The relationship between vitamin D and the renin-angiotensin system in the pathophysiology of hypertension, kidney disease, and diabetes

Vaidya, Anand; Williams, Jonathan S.

doi:10.1016/j.metabol.2011.09.007

Cited by 151Renin-Angiotensin System StudiesVitamin D Research StudiesParathyroid Disorders and Treatments

The relationship between vitamin D and the renin-angiotensin system in the pathophysiology of hypertension, kidney disease, and diabetes

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Vaidya, Anand, Williams, Jonathan S.·2012·Metabolism

DOI 10.1016/j.metabol.2011.09.007PMC PMC3290690

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Abstract

Vitamin D has been implicated in the pathophysiology of extraskeletal conditions such as hypertension, kidney disease, and diabetes via its ability to negatively regulate the renin-angiotensin system (RAS). This article reviews the evidence supporting a link between vitamin D and the RAS in these conditions, with specific emphasis on translational observations and their limitations. A literature review of animal and human studies evaluating the role of vitamin D in hypertension, kidney disease, and diabetes was performed. Excess activity of the RAS has been implicated in the pathogenesis of hypertension, chronic kidney disease, decreased insulin secretion, and insulin resistance. Animal studies provide strong support for 1,25-dihydroxyvitamin D(3)-mediated downregulation of renin expression and RAS activity via its interaction with the vitamin D receptor. Furthermore, the activity of vitamin D metabolites in animals is associated with reductions in blood pressure, proteinuria and renal injury, and with improved β-cell function. Many observational, and a few interventional, studies in humans have supported these findings; however, there is a lack of well-designed prospective human interventional studies to definitively assess clinical outcomes. There is a need for more well-designed prospective interventional studies to validate this hypothesis in human clinical outcomes.

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Vitamin D Deficiency
Holick, M. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmra070553 · Cited by 13,720 · see citing works
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Pitt, B., Zannad, F., Remme, W. J., Cody, R., Castaigne, A., Perez, A., Palensky, J., & Wittes, J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411001 · Cited by 9,214 · see citing works
Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663 · see citing works
Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (LIFE): A randomised trial against atenolol
Dahlöf, B., Devereux, R. B., Kjeldsen, S. E., Julius, S., Beevers, G., de Faire, U., Fyhrquist, F., Ibsen, H., Kristiansson, K., Lederballe-Pedersen, O., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08089-3 · Cited by 5,407 · see citing works
Vitamin D
Norman, A. W. (1979) · Cited by 3,770 · see citing works
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Pitt, B., Zannad, F. M., Remme, W. J., Cody, R. J., Castaigne, A., Pérez, A. J. P., Palensky, J., & Wittes, J. T. (2000) · Survey of Anesthesiology · doi:10.1097/00132586-200006000-00059 · Cited by 2,927 · see citing works
Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study
Hyppönen, E., Läärä, E., Reunanen, A., Järvelin, M., & Virtanen, S. M. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06580-1 · Cited by 1,920 · see citing works
Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Bouillon, R., Carmeliet, G., Verlinden, L., van Etten, E., Verstuyf, A., Luderer, H. F., Lieben, L., Mathieu, C., & Demay, M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0004 · Cited by 1,783 · see citing works
1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
Li, Y. C., Kong, J., Wei, M., Chen, Z.-F., Liu, S. Q., & Cao, L.-P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215219 · Cited by 1,625 · see citing works
Textbook of Endocrinology
Williams, R. M., Wilson, J. D., & Foster, D. W. (1952) · Diabetes · doi:10.2337/diab.1.2.159 · Cited by 1,449 · see citing works
Vitamin D: modulator of the immune system
Baeke, F., Takiishi, T., Korf, H., Gysemans, C. A., & Mathieu, C. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.04.001 · Cited by 1,312 · see citing works
Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis
Elliott, W. J., & Meyer, P. M. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60108-1 · Cited by 1,016 · see citing works
Serum 25-Hydroxyvitamin D, Diabetes, and Ethnicity in the Third National Health and Nutrition Examination Survey
Scragg, R. K. R., Sowers, M. R., & Bell, C. (2004) · Diabetes Care · doi:10.2337/diacare.27.12.2813 · Cited by 964 · see citing works
Survival of Patients Undergoing Hemodialysis with Paricalcitol or Calcitriol Therapy
Teng, M. F., Wolf, M. S., Lowrie, E. G., Ofsthun, N. J., Lazarus, J. M., & Thadhani, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022536 · Cited by 922 · see citing works
Plasma 25-Hydroxyvitamin D Levels and Risk of Incident Hypertension
Forman, J. P., Giovannucci, E. L., Holmes, M. D., Bischoff-Ferrari, H. A., Tworoger, S. S., Willett, W. C., & Curhan, G. C. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.087288 · Cited by 896 · see citing works
A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolutionPreprint
Ramagopalan, S. V., Heger, A., Berlanga‐Taylor, A. J., Maugeri, N., Lincoln, M. R., Burrell, A. M., Handunnetthi, L., Handel, A. E., Disanto, G., Orton, S. M., et al. (2010) · Genome Research · doi:10.1101/gr.107920.110 · Cited by 871 · see citing works
1,25-Dihydroxyvitamin D3 increases the expression of the CaT1 epithelial calcium channel in the Caco-2 human intestinal cell line
Wood, R. J., Tchack, L., & Taparia, S. (2001) · BMC Physiology · doi:10.1186/1472-6793-1-11 · Cited by 852 · see citing works
Activated Injectable Vitamin D and Hemodialysis Survival
Teng, M. F., Wolf, M. S., Ofsthun, M. N., Lazarus, J. M., Hernán, M. Á., Camargo, C. A., & Thadhani, R. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004070573 · Cited by 777 · see citing works
Systematic Review: Vitamin D and Cardiometabolic Outcomes
Pittas, A. G., Chung, M. C., Trikalinos, T., Mitri, J., Brendel, M., Patel, K., Lichtenstein, A. H., Lau, J., & Balk, E. M. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-5-201003020-00009 · Cited by 753 · see citing works
Effect of ramipril on the incidence of diabetes
(2006) · New England Journal of Medicine · doi:10.1056/nejmoa065061 · Cited by 737 · see citing works
Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)2vitamin D3: Genomic and non-genomic mechanisms
Haussler, M. R., Jurutka, P. W., Mizwicki, M. T., & Norman, A. W. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2011.05.010 · Cited by 696 · see citing works
Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial
de Zeeuw, D., Agarwal, R., Amdahl, M., Audhya, P., Coyne, D. W., Garimella, T. S., Parving, H., Pritchett, Y., Remuzzi, G., Ritz, E., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61032-x · Cited by 694 · see citing works
Effect of valsartan on the incidence of diabetes and cardiovascular events
(2010) · New England Journal of Medicine · doi:10.1056/nejmoa1001121 · Cited by 660 · see citing works
Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient – a randomised, placebo-controlled trial
von Hurst, P. R., Stonehouse, W., & Coad, J. (2010) · British Journal of Nutrition · doi:10.1017/s0007114509992017 · Cited by 624 · see citing works
Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance
Forouhi, N. G., Luan, J., Cooper, A., Boucher, B. J., & Wareham, N. J. (2008) · Diabetes · doi:10.2337/db08-0593 · Cited by 613 · see citing works
Effects of a Short-Term Vitamin D3 and Calcium Supplementation on Blood Pressure and Parathyroid Hormone Levels in Elderly Women1
Pfeifer, M., Begerow, B., Minne, H. W., Nachtigall, D., & Hansen, C. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.4.7393 · Cited by 593 · see citing works
Serum 25-hydroxyvitamin D, Ethnicity, and Blood Pressure in the Third National Health and Nutrition Examination Survey
Scragg, R. K. R., Sowers, M., & BELL, C. (2007) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2007.01.017 · Cited by 577 · see citing works
Vitamin D and type 2 diabetes: a systematic review
Mitri, J., Muraru, M., & Pittas, A. G. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.118 · Cited by 577 · see citing works
Serum Aldosterone and the Incidence of Hypertension in Nonhypertensive Persons
Vasan, R. S., Evans, J. C., Larson, M. G., Wilson, P. W. F., Meigs, J. B., Rifai, N., Benjamin, E. J., & Levy, D. A. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033263 · Cited by 573 · see citing works
Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems
Xiang, W., Kong, J., Chen, S., Cao, L., Qiao, G., Zheng, W., Liu, W., Li, X., Gardner, D. G., & Li, Y. C. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00224.2004 · Cited by 570 · see citing works
Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers
Zittermann, A., Frisch, S., Berthold, H. K., Götting, C., Kühn, J., Kleesiek, K., Stehle, P., Koertke, H., & Köerfer, R. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27004 · Cited by 556 · see citing works
Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels
Sugden, J., Davies, J. I., Witham, M. D., Morris, A. D., & Struthers, A. D. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02360.x · Cited by 554 · see citing works
Ultraviolet B and blood pressure
Krause, R., Bühring, M., Hopfenmüller, W., Holick, M. F., & Sharma, A. M. (1998) · The Lancet · doi:10.1016/s0140-6736(05)60827-6 · Cited by 514 · see citing works
1,25-Dihydroxyvitamin D3 Suppresses Renin Gene Transcription by Blocking the Activity of the Cyclic AMP Response Element in the Renin Gene Promoter
Yuan, W., Pan, W., Kong, J., Zheng, W., Szeto, F. L., Wong, K. E., Cohen, R., Kłopot, A., Zhang, Z., & Li, Y. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705495200 · Cited by 491 · see citing works
Ultraviolet Light May Contribute to Geographic and Racial Blood Pressure Differences
Rostand, S. G. (1997) · Hypertension · doi:10.1161/01.hyp.30.2.150 · Cited by 472 · see citing works
Vitamin D Insufficiency and Deficiency in Chronic Kidney Disease
González, E. A., Sachdeva, A., Oliver, D. A., & Martin, K. J. (2004) · American Journal of Nephrology · doi:10.1159/000081023 · Cited by 439 · see citing works
Vitamin D levels and patient outcome in chronic kidney disease
Ravani, P., Malberti, F., Tripepi, G. L., Pecchini, P., Cutrupi, S., Pizzini, P., Mallamaci, F., & Zoccali, C. (2008) · Kidney International · doi:10.1038/ki.2008.501 · Cited by 435 · see citing works
Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus
Available, N. A. N. (1999) · Diabetologia · doi:10.1007/s001250051112 · Cited by 420 · see citing works
Effect of Vitamin D Deficiency and Replacement on Endothelial Function in Asymptomatic Subjects
Tarçın, Ö., Yavuz, D. G., Özben, B., Telli, A., Öğünç, A. V., Yüksel, M., Toprak, A. C., Yazıcı, D., Sancak, S., Deyneli, O., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1212 · Cited by 418 · see citing works
Vitamin D and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
Elamin, M. B., Elnour, N. O. A., Elamin, K. B., Fatourechi, M. M., Alkatib, A. A., Almandoz, J. P., Liu, H., Lane, M. A., Mullan, R. J., Hazem, A., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0398 · Cited by 412 · see citing works
Vitamin D status and arterial hypertension: a systematic review
Pilz, S., Tomaschitz, A., Ritz, E., & Pieber, T. R. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.135 · Cited by 397 · see citing works
Effect of vitamin D on blood pressure: a systematic review and meta-analysis
Witham, M. D., Nadir, M. A., & Struthers, A. D. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32832f075b · Cited by 396 · see citing works
Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1α-hydroxylase knockout mice
Zhou, C., Lu, F., Cao, K., Xu, D., Goltzman, D., & Miao, D. (2008) · Kidney International · doi:10.1038/ki.2008.101 · Cited by 391 · see citing works
25-Hydroxyvitamin D, IGF-1, and Metabolic Syndrome at 45 Years of Age
Hyppönen, E., Boucher, B. J., Berry, D. J., & Power, C. (2007) · Diabetes · doi:10.2337/db07-1122 · Cited by 388 · see citing works
Antiproteinuric effect of oral paricalcitol in chronic kidney disease
Agarwal, R., Acharya, M., Tian, J., Hippensteel, R., Melnick, J. Z., Qiu, P., Williams, L. A., & BATLLE, D. C. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00755.x · Cited by 375 · see citing works
Calcium-Regulating Hormones in Essential Hypertension
Resnick, L. M., MÜLLER, F. B., & LARAGH, J. H. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-5-649 · Cited by 371 · see citing works
Calcium Plus Vitamin D Supplementation and the Risk of Incident Diabetes in the Women's Health Initiative
de Boer, I. H., Tinker, L. F., Connelly, S., Curb, J. D., Howard, B. V., Kestenbaum, B. R., Larson, J. C., Manson, J. E., Margolis, K. L., Siscovick, D. S., et al. (2008) · Diabetes Care · doi:10.2337/dc07-1829 · Cited by 366 · see citing works
Vitamin D Status Is Associated With Arterial Stiffness and Vascular Dysfunction in Healthy Humans
Mheid, I. A., Patel, R. S., Murrow, J. R., Morris, A. A., Rahman, A. M., Fike, L. V., Kavtaradze, N., Uphoff, I., Hooper, C. W., Tangpricha, V., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.02.051 · Cited by 361 · see citing works
25-Hydroxyvitamin D Deficiency Is Associated With Inflammation-Linked Vascular Endothelial Dysfunction in Middle-Aged and Older Adults
Jablonski, K., Chonchol, M., Pierce, G. L., Walker, A. E., & Seals, D. R. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.160929 · Cited by 360 · see citing works
Vitamin D status and health correlates among German adults
Hintzpeter, B., Mensink, G., Thierfelder, W., Müller, M., & Scheidt‐Nave, C. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602825 · Cited by 358 · see citing works
Vitamin D regulation of the renin–angiotensin system
Li, Y. C. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10343 · Cited by 357 · see citing works
Lower risk for cardiovascular mortality in oral 1 -hydroxy vitamin D3 users in a haemodialysis population
Shoji, T., Shinohara, K., Kimoto, E., Emoto, M., Tahara, H., Koyama, H., Inaba, M., Fukumoto, S., Ishimura, E., Miki, T., et al. (2003) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg513 · Cited by 350 · see citing works
Tissue Renin-Angiotensin-Aldosterone Systems: Targets for Pharmacological Therapy
Bäder, M. (2010) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105610 · Cited by 344 · see citing works
Serum 25-Hydroxyvitamin D Concentration and Subsequent Risk of Type 2 Diabetes
Sarkkola, C., Knekt, P., Männistö, S., Rissanen, H. A., Laaksonen, M. A., Montonen, J., & Reunanen, A. (2007) · Diabetes Care · doi:10.2337/dc07-0292 · Cited by 336 · see citing works
Plasma 25-Hydroxyvitamin D Levels and Risk of Incident Hypertension Among Young Women
Forman, J. P., Curhan, G. C., & Taylor, E. N. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.117630 · Cited by 334 · see citing works
Effects of a Short-Term Vitamin D3 and Calcium Supplementation on Blood Pressure and Parathyroid Hormone Levels in Elderly Women
Pfeifer, M. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.4.1633 · Cited by 334 · see citing works
Plasma 25-Hydroxyvitamin D and Regulation of the Renin-Angiotensin System in Humans
Forman, J. P., Williams, J. S., & Fisher, N. D. L. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.148619 · Cited by 331 · see citing works
Self-citation
Paricalcitol Reduces Albuminuria and Inflammation in Chronic Kidney Disease
Alborzi, P., Patel, N. K., Peterson, C., Bills, J. E., Bekele, D. M., Bunaye, Z., Light, R. P., & Agarwal, R. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.113159 · Cited by 331 · see citing works
Serum Vitamin D and Subsequent Occurrence of Type 2 Diabetes
Knekt, P., Laaksonen, M. A., Sarkkola, C., Härkänen, T., Marniemi, J., Heliövaara, M., Rissanen, H. A., Montonen, J., & Reunanen, A. (2008) · Epidemiology · doi:10.1097/ede.0b013e318176b8ad · Cited by 329 · see citing works
A double‐blind, randomized, placebo‐controlled trial of the short‐term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle‐aged, centrally obese men
Nagpal, J., Pande, J. N., & Bhartia, A. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2008.02636.x · Cited by 313 · see citing works
Plasma 25-Hydroxyvitamin D Is Associated with Markers of the Insulin Resistant Phenotype in Nondiabetic Adults
Liu, E., Meigs, J. B., Pittas, A. G., McKeown, N. M., Economos, C. D., Booth, S. L., & Jacques, P. F. (2008) · Journal of Nutrition · doi:10.3945/jn.108.093831 · Cited by 310 · see citing works
The EURODIAB Substudy 2 Study Group Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus
de Beaufort, C. E. (1999) · Diabetologia · Cited by 307 · see citing works
Vitamin D Supplementation in Chronic Kidney Disease
Kandula, P., Dobre, M. A., Schold, J. D., Schreiber, M. J., Mehrotra, R., & Navaneethan, S. D. (2010) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03940510 · Cited by 300 · see citing works
25-Hydroxyvitamin D Levels and Albuminuria in the Third National Health and Nutrition Examination Survey (NHANES III)
de Boer, I. H., Ioannou, G. N., Kestenbaum, B. R., Brunzell, J. D., & Weiss, N. S. (2007) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2007.04.015 · Cited by 293 · see citing works
Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: Blockade of compensatory renin increase
Zhang, Z., Zhang, Y., Ning, G., Deb, D. K., Kong, J., & Li, Y. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803751105 · Cited by 289 · see citing works
Improved Islet Morphology after Blockade of the Renin- Angiotensin System in the ZDF Rat
Tikellis, C., Wookey, P. J., Candido, R., Andrikopoulos, S., Thomas, M. C., & Cooper, M. E. (2004) · Diabetes · doi:10.2337/diabetes.53.4.989 · Cited by 286 · see citing works
Vitamin D, Parathyroid Hormone Levels, and the Prevalence of Metabolic Syndrome in Community-Dwelling Older Adults
Reis, J. P., von Mühlen, D. G., Kritz‐Silverstein, D. C., Wingard, D. L., & Barrett-Connor, E. L. (2007) · Diabetes Care · doi:10.2337/dc06-2438 · Cited by 281 · see citing works
Daily consumption of vitamin D– or vitamin D + calcium–fortified yogurt drink improved glycemic control in patients with type 2 diabetes: a randomized clinical trial
Nikooyeh, B., Neyestani, T. R., Farvid, M., Alavi-Majd, H., Houshiarrad, A., Kalayi, A., Shariatzadeh, N., Gharavi, A., Heravifard, S., Tayebinejad, N., et al. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.007336 · Cited by 277 · see citing works
Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome
Li, R., Brereton, R. E., Anderson, R. A., Wallace, A. M., & Ho, C. K. M. (2011) · Metabolism · doi:10.1016/j.metabol.2011.03.002 · Cited by 264 · see citing works
Association of Oral Calcitriol with Improved Survival in Nondialyzed CKD
Shoben, A. B., Rudser, K. D., de Boer, I. H., Young, B. A., & Kestenbaum, B. R. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007111164 · Cited by 254 · see citing works
Supplementation with calcium + vitamin D enhances the beneficial effect of weight loss on plasma lipid and lipoprotein concentrations.
Major, G. C., Alarie, F. P., Doré, J., Phouttama, S., & Tremblay, A. (2007) · PubMed · doi:10.1093/ajcn/85.1.54 · Cited by 251 · see citing works
Effect of Calcium and Vitamin D Supplementation on Blood Pressure
Margolis, K. L., Ray, R. M., Horn, L. V., Manson, J. E., Allison, M., Black, H. R., Beresford, S. A. A., Connelly, S. A., Curb, J. D., Grimm, R. H., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.114991 · Cited by 251 · see citing works
Blood 25-hydroxyvitamin D concentration and hypertension: a meta-analysis
Burgaz, A., Orsini, N., Larsson, S. C., & Wolk, A. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834320f9 · Cited by 249 · see citing works
Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin–angiotensin system
Tomaschitz, A., Pilz, S., Ritz, E., Grammer, T., Drechsler, C., Boehm, B. O., & März, W. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.05.037 · Cited by 246 · see citing works
Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels
Jorde, R., & Figenschau, Y. (2009) · European Journal of Nutrition · doi:10.1007/s00394-009-0020-3 · Cited by 244 · see citing works
Vitamin D Receptor Attenuates Renal Fibrosis by Suppressing the Renin-Angiotensin System
Zhang, Y., Kong, J., Deb, D. K., Chang, A., & Li, Y. C. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009080872 · Cited by 242 · see citing works
Serum 25-Hydroxyvitamin D, Calcium Intake, and Risk of Type 2 Diabetes After 5 Years
Gagnon, C., Lu, Z. X., Magliano, D. J., Dunstan, D. W., Shaw, J. E., Zimmet, P., Sikaris, K. A., Grantham, N., Ebeling, P. R., & Daly, R. M. (2011) · Diabetes Care · doi:10.2337/dc10-2167 · Cited by 241 · see citing works
Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets
Lau, T., Carlsson, P., & Leung, P. S. (2004) · Diabetologia · doi:10.1007/s00125-003-1295-1 · Cited by 230 · see citing works
Vitamin D status and parathyroid hormone levels in relation to blood pressure: a population‐based study in older men and women
Snijder, M. B., Lips, P. T. A. M., Seidell, J. C., Visser, M., Deeg, D. J. H., Dekker, J. M., & van Dam, R. M. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01778.x · Cited by 230 · see citing works
No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year
Jorde, R., Sneve, M., Torjesen, P. A., & Figenschau, Y. (2009) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02181.x · Cited by 229 · see citing works
Plasma 25-Hydroxyvitamin D Concentration and Risk of Incident Type 2 Diabetes in Women
Pittas, A. G., Sun, Q., Manson, J. E., Dawson-Hughes, B. F., & Hu, F. B. (2010) · Diabetes Care · doi:10.2337/dc10-0790 · Cited by 218 · see citing works
Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination Survey
Judd, S. E., Nanes, M. S., Ziegler, T. R., Wilson, P. W. F., & Tangpricha, V. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.136 · Cited by 215 · see citing works
Adiponectin: A Key Player in Obesity Related Disorders
Matsuzawa, Y. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210791208893 · Cited by 203 · see citing works
Oral active vitamin D is associated with improved survival in hemodialysis patients
Naves‐Díaz, M., Álvarez-Hernández, D., Passlick‐Deetjen, J., Guinsburg, A. M., Marelli, C., Rodrı́guez-Puyol, D., & Cannata-Andía, J. B. (2008) · Kidney International · doi:10.1038/ki.2008.343 · Cited by 194 · see citing works
Oral Paricalcitol in the Treatment of Patients With CKD and Proteinuria: A Randomized Trial
Fishbane, S. N., Chittineni, H., Packman, M., Dutka, P., Ali, N. M., & Durie, N. M. (2009) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2009.04.036 · Cited by 190 · see citing works
Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population
Gannagé‐Yared, M., Chédid, R., Khalifé, S., Azzi, E., Zoghbi, F., & Halaby, G. (2009) · European Journal of Endocrinology · doi:10.1530/eje-08-0952 · Cited by 182 · see citing works
Angiotensin II Type 1 Receptor Blockade Improves β-Cell Function and Glucose Tolerance in a Mouse Model of Type 2 Diabetes
Chu, K. Y., Lau, T., Carlsson, P., & Leung, P. S. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1022 · Cited by 179 · see citing works
Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the Framingham Offspring Study
Liu, E., Meigs, J. B., Pittas, A. G., Economos, C. D., McKeown, N. M., Booth, S. L., & Jacques, P. F. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28441 · Cited by 169 · see citing works
Vitamin D Levels and Mortality in Type 2 Diabetes
Joergensen, C., Gall, M.-A., Schmedes, A., Tarnow, L., Parving, H., & Rossing, P. R. (2010) · Diabetes Care · doi:10.2337/dc10-0582 · Cited by 167 · see citing works
Vitamin D Affects Survival Independently of Vascular Calcification in Chronic Kidney Disease
Barreto, D. V., Barreto, F. C., Liabeuf, S., Temmar, M., Boitte, F., Choukroun, G. J., Fournier, A. E., & Massy, Z. A. (2009) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00260109 · Cited by 167 · see citing works
Impact of Activated Vitamin D and Race on Survival among Hemodialysis Patients
Wolf, M. S., Betancourt, J. R., Chang, Y., Shah, A., Teng, M. F., Tamez, H. E., Gutiérrez, O. M., Camargo, C. A., Melamed, M. L., Norris, K. C., et al. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007091002 · Cited by 161 · see citing works
Vitamin D3 Supplementation for 16 Weeks Improves Flow-Mediated Dilation in Overweight African-American Adults
Harris, R. A., Pedersen-White, J., Guo, D.-H., Stallmann-Jorgensen, I. S., Keeton, D., Huang, Y., Shah, Y., Zhu, H., & Dong, Y. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.12 · Cited by 159 · see citing works
No association of vitamin D intake or 25-hydroxyvitamin D levels in childhood with risk of islet autoimmunity and type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY)
Simpson, M. D., Brady, H. L., Yin, X., Seifert, J. A., Barriga, K. J., Hoffman, M., Bugawan, T. L., Barón, A. E., Sokol, R. J., Eisenbarth, G. S., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2278-2 · Cited by 156 · see citing works
25‐Hydroxyvitamin D Concentration Correlates With Insulin‐Sensitivity and BMI in Obesity
Muscogiuri, G., Sorice, G. P., Prioletta, A., Policola, C., Casa, S. D., Pontecorvi, A., & Giaccari, A. (2010) · Obesity · doi:10.1038/oby.2010.11 · Cited by 151 · see citing works
Vitamin D and Hypertension
Vaidya, A., & Forman, J. P. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.140160 · Cited by 147 · see citing works
Self-citation
Association of A1C Levels With Vitamin D Status in U.S. Adults
Kositsawat, J., Freeman, V. L., Gerber, B. S., & Geraci, S. A. (2010) · Diabetes Care · doi:10.2337/dc09-2150 · Cited by 138 · see citing works
The impact of vitamin D deficiency on diabetes and cardiovascular risk
Baz-Hecht, M., & Goldfine, A. B. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283372859 · Cited by 135 · see citing works
Serum 25-Hydroxyvitamin D Levels Are Strongly Related to Systolic Blood Pressure But Do Not Predict Future Hypertension
Jorde, R., Figenschau, Y., Emaus, N., Hutchinson, M. S., & Grimnes, G. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.143990 · Cited by 135 · see citing works
Oral cholecalciferol decreases albuminuria and urinary TGF-β1 in patients with type 2 diabetic nephropathy on established renin–angiotensin–aldosterone system inhibition
Kim, M.-J., Frankel, A., Donaldson, M., Darch, S. J., Pusey, C. D., Hill, P. D., Mayr, M., & Tam, F. W. K. (2011) · Kidney International · doi:10.1038/ki.2011.224 · Cited by 133 · see citing works
Vitamin D Deficiency Is Associated with Depletion of Circulating Endothelial Progenitor Cells and Endothelial Dysfunction in Patients with Type 2 Diabetes
Yiu, Y.-F., Chan, Y., Yiu, K., Siu, C., Li, S.-W., Wong, L.-Y., Lee, S. W. L., Tam, S., Wong, E. W. K., Cheung, B. M. Y., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2212 · Cited by 133 · see citing works
Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes
Deb, D. K., Sun, T., Wong, K. E., Zhang, Z., Ning, G., Zhang, Y., Kong, J., Shi, H., Chang, A., & Li, Y. C. (2010) · Kidney International · doi:10.1038/ki.2010.22 · Cited by 128 · see citing works
Effect of winter oral vitamin D3 supplementation on cardiovascular risk factors in elderly adults.
Scragg, R. K. R., Khaw, K., & Murphy, S. W. (1995) · PubMed · Cited by 126 · see citing works
Serum 25-Hydroxyvitamin D and Change in Estimated Glomerular Filtration Rate
de Boer, I. H., Katz, R., Chonchol, M., Ix, J. H., Sarnak, M. J., Shlipak, M. G., Siscovick, D. S., & Kestenbaum, B. R. (2011) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02640311 · Cited by 121 · see citing works
Association of Kidney Function, Vitamin D Deficiency, and Circulating Markers of Mineral and Bone Disorders in CKD
Ureña, P., Metzger, M., Haymann, J., Karras, A., Boffa, J., Flamant, M., Vrtovsnik, F., Gauci, C., Froissart, M., Houillier, P., et al. (2011) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2011.04.029 · Cited by 118 · see citing works
Vitamin D Levels, Microvascular Complications, and Mortality in Type 1 Diabetes
Joergensen, C., Hovind, P. H., Schmedes, A., Parving, H., & Rossing, P. R. (2011) · Diabetes Care · doi:10.2337/dc10-2459 · Cited by 117 · see citing works
Low-salt diet increases insulin resistance in healthy subjects
Garg, R., Williams, G. H., Hurwitz, S., Brown, N. J., Hopkins, P. N., & Adler, G. K. (2010) · Metabolism · doi:10.1016/j.metabol.2010.09.005 · Cited by 108 · see citing works
Oral Calcitriol for the Treatment of Persistent Proteinuria in Immunoglobulin A Nephropathy: An Uncontrolled Trial
Szeto, C., Chow, K., Kwan, B. C., Chung, K.-Y., Leung, C., & Li, P. K. (2008) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2007.12.038 · Cited by 100 · see citing works
Aldosterone Production and Insulin Resistance in Healthy Adults
Garg, R., Hurwitz, S., Williams, G. H., Hopkins, P. N., & Adler, G. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2521 · Cited by 96 · see citing works
Subacute infusion of physiological doses of parathyroid hormone raises blood pressure in humans
Fliser, D., Franek, E., FODE, P., Stefański, A., Schmitt, C. P., Lyons, M., & Ritz, E. (1997) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/12.5.933 · Cited by 94 · see citing works
The Independent Association Between 25‐Hydroxyvitamin D and Adiponectin and Its Relation With BMI in Two Large Cohorts: The NHS and the HPFS
Vaidya, A., Williams, J. S., & Forman, J. P. (2011) · Obesity · doi:10.1038/oby.2011.210 · Cited by 93 · see citing works
Self-citation
25-Hydroxyvitamin D is associated with plasma renin activity and the pressor response to dietary sodium intake in Caucasians
Vaidya, A., Forman, J. P., Hopkins, P. N., Seely, E. W., & Williams, J. S. (2011) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320310391922 · Cited by 93 · see citing works
Self-citation
Vitamin D receptor agonist doxercalciferol modulates dietary fat-induced renal disease and renal lipid metabolism
Wang, X. X., Jiang, T., Shen, Y., Santamaria, H., Solis, N., ARBEENY, C. M., & Levi, M. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00338.2010 · Cited by 89 · see citing works
Vitamin D, the renin-angiotensin system, and insulin resistance
Rammos, G., Tseke, P., & Ziakka, S. (2008) · International Urology and Nephrology · doi:10.1007/s11255-007-9244-4 · Cited by 87 · see citing works
A novel role for vitamin D: modulation of expression and function of the local renin–angiotensin system in mouse pancreatic islets
Cheng, Q., Li, Y. C., Boucher, B. J., & Leung, P. S. (2011) · Diabetologia · doi:10.1007/s00125-011-2100-1 · Cited by 87 · see citing works
Ramipril treatment suppresses islet fibrosis in Otsuka Long–Evans Tokushima fatty rats
Ko, S., Kwon, H., Kim, S., Moon, S. D., Ahn, Y., Song, K., Son, H.-S., Cha, B., Lee, K., Son, H., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.023 · Cited by 87 · see citing works
The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets
Lupi, R., Guerra, S. D., Bugliani, M., Boggi, U., Mosca, F., Torri, S., Prato, S. D., & Marchetti, P. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02086 · Cited by 87 · see citing works
High glucose increases extracellular matrix production in pancreatic stellate cells by activating the renin–angiotensin system
Ko, S., Hong, O., Kim, J., Ahn, Y.-B., Song, K., Cha, B., Son, H., Kim, M., Jeong, I., & Yoon, K. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20797 · Cited by 86 · see citing works
The association between vitamin D status and circulating adiponectin independent of adiposity in subjects with abnormal glucose tolerance
Nimitphong, H., Chanprasertyothin, S., Jongjaroenprasert, W., & Ongphiphadhanakul, B. (2009) · Endocrine · doi:10.1007/s12020-009-9216-9 · Cited by 83 · see citing works
Vitamin D and Cardiometabolic Outcomes: A Systematic Review
Pittas, A. G., Chung, M. C., Trikalinos, T. A., Mitri, J., Brendel, M., Patel, K., Lichtenstein, A. H., Lau, J., & Balk, E. M. (2010) · Annals of Internal Medicine · doi:10.1059/0003-4819-152-5-201003020-00009 · Cited by 82 · see citing works
Influence of obesity on vitamin D–binding protein and 25-hydroxy vitamin D levels in African American and white women
Winters, S. J., Chennubhatla, R., Wang, C., & Miller, J. J. (2009) · Metabolism · doi:10.1016/j.metabol.2008.10.017 · Cited by 80 · see citing works
The renin-angiotensin system and insulin resistance
Liu, Z. (2007) · Current Diabetes Reports · doi:10.1007/s11892-007-0007-5 · Cited by 75 · see citing works
Salt intake and insulin sensitivity in healthy human volunteers
Townsend, R. R., Kapoor, S. C., & McFadden, C. B. (2007) · Clinical Science · doi:10.1042/cs20060361 · Cited by 66 · see citing works
Vitamin D and Subsequent Systolic Hypertension Among Women
Griffin, F. C., Gadegbeku, C. A., & Sowers, M. R. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.226 · Cited by 56 · see citing works
Role of the Renin-Angiotensin System and Aldosterone on Cardiometabolic Syndrome
Stiefel, P., Vallejo‐Vaz, A. J., Morillo, J. S. G., & Villar, J. (2011) · International Journal of Hypertension · doi:10.4061/2011/685238 · Cited by 55 · see citing works
No effect of ultraviolet radiation on blood pressure and other cardiovascular risk factors
Scragg, R. K. R., Wishart, J., Stewart, A. W., Ofanoa, M., Kerse, N. M., Dyall, L., & Lawes, C. M. M. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e328349666d · Cited by 54 · see citing works
The influence of body mass index and renin–angiotensin–aldosterone system activity on the relationship between 25-hydroxyvitamin D and adiponectin in Caucasian men
Vaidya, A., Forman, J. P., UNDERWOOD, P. C., Hopkins, P. N., Williams, G. H., Pojoga, L. H., & Williams, J. S. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0025 · Cited by 54 · see citing works
Self-citation
1,25-Dihydroxyvitamin D as a Cardiovascular Hormone Effects on Calcium Current and Cytosolic Free Calcium in Vascular Smooth Muscle Cells
Shan, J. J., Resnick, L. M., Lewanczuk, R. Z., Karpinski, E., Li, B., & Pang, P. K. T. (1993) · American Journal of Hypertension · doi:10.1093/ajh/6.12.983 · Cited by 54 · see citing works
Relationship between serum parathyroid hormone levels in the elderly and 24 h ambulatory blood pressures
Morfis, L., Smerdely, P., & Howes, L. G. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715110-00011 · Cited by 53 · see citing works
Long-term effect of calcium-vitamin D3 fortified milk on blood pressure and serum lipid concentrations in healthy older men
Daly, R. M., & Nowson, C. A. (2009) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2008.79 · Cited by 52 · see citing works
Vitamin D and the vascular sensitivity to angiotensin II in obese Caucasians with hypertension
Vaidya, A., Forman, J. P., & Williams, J. S. (2011) · Journal of Human Hypertension · doi:10.1038/jhh.2010.110 · Cited by 52 · see citing works
Self-citation
Effects of hyperglycemia on angiotensin II receptor type 1 expression and insulin secretion in an INS-1E pancreatic beta-cell line.
Leung, K. K., & Leung, P. S. (2008) · PubMed · Cited by 47 · see citing works
No significant effect of calcium and vitamin D supplementation on blood pressure and calcium metabolism in elderly Chinese.
Pan, W., Wang, C.-Y., La, L., Kao, L. S., & Yeh, S. ‐. (1993) · PubMed · Cited by 46 · see citing works
Role of Vitamin D in Chronic Kidney Disease
Patel, T. V., & Singh, A. (2009) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2009.01.004 · Cited by 43 · see citing works
Relationship of mineral metabolism and long-term calcium and cholecalciferol supplementation to blood pressure in normotensive men
ORWOLL, E. S., & Oviatt, S. K. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/52.4.717 · Cited by 43 · see citing works
Confirmed hypertension and plasma 25(OH)D concentrations amongst elderly men
Burgaz, A., Byberg, L., Rautiainen, S., Orsini, N., Håkansson, N., Ärnlöv, J., Sundström, J., Lind, L., Melhus, H., Michaëlsson, K., et al. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02309.x · Cited by 38 · see citing works
Diabetes prevalence is associated with serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in US middle-aged Caucasian men and women: a cross-sectional analysis within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Brock, K. E., Huang, W., Fraser, D. R., Ke, L., Tseng, M., Mason, R. S., Stolzenberg‐Solomon, R. Z., Freedman, D. M., Ahn, J., Peters, U., et al. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511001590 · Cited by 37 · see citing works
Decreased insulin sensitivity during dietary sodium restriction is not mediated by effects of angiotensin II on insulin action
Perry, C. G., Palmer, T., CLELAND, S. J., Morton, I., Salt, I. P., Petrie, J. R., Gould, G. W., & Connell, J. (2003) · Clinical Science · doi:10.1042/cs20020320 · Cited by 35 · see citing works
Effect of Combination Therapy with Angiotensin Receptor Blocker and 1,25-Dihydroxyvitamin D3 in Type 2 Diabetic Nephropathy in KK-Ay/Ta Mice
Ohara, I., Tanimoto, M., Gohda, T., Yamazaki, T., Hagiwara, S., Murakoshi, M., Aoki, T., Toyoda, H., Ishikawa, Y., Funabiki, K., et al. (2010) · Nephron Experimental Nephrology · doi:10.1159/000320284 · Cited by 33 · see citing works
Inhibition of renin: an updated review of the development of renin inhibitors.
Li, Y. C. (2007) · PubMed · Cited by 30 · see citing works
Regulation of parathyroid hormone and vitamin D in essential hypertension*
Young, E. W., Morris, C. D., Holcomb, S., McMillan, G., & McCarron, D. A. (1995) · American Journal of Hypertension · doi:10.1016/0895-7061(95)00214-6 · Cited by 23 · see citing works
Which antihypertensive drugs are the most nephroprotective and why?
Cravedi, P., Ruggenenti, P. L., & Remuzzi, G. (2010) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2010.521742 · Cited by 23 · see citing works
Calciotropic hormones in salt-sensitive essential hypertension: 1,25-dihydroxyvitamin D and parathyroid hypertensive factor.
Lm, R. (1994) · PubMed · Cited by 17 · see citing works
Current Research of the RAS in Diabetes Mellitus
Leung, P. S. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-90-481-9060-7_8 · Cited by 11 · see citing works

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A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm
Garvin, M. R., Alvarez, C., Miller, J. I., Prates, E. T., Walker, A. M., Amos, B. K., Mast, A. E., Justice, A. C., Aronow, B. J., & Jacobson, D. (2020) · eLife · doi:10.7554/elife.59177 · Cited by 368 · see citing works
Vitamin D and Cardiovascular Disease
Mheid, I. A., & Quyyumi, A. A. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.05.031 · Cited by 218 · see citing works
Aldosterone and parathyroid hormone interactions as mediators of metabolic and cardiovascular disease
Tomaschitz, A., Ritz, E., Pieske, B. M., Rus-Machan, J., Kienreich, K., Verheyen, N., Gaksch, M., Grübler, M. R., Fahrleitner‐Pammer, A., Mrak, P., et al. (2013) · Metabolism · doi:10.1016/j.metabol.2013.08.016 · Cited by 167 · see citing works
Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives
Cosentino, N., Campodonico, J., Milazzo, V., Metrio, M. D., Brambilla, M., Camera, M., & Marenzi, G. (2021) · Nutrients · doi:10.3390/nu13103603 · Cited by 152 · see citing works
Vitamin D and cardiovascular disease: is the evidence solid?
Mheid, I. A., Patel, R. S., Tangpricha, V., & Quyyumi, A. A. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht166 · Cited by 141 · see citing works
Mineral Bone Disorders in Kidney Disease Patients: The Ever-Current Topic
Hu, L., Napoletano, A., Provenzano, M., Garofalo, C., Bini, C., Comai, G., & Manna, G. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012223 · Cited by 135 · see citing works
Vitamin D supplementation and glycemic control in type 2 diabetes patients: A systematic review and meta-analysis
Wu, C., Qiu, S., Zhu, X., & Li, L. (2017) · Metabolism · doi:10.1016/j.metabol.2017.05.006 · Cited by 133 · see citing works
Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder
Mansueto, P., Seidita, A., Vitale, G., Gangemi, S., Iaria, C., & Cascio, A. (2015) · BioMed Research International · doi:10.1155/2015/735615 · Cited by 108 · see citing works
The renin–angiotensin–aldosterone system and calcium-regulatory hormones
Vaidya, A., Brown, J. M., & Williams, J. S. (2015) · Journal of Human Hypertension · doi:10.1038/jhh.2014.125 · Cited by 93 · see citing works
Self-citation
Vitamin D
Feldman, D., Krishnan, A. V., & Swami, S. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00013-3 · Cited by 92 · see citing works
Human Interventions to Characterize Novel Relationships Between the Renin–Angiotensin–Aldosterone System and Parathyroid Hormone
Brown, J. M., Williams, J. S., Luther, J. M., Garg, R., Garza, A. E., Pojoga, L. H., Ruan, D. T., Williams, G. H., Adler, G. K., & Vaidya, A. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.01910 · Cited by 88 · see citing works
Self-citation
Vitamin D Deficiency Aggravates Chronic Kidney Disease Progression after Ischemic Acute Kidney Injury
Gonçalves, J. G., de Bragança, A. C., Canale, D., Shimizu, M. H. M., Sanches, T. R., Moysés, R. M. A., Andrade, L., Seguro, A. C., & Volpini, R. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107228 · Cited by 83 · see citing works
Tissue Renin–Angiotensin Systems: A Unifying Hypothesis of Metabolic Disease
Skov, J., Persson, F., Frøkiær, J., & Christiansen, J. S. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00023 · Cited by 82 · see citing works
Effect of Vitamin D Supplementation on Glucose Control and Inflammatory Response in Type II Diabetes: A Double Blind, Randomized Clinical Trial
Al‐Sofiani, M. E., Jammah, A. A., Racz, M. J., Khawaja, R. A., Hasanato, R. M. W., El‐Fawal, H. A. N., Mousa, S. A., & Mason, D. (2015) · Intern J Endocrinol Metab · doi:10.5812/ijem.22604 · Cited by 82 · see citing works
Role and Treatment of Insulin Resistance in Patients with Chronic Kidney Disease: A Review
Nakashima, A., Kato, K., Ohkido, I., & Yokoo, T. (2021) · Nutrients · doi:10.3390/nu13124349 · Cited by 78 · see citing works
Associations of 25(OH) and 1,25(OH)2Vitamin D With Long-Term Outcomes in Stable Renal Transplant Recipients
Velde‐Keyzer, C. A. T., Riphagen, I. J., Joosten, M. M., Navis, G. J., Kobold, A. C. M., Kema, I. P., Bakker, S. J. L., & de Borst, M. H. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3012 · Cited by 78 · see citing works
Vitamin D supplementation in the prevention and management of major chronic diseases not related to mineral homeostasis in adults: research for evidence and a scientific statement from the European society for clinical and economic aspects of osteoporosis and osteoarthritis (ESCEO)
Cianferotti, L., Bertoldo, F., Bischoff-Ferrari, H. A., Bruyère, O., Cooper, C. C., Cutolo, M., Kanis, J. А., Kaufman, J., Reginster, J., Rizzoli, R., et al. (2017) · Endocrine · doi:10.1007/s12020-017-1290-9 · Cited by 72 · see citing works
Vitamin D3 Therapy Corrects the Tissue Sensitivity to Angiotensin II Akin to the Action of a Converting Enzyme Inhibitor in Obese Hypertensives: An Interventional Study
Vaidya, A., Sun, B., Larson, C., Forman, J. P., & Williams, J. S. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1156 · Cited by 68 · see citing works
Self-citation
Modulation of hypovitaminosis D-induced islet dysfunction and insulin resistance through direct suppression of the pancreatic islet renin–angiotensin system in mice
Cheng, Q., Boucher, B. J., & Leung, P. S. (2012) · Diabetologia · doi:10.1007/s00125-012-2801-0 · Cited by 64 · see citing works
Fibroblast growth factor 23 and α-Klotho co-dependent and independent functions
Quarles, L. D. (2018) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000467 · Cited by 63 · see citing works
Vitamin D and hypertension: Prospective study and meta-analysis
Qi, D., Nie, X.-L., Wu, S., & Cai, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174298 · Cited by 60 · see citing works
The role of vitamin D deficiency in cardiovascular disease: where do we stand in 2013?
Pilz, S., Gaksch, M., O’Hartaigh, B. W. J., Tomaschitz, A., & März, W. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1152-z · Cited by 60 · see citing works
Vitamin D deficiency aggravates ischemic acute kidney injury in rats
de Bragança, A. C., Volpini, R. A., Canale, D., Gonçalves, J. G., Shimizu, M. H. M., Sanches, T. R., Seguro, A. C., & Andrade, L. (2015) · Physiological Reports · doi:10.14814/phy2.12331 · Cited by 57 · see citing works
Vitamin D and Diabetic Complications: True or False Prophet?
Alam, U., Arul-Devah, V., Javed, S., & Malik, R. A. (2016) · Diabetes Therapy · doi:10.1007/s13300-016-0159-x · Cited by 56 · see citing works
Altered gut microbial metabolites could mediate the effects of risk factors in Covid‐19
Chen, J., Hall, S., & Vitetta, L. (2021) · Reviews in Medical Virology · doi:10.1002/rmv.2211 · Cited by 55 · see citing works
Effect of vitamin D on ventricular remodelling in heart failure: a meta-analysis of randomised controlled trials
Zhao, J.-D., Jia, J., Dong, P., Zhao, D., yang, X.-M., Li, D., & Zhang, H. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-020545 · Cited by 53 · see citing works
Vitamin D3 as Potential Treatment Adjuncts for COVID-19
Malaguarnera, L. (2020) · Nutrients · doi:10.3390/nu12113512 · Cited by 52 · see citing works
Meta‐analysis of Vitamin D Deficiency and Risk of Atrial Fibrillation
Zhang, Z., Yang, Y., Ng, C. Y., Wang, D., Wang, J., Li, G., & Liu, T. (2016) · Clinical Cardiology · doi:10.1002/clc.22563 · Cited by 53 · see citing works
Cardiovascular Interactions between Fibroblast Growth Factor-23 and Angiotensin II
Pi, M., Ye, R.-S., Han, X., Armstrong, B., Liu, X., Chen, Y., Sun, Y., & Quarles, L. D. (2018) · Scientific Reports · doi:10.1038/s41598-018-30098-1 · Cited by 51 · see citing works
Vitamin D Deficiency, Supplementation, and Cardiovascular Health
Trehan, N., Afonso, L., Levine, D. L., & Levy, P. D. (2017) · Critical Pathways in Cardiology A Journal of Evidence-Based Medicine · doi:10.1097/hpc.0000000000000122 · Cited by 50 · see citing works
Current and Emerging Classes of Pharmacological Agents for the Management of Hypertension
Ojha, U., Ruddaraju, S., Sabapathy, N., Ravindran, V., Worapongsatitaya, P., Haq, J., Mohammed, R., & Patel, V. (2021) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-021-00510-9 · Cited by 49 · see citing works
The effect of vitamin D supplementation on hypertension in non-CKD populations: A systemic review and meta-analysis
Qi, D., Nie, X., & Cai, J. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.11.040 · Cited by 45 · see citing works
Hypertension and Insulin Resistance: Implications of Mitochondrial Dysfunction
Manucha, W. A., Ritchie, B., & Ferder, L. (2014) · Current Hypertension Reports · doi:10.1007/s11906-014-0504-2 · Cited by 43 · see citing works
Interactions Among Vitamin D, Atrial Fibrillation, and the Renin-Angiotensin-Aldosterone System
Turin, A., Bax, J. J., Doukas, D. G., Joyce, C., López, J. J., Mathew, V., Pontone, G., Shah, F., Singh, S., Wilber, D. J., et al. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.05.013 · Cited by 41 · see citing works
Aging, the Metabolic Syndrome, and Ischemic Stroke
Lucke-Wold, B. P., Logsdon, A. F., Turner, R. C., Rosen, C. L., & Huber, J. D. (2014) · Advances in pharmacology · doi:10.1016/bs.apha.2014.07.001 · Cited by 41 · see citing works
Effects of vitamin D on the renin-angiotensin system
Pashova-Stoyanova, L. Z., & Toleкova, A. (2019) · Trakia Journal of Sciences · doi:10.15547/tjs.2019.03.017 · Cited by 40 · see citing works
Interactions between adrenal-regulatory and calcium-regulatory hormones in human health
Brown, J. M., & Vaidya, A. (2014) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000062 · Cited by 39 · see citing works
Self-citation
Health implication of vitamin D on the cardiovascular and the renal system
AL-Ishaq, R. K., Kubatka, P., Brozmanova, M., Gazdíková, K., Čaprnda, M., & Büsselberg, D. (2019) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2019.1628064 · Cited by 39 · see citing works
Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-regression and updated meta-analysis
Zhai, N., Bidares, R., Makoui, M. H., Aslani, S., Mohammadi, P., Razi, B., Imani, D., Yazdchi, M., & Mikaeili, H. (2020) · BMC Endocrine Disorders · doi:10.1186/s12902-020-00575-8 · Cited by 39 · see citing works
Effect of vitamin D supplementation versus placebo on essential hypertension in patients with vitamin D deficiency: a double‐blind randomized clinical trial
Sheikh, V., Mozayanimonfared, A., Gharakhani, M., Poorolajal, J., & Ph., D. (2020) · Journal of Clinical Hypertension · doi:10.1111/jch.13926 · Cited by 39 · see citing works
Vitamin D deficiency amongst minority ethnic groups in the UK: a cross sectional study
Patel, J. V., Chackathayil, J., Hughes, E. A., Webster, C., Lip, G. Y. H., & Gill, P. S. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.05.081 · Cited by 35 · see citing works
Association betweenBsm1Polymorphism in Vitamin D Receptor Gene and Diabetic Retinopathy of Type 2 Diabetes in Korean Population
Hong, Y. J., Kang, E. S., Ji, M. J., Choi, H. J., Oh, T., Koong, S.-S., & Jeon, H. J. (2015) · Endocrinology and Metabolism · doi:10.3803/enm.2015.30.4.469 · Cited by 35 · see citing works
Does Vitamin D Deficiency Lead to Hypertension?
Mehta, V., & Agarwal, S. (2017) · Cureus · doi:10.7759/cureus.1038 · Cited by 35 · see citing works
Association of Vitamin D receptor gene polymorphisms with metabolic syndrome and its components among adult Arabs from the United Arab Emirates
Hasan, H. A., AbuOdeh, R., Muda, W. A. M. W., Mohamed, H. J. B. J., & Samsudin, A. R. (2017) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2017.03.047 · Cited by 35 · see citing works
High Prevalence of Vitamin D Deficiency and Correlation of Serum Vitamin D with Cardiovascular Risk in Patients with Metabolic Syndrome
Alkhatatbeh, M. J., Abdul‐Razzak, K. K., Khasawneh, L. Q., & Saadeh, N. A. (2017) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2017.0003 · Cited by 33 · see citing works
Vitamin D Deficiency Aggravates the Renal Features of Moderate Chronic Kidney Disease in 5/6 Nephrectomized Rats
de Bragança, A. C., Canale, D., Gonçalves, J. G., Shimizu, M. H. M., Seguro, A. C., & Volpini, R. A. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00282 · Cited by 32 · see citing works
Genetic susceptibility of hypertension‐induced kidney disease
Zhang, C., Fang, X., Zhang, H., Gao, W., Hsu, H. J., Roman, R. J., & Fan, F. (2020) · Physiological Reports · doi:10.14814/phy2.14688 · Cited by 34 · see citing works
Serum vitamin D status and metabolic syndrome: a systematic review and dose-response meta-analysis
Lee, K., & Kim, J. (2021) · Nutrition Research and Practice · doi:10.4162/nrp.2021.15.3.329 · Cited by 30 · see citing works
The acute impact of polyphenols from Hibiscus sabdariffa in metabolic homeostasis: an approach combining metabolomics and gene-expression analyses
Beltrán‐Debón, R., Rodríguez‐Gallego, E., Fernández‐Arroyo, S., Senan, O., Massucci, F. A., Hernández‐Aguilera, A., Sales‐Pardo, M., Guimerà, R., Camps, J., Menéndez, J. A., et al. (2015) · Food & Function · doi:10.1039/c5fo00696a · Cited by 29 · see citing works
Vitamin D supplementation does not improve CVD risk factors in vitamin D-insufficient subjects
Kubiak, J., Thorsby, P. M., Kamycheva, E., & Jorde, R. (2018) · Endocrine Connections · doi:10.1530/ec-18-0144 · Cited by 29 · see citing works
Allelic variations in the vitamin D receptor gene, insulin secretion and parents' heights are independently associated with height in obese children and adolescents
Ferrarezi, D. A. F., Bellili-Muñoz, N., Nicolau, C. Y., Cheurfa, N., Guazzelli, I. C., Frazzatto, E., Velho, G., & Villares, S. M. (2012) · Metabolism · doi:10.1016/j.metabol.2012.03.018 · Cited by 28 · see citing works
Contribution of vitamin D deficiency to the risk of coronary heart disease in subjects with essential hypertension
Nargesi, A. A., Heidari, B., Esteghamati, S., Hafezi‐Nejad, N., Sheikhbahaei, S., Pajouhi, A., Nakhjavani, M., & Esteghamati, A. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.11.020 · Cited by 28 · see citing works
Association between Vitamin D and Heart Failure Mortality in 10,974 Hospitalized Individuals
Kusunose, K., Okushi, Y., Okayama, Y., Zheng, R., Abe, M., Nakai, M., Sumita, Y., Ise, T., Tobiume, T., Yamaguchi, K., et al. (2021) · Nutrients · doi:10.3390/nu13020335 · Cited by 27 · see citing works
Dietary contributors to hypertension in adults reviewed
McCartney, D. M. A., Byrne, D., & Turner, M. J. (2014) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-014-1181-5 · Cited by 25 · see citing works
Vitamin D therapy in diabetic kidney disease.
Rafieian‐Kopaei, M., & Nasri, H. (2014) · PubMed Central · Cited by 25 · see citing works
Vitamin D Is Inversely Related to Obesity: Cross-Sectional Study in a Small Cohort of Serbian Adults
Pantović, A., Zec, M. M., Zeković, M., Obrenović, R., Stankovic, S. D., & Glibetić, M. (2019) · Journal of the American College of Nutrition · doi:10.1080/07315724.2018.1538828 · Cited by 25 · see citing works
Inhibition of Renin-Angiotensin System: Implications for Diabetes Control and Prevention
Prabhakar, S. S. (2013) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e31828298ce · Cited by 25 · see citing works
Vitamin D and insulin sensitivity: can gene association and pharmacogenetic studies of the vitamin D receptor provide clarity?
Vaidya, A., & Williams, J. S. (2012) · Metabolism · doi:10.1016/j.metabol.2011.12.009 · Cited by 25 · see citing works
Self-citation
Effects of vitamin D supplementation on 25(OH)D concentrations and blood pressure in the elderly: a systematic review and meta-analysis
Farapti, F., Fadilla, C., Yogiswara, N., & Adriani, M. (2020) · F1000Research · doi:10.12688/f1000research.24623.3 · Cited by 24 · see citing works
Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link
Awasthi, R., Manger, P. T., & Khare, R. K. (2023) · Clinical Hypertension · doi:10.1186/s40885-022-00229-y · Cited by 24 · see citing works
Managing Hypertension by Polyphenols
Fernández‐Arroyo, S., Camps, J., Menéndez, J. A., & Joven, J. (2015) · Planta Medica · doi:10.1055/s-0034-1396310 · Cited by 23 · see citing works
Serum 25-Hydroxyvitamin D and Orthostatic Hypotension in Old People
Veronese, N., Bolzetta, F., RUI, M. D., Zambon, S., Corti, M., Musacchio, E., Baggio, G., Crepaldi, G., Perissinotto, E., Manzato, E., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03143 · Cited by 22 · see citing works
Vitamin D Deficiency Is a Potential Risk for Blood Pressure Elevation and the Development of Hypertension
Karadeniz, Y., Karadeniz, F. Ö., Ahbab, S., Ataoğlu, H. E., & Can, G. (2021) · Medicina · doi:10.3390/medicina57121297 · Cited by 21 · see citing works
Vitamin D3 (Cholecalciferol) Boosts Hydrogen Sulfide Tissue Concentrations in Heart and other Mouse Organs
Wiliński, B., Wiliński, J., Somogyi, E., Piotrowska, J., & Opoka, W. (2012) · Folia Biologica · doi:10.3409/fb60_3-4.243-247 · Cited by 20 · see citing works
Evaluating hormonal mechanisms of vitamin D receptor agonist therapy in diabetic kidney disease: the VALIDATE-D study
Brown, J. M., Secinaro, K., Williams, J. S., & Vaidya, A. (2013) · BMC Endocrine Disorders · doi:10.1186/1472-6823-13-33 · Cited by 20 · see citing works
Self-citation
Non-canonical signalling and roles of the vasoactive peptides angiotensins and kinins
Costa-Neto, C. M., Duarte, D. Â., Lima, V. M., Maria, A. G., Munhoz, É. P., Rodríguez-Sarmiento, D. Y., Santos, G. A., de Souza, P. C., & Parreiras‐e‐Silva, L. T. (2014) · Clinical Science · doi:10.1042/cs20130414 · Cited by 20 · see citing works
Vitamin D therapy in diabetic kidney disease; current knowledge on a public health problem
Ardalan, M., & Sanadgol, H. (2014) · Journal of Parathyroid Disease · Cited by 19 · see citing works
Associations Between Vitamin D Levels and Risk of Heart Failure: A Bidirectional Mendelian Randomization Study
Gao, N., Li, X., Kong, M., Ni, M., Wei, D., Zhu, X., Wang, Y., Hong, Z., & Dong, A. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.910949 · Cited by 19 · see citing works
Vitamin D: Metabolism, molecular mechanisms, and mutations to malignancies
Nemazannikova, N., Antonas, K., & Dass, C. R. (2013) · Molecular Carcinogenesis · doi:10.1002/mc.21999 · Cited by 19 · see citing works
Vitamin D Status, Cardiometabolic, Liver, and Mental Health Status in Obese Youth Attending a Pediatric Weight Management Center
MacDonald, K., Godziuk, K., Yap, J. Y. K., LaFrance, R., Ansarian, M., Haqq, A. M., & Mager, D. R. (2017) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001598 · Cited by 19 · see citing works
Relationship between vitamin D status in the first trimester of pregnancy and gestational diabetes mellitus - A nested case–control study
Salakos, E., Rabeony, T., Courbebaisse, M., Taieb, J., Tsatsaris, V., Guibourdenche, J., Sénat, M., Haidar, H., Jani, J. C., Barglazan, D., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.04.028 · Cited by 19 · see citing works
Which ones, when and why should renin-angiotensin system inhibitors work against COVID-19?
Montanari, M., Canonico, B., Nordi, E., Vandini, D., Barocci, S., Benedetti, S., Carlotti, E., & Zamai, L. (2021) · Advances in Biological Regulation · doi:10.1016/j.jbior.2021.100820 · Cited by 18 · see citing works
Vitamin D and cardio-metabolic disease
Vaidya, A. (2013) · Metabolism · doi:10.1016/j.metabol.2013.08.009 · Cited by 18 · see citing works
Self-citation
1,25-Dihydroxyvitamin D3 protects against placental inflammation by suppressing NLRP3-mediated IL-1β production via Nrf2 signaling pathway in preeclampsia
Liu, X., Zhang, X., Ma, L., Qiang, N., Wang, J., Huang, Y., Yuan, X., Lu, C., Cao, Y., & Xu, J. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156058 · Cited by 17 · see citing works
The effect of vitamin D treatment on clinical and biochemical outcomes of primary aldosteronism
Ismail, N. A., Kamaruddin, N. A., Shah, S. A., & Sukor, N. (2020) · Clinical Endocrinology · doi:10.1111/cen.14177 · Cited by 17 · see citing works
Fibroblast Growth Factors in Cardiovascular Disease
Morita, H., & Hoshiga, M. (2024) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv22025 · Cited by 16 · see citing works
Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cells
George, B., Revikumar, A., Paul, A. M., Santhoshkumar, T. R., Pillai, M. R., & Kumar, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-87703-z · Cited by 15 · see citing works
Vitamin D status in apparently healthy medication-free Slovaks: Association to blood pressure, body mass index, self-reported smoking status and physical activity
Šebeková, K., Krivošíková, Z., Gajdos, M., & Podracká, Ľ. (2017) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2016_135 · Cited by 15 · see citing works
A randomized intervention study to evaluate the effect of calcitriol therapy on the renin-angiotensin system in diabetes
Zaheer, S., Taquechel, K., Brown, J. M., Adler, G. K., Williams, J. S., & Vaidya, A. (2018) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320317754178 · Cited by 14 · see citing works
Self-citation
RETRACTED ARTICLE: Renoprotective effects of vitamin D3 supplementation in a rat model of metabolic syndrome
Wahba, N. S., Ghareib, S. A., Abdel-Ghany, R. H., Abdel-Aal, M., & Alsemeh, A. E. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02249-6 · Cited by 14 · see citing works
Retracted
Network and 16S rRNA Sequencing-Combined Approach Provides Insightal Evidence of Vitamin K2 for Salt-Sensitive Hypertension
Liu, T., Chen, M., Tu, W.-Q., Liang, Q., Tao, W.-C., Jin, Z., Xiao, Y., & Chen, L. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.639467 · Cited by 14 · see citing works
The Restoration of Vitamin D Levels Slows the Progression of Renal Ischemic Injury in Rats Previously Deficient in Vitamin D
dos Santos, M. S., Canale, D., Bernardo, D. R. D., Shimizu, M. H. M., Seguro, A. C., Volpini, R. A., & de Bragança, A. C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.625647 · Cited by 14 · see citing works
Adiposity and the relationship between vitamin D and blood pressure
Sulistyoningrum, D. C., Gašević, D., Green, T., Lear, S. A., & Devlin, A. M. (2013) · Metabolism · doi:10.1016/j.metabol.2013.07.009 · Cited by 13 · see citing works
The relationship between preoperative serum vitamin D deficiency and postoperative atrial fibrillation: A systematic review and meta-analysis
Rahimi, M., Sadeghi, M. T., Nikniaz, L., & Pashazadeh, F. (2021) · Journal of Cardiovascular and Thoracic Research · doi:10.34172/jcvtr.2021.25 · Cited by 13 · see citing works
Effects of vitamin D supplementation on 25(OH)D levels and blood pressure in the elderly: a systematic review and meta-analysis
Farapti, F., Fadilla, C., & Yogiswara, N. (2020) · F1000Research · doi:10.12688/f1000research.24623.1 · Cited by 12 · see citing works
The association between vitamin D deficiency and risk of renal event: Results from the Korean cohort study for outcomes in patients with chronic kidney disease (KNOW-CKD)
Lee, J., Bae, E. H., Kim, S. W., Chung, W., Kim, Y. H., Oh, Y. K., Kim, Y., Oh, K., & Park, S. K. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1017459 · Cited by 12 · see citing works
Vitamin D deficiency enhances vascular oxidative stress, inflammation, and angiotensin II levels in the microcirculation of diabetic patients
Wee, C. L., Azemi, A. K., Mokhtar, S. S., Yahaya, S., Yaacob, N. S., & Rasool, A. H. G. (2023) · Microvascular Research · doi:10.1016/j.mvr.2023.104574 · Cited by 13 · see citing works
The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes
Vaidya, A., UNDERWOOD, P. C., Annes, J. P., Sun, B., Williams, G. H., Forman, J. P., & Williams, J. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.10.001 · Cited by 12 · see citing works
Self-citation
Circulating Vitamin D Level and Risk of Sudden Cardiac Death and Cardiovascular Mortality: A Dose-Response Meta-Analysis of Prospective Studies
Kong, S. Y., Jung, E., Hwang, S.-S., Ro, Y. S., Shin, S. D., Cha, K., & Hwang, S. O. (2023) · Journal of Korean Medical Science · doi:10.3346/jkms.2023.38.e260 · Cited by 11 · see citing works
Vitamin D Deficiency and Supplementation in Cardiovascular Disorders
Mihos, C. G., Cruz, J. A. D. L., Hernández, A. C., & Santana, O. (2017) · Cardiology in Review · doi:10.1097/crd.0000000000000138 · Cited by 11 · see citing works
The Effect of Vitamin D Supplementation on Metabolic Phenotypes in Thais with Prediabetes.
Nimitphong, H., Samittarucksa, R., Saetung, S., Bhirommuang, N., Chailurkit, L., & Ongphiphadhanakul, B. (2015) · PubMed · Cited by 11 · see citing works
Vitamin D deficiency is associated with neurocognitive impairment in HIV-infected subjects
Vergori, A., Pinnetti, C., Lorenzini, P., Brita, A. C., Libertone, R., Mastrorosa, I., Cicalini, S., Antinori, A., & Ammassari, A. (2019) · Infection · doi:10.1007/s15010-019-01313-6 · Cited by 10 · see citing works
Interrelationship Between Vitamin D Insufficiency, Calcium Homeostasis, Hyperaldosteronism, and Autoimmunity
Armanini, D., Andrisani, A., Ambrosini, G., Donà, G., Camozzi, V., Bordin, L., & Sabbadin, C. (2016) · Journal of Clinical Hypertension · doi:10.1111/jch.12822 · Cited by 10 · see citing works
Low serum 25-hydroxyvitamin D levels may increase the detrimental effect of VDR variants on the risk of essential hypertension
Shen, F., Guo, C., Wang, Y., Yu, F., Zhang, D., Liu, X., Ba, Y., Wang, C., Li, W., & Li, X. (2019) · European Journal of Clinical Nutrition · doi:10.1038/s41430-019-0543-5 · Cited by 10 · see citing works
Effect of Vitamin D3 on Chemerin and Adiponectin Levels in Uterus of Polycystic Ovary Syndrome Rats
Pich, K., Rajewska, J., Kamińska, K., Tchurzyk, M., Szlaga, A., Sambak, P., Błasiak, A., Grzesiak, M., & Rak, A. (2023) · Cells · doi:10.3390/cells12162026 · Cited by 9 · see citing works
Evaluation of the Relationship between Serum 25-Hydroxyvitamin D and Hypertension in Hamadan, Iran-A Case Control Study
Naghshtabrizi, B. (2017) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2017/25522.10187 · Cited by 9 · see citing works
The Importance of Correlation between Aldosterone and Parathyroid Hormone in Patients with Primary Hyperparathyroidism
Stanić, B. M., Ilinčić, B., Žeravica, R., Ivanovski, D. M., Čabarkapa, V., & Mijović, R. (2022) · International Journal of Endocrinology · doi:10.1155/2022/3804899 · Cited by 8 · see citing works
Sex influences the effect of adiposity on arterial stiffness and renin‐angiotensin aldosterone system activity in young adults
Kalenga, C. Z., Ramesh, S., Dumanski, S. M., MacRae, J. M., Nerenberg, K. A., Metcalfe, A., Sola, D. Y., & Ahmed, S. B. (2021) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.317 · Cited by 8 · see citing works
Association between Vitamin D Status and Risk of Peripheral Arterial Disease: The Dong-gu Study
Oh, S., Kweon, S., Choi, J., Rhee, J.-A., Lee, Y. H., Nam, H., Jeong, S., Park, K.-S., Ryu, S. Y., Choi, S.-W., et al. (2016) · Chonnam Medical Journal · doi:10.4068/cmj.2016.52.3.212 · Cited by 8 · see citing works
The association of vitamin D status and dietary calcium intake with individual components of the metabolic syndrome: a population-based study in Victoria, Australia
Pannu, P. K., Soares, M. J., Piers, L. S., Zhao, Y., & Ansari, Z. (2017) · Cardiovascular Endocrinology · doi:10.1097/xce.0000000000000133 · Cited by 7 · see citing works

Connecting the dots: renin-angiotensin-aldosterone system, vitamin D, and hypertension
Loh, H. H., Azizan, E. A., & Sukor, N. (2025) · Journal of Hypertension · doi:10.1097/hjh.0000000000004046 · Cited by 6 · see citing works
Vitamin D regulation of the renin–angiotensin system
Li, Y. C. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10343 · Cited by 357 · see citing works
Vitamin D and the Renin-Angiotensin System
Li, Y. C. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-381978-9.10040-x · Cited by 21 · see citing works
Vitamin D: a negative endocrine regulator of the renin–angiotensin system and blood pressure
Li, Y. C., Qiao, G., Uskoković, M. R., Xiang, W., Zheng, W., & Kong, J. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.03.004 · Cited by 616 · see citing works
The effect of vitamin D on renin–angiotensin system activation and blood pressure
McMullan, C. J., Borgi, L., Curhan, G. C., Fisher, N. D. L., & Forman, J. P. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001220 · Cited by 125 · see citing works

Authors: Vaidya, A., & Williams, J. S.
Affiliations: Brigham and Women's Hospital (US)
ORCID: Vaidya, Anand
Williams, Jonathan S.
Venue: Metabolism
Publisher: Elsevier BV
Published: 2012-04
Volume: 61
Issue: 4
Pages: 450-458
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/j.metabol.2011.09.007
PMC: PMC3290690
OpenAlex: W1978517521
Cited by: 151
References: 149
Citations by year: 2026: 4 · 2024: 7 · 2023: 11 · 2022: 6 · 2021: 20 · 2020: 17 · 2019: 9 · 2018: 9 · 2017: 14 · 2016: 8 · 2015: 12 · 2014: 13 · 2013: 12 · 2012: 9
FWCI: 1.83
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (K23HL084236, K23HL08236-03, F32HL104776, K23HL111771)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Keywords: vitamin D, renin-angiotensin system, hypertension, chronic kidney disease, diabetes mellitus, insulin resistance, 1,25-dihydroxyvitamin D3, vitamin D receptor, renin expression, proteinuria, beta-cell function, blood pressure
MeSH terms: Animals, Diabetes Mellitus, Female, Humans, Hypertension, Kidney Diseases, Male, Renin-Angiotensin System, Vitamin D, Receptors, Calcitriol, Models, Animal

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The relationship between vitamin D and the renin-angiotensin system in the pathophysiology of hypertension, kidney disease, and diabetes

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