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Cited by 345

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Tissue Renin-Angiotensin-Aldosterone Systems: Targets for Pharmacological Therapy

Bader, Michael·2010·Annual Review of Pharmacology and Toxicology
DOI 10.1146/annurev.pharmtox.010909.105610
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Abstract

The renin-angiotensin-aldosterone system is one of the most important systems in cardiovascular control and in the pathogenesis of cardiovascular diseases. Therefore, it is already a very successful drug target for the therapy of these diseases. However, angiotensins are generated not only in the plasma but also locally in tissues from precursors and substrates either locally expressed or imported from the circulation. In most areas of the brain, only locally generated angiotensins can exert effects on their receptors owing to the blood-brain barrier. Other tissue renin-angiotensin-aldosterone systems are found in cardiovascular organs such as kidney, heart, and vessels and play important roles in the function of these organs and in the deleterious actions of hypertension and diabetes on these tissues. Novel components with mostly opposite actions to the classical renin-angiotensin-aldosterone systems have been described and need functional characterization to evaluate their suitability as novel drug targets.

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Crossref · 10.1146/annurev.pharmtox.010909.105610

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Metadata

Authors
Bader, M.
Venue
Annual Review of Pharmacology and Toxicology
Publisher
Annual Reviews
Published
2010-02-01
Volume
50
Issue
1
Pages
439-465
ISSN
  • 0362-1642 (ISSN-L)
  • 1545-4304
DOI
10.1146/annurev.pharmtox.010909.105610
OpenAlex
W2157466080
Cited by
345
References
9
FWCI
4.04
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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