The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
S ARCOPENIA, W EIGHT L OSS, AND N UTRITIONAL F RAILTY IN THE E LDERLY
Abstract
▪ Abstract The progression of the aging process leads to a decreased margin of homeostatic reserve and a reduced ability to accommodate metabolic challenges, including nutritional stress. Nutritional frailty refers to the disability that occurs in old age owing to rapid, unintentional loss of body weight and loss of lean body mass (sarcopenia). Sarcopenia, a loss of muscle mass and strength, contributes to functional impairment. Weight loss is commonly due to a reduction in food intake; its possible etiology includes a host of physiological and nonphysiological causes. The release of cytokines during chronic disease may also be an important determinant of frailty. In addition to being anorectic, cytokines also contribute to lipolysis, muscle protein breakdown, and nitrogen loss. Whereas the multiple causes of nutritional frailty are not completely understood, clinical interventions for weight loss, sarcopenia, and cytokine alterations have been used with modest success.
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Citations
Cites
1 retracted
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Cited by
Garvey, W. T., Mechanick, J. I., Brett, E. M., Garber, A. J., Hurley, D. L., Jastreboff, A. M., Nadolsky, K., Pessah-Pollack, R., & Plodkowski, R. (2016) · Endocrine Practice · doi:10.4158/ep161365.gl · Cited by 1,914
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Molecular inflammation: Underpinnings of aging and age-related diseases
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Sarcopenic obesity: a critical appraisal of the current evidence
Prado, C. M. M., Wells, J. C. K., Smith, S. R., Stephan, B. C. M., & Siervo, M. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.06.010 · Cited by 589
Metadata
- Authors
- Bales, C. W., & Ritchie, C. S.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2002-07
- Volume
- 22
- Issue
- 1
- Pages
- 309-323
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2130431850
- Cited by
- 346
- References
- 90
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: S ARCOPENIA, W EIGHT L OSS, AND N UTRITIONAL F RAILTY IN THE E LDERLY. https://app.cochat.ai/papers/10.1146/annurev.nutr.22.010402.102715
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- Bales, C. W., & Ritchie, C. S. (2002). S ARCOPENIA, W EIGHT L OSS, AND N UTRITIONAL F RAILTY IN THE E LDERLY. Annual Review of Nutrition. https://doi.org/10.1146/annurev.nutr.22.010402.102715
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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