The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Novel Thiols of Prokaryotes
Abstract
▪ Abstract Glutathione metabolism is associated with oxygenic cyanobacteria and the oxygen-utilizing purple bacteria, but is absent in many other prokaryotes. This review focuses on novel thiols found in those bacteria lacking glutathione. Included are glutathione amide and its perthiol, produced by phototrophic purple sulfur bacteria and apparently involved in their sulfide metabolism. Among archaebacteria, coenzyme M (2-mercaptoethanesulfonic acid) and coenzyme B (7-mercaptoheptanoylthreonine phosphate) play central roles in the anaerobic production of CH 4 and associated energy conversion by methanogens, whereas the major thiol in the aerobic phototrophic halobacteria is γ-glutamylcysteine. The highly aerobic actinomycetes produce mycothiol, a conjugate of N-acetylcysteine with a pseudodisaccharide of glucosamine and myo-inositol, AcCys-GlcNα(1 → 1)Ins, which appears to play an antioxidant role similar to glutathione. Ergothioneine, also produced by actinomycetes, remains a mystery despite many years of study. Available data on the biosynthesis and metabolism of these and other novel thiols is summarized and key areas for additional study are identified.
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“ERG reacts fast with hydroxyl radicals, and its reaction with hydrogen peroxide and superoxide radical anion is somewhat slower (Fahey 2001).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Fahey 2001
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Cites
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
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Metadata
- Authors
- Fahey, R. C.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Fahey, Robert C.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2001-10
- Volume
- 55
- Issue
- 1
- Pages
- 333-356
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2146918483
- Cited by
- 266
- References
- 133
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 9 · 2020: 11 · 2019: 9 · 2018: 15 · 2017: 9 · 2016: 11 · 2015: 10 · 2014: 18 · 2013: 14 · 2012: 17
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI 49174)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Keywords
- glutathione, purple sulfur bacteria, sulfide metabolism, coenzyme M, coenzyme B, methanogenic archaea, methane production, halobacteria, gamma-glutamylcysteine, mycothiol, actinomycetes, ergothioneine, antioxidant defense
- MeSH terms
- Cysteine, Disaccharides, Ergothioneine, Glutathione, Glycopeptides, Inositol, Models, Chemical, Phosphothreonine, Prokaryotic Cells, Pyrazoles, Sulfhydryl Compounds, Mesna
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