STING and the innate immune response to nucleic acids in the cytosol

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Ishikawa, H., & Barber, G. N. (2008) · Nature · doi:10.1038/nature07317 · Cited by 3,576 · see citing works

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

Ishikawa, H., Ma, Z., & Barber, G. N. (2009) · Nature · doi:10.1038/nature08476 · Cited by 2,759 · see citing works

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

Takaoka, A., Wang, Z., Choi, M. K., Yanai, H., Negishi, H., Ban, T., Lu, Y., Miyagishi, M., Kodama, T., Honda, K., et al. (2007) · Nature · doi:10.1038/nature06013 · Cited by 1,704 · see citing works

IFI16 is an innate immune sensor for intracellular DNA

Unterholzner, L., Keating, S. E., Baran, M., Horan, K. A., Jensen, S. B., Sharma, S., Sirois, C. M., Jin, T., Latz, E., Xiao, T. S., et al. (2010) · Nature Immunology · doi:10.1038/ni.1932 · Cited by 1,643 · see citing works

STING is a direct innate immune sensor of cyclic di-GMP

Burdette, D. L., Monroe, K. M., Sotelo-Troha, K., Iwig, J. S., Eckert, B., Hyodo, M., Hayakawa, Y., & Vance, R. E. (2011) · Nature · doi:10.1038/nature10429 · Cited by 1,570 · see citing works

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

Zhong, B., Yang, Y., Li, S., Wang, Y., Li, Y., Diao, F., Lei, C., He, X., Zhang, L., Tien, P., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.09.003 · Cited by 1,513 · see citing works

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

Tanaka, Y., & Chen, Z. J. (2012) · Science Signaling · doi:10.1126/scisignal.2002521 · Cited by 1,317 · see citing works

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

Chiu, Y., MacMillan, J. B., & Chen, Z. J. (2009) · Cell · doi:10.1016/j.cell.2009.06.015 · Cited by 1,185 · see citing works

Phospholipid synthesis in a membrane fraction associated with mitochondria.

Vance, J. E. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39106-9 · Cited by 1,153 · see citing works

Toll-like receptors in systemic autoimmune disease

Marshak-Rothstein, A. (2006) · Nature Reviews Immunology · doi:10.1038/nri1957 · Cited by 1,116 · see citing works

Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune Response

Stetson, D. B., & Medzhitov, R. M. (2006) · Immunity · doi:10.1016/j.immuni.2005.12.003 · Cited by 1,003 · see citing works

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

Ablasser, A., Bauernfeind, F. G., Hartmann, G., Latz, E., Fitzgerald, K. A., & Hornung, V. (2009) · Nature Immunology · doi:10.1038/ni.1779 · Cited by 892 · see citing works

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

Zhang, Z., Yuan, B., Bao, M., Lu, N., Kim, T., & Liu, Y. (2011) · Nature Immunology · doi:10.1038/ni.2091 · Cited by 874 · see citing works

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

Sun, W., Li, Y., Chen, L., Chen, H., You, F., Zhou, X., Zhou, Y., Zhai, Z., Chen, D., & Jiang, Z. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900850106 · Cited by 862 · see citing works

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

Saitoh, T., Fujita, N., Hayashi, T., Takahara, K., Satoh, T., Lee, H., Matsunaga, K., Kageyama, S., Omori, H., Noda, T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911267106 · Cited by 854 · see citing works

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

Woodward, J. J., Iavarone, A. T., & Portnoy, D. A. (2010) · Science · doi:10.1126/science.1189801 · Cited by 813 · see citing works

Structure and evolution of transcriptional regulatory networks

Babu, M. M., Luscombe, N. M., Aravind, L., Gerstein, M., & Teichmann, S. A. (2004) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2004.05.004 · Cited by 764 · see citing works

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

Upton, J. W., Kaiser, W. J., & Mocarski, E. S. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.01.016 · Cited by 758 · see citing works

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

Watson, R. O., Manzanillo, P. S., & Cox, J. S. (2012) · Cell · doi:10.1016/j.cell.2012.06.040 · Cited by 755 · see citing works

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

Kerur, N., Veettil, M. V., Sharma-Walia, N., Bottero, V., Sadagopan, S., Otageri, P., & Chandran, B. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.008 · Cited by 702 · see citing works

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

Ishii, K. J., Kawagoe, T., Koyama, S., Matsui, K., Kumar, H., Kawai, T., Uematsu, S., Takeuchi, O., Takeshita, F., Coban, C., et al. (2008) · Nature · doi:10.1038/nature06537 · Cited by 628 · see citing works

Nucleic acid recognition by the innate immune system

Barbalat, R., Ewald, S. E., Mouchess, M. L., & Barton, G. M. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101340 · Cited by 577 · see citing works

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

Sauer, J., Troha, K., von Moltke, J., Monroe, K. M., Rae, C. S., Brubaker, S. W., Hyodo, M., Hayakawa, Y., Woodward, J. J., Portnoy, D. A., et al. (2010) · Infection and Immunity · doi:10.1128/iai.00999-10 · Cited by 528 · see citing works

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

Yan, N., Regalado-Magdos, A. D., Stiggelbout, B., Lee‐Kirsch, M. A., & Lieberman, J. (2010) · Nature Immunology · doi:10.1038/ni.1941 · Cited by 522 · see citing works

Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease

Gall, A., Treuting, P., Elkon, K. B., Loo, Y.-M., Gale, M., Barber, G. N., & Stetson, D. B. (2012) · Immunity · doi:10.1016/j.immuni.2011.11.018 · Cited by 510 · see citing works

The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA

Tsuchida, T., Zou, J. P., Saitoh, T., Kumar, H., Abe, T., Matsuura, Y., Kawai, T., & Akira, S. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.013 · Cited by 488 · see citing works

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

Jones, J. W. M., Kayagaki, N., Brož, P., Henry, T., Newton, K., O’Rourke, K. M., Chan, S. B., Dong, J. J., Qu, Y., Roose-Girma, M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003738107 · Cited by 487 · see citing works

Roles of Cyclic Diguanylate in the Regulation of Bacterial Pathogenesis

Tamayo, R., Pratt, J. T., & Camilli, A. (2007) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093426 · Cited by 487 · see citing works

The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA

Zhong, B., Zhang, L., Lei, C., Li, Y., Mao, A., Yang, Y. F., Wang, Y., Zhang, X., & Shu, H. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.008 · Cited by 478 · see citing works

Mycobacterium Tuberculosis Activates the DNA-Dependent Cytosolic Surveillance Pathway within Macrophages

Manzanillo, P. S., Shiloh, M. U., Portnoy, D. A., & Cox, J. S. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.03.007 · Cited by 456 · see citing works

MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

Jin, L., Waterman, P. M., Jonscher, K. R., Short, C. M., Reisdorph, N. A., & Cambier, J. C. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00640-08 · Cited by 451 · see citing works

Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates

Witte, G., Hartung, S., Büttner, K., & Hopfner, K. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.020 · Cited by 429 · see citing works

DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation

Fuller-Pace, F. V. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl460 · Cited by 426 · see citing works

Coordinated Regulation of Accessory Genetic Elements Produces Cyclic Di-Nucleotides for V. cholerae Virulence

Davies, B. W., Bogard, R. W., Young, T. S., & Mekalanos, J. J. (2012) · Cell · doi:10.1016/j.cell.2012.01.053 · Cited by 425 · see citing works

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

Parvatiyar, K., Zhang, Z., Teles, R. M. B., Ouyang, S., Jiang, Y., Iyer, S. S., Zaver, S. A., Schenk, M., Zeng, S., Zhong, W., et al. (2012) · Nature Immunology · doi:10.1038/ni.2460 · Cited by 407 · see citing works

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a β-catenin-dependent pathway

Yang, P., An, H., Liu, X., Wen, M., Zheng, Y., Rui, Y., & Cao, X. (2010) · Nature Immunology · doi:10.1038/ni.1876 · Cited by 392 · see citing works

TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination

Zhang, J., Hu, M., Wang, Y., & Shu, H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.362608 · Cited by 390 · see citing works

DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells

Zhang, Z., Kim, T., Bao, M., Facchinetti, V., Jung, S. Y., Ghaffari, A. A., Qin, J., Cheng, G., & Liu, Y. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.027 · Cited by 376 · see citing works

Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

Chen, H., Sun, H., You, F., Sun, W., Zhou, X., Chen, L., Yang, J., Wang, Y., Tang, H., Guan, Y., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.022 · Cited by 372 · see citing works

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF‐κB

Rebsamen, M., Heinz, L. X., Meylan, E., Michallet, M., Schroder, K., Hofmann, K., Vázquez, J., Benedict, C. A., & Tschopp, J. (2009) · EMBO Reports · doi:10.1038/embor.2009.109 · Cited by 365 · see citing works

Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

Ouyang, S., Song, X., Wang, Y., Ru, H., Shaw, N., Jiang, Y., Niu, F., Zhu, Y., Qiu, W., Parvatiyar, K., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.019 · Cited by 355 · see citing works

Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules

Wang, Z., Choi, M. K., Ban, T., Yanai, H., Negishi, H., Lu, Y., Tamura, T., Takaoka, A., Nishikura, K., & Taniguchi, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801295105 · Cited by 337 · see citing works

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

Kim, T., Pazhoor, S., Bao, M., Zhang, Z., Hanabuchi, S., Facchinetti, V., Bover, L. C., Plumas, J., Chaperot, L., Qin, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006539107 · Cited by 332 · see citing works

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

Shu, C., Yi, G., Watts, T., Kao, C. C., & Li, P. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2331 · Cited by 311 · see citing works

Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16

Li, T., Diner, B. A., Chen, J., & Cristea, I. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203447109 · Cited by 297 · see citing works

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

McWhirter, S. M., Barbalat, R., Monroe, K. M., Fontana, M. F., Hyodo, M., Joncker, N. T., Ishii, K. J., Akira, S., Colonna, M., Chen, Z. J., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082874 · Cited by 293 · see citing works

MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP

Jin, L., Hill, K. K., Filak, H. C., Mogan, J., Knowles, H. M., Zhang, B., Perraud, A., Cambier, J. C., & Lenz, L. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100088 · Cited by 285 · see citing works

Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING

Yin, Q., Tian, Y., Kabaleeswaran, V., Jiang, X., Tu, D., Eck, M. J., Chen, Z. J., & Wu, H. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.029 · Cited by 280 · see citing works

Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling

Sun, L., Xing, Y., Chen, X., Zheng, Y., Yang, Y., Nichols, D. B., Clementz, M. A., Banach, B. S., Li, K., Baker, S. C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030802 · Cited by 269 · see citing works

Innate Immune Recognition of an AT-Rich Stem-Loop DNA Motif in the Plasmodium falciparum Genome

Sharma, S., DeOliveira, R. B., Kalantari, P., Parroche, P., Goutagny, N., Jiang, Z., Chan, J., Bartholomeu, D. C., Lauw, F. N., Hall, J. P., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.016 · Cited by 258 · see citing works

Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN

Zhang, X., Brann, T. W., Zhou, M., Yang, J., Oguariri, R. M., Lidie, K. B., Imamichi, H., Huang, D.-W., Lempicki, R. A., Baseler, M. W., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003389 · Cited by 249 · see citing works

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

Holm, C. K., Jensen, S. B., Jakobsen, M. R., Cheshenko, N., Horan, K., Moeller, H. B., Gonzalez‐Dosal, R., Rasmussen, S. B., Christensen, M. H., Yarovinsky, T. O., et al. (2012) · Nature Immunology · doi:10.1038/ni.2350 · Cited by 247 · see citing works

Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

Shang, G., Zhu, D., Li, N., Zhang, J., Zhu, C., Lu, D., Liu, C., Yu, Q., Zhao, Y., Xu, S., et al. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2332 · Cited by 232 · see citing works

The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor for Human Cytomegalovirus Replication

Gariano, G. R., Dell'Oste, V., Bronzini, M., Gatti, D., Luganini, A., De Andrea, M., Gribaudo, G., Gariglio, M., & Landolfo, S. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002498 · Cited by 227 · see citing works

Bacterial c-di-GMP Is an Immunostimulatory Molecule

Karaolis, D. K. R., Means, T. K., Yang, D., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2171 · Cited by 222 · see citing works

Innate immune recognition of, and regulation by, DNA

Ishii, K. J., & Akira, S. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.09.002 · Cited by 222 · see citing works

The structural basis for the sensing and binding of cyclic di-GMP by STING

Huang, Y.-H., Liu, X., Du, X., Jiang, Z., & Su, X. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2333 · Cited by 213 · see citing works

Human Cytomegalovirus Induces the Interferon Response via the DNA Sensor ZBP1

DeFilippis, V. R., Alvarado, D. M., Sali, T. M., Rothenburg, S., & Früh, K. (2009) · Journal of Virology · doi:10.1128/jvi.01748-09 · Cited by 204 · see citing works

DHX9 Pairs with IPS-1 To Sense Double-Stranded RNA in Myeloid Dendritic Cells

Zhang, Z., Yuan, B., Lu, N., Facchinetti, V., & Liu, Y. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101307 · Cited by 184 · see citing works

Streptococcus pneumoniae DNA Initiates Type I Interferon Signaling in the Respiratory Tract

Parker, D., Martin, F. J., Soong, G., Harfenist, B. S., Aguilar, J. L., Ratner, A. J., Fitzgerald, K. A., Schindler, C., & Prince, A. S. (2011) · mBio · doi:10.1128/mbio.00016-11 · Cited by 151 · see citing works

Type I Interferon Production Induced by Streptococcus pyogenes-Derived Nucleic Acids Is Required for Host Protection

Gratz, N., Hartweger, H., Matt, U., Kratochvill, F., Janos, M., Sigel, S., Drobits, B., Li, X.-D., Knapp, S., & Kovarik, P. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001345 · Cited by 131 · see citing works

STING Mediates Neuronal Innate Immune Response Following Japanese Encephalitis Virus Infection

Nazmi, A., Mukhopadhyay, R., Dutta, K., & Basu, A. (2012) · Scientific Reports · doi:10.1038/srep00347 · Cited by 129 · see citing works

Identification and characterization of a loss-of-function human MPYS variant

Jin, L., Xu, L., Yang, I. V., Davidson, E. J., Schwartz, D. A., Wurfel, M. M., & Cambier, J. C. (2011) · Genes and Immunity · doi:10.1038/gene.2010.75 · Cited by 127 · see citing works

Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16

Conrady, C. D., Zheng, M., Fitzgerald, K. A., Liu, C.-J., & Carr, D. J. J. (2012) · Mucosal Immunology · doi:10.1038/mi.2011.63 · Cited by 118 · see citing works

Streptococcus pneumoniae Stimulates a STING- and IFN Regulatory Factor 3-Dependent Type I IFN Production in Macrophages, which Regulates RANTES Production in Macrophages, Cocultured Alveolar Epithelial Cells, and Mouse Lungs

Koppe, U., Högner, K., Doehn, J.-M., Müller, H. C., Witzenrath, M., Gutbier, B., Bauer, S., Pribyl, T. M., Hammerschmidt, S., Lohmeyer, J., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004143 · Cited by 113 · see citing works

Stimulator of IFN Gene Is Critical for Induction of IFN-β during Chlamydia muridarum Infection

Prantner, D., Darville, T. L., & Nagarajan, U. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903704 · Cited by 109 · see citing works

Activation of Autophagy by α-Herpesviruses in Myeloid Cells Is Mediated by Cytoplasmic Viral DNA through a Mechanism Dependent on Stimulator of IFN Genes

Rasmussen, S. B., Horan, K., Holm, C. K., Stranks, A. J., Mettenleiter, T. C., Simon, A. K., Jensen, S. B., Rixon, F. J., He, B., & Paludan, S. R. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100949 · Cited by 103 · see citing works

IFNβ responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI)

Lippmann, J., Rothenburg, S., Deigendesch, N., Eitel, J., Meixenberger, K., van Laak, V., Slevogt, H., N’Guessan, P. D., Hippenstiel, S., Chakraborty, T., et al. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01232.x · Cited by 89 · see citing works

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice

Lippmann, J., Müller, H. C., Naujoks, J., Tabeling, C., Shin, S., Witzenrath, M., Hellwig, K., Kirschning, C. J., Taylor, G. A., Barchet, W., et al. (2011) · Cellular Microbiology · doi:10.1111/j.1462-5822.2011.01646.x · Cited by 87 · see citing works

Interferon action: nucleolar and nucleoplasmic localization of the interferon-inducible 72-kD protein that is encoded by the Ifi 204 gene from the gene 200 cluster.

Choubey, D., & Lengyel, P. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.116.6.1333 · Cited by 86 · see citing works

MyD88 and STING Signaling Pathways Are Required for IRF3-Mediated IFN-β Induction in Response to Brucella abortus Infection

de Almeida, L. A., Carvalho, N. B., Oliveira, F. S., Lacerda, T. L. S., Vasconcelos, A. C., Nogueira, L. D. L., Báfica, A. L. B., Silva, A. M., & Oliveira, S. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023135 · Cited by 83 · see citing works

A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells

Furr, S. R., Chauhan, V. S., Moerdyk-Schauwecker, M. J., & Marriott, I. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-99 · Cited by 74 · see citing works

Cytosolic DNA-Activated Human Dendritic Cells Are Potent Activators of the Adaptive Immune Response

Kis‐Tóth, K., Szántó, A., Thai, T., & Tsokos, G. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100469 · Cited by 68 · see citing works

Sensing Adenovirus Infection: Activation of Interferon Regulatory Factor 3 in RAW 264.7 Cells

Stein, S. C., & Falck-Pedersen, E. (2012) · Journal of Virology · doi:10.1128/jvi.07071-11 · Cited by 67 · see citing works

Cellular Reactive Oxygen Species Inhibit MPYS Induction of IFNβ

Jin, L., Lenz, L. L., & Cambier, J. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015142 · Cited by 43 · see citing works

DNA-dependent activator of interferon-regulatory factors inhibits hepatitis B virus replication

Chen, Q. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i22.2850 · Cited by 18 · see citing works

Control of adaptive immunity by the innate immune system

Iwasaki, A., & Medzhitov, R. (2015) · Nature Immunology · doi:10.1038/ni.3123 · Cited by 2,160 · see citing works

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

Corrales, L., Glickman, L. H., McWhirter, S. M., Kanne, D. B., Sivick, K. E., Katibah, G. E., Woo, S.-R., Lemmens, E., Banda, T., Leong, J. J., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.031 · Cited by 1,560 · see citing works

Combination strategies with PD-1/PD-L1 blockade: current advances and future directions

Yi, M., Zheng, X., Niu, M., Zhu, S., Ge, H., & Wu, K. (2022) · Molecular Cancer · doi:10.1186/s12943-021-01489-2 · Cited by 1,445 · see citing works

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF-κB Activation through TBK1

Abe, T., & Barber, G. N. (2014) · Journal of Virology · doi:10.1128/jvi.00037-14 · Cited by 767 · see citing works

cGAS-STING, an important pathway in cancer immunotherapy

Jiang, M., Chen, P., Wang, L., Li, W., Chen, B., Liu, Y., Wang, H., Zhao, S., Ye, L., He, Y., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00916-z · Cited by 647 · see citing works

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

Watson, R. O., Bell, S. L., MacDuff, D. A., Kimmey, J. M., Diner, E. J., Olivas, J., Vance, R. E., Stallings, C. L., Virgin, H. W., & Cox, J. S. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.05.004 · Cited by 645 · see citing works

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

Huang, L. S., Hong, Z., Wu, W., Xiong, S., Zhong, M., Gao, X., Rehman, J., & Malik, A. B. (2020) · Immunity · doi:10.1016/j.immuni.2020.02.002 · Cited by 435 · see citing works

Activating cGAS-STING pathway for the optimal effect of cancer immunotherapy

Li, A., Yi, M., Qin, S., Song, Y., Chu, Q., & Wu, K. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0721-x · Cited by 413 · see citing works

Molecular Mechanisms of Radiation-Induced Cancer Cell Death: A Primer

Sia, J., Szmyd, R., Hau, E., & Gee, H. E. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00041 · Cited by 378 · see citing works

The molecular basis of tight nuclear tethering and inactivation of cGAS

Zhao, B., Xu, P., Rowlett, C. M., Jing, T., Shinde, O., Lei, Y., West, A. P., Liu, W. R., & Li, P. (2020) · Nature · doi:10.1038/s41586-020-2749-z · Cited by 261 · see citing works

Role of the cGAS–STING pathway in cancer development and oncotherapeutic approaches

Khoo, L. T., & Chen, L. (2018) · The EMBO Reports · doi:10.15252/embr.201846935 · Cited by 204 · see citing works

Accumulation of Cytoplasmic DNA Due to ATM Deficiency Activates the Microglial Viral Response System with Neurotoxic Consequences

Song, X., Ma, F., & Herrup, K. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0774-19.2019 · Cited by 133 · see citing works

Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant.

Folcher, M., Oesterle, S., Zwicky, K., Thekkottil, T., Heymoz, J., Hohmann, M., Christen, M., Daoud El-Baba, M., Buchmann, P., & Fussenegger, M. (2014) · Nature Communications · doi:10.1038/ncomms6392 · Cited by 130 · see citing works

Multiplexed Digital Spatial Protein Profiling Reveals Distinct Phenotypes of Mononuclear Phagocytes in Livers with Advanced Fibrosis

Lee, J., Kim, C. M., Cha, J. H., Park, J. Y., Yu, Y. S., Wang, H. J., Sung, P. S., Jung, E. S., & Bae, S. H. (2022) · Cells · doi:10.3390/cells11213387 · Cited by 16 · see citing works

Self-assembled cGAMP-STINGΔTM signaling complex as a bioinspired platform for cGAMP delivery

He, Y., Hong, C., Yan, E. Z., Fletcher, S. J., Zhu, G., Yang, M., Li, Y., Sun, X., Irvine, D. J., Li, J., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba7589 · Cited by 61 · see citing works

In vitro STING Activation with the cGAMP-STINGΔTM Signaling Complex

He, Y., Hong, C., Irvine, D. J., et al. (2021) · BIO-PROTOCOL · doi:10.21769/bioprotoc.3905 · Cited by 4 · see citing works

STING inhibitors target the cyclic dinucleotide binding pocket

Hong, Z., Mei, J., Li, C., Bai, G., Maimaiti, M., Hu, H., Yu, W., Sun, L., Zhang, L., Cheng, D., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2105465118 · Cited by 291 · see citing works

Prolonged activation of innate immune pathways by a polyvalent STING agonist

Li, S., Luo, M., Wang, Z., Feng, Q., Wilhelm, J., Wang, X., Li, W., Wang, J., Cholka, A., Fu, Y., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-020-00675-9 · Cited by 323 · see citing works

Taking the STING out of cytosolic DNA sensing

Diner, E. J., & Vance, R. E. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.10.011 · Cited by 18 · see citing works