The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
ChREBP, a Transcriptional Regulator of Glucose and Lipid Metabolism
Abstract
Dysregulations in hepatic lipid synthesis are often associated with obesity and type 2 diabetes, and therefore a perfect understanding of the regulation of this metabolic pathway appears essential to identify potential therapeutic targets. Recently, the transcription factor ChREBP (carbohydrate-responsive element-binding protein) has emerged as a major mediator of glucose action on lipogenic gene expression and as a key determinant of lipid synthesis in vivo. Indeed, liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in obese ob/ob mice. Since ChREBP cellular localization is a determinant of its functional activity, a better knowledge of the mechanisms involved in regulating its nucleo-cytoplasmic shuttling and/or its post-translational activation is crucial in both physiology and physiopathology. Here, we review some of the studies that have begun to elucidate the regulation and function of this key transcription factor in liver.
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Nonalcoholic Fatty Liver Disease
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Self-citationVaulont, S., Munnich, A., Decaux, J. F., & Kahn, A. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57443-9 · Cited by 147
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Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028
Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation
Lefebvre, P., Cariou, B., Lien, F., Kuipers, F., & Staels, B. (2009) · Physiological Reviews · doi:10.1152/physrev.00010.2008 · Cited by 1,678
Bile acid signaling in metabolic disease and drug therapy
Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935
The randle cycle revisited: a new head for an old hat.
Hue, L., & Taegtmeyer, H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00093.2009 · Cited by 743
Kammoun, H. L., Chabanon, H., Hainault, I., Luquet, S., Magnan, C., Koike, T., Ferré, P., & Foufelle, F. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37007 · Cited by 732
Metadata
- Authors
- Postic, C., Dentin, R., Denechaud, P.-D., & Girard, J.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2007-08-01
- Volume
- 27
- Issue
- 1
- Pages
- 179-192
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2139450675
- Cited by
- 283
- References
- 6
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Postic, C., Dentin, R., Denechaud, P.-D., & Girard, J. (2007). ChREBP, a Transcriptional Regulator of Glucose and Lipid Metabolism. Annual Review of Nutrition. https://doi.org/10.1146/annurev.nutr.27.061406.093618
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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