The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Sugar Absorption in the Intestine: The Role of GLUT2
Abstract
Intestinal glucose absorption comprises two components. One is classical active absorption mediated by the Na+/glucose cotransporter. The other is a diffusive component, formerly attributed to paracellular flow. Recent evidence, however, indicates that the diffusive component is mediated by the transient insertion of glucose transporter type 2 (GLUT2) into the apical membrane. This apical GLUT2 pathway of intestinal sugar absorption is present in species from insect to human, providing a major route at high sugar concentrations. The pathway is regulated by rapid trafficking of GLUT2 to the apical membrane induced by glucose during assimilation of a meal. Apical GLUT2 is therefore a target for multiple short-term and long-term nutrient-sensing mechanisms. These include regulation by a newly recognized pathway of calcium absorption through the nonclassical neuroendocrine l-type channel Ca v 1.3 operating during digestion, activation of intestinal sweet taste receptors by natural sugars and artificial sweeteners, paracrine and endocrine hormones, especially insulin and GLP-2, and stress. Permanent apical GLUT2, resulting in increased sugar absorption, is a characteristic of experimental diabetes and of insulin-resistant states induced by fructose and fat. The nutritional consequences of apical and basolateral GLUT2 regulation are discussed in the context of Western diet, processed foods containing artificial sweeteners, obesity, and diabetes.
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Citations
Cites
Biology of Incretins: GLP-1 and GIP
Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
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T1R3 and gustducin in gut sense sugars to regulate expression of Na + -glucose cotransporter 1
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Active sugar transport in health and disease
Wright, E. M., Hirayama, B. A., & Loo, D. F. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01746.x · Cited by 627
Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo
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Glucose sensing in the intestinal epithelium
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Cited by
The SLC2 (GLUT) family of membrane transporters
Mueckler, M., & Thorens, B. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.07.001 · Cited by 1,328
Glucose transporters in the 21st Century
Thorens, B., & Mueckler, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00712.2009 · Cited by 1,013
Roopchand, D. E., Carmody, R. N., Kuhn, P., Moskal, K., Rojas-Silva, P., Turnbaugh, P. J., & Raskin, I. (2015) · Diabetes · doi:10.2337/db14-1916 · Cited by 678
Gorboulev, V., Schürmann, A., Vallon, V., Kipp, H., Jaschke, A., Klessen, D., Friedrich, A., Scherneck, S., Rieg, T., Cunard, R., et al. (2012) · Diabetes · doi:10.2337/db11-1029 · Cited by 687
Seed filling in domesticated maize and rice depends on SWEET-mediated hexose transport
Sosso, D., Luo, D., Li, Q.-B., Sasse, J., Yang, J., Gendrot, G., Suzuki, M., Koch, K. E., McCarty, D. R., Chourey, P. S., et al. (2015) · Nature Genetics · doi:10.1038/ng.3422 · Cited by 506
Metadata
- Authors
- Kellett, G. L., Brot-Laroche, E., Mace, O. J., & Leturque, A.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2008-08-01
- Volume
- 28
- Issue
- 1
- Pages
- 35-54
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2109132990
- Cited by
- 492
- References
- 7
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kellett, G. L., Brot-Laroche, E., Mace, O. J., & Leturque, A. (2008). Sugar Absorption in the Intestine: The Role of GLUT2. Annual Review of Nutrition. https://doi.org/10.1146/annurev.nutr.28.061807.155518
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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