Urokinase plasminogen activator receptor is expressed in invasive cells in gastric carcinomas from high‐ and low‐risk countries

Alpízar‐Alpízar, Warner; Nielsen, Boye Schnack; Sierra, Rafaela; Illemann, Martin; Ramírez, Jose A.; Arias, Adriana; Durán, Sundry; Skarstein, Arne; Ovrebo, Kjell; Lund, Leif R.; Laerum, Ole D.

doi:10.1002/ijc.24755

Cited by 36Protease and Inhibitor MechanismsHelicobacter pylori-related gastroenterology studiesGastric Cancer Management and Outcomes

Urokinase plasminogen activator receptor is expressed in invasive cells in gastric carcinomas from high‐ and low‐risk countries

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Alpízar‐Alpízar, Warner, Nielsen, Boye Schnack, Sierra, Rafaela, Illemann, Martin, Ramírez, Jose A., Arias, Adriana, Durán, Sundry, Skarstein, Arne +3 more·2010·International Journal of Cancer

DOI 10.1002/ijc.24755

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Abstract

Gastric cancer is the second cancer causing death worldwide. Both incidence and mortality rates vary according to geographical regions. The receptor for urokinase plasminogen activator (uPAR) is involved in extracellular matrix degradation by mediating cell surface associated plasminogen activation, and its presence on gastric cancer cells is linked to micro‐metastasis and poor prognosis. Immunohistochemical analyses of a set of 44 gastric cancer lesions from Costa Rica showed expression of uPAR in cancer cells in both intestinal subtype (14 of 27) and diffuse subtype (10 of 17). We compared the expression pattern of uPAR in gastric cancers from a high‐risk country (Costa Rica) with a low‐risk country (Norway). We found uPAR on gastric cancer cells in 24 of 44 cases (54%) from Costa Rica and in 13 of 23 cases (56%) from Norway. uPAR was seen in macrophages and neutrophils in all cases. We also examined the nonneoplastic mucosa and found that uPAR was more frequently seen in epithelial cells located at the luminal edge of the crypts in cases with Helicobacter pylori infection than in similar epithelial cells in noninfected mucosa ( p = 0.033; χ 2 = 4.54). In conclusion, the expression of uPAR in cancer cells in more than half of the gastric cancer cases suggests that their uPAR‐positivity do not contribute to explain the different mortality rates between the 2 countries, however, the actual prevalence of uPAR‐positive cancer cells in the gastric cancers may still provide prognostic information.

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Unlike normal tissues, uPA and uPAR levels are constitutively increased in majority of cancer types.
“Unlike normal tissues, uPA and uPAR levels are constitutively increased in majority of cancer types.153,154”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [153]

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Authors: Alpízar‐Alpízar, W., Nielsen, B. S., Sierra, R., Illemann, M., Ramírez, J. A., Arias, A., Durán, S., Skarstein, A., Ovrebo, K., Lund, L. R., & Laerum, O. D.
Affiliations: Haukeland University Hospital (NO)
Rigshospitalet (DK)
Universidad de Costa Rica (CR)
University of Copenhagen (DK)
Corresponding author: Alpízar‐Alpízar, Warner
ORCID: Alpízar‐Alpízar, Warner
Nielsen, Boye Schnack
Illemann, Martin
Venue: International Journal of Cancer
Publisher: Wiley
Published: 2009-08-24
Volume: 126
Issue: 2
Pages: 405-415
ISSN: 0020-7136 (ISSN-L)
1097-0215
DOI: 10.1002/ijc.24755
OpenAlex: W2069768752
Cited by: 36
References: 62
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 6
FWCI: 1.11
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations: International Journal of Cancer (publishedVersion)
PubMed (publishedVersion)
Americanae (AECID Library) (submittedVersion, cc-by-nc)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Lundbeckfonden
Universidad de Costa Rica
Haukeland Universitetssjukehus
H. Lundbeck A/S
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gastric Cancer Management and Outcomes
Keywords: urokinase-type plasminogen activator receptor, gastric cancer, gastric cancer incidence, Helicobacter pylori infection, gastric mucosa, macrophages, neutrophils, extracellular matrix degradation, plasminogen activation, tumor invasion, prognostic factors, Costa Rica, Norway
MeSH terms: Antibodies, Bacterial, Costa Rica, Fluorescent Antibody Technique, Gastric Mucosa, Immunohistochemistry, Macrophages, Neoplasm Invasiveness, Neutrophils, Norway, Prognosis, Stomach Neoplasms, Helicobacter pylori, Helicobacter Infections, Microscopy, Confocal, Receptors, Urokinase Plasminogen Activator

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Urokinase plasminogen activator receptor is expressed in invasive cells in gastric carcinomas from high‐ and low‐risk countries

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