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Cited by 743Metabolism, Diabetes, and CancerAdipose Tissue and MetabolismLipid metabolism and biosynthesis

The randle cycle revisited: a new head for an old hat.

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Hue, Louis, Taegtmeyer, Heinrich·2009·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.00093.2009PMC PMC2739696
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Abstract

In 1963, Lancet published a paper by Randle et al. that proposed a “glucose-fatty acid cycle” to describe fuel flux between and fuel selection by tissues. The original biochemical mechanism explained the inhibition of glucose oxidation by fatty acids. Since then, the principle has been confirmed by many investigators. At the same time, many new mechanisms controlling the utilization of glucose and fatty acids have been discovered. Here, we review the known short- and long-term mechanisms involved in the control of glucose and fatty acid utilization at the cytoplasmic and mitochondrial level in mammalian muscle and liver under normal and pathophysiological conditions. They include allosteric control, reversible phosphorylation, and the expression of key enzymes. However, the complexity is formidable. We suggest that not all chapters of the Randle cycle have been written.

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Cited by

Sorted by citations

Authors
Hue, L., & Taegtmeyer, H.
Affiliations
de Duve Institute (BE)
ORCID
Taegtmeyer, Heinrich
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
2009-09
Volume
297
Issue
3
Pages
E578-E591
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.00093.2009
PMC
PMC2739696
OpenAlex
W2119901011
Cited by
743
References
21
Citations by year
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FWCI
2.17
Type
journal article
Language
en
Open access
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Libraries (submittedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R01HL061483, R01HL073162)
  • National Center for Research Resources (M01RR002558)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
Randle cycle, glucose-fatty acid cycle, glucose oxidation, fatty acid oxidation, fuel selection, allosteric regulation, reversible phosphorylation, enzyme expression, skeletal muscle, liver, mitochondrial metabolism, glucose utilization, fatty acid utilization
MeSH terms
Animals, Energy Metabolism, Fatty Acids, Glucose, Humans, Insulin Resistance, Mitochondria, Models, Biological, Stress, Physiological, Substrate Cycling

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