Cited by 132Biochemical Acid Research StudiesDietary Effects on HealthAlcoholism and Thiamine Deficiency

Regulation of the pyruvate dehydrogenase multienzyme complex

Behal, R. H., Buxton, D. B., Robertson, J. G., Olson, M. S.·1993·Annual Review of Nutrition

Abstract

The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved ...Read More

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Crossref · 10.1146/annurev.nu.13.070193.002433

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  • The PDHC is allosterically inhibited by NADH, acetyl-CoA, and ATP, making it a potent sensor of TCA cycle activity and a critical node of TCA cycle regulation.

    “The PDHC is allosterically inhibited by NADH, acetyl-CoA, and ATP, making it a potent sensor of TCA cycle activity and thus a critical node of TCA cycle regulation (discussed further) (52).”

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Authors
Behal, R. H., Buxton, D. B., Robertson, J. G., & Olson, M. S.
Affiliations
The University of Texas at San Antonio Health Science Center (US)
Venue
Annual Review of Nutrition
Published
1993-07
Volume
13
Issue
1
Pages
497-520
ISSN
  • 0199-9885 (ISSN-L)
  • 1545-4312
OpenAlex
W2173424827
Cited by
132
References
0
Citations by year
2026: 3 · 2025: 3 · 2024: 7 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 3 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 4
FWCI
3.63
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hl024654-10)
  • National Heart, Lung, and Blood Institute (HL-24654)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
Keywords
pyruvate dehydrogenase complex, enzyme regulation, intermittent fasting, health benefits of fasting, physiological mechanisms, metabolic regulation
MeSH terms
Animals, Catalysis, Homeostasis, Hormones, Humans, Pyruvate Dehydrogenase Complex, Pyruvate Dehydrogenase Complex Deficiency Disease

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