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Roles of Cyclic Diguanylate in the Regulation of Bacterial Pathogenesis
Open accessAbstract
Cyclic diguanylate (c-di-GMP) is a bacterial second messenger of growing recognition involved in the regulation of a number of complex physiological processes. This review describes the biosynthesis and hydrolysis of c-di-GMP and several mechanisms of regulation of c-di-GMP metabolism. The contribution of c-di-GMP to regulating biofilm formation and motility, processes that affect pathogenesis of many bacteria, is described, as is c-di-GMP regulation of virulence gene expression. Finally, ways in which c-di-GMP may mediate these regulatory effects are proposed.
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Cited by
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Fu, J., Kanne, D. B., Leong, M., Glickman, L. H., McWhirter, S. M., Lemmens, E., Mechette, K., Leong, J. J., Lauer, P., Liu, W., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa4306 · Cited by 720
STING and the innate immune response to nucleic acids in the cytosol
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Sambanthamoorthy, K., Sloup, R. E., Parashar, V., Smith, J. M., Kim, E. E., Semmelhack, M. F., Neiditch, M. B., & Waters, C. M. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01396-12 · Cited by 151
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Metadata
- Authors
- Tamayo, R., Pratt, J. T., & Camilli, A.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2007-10-01
- Volume
- 61
- Issue
- 1
- Pages
- 131-148
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2120077910
- Cited by
- 486
- References
- 0
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- green
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
