
- Published
- 2011-02-16
- Volume
- 14
- Issue
- 1
- Pages
- 67
- ISSN
- 1482-1826 (ISSN-L)
- OpenAlex
- W1571365882
- Cited by
- 566
- References
- 85
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- gold
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- Chidambaram, M., Manavalan, R., & Kathiresan, K. (2011). Nanotherapeutics to Overcome Conventional Cancer Chemotherapy Limitations. Journal of Pharmacy & Pharmaceutical Sciences. https://doi.org/10.18433/j30c7d
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
