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Cited by 268Sulfur Compounds in BiologyRedox biology and oxidative stressMicrobial metabolism and enzyme function

The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.

Novel Thiols of Prokaryotes

Fahey, Robert C.·2001·Annual Review of Microbiology
DOI 10.1146/annurev.micro.55.1.333
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Abstract

▪ Abstract Glutathione metabolism is associated with oxygenic cyanobacteria and the oxygen-utilizing purple bacteria, but is absent in many other prokaryotes. This review focuses on novel thiols found in those bacteria lacking glutathione. Included are glutathione amide and its perthiol, produced by phototrophic purple sulfur bacteria and apparently involved in their sulfide metabolism. Among archaebacteria, coenzyme M (2-mercaptoethanesulfonic acid) and coenzyme B (7-mercaptoheptanoylthreonine phosphate) play central roles in the anaerobic production of CH 4 and associated energy conversion by methanogens, whereas the major thiol in the aerobic phototrophic halobacteria is γ-glutamylcysteine. The highly aerobic actinomycetes produce mycothiol, a conjugate of N-acetylcysteine with a pseudodisaccharide of glucosamine and myo-inositol, AcCys-GlcNα(1 → 1)Ins, which appears to play an antioxidant role similar to glutathione. Ergothioneine, also produced by actinomycetes, remains a mystery despite many years of study. Available data on the biosynthesis and metabolism of these and other novel thiols is summarized and key areas for additional study are identified.

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Crossref · 10.1146/annurev.micro.55.1.333

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Research works printed but not linked: 7

  1. Dolphin D, 1989, Glutathione: Chemical, Biochemical, and Medical Aspects, Parts A and B.
  2. Fairlamb AH, 1999, Medicina, 59, 179
  3. 10.1016/S0168-6445(98)00035-7 · DOI
  4. Melville DB, 1957, J. Bacteriol., 224, 871
  5. Newton GL, Fahey RC. 1989. Glutathione in procaryotes. InGlutathione: Metabolism and Physiological Functions, ed. J Viña, pp. 69–77. Boca Raton, FL: CRC Press
  6. Tabor H, 1976, Italian J. Biochem., 25, 70
  7. Tanret MC, 1909, Compt. Rend., 49, 222

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Metadata

Authors
Fahey, R. C.
Affiliations
University of California San Diego (US)
Corresponding author
Fahey, Robert C.
Venue
Annual Review of Microbiology
Publisher
Annual Reviews
Published
2001-10
Volume
55
Issue
1
Pages
333-356
ISSN
  • 0066-4227 (ISSN-L)
  • 1545-3251
DOI
10.1146/annurev.micro.55.1.333
OpenAlex
W2146918483
Cited by
266
References
133
Citations by year
2026: 4 · 2025: 3 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 9 · 2020: 11 · 2019: 9 · 2018: 15 · 2017: 9 · 2016: 11 · 2015: 10 · 2014: 18 · 2013: 14 · 2012: 17
FWCI
1.02
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Allergy and Infectious Diseases (AI 49174)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
Keywords
glutathione, purple sulfur bacteria, sulfide metabolism, coenzyme M, coenzyme B, methanogenic archaea, methane production, halobacteria, gamma-glutamylcysteine, mycothiol, actinomycetes, ergothioneine, antioxidant defense
MeSH terms
Cysteine, Disaccharides, Ergothioneine, Glutathione, Glycopeptides, Inositol, Models, Chemical, Phosphothreonine, Prokaryotic Cells, Pyrazoles, Sulfhydryl Compounds, Mesna

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