The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
ChREBP, a Transcriptional Regulator of Glucose and Lipid Metabolism
Abstract
Dysregulations in hepatic lipid synthesis are often associated with obesity and type 2 diabetes, and therefore a perfect understanding of the regulation of this metabolic pathway appears essential to identify potential therapeutic targets. Recently, the transcription factor ChREBP (carbohydrate-responsive element-binding protein) has emerged as a major mediator of glucose action on lipogenic gene expression and as a key determinant of lipid synthesis in vivo. Indeed, liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in obese ob/ob mice. Since ChREBP cellular localization is a determinant of its functional activity, a better knowledge of the mechanisms involved in regulating its nucleo-cytoplasmic shuttling and/or its post-translational activation is crucial in both physiology and physiopathology. Here, we review some of the studies that have begun to elucidate the regulation and function of this key transcription factor in liver.
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The role of ChREBP in carbohydrate sensing and NAFLD development
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Metadata
- Authors
- Postic, C., Dentin, R., Denechaud, P.-D., & Girard, J.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2007-08-01
- Volume
- 27
- Issue
- 1
- Pages
- 179-192
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2139450675
- Cited by
- 283
- References
- 6
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
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