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Calcium Action in Synaptic Transmitter Release
Abstract
In this review we are concerned with the mechanisms by which the electrical potential across the membrane of presynaptic nerve terminals regulates the release of neurotransmitter substances into the synaptic cleft . ions play a central role in this process: Release occurs when a voltage-depen dent channel in the presynaptic membrane opens, thus permitting an influx of ions and diffusion of in cytoplasm, followed by binding of at some cytoplasmic site that triggers the exocytotic release of quanta of neurotransmitter. These concepts, introduced mainly by the work of Katz and associates (Katz 1 969), comprise the Ca of trans mitter release, a hypothesis now widely accepted. Although the general role of as a presynaptic messenger is well supported, many important specifics of its action remain to be resolved. We review progress with these details in three parts, corresponding to
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Cited by
Multiple types of neuronal calcium channels and their selective modulation
Tsien, R. W., Lipscombe, D., Madison, D. V., Bley, K. R., & Fox, A. P. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90194-4 · Cited by 1,381
Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface
Brose, N., Petrenko, A. G., Südhof, T. C., & Jahn, R. (1992) · Science · doi:10.1126/science.1589771 · Cited by 979
Exocytotic Ca2+ channels in mammalian central neurons
Dunlap, K., Luebke, J. I., & Turner, T. J. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)80030-6 · Cited by 915
Dominant Role of N-Type Ca 2+ Channels in Evoked Release of Norepinephrine from Sympathetic Neurons
Hirning, L. D., Fox, A. P., McCleskey, E. W., Olivera, B. M., Thayer, S. A., Miller, R. J., & Tsien, R. W. (1988) · Science · doi:10.1126/science.2447647 · Cited by 853
Calcium-binding proteins: selective markers of nerve cells
Andressen, C., Bl�mcke, I., & Celio, M. R. (1993) · Cell and Tissue Research · doi:10.1007/bf00318606 · Cited by 699
Metadata
- Authors
- Augustine, G. J., Charlton, M. P., & Smith, S. J.
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 1987-03
- Volume
- 10
- Issue
- 1
- Pages
- 633-693
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2176475744
- Cited by
- 738
- References
- 0
- FWCI
- 23.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Augustine, G. J., Charlton, M. P., & Smith, S. J. (1987). Calcium Action in Synaptic Transmitter Release. Annual Review of Neuroscience. https://doi.org/10.1146/annurev.ne.10.030187.003221
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
