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Surface Treatments of Polymers for Biocompatibility
Abstract
Biological recognition mediates cell and tissue interactions with biomaterials, be the materials employed in a biotechnical environment in vitro or a biomedical environment in vivo. These interactions are typically mediated by proteins that have adsorbed to the biomaterial surface. The principles of protein adsorption and biological recognition are described. Polymer surface modifications to reduce protein adsorption upon biomaterial surfaces are summarized, as are modifications to enhance the irreversible adsorption of proteins. Using these approaches, it may be possible to reduce the extent to which the biomaterial surface and the protein-biomaterial surface are recognized by cells and tissues. Polymer surface modifications to incorporate oligopeptide-, saccharide-, and oligosaccharide-based receptor-binding sequences are described to enable direct binding of cells with the polymer surface. With use of these approaches, it is possible to endow an entirely synthetic material with the biological recognition characteristics of biological macromolecules.
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Cited by
Polymeric Scaffolds in Tissue Engineering Application: A Review
Dhandayuthapani, B., Yoshida, Y., Maekawa, T., & Kumar, D. S. (2011) · International Journal of Polymer Science · doi:10.1155/2011/290602 · Cited by 1,773
Nano-engineering block copolymer aggregates for drug delivery
Allen, C., Maysinger, D., & Eisenberg, A. (1999) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/s0927-7765(99)00058-2 · Cited by 1,358
Polyethylene glycol (PEG): A versatile polymer for pharmaceutical applications
D’souza, A. A., & Shegokar, R. (2016) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2016.1182485 · Cited by 1,282
Biocompatible polymer materials: Role of protein–surface interactions
Chen, H., Yuan, L., Song, W., Wu, Z., & Li, D. (2008) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2008.07.006 · Cited by 706
Proteins, platelets, and blood coagulation at biomaterial interfaces
Xu, L.-C., Bauer, J. W., & Siedlecki, C. A. (2014) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2014.09.040 · Cited by 391
Metadata
- Authors
- Elbert, D. L., & Hubbell, J. A.
- Venue
- Annual Review of Materials Science
- Publisher
- Annual Reviews
- Published
- 1996-08
- Volume
- 26
- Issue
- 1
- Pages
- 365-394
- ISSN
- 0084-6600 (ISSN-L)
- OpenAlex
- W2126758920
- Cited by
- 531
- References
- 0
- FWCI
- 10.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Elbert, D. L., & Hubbell, J. A. (1996). Surface Treatments of Polymers for Biocompatibility. Annual Review of Materials Science. https://doi.org/10.1146/annurev.ms.26.080196.002053
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