The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
SigB-Dependent General Stress Response in Bacillus subtilis and Related Gram-Positive Bacteria
Abstract
One of the strongest and most noticeable responses of Bacillus subtilis cells to a range of stress and starvation stimuli is the dramatic induction of about 150 SigB-dependent general stress genes. The activity of SigB itself is tightly regulated by a complex signal transduction cascade with at least three main signaling pathways that respond to environmental stress, energy depletion, or low temperature. The SigB-dependent response is conserved in related gram-positive bacteria but is missing in strictly anaerobic or in some facultatively anaerobic gram-positive bacteria. It covers functions from nonspecific and multiple stress resistance to the control of virulence in pathogenic bacteria. A comprehensive understanding of this crucial stress response is essential not only for bacterial physiology but also for applied microbiology, including pathogenicity and pathogen control.
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Cites
Essential Bacillus subtilis genes
Kobayashi, K., Ehrlich, S. D., Albertini, A., Amati, G., Andersen, K. K., Arnaud, M., Asai, K., Ashikaga, S., Aymerich, S., Bessieres, P., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730515100 · Cited by 1,328
Self-citationgisela-storz (2000) · Cited by 866
Horsburgh, M. J., Aish, J. L., White, I. J., Shaw, L., Lithgow, J. K., & Foster, S. J. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.19.5457-5467.2002 · Cited by 699
The sigma factors of Bacillus subtilis
Haldenwang, W. G. (1995) · Microbiological Reviews · doi:10.1128/mmbr.59.1.1-30.1995 · Cited by 576
Global Analysis of the General Stress Response of Bacillus subtilis
Petersohn, A., Brigulla, M., Haas, S., Hoheisel, J. D., Völker, U., & Hecker, M. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.19.5617-5631.2001 · Cited by 433
Self-citationMicroarray-Based Analysis of the Staphylococcus aureus σBRegulon
Bischoff, M., Dunman, P., Kormanec, J., Macapagal, D., Murphy, E., Mounts, W., Berger-Bächi, B., & Projan, S. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.13.4085-4099.2004 · Cited by 401
Listeria monocytogenes σBRegulates Stress Response and Virulence Functions
Kazmierczak, M. J., Mithoe, S. C., Boor, K. J., & Wiedmann, M. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.19.5722-5734.2003 · Cited by 370
General stress response of Bacillus subtilis and other bacteria
Hecker, M., & Völker, U. (2001) · Advances in Microbial Physiology · doi:10.1016/s0065-2911(01)44011-2 · Cited by 328
Self-citationMilohanic, E., Glaser, P., Coppée, J., Frangeul, L., Vega, Y., Vázquez‐Boland, J. A., Kunst, F., Cossart, P., & Buchrieser, C. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03413.x · Cited by 325
Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon
Mascher, T., Margulis, N. G., Wang, T., Ye, R. W., & Helmann, J. D. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03786.x · Cited by 310
Cited by
Stress-activated Genomic Expression Changes Serve a Preparative Role for Impending Stress in Yeast
Berry, D. B., & Gasch, A. P. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-07-0680 · Cited by 326
Bervoets, I., & Charlier, D. (2019) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuz001 · Cited by 180
Hoffmann, T., Wensing, A., Brosius, M., Steil, L., Volker, U., & Bremer, E. (2013) · Journal of Bacteriology · doi:10.1128/jb.01505-12 · Cited by 109
Management of Osmotic Stress by Bacillus Subtilis: Genetics and Physiology
Hoffmann, T., & Bremer, E. (2016) · Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria · doi:10.1002/9781119004813.ch63 · Cited by 39
de Jong, I. G., Veening, J., & Kuipers, O. P. (2012) · Environmental Microbiology · doi:10.1111/j.1462-2920.2012.02892.x · Cited by 36
Metadata
- Authors
- Hecker, M., Pané-Farré, J., & Uwe, V.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2007-10-01
- Volume
- 61
- Issue
- 1
- Pages
- 215-236
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2167468292
- Cited by
- 474
- References
- 70
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: SigB-Dependent General Stress Response in Bacillus subtilis and Related Gram-Positive Bacteria. https://app.cochat.ai/papers/10.1146/annurev.micro.61.080706.093445
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- Hecker, M., Pané-Farré, J., & Uwe, V. (2007). SigB-Dependent General Stress Response in Bacillus subtilis and Related Gram-Positive Bacteria. Annual Review of Microbiology. https://doi.org/10.1146/annurev.micro.61.080706.093445
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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