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Cited by 4,794

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, Jay D., Goldstein, Joseph L., Brown, Michael S.·2002·Journal of Clinical Investigation
DOI 10.1172/jci15593
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Abstract

Lipid homeostasis in vertebrate cells is regulated by a family of membrane-bound transcription factors designated sterol regulatory element-binding proteins (SREBPs).SREBPs directly activate the expression of more than 30 genes dedicated to the synthesis and uptake of cholesterol, fatty acids, triglycerides, and phospholipids, as well as the NADPH cofactor required to synthesize these molecules (1-4).In the liver, three SREBPs regulate the production of lipids for export into the plasma as lipoproteins and into the bile as micelles.The complex, interdigitated roles of these three SREBPs have been dissected through the study of ten different lines of gene-manipulated mice.These studies form the subject of this review.

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Crossref · 10.1172/jci0215593

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Research works printed but not linked: 45

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Metadata

Authors
Horton, J. D., Goldstein, J. L., & Brown, M. S.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2002-05-01
Volume
109
Issue
9
Pages
1125-1131
ISSN
0021-9738
DOI
10.1172/jci15593
Cited by
4,794
References
2
Language
en

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