The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Nutrigenomics, Rumen-Derived Bioactive Fatty Acids, and the Regulation of Milk Fat Synthesis
Abstract
Mammary synthesis of milk fat continues to be an active research area, with significant advances in the regulation of lipid synthesis by bioactive fatty acids (FAs). The biohydrogenation theory established that diet-induced milk fat depression (MFD) in the dairy cow is caused by an inhibition of mammary synthesis of milk fat by specific FAs produced during ruminal biohydrogenation. The first such FA shown to affect milk fat synthesis was trans-10, cis-12 conjugated linoleic acid, and its effects have been well characterized, including dose-response relationships. During MFD, lipogenic capacity and transcription of key mammary lipogenic genes are coordinately down-regulated. Results provide strong evidence for sterol response element-binding protein-1 (SREBP1) and Spot 14 as biohydrogenation intermediate responsive lipogenic signaling pathway for ruminants and rodents. The study of MFD and its regulation by specific rumen-derived bioactive FAs represents a successful example of nutrigenomics in present-day animal nutrition research and offers several potential applications in animal agriculture.
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Cites
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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794
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Self-citationN UTRITIONAL R EGULATION OF M ILK F AT S YNTHESIS
Bauman, D. E., & Griinari, J. M. (2003) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.23.011702.073408 · Cited by 1,163
Self-citationThe Composition of Bovine Milk Lipids: January 1995 to December 2000
Jensen, R. G. (2002) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(02)74079-4 · Cited by 1,076
Conjugated Linoleic Acid Is Synthesized Endogenously in Lactating Dairy Cows by Δ9-Desaturase
Griinari, J. M., Nurmela, K. V. V., Corl, B. A., Lacy, S. H., Chouinard, P. Y., & Bauman, D. E. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.9.2285 · Cited by 1,054
Self-citationNutrient sensing and inflammation in metabolic diseases
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Digestion and metabolism in the ruminant
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Feed and Animal Factors Influencing Milk Fat Composition
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Cited by
Effects of a spoilage yeast from silage on in vitro ruminal fermentation
Santos, M. C., Lock, A. L., Mechor, G. D., & Kung, L. (2015) · Journal of Dairy Science · doi:10.3168/jds.2014-8683 · Cited by 27
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Metadata
- Authors
- Bauman, D. E., Harvatine, K. J., & Lock, A. L.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2011-08-21
- Volume
- 31
- Issue
- 1
- Pages
- 299-319
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2153488254
- Cited by
- 317
- References
- 122
- FWCI
- 9.28
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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