Risk factors for myocardial infarction and death in newly detected NIDDM: the Diabetes Intervention Study, 11-year follow-up
Open accessAbstract
The Diabetes Intervention Study (DIS) is a prospective population-based multicentre trial of newly detected cases of non-insulin-dependent diabetes mellitus (NIDDM). This report analyses the risk factors for subsequent coronary heart disease and all-cause death during the 11-year follow-up. The prognostic significance of the categories of the NIDDM Policy Group was validated with respect to the incidence of coronary heart disease and mortality. At baseline 1139 subjects, aged 30-55 years at the time of diabetes detection and classified as diet controlled after a 6-week screening phase, were included. Of the patients 112 (15.2%) suffered from myocardial infarction, 197 (19.82%) of 994 had died. The odds ratio for all-cause mortality compared to the general population for males at the age of 36-45 years was 5.1 and for females 7.0. In multivariate analysis age, blood pressure and smoking were independent risk factors for myocardial infarction and male sex, age, blood pressure, triglycerides, postprandial blood glucose and smoking for death, respectively. The categories of the NIDDM Policy Group target parameters for blood glucose, triglycerides and blood pressure were significant predictors of both CHD and death. Thus, it appears that in NIDDM good control of blood glucose, blood pressure and triglycerides is associated with a lower incidence of coronary heart disease and death rate respectively.
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Postprandial hyperglycemia is a risk factor for CVD, particularly in diabetic patients.
“Postprandial hyperglycemia is a risk factor for CVD, particularly in diabetic patients [49-51].”
From The case for low carbohydrate diets in diabetes management (2005) · cites this paper as [49]
The adverse effect of post-prandial or post-challenge hyperglycaemia appears stronger than that of fasting hyperglycaemia.
“The adverse impact of post-prandial or post-challenge (OGTT) hyperglycaemia seems to be even stronger than that of fasting hyperglycaemia [5][6][7][8][9].”
From Prevalence and correlates of post-prandial hyperglycaemia in a large sample of patients with type 2 diabetes mellitus (2006) · cites this paper as [5]
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- Authors
- Hanefeld, M., Fischer, S., Julius, U., Schulze, J., Schwanebeck, U., Schmechel, H., Ziegelasch, H. J., & Lindner, J.
- Affiliations
- Technische Universität Dresden (DE)
- Klinikum Chemnitz (DE)
- Venue
- Diabetologia
- Published
- 1996-11-21
- Volume
- 39
- Issue
- 12
- Pages
- 1577-1583
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2076693232
- Cited by
- 873
- References
- 20
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 7 · 2023: 10 · 2022: 14 · 2021: 17 · 2020: 18 · 2019: 13 · 2018: 25 · 2017: 27 · 2016: 27 · 2015: 18 · 2014: 36 · 2013: 34 · 2012: 41
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- type 2 diabetes, myocardial infarction, coronary artery disease, all-cause mortality, risk factors, glycemic control, blood pressure, triglycerides, postprandial blood glucose, smoking, sex differences, newly diagnosed diabetes
- MeSH terms
- Adult, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction, Prospective Studies, Risk Factors, Sex Factors, Time Factors, Cohort Studies, Incidence, Multivariate Analysis
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