Cited by 1,011Inflammatory mediators and NSAID effectsReceptor Mechanisms and SignalingEicosanoids and Hypertension Pharmacology

The DOI matches its Crossref record; 154 of the 154 references it cites were found in a registry or an index.

Prostanoid Receptors: Subtypes and Signaling

Breyer, Richard M, Bagdassarian, Carey K, Myers, Scott A, Breyer, Matthew D·2001·Annual Review of Pharmacology and Toxicology

DOI 10.1146/annurev.pharmtox.41.1.661

Open this paper in CoChat — free account

Abstract

Cyclooxygenases metabolize arachidonate to five primary prostanoids: PGE 2, PGF 2α, PGI 2, TxA 2, and PGD 2. These autacrine lipid mediators interact with specific members of a family of distinct G-protein-coupled prostanoid receptors, designated EP, FP, IP, TP, and DP, respectively. Each of these receptors has been cloned, expressed, and characterized. This family of eight prostanoid receptor complementary DNAs encodes seven transmembrane proteins which are typical of G-protein-coupled receptors and these receptors are distinguished by their ligand-binding profiles and the signal transduction pathways activated on ligand binding. Ligand-binding selectivity of these receptors is determined by both the transmembrane sequences and amino acid residues in the putative extracellular-loop regions. The selectivity of interaction between the receptors and G proteins appears to be mediated at least in part by the C-terminal tail region. Each of the EP 1, EP 3, FP, and TP receptors has alternative splice variants described that alter the coding sequence in the C-terminal intracellular tail region. The C-terminal variants modulate signal transduction, phosphorylation, and desensitization of these receptors, as well as altering agonist-independent constitutive activity.

Integrity signals

Registry

Crossref · 10.1146/annurev.pharmtox.41.1.661

Cites

154 of 154 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
Moncada, S., Gryglewski, R. J., Bunting, S., & Vane, J. R. (1976) · Nature · doi:10.1038/263663a0 · Cited by 3,593
Prostanoid Receptors: Structures, Properties, and Functions
Narumiya, S., Sugimoto, Y., & Ushikubi, F. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1193 · Cited by 2,417
International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.
Coleman, R. A., Smith, W. L., & Narumiya, S. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06784-5 · Cited by 1,747
G Protein-coupled Receptors
Ji, T. H., Grossmann, M., & Ji, I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17299 · Cited by 1,281
G-protein-coupled receptor heterodimerization modulates receptor function
Jordan, B. A., & Devi, L. A. (1999) · Nature · doi:10.1038/21441 · Cited by 1,169
The probable arrangement of the helices in G protein‐coupled receptors.
Baldwin, J. M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05814.x · Cited by 968
Prostacyclin Synthase Expression Is Decreased in Lungs from Patients with Severe Pulmonary Hypertension
Tuder, R. M., Cool, C. D., Geraci, M. W., Wang, J., Abman, S. H., Wright, L. A., Badesch, D. B., & Voelkel, N. F. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.6.9804054 · Cited by 804
Altered pain perception and inflammatory response in mice lacking prostacyclin receptor
Murata, T., Ushikubi, F., Matsuoka, T., Hirata, M., Yamasaki, A., Sugimoto, Y., Ichikawa, A., Aze, Y., Tanaka, T., Yoshida, N., et al. (1997) · Nature · doi:10.1038/41780 · Cited by 773
Cloning and expression of cDNA for a human thromboxane A2 receptor
Hirata, M., Hayashi, Y., Ushikubi, F., Yokota, Y., Kageyama, R., Nakanishi, S., & Narumiya, S. (1991) · Nature · doi:10.1038/349617a0 · Cited by 679
Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3
Ushikubi, F., Segi, E., Sugimoto, Y., Murata, T., Matsuoka, T., Kobayashi, T., Hizaki, H., Tuboi, K., Katsuyama, M., Ichikawa, A., et al. (1998) · Nature · doi:10.1038/26233 · Cited by 677

Show all 152 references

Research works printed but not linked: 18

Coleman RA, 1994, Pharmacol. Rev., 46, 205
Leach AR. 1996.Molecular Modelling. Essex, England: Longman Ltd.pp. 25–90
Kolakowski L, 1994, Mol. Pharmacol. Recept. Channels, 2, 1
Morinelli TA, 1989, J. Pharmacol. Exp. Ther., 251, 557
Kinsella BT, 1997, J. Pharmacol. Exp. Ther., 281, 957
Funk CD, 1993, Mol. Pharmacol., 44, 934
Sakamoto K, 1994, J. Biol. Chem., 5, 3381
Fujino H, 2000, Mol. Pharmacol., 57, 353
Coleman RA, Kennedy I, Humphrey PPA, Bunce K, Lumley P. 1990.Prostanoids and their receptors.InComprehensive Medicinal Chemistry, ed. JC Emmet, pp. 643–714. Oxford, UK: Pergamon
Abramovitz M, 1995, Adv. Prostaglandin Thromboxane Leukot. Res., 23, 499
Regan JW, 1994, Mol. Pharmacol., 46, 213
Guan Y, 1996, J. Am. Soc. Nephrol, 7, 1646
Nishigaki N, 1996, Mol. Pharmacol., 50, 1031
Perkins W, 1991, J. Pharmacol. Exp. Ther., 259, 1004
10.1042/0264-6021:3400365 · DOI
Audoly L, 1999, J. Pharmacol. Exp. Ther., 289, 140
Edwards RM, 1985, Am. J. Physiol., 248, F779
Kotani M, 1995, Mol. Pharmacol., 48, 869

Sorted by citations

Items 601–700 of 1,000

Inflammation and tumor microenvironment.
Niu, T., & Zhou, F. (2023) · PubMed Central · doi:10.11817/j.issn.1672-7347.2023.230231 · Cited by 17
Discovery of novel prostaglandin analogs of PGE2 as potent and selective EP2 and EP4 receptor agonists
Xiao, Y., Araldi, G. L., Zhao, Z. Z., Brügger, N., Karra, S. R., Fischer, D., & Palmer, E. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.05.025 · Cited by 16
Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists
Jin, J. J., Morales-Ramos, Á. I., Eidam, P. M., Mecom, J. S., Li, Y., Brooks, C. A., Hilfiker, M. A., Zhang, D. E. W., Wang, N., Shi, D., et al. (2010) · ACS Medicinal Chemistry Letters · doi:10.1021/ml100077x · Cited by 16
Thromboxane Receptor Signaling Is Required for Fibronectin-induced Matrix Metalloproteinase 9 Production by Human and Murine Macrophages and Is Attenuated by the Arhgef1 Molecule
Hartney, J. M., Gustafson, C. E., Bowler, R. P., Pelanda, R., & Torres, R. M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.282772 · Cited by 16
The Potential Role of Prostaglandin D2 in Nasal Congestion Observed in a Guinea Pig Model of Allergic Rhinitis
Takahashi, G., Tanaka, H., Higuchi, N., Ikeda, M., Inagaki, N., & Shichijo, M. (2012) · International Archives of Allergy and Immunology · doi:10.1159/000334555 · Cited by 16
CYP2C8- and CYP3A-Mediated C-Demethylation of (3-{[(4-tert-Butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic Acid (CP-533,536), an EP2 Receptor-Selective Prostaglandin E2 Agonist: Characterization of Metabolites by High-Resolution Liquid Chromatography-Tandem Mass Spectrometry and Liquid Chromatography/Mass Spectrometry-Nuclear Magnetic Resonance
Prakash, C., Wang, W., O’Connell, T. N., & Johnson, K. A. (2008) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.022897 · Cited by 16
Prostaglandin E receptor‐4 receptor mediates endothelial barrier–enhancing and anti‐inflammatory effects of oxidized phospholipids
Oskolkova, O., Gawlak, G., Tian, Y., Ke, Y., Sarich, N. A., Son, S., Andreasson, K. I., Bochkov, V. N., Birukova, A. A., & Birukov, K. G. (2017) · The FASEB Journal · doi:10.1096/fj.201601232rr · Cited by 16
Eicosanoids in Exhaled Breath Condensate and Bronchoalveolar Lavage Fluid of Patients with Primary Lung Cancer
Ciebiada, M., Górski, P., & Antczak, A. J. (2012) · Disease Markers · doi:10.1155/2012/562862 · Cited by 16
Time-dependent changes in inhibitory action of lipopolysaccharide on intestinal motility in rat
Mikawa, S., Yasuhiro, O. H. T. A., Kaji, N., Islam, M. S., Murata, T., Ozaki, H., & Hori, M. (2015) · Journal of Veterinary Medical Science · doi:10.1292/jvms.15-0198 · Cited by 16
Effects of prostaglandin E2 on the subcellular localization of Epac-1 and Rap1 proteins during Fcγ-receptor-mediated phagocytosis in alveolar macrophages
Brock, T. G., Serezani, C. H., Carstens, J. K., Peters-Golden, M. L., & Aronoff, D. M. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.10.011 · Cited by 16
The EP1 subtype of prostaglandin E2 receptor: Role in keratinocyte differentiation and expression in non-melanoma skin cancer
Konger, R. L., Billings, S. D., Prall, N. C., Katona, T. M., DaSilva‐Arnold, S. C., Kennedy, C., Badve, S., Perkins, S. M., & LaCelle, P. T. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.05.025 · Cited by 16
Corneal Neovascularization and Ocular Irritancy Responses in Dogs Following Topical Ocular Administration of an EP4-Prostaglandin E 2 Agonist
Aguirre, S. A., Huang, W., Prasanna, G., & Jessen, B. A. (2009) · Toxicologic Pathology · doi:10.1177/0192623309351724 · Cited by 16
The Role of Prostaglandins as Major Inflammatory Mediators in Colorectal Cancer
Macia-Guardado, M., Lutz, V., Hengstschläger, M., & Dolznig, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262412191 · Cited by 17
PGE2 synthesis and signaling in the liver physiology and pathophysiology: An update
Qiang, E., & Xu, H. (2024) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2024.106875 · Cited by 16
Prostaglandin E2 inhibits in‐vitro mineral deposition by human periodontal ligament cells via modulating the expression of TWIST 1 and RUNX 2
Manokawinchoke, J., Pimkhaokhum, A., Everts, V. E., & Pavasant, P. (2014) · Journal of Periodontal Research · doi:10.1111/jre.12162 · Cited by 15
Prostanoid F receptors elicit an inotropic effect in rat left ventricle by enhancing myosin light chain phosphorylation
Riise, J., Nguyen, C. H. T., Qvigstad, E., Sandnes, D., Osnes, J. B., Skomedal, T., Levy, F. O., & Krobert, K. A. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn216 · Cited by 15
The 3D Structure of Human DP Prostaglandin G-Protein-Coupled Receptor Bound to Cyclopentanoindole Antagonist, Predicted Using the DuplexBiHelix Modification of the GEnSeMBLE Method
Shankar, V., Goddard, W. A., Kim, S., Abrol, R., & Liu, F. (2017) · Journal of Chemical Theory and Computation · doi:10.1021/acs.jctc.7b00842 · Cited by 15
EP3 receptor antagonist L798,106 reduces proliferation and migration of SK-BR-3 breast cancer cells
Hester, A., Salzmann, B., Rahmeh, M., Kolben, T., Czogalla, B., Ditsch, N. C., Mahner, S., Jeschke, U., & Kolben, T. M. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s204919 · Cited by 15
Prostaglandin Total Synthesis Enabled by the Organocatalytic Dimerization of Succinaldehyde
Bennett, S. H., Coulthard, G., & Aggarwal, V. K. (2020) · The Chemical Record · doi:10.1002/tcr.202000054 · Cited by 15
Prostaglandin D2 and F2α as Regulators of Adipogenesis and Obesity
Fujimori, K. (2022) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b22-00210 · Cited by 15
EP4 upregulation of Ras signaling and feedback regulation of Ras in human colon tissues and cancer cells
Wu, C., Shih, Y., Chang, C.-H., Ou, T., Huang, C., Hsu, J., & Wang, C. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0562-4 · Cited by 15
Prostaglandin E and F receptors in the uterus
(2014) · Receptors & Clinical Investigation · doi:10.14800/rci.115 · Cited by 15
Prostaglandin E2 elevates calcium in differentiated neuroectodermal stem cells
Davidson, J. M., Wong, C. T., Rai‐Bhogal, R., Li, H., & Crawford, D. A. (2016) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2016.03.010 · Cited by 15
Dietary polyunsaturated fatty acids and their metabolites: Implications for diabetes pathophysiology, prevention, and treatment
Neuman, J. C., Fenske, R. J., & Kimple, M. E. (2016) · Nutrition and Healthy Aging · doi:10.3233/nha-160004 · Cited by 15
Chronic effects of celecoxib, a cyclooxygenase-2 inhibitor, cause enhanced alcohol-induced liver steatosis in rats
Bykov, I. L., Palmén, M., Rainsford, K. D., & Lindros, K. O. (2006) · Inflammopharmacology · doi:10.1007/s10787-006-1506-8 · Cited by 15
ABNORMAL PGE2 REGULATION OF MONOCYTE TNF-?? LEVELS IN TRAUMA PATIENTS PARALLELS DEVELOPMENT OF A MORE MACROPHAGE-LIKE PHENOTYPE
Laudański, K., De, A. K., Brouxhon, S. M., Kyrkanides, S., & Miller‐Graziano, C. L. (2004) · Shock · doi:10.1097/01.shk.0000135289.62159.ad · Cited by 15
Aromatase expression in a human osteoblastic cell line increases in response to prostaglandin E2 in a dexamethasone-dependent fashion
Watanabe, M., Noda, M., & Nakajin, S. (2007) · Steroids · doi:10.1016/j.steroids.2007.05.006 · Cited by 16
Profiling of prostanoids in zebrafish embryonic development
Yeh, H.-C., & Wang, L. (2006) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2006.08.001 · Cited by 15
E-Ring Isoprostanes Stimulate a Cl− Conductance in Airway Epithelium via Prostaglandin E2-Selective Prostanoid Receptors
Seto, V., Hirota, C. L., Hirota, S. A., & Janssen, L. J. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0117oc · Cited by 15
Cyclooxygenase-2 inhibitors and atherosclerosis**Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Belton, O., & Fitzgerald, D. J. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00305-x · Cited by 15
Unexpected [M − H]+ ions in cyclopenta[b]indoles detection by electrospray ionization mass spectrometry
He, G., Xu, X., Fang, D., Luo, S., Wang, L., Zhang, G., & Wu, Z. (2013) · Journal of Mass Spectrometry · doi:10.1002/jms.3285 · Cited by 14
Molecular characterization of prostaglandin F receptor (FP) and E receptor subtype 1 (EP1) in zebrafish
Kwok, A. H. Y., Wang, Y., & Leung, F. C.-C. (2012) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2012.05.002 · Cited by 14
Bacterial toll-like receptor agonists induce sequential NF-κB-mediated leukotriene B4 and prostaglandin E2 production in chicken heterophils
Kogut, M. H., He, H., & Genovese, K. J. (2011) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2011.11.003 · Cited by 14
The effect of the EP3 antagonist DG-041 on male mice with diet-induced obesity
Ceddia, R. P., Downey, J. D., Morrison, R. D., Kraemer, M. P., Davis, S. E., Wu, J. F., Lindsley, C. W., Yin, H., Daniels, J. S., & BREYER, R. M. (2019) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2019.106353 · Cited by 14
Self-citation
Roles of EP Receptors in the Regulation of Fluid Balance and Blood Pressure
Wang, L., Wu, Y., Jia, Z., Yu, J., & Huang, S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.875425 · Cited by 14
Niacin promotes adipogenesis by reducing production of anti-adipogenic PGF2α through suppression of C/EBPβ-activated COX-2 expression
Fujimori, K., & Amano, F. (2011) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2011.01.002 · Cited by 14
Discovery of brain penetrant, soluble, pyrazole amide EP1 receptor antagonists
Hall, A., Billinton, A., Bristow, A. K., Brown, S. H., Chowdhury, A., Cutler, L., Giblin, G. M. P., Goldsmith, P., Hayhow, T. G., Kilford, I. R., et al. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.05.118 · Cited by 14
Endothelium-Dependent Vasoconstriction in Isolated Vessel Grafts: A Novel Mechanism of Vasospasm?
Hoenicka, M., Keyser, A., Rupprecht, L., Puehler, T., Hirt, S. W., & Schmid, Ç. (2011) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2011.05.114 · Cited by 14
Variants of CCR5, which are permissive for HIV-1 infection, show distinct functional responses to CCL3, CCL4 and CCL5
Dong, H.-F., Wigmore, K., Carrington, M. N., Dean, M. C., Turpin, J. A., & Howard, O. M. Z. (2005) · Genes and Immunity · doi:10.1038/sj.gene.6364247 · Cited by 14
Regulation of zebrafish gonadal sex differentiation
Pradhan, A., & Olsson, P. (2016) · AIMS molecular science · doi:10.3934/molsci.2016.4.567 · Cited by 14
Reciprocal interactions between prostaglandin E2- and estradiol-dependent signaling pathways in the injured zebra finch brain
Pedersen, A. L., & Saldanha, C. J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1040-1 · Cited by 14
Is there a role for prostanoid-mediated inhibition of IL-6trans-signalling in the management of pulmonary arterial hypertension?
Durham, G. A., & Palmer, T. M. (2019) · Biochemical Society Transactions · doi:10.1042/bst20190046 · Cited by 14
Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS‐1 (832/3) cell glucose‐stimulated insulin secretion
Sandhu, H. K., Neuman, J. C., Schaid, M. D., Davis, S. E., Connors, K. M., Challa, R., Guthery, E., Fenske, R. J., Patibandla, C., BREYER, R. M., et al. (2021) · Pharmacology Research & Perspectives · doi:10.1002/prp2.736 · Cited by 14
Self-citation
Eicosanoids in non-febrile thermoregulation
Aronoff, D. M., & Romanovsky, A. A. (2007) · Progress in brain research · doi:10.1016/s0079-6123(06)62002-5 · Cited by 14
Expression of NAD+ dependent 15‐hydroxyprostaglandin dehydrogenase and protection of prostaglandins in human hair follicle
Michelet, J. F., Colombe, L., Gautier, B., Gaillard, O., Benech, F., Pereira, R., Boulle, C., Dalko‐Csiba, M., Rozot, R., Neuwels, M., et al. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00706.x · Cited by 14
Possible involvement of brain prostaglandin E2 and prostanoid EP3 receptors in prostaglandin E2 glycerol ester-induced activation of central sympathetic outflow in the rat
Shimizu, T., Tanaka, K., Nakamura, K., Taniuchi, K., Yawata, T., Higashi, Y., Ueba, T., Dimitriadis, F., Shimizu, S., Yokotani, K., et al. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.03.005 · Cited by 14
Synthesis and evaluation of a γ-lactam as a highly selective EP2 and EP4 receptor agonist
Xiao, Y., Araldi, G. L., Zhao, Z. Z., Reddy, A. P., Karra, S. R., Brügger, N., Fischer, D., Palmer, E., Bao, B., & McKenna, S. D. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.11.020 · Cited by 14
Prostaglandin E2 Signals Monocyte/Macrophage Survival to Peroxynitrite via Protein Kinase A Converging in Bad Phosphorylation with the Protein Kinase Cα-Dependent Pathway Driven by 5-Hydroxyeicosatetraenoic Acid
Tommasini, I., Cerioni, L., Palomba, L., & Cantoni, O. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.8.5637 · Cited by 14
Eicosanoids
STANLEY, D. W. (2005) · Elsevier eBooks · doi:10.1016/b0-44-451924-6/00054-5 · Cited by 14
1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists. Structure–activity relationships of 6-substituted and 5,6-disubstituted benzoic acid derivatives
Hall, A., Brown, S. H., Chessell, I. P., Chowdhury, A., Clayton, N. M., Coleman, T., Giblin, G. M. P., Hammond, B., Healy, M. P., Johnson, M. R., et al. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.11.059 · Cited by 14
The role of COX-2 and its use as a therapeutic target in IBD and related colorectal cancer
Yang, L., Akanyibah, F. A., Yao, D., Jin, T., & Mao, F. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110516 · Cited by 13
Bioactive Lipids in Inflammation After Central Nervous System Injury
López‐Vales, R., & David, S. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-11488-6_12 · Cited by 13
Effects of centrally administered prostaglandin E3 and thromboxane A3 on plasma noradrenaline and adrenaline in rats: Comparison with prostaglandin E2 and thromboxane A2
Shimizu, T., & Yokotani, K. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.03.057 · Cited by 13
Upregulation of Prostaglandin Receptor EP1 Expression Involves Its Association with Cyclooxygenase-2
Sood, R., Flint-Ashtamker, G., Borenstein, D., & Barki‐Harrington, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091018 · Cited by 13
PGE2 enhanced TNFα-mediated IL-8 induction in monocytic cell lines and PBMC
Neuschäfer‐Rube, F., Pathe‐Neuschäfer‐Rube, A., Hippenstiel, S., & Püschel, G. P. (2018) · Cytokine · doi:10.1016/j.cyto.2018.06.020 · Cited by 13
Prostaglandin E2induces contraction of liver myofibroblasts by activating EP3and FP prostanoid receptors
Ayabe, S., Murata, T., Maruyama, T., Hori, M., & Ozaki, H. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00051.x · Cited by 13
Enantioselective Synthesis and Biological Activity of (3S,4R)- and (3S,4S)-3-Hydroxy-4-hydroxymethyl- 4-butanolides in Relation to PGE2
Miranda, P. O., Estévez, F., Quintana, J., García, C. I., Brouard, I., Padrón, J. I., Pivel, J. P., & Bermejo, J. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm034216y · Cited by 13
Phospholipase D1 Increases Bcl-2 Expression During Neuronal Differentiation of Rat Neural Stem Cells
Park, S., Ma, W., Yoon, S. N., Kang, M. J., & Han, J. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8773-y · Cited by 13
Prostaglandins and the colon cancer connection
Chan, T. A.-T. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.04.006 · Cited by 13
Parathyroid Hormone Induces Mitogen‐Activated Kinase Phosphatase 1 in Murine Osteoblasts Primarily Through cAMP‐Protein Kinase A Signaling
Aghaloo, T. L., Pirih, F. Q. M., Shi, A., Bezouglaia, O., & Tetradis, S. (2006) · Journal of Periodontology · doi:10.1902/jop.2006.77.1.21 · Cited by 13
Cyclooxygenase-2 and antagonists in pain management
Samad, T. A., & Abdi, S. (2001) · Current Opinion in Anaesthesiology · doi:10.1097/00001503-200110000-00011 · Cited by 13
The protection of meloxicam against chronic aluminium overload-induced liver injury in rats
Yang, Y., He, Q., Wang, H., Hu, X., Luo, Y., Liang, G., Kuang, S., Mai, S., Ma, J., Tian, X., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15588 · Cited by 13
Inhibition of cyclooxygenase-2: a new targeted therapy for B-cell lymphoma?
Phipps, R. P., Ryan, E. P., & Bernstein, S. H. (2003) · Leukemia Research · doi:10.1016/s0145-2126(03)00260-1 · Cited by 13
Three paradigms of airway smooth muscle hyperresponsiveness in young guinea pigsThis article is one of a selection of papers published in the Special Issue on Recent Advances in Asthma Research.
Chitano, P., Wang, L., & Murphy, T. M. (2007) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y07-063 · Cited by 13
Latanoprost (Xalatan): A Prostanoid FP Agonist for Glaucoma
Nair, S. K., & Henegar, K. E. (2010) · Wiley eBooks · doi:10.1002/9780470768594.ch21 · Cited by 13
Exploring the Potential Molecular Mechanism of the Shugan Jieyu Capsule in the Treatment of Depression through Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation
Liu, Z., Huang, H., Yu, Y., Jia, Y., Li, L., Shi, X., & Wang, F. (2023) · Current Computer - Aided Drug Design · doi:10.2174/1573409919666230619105254 · Cited by 13
Prostaglandin E2 signal inhibits T regulatory cell differentiation during allergic rhinitis inflammation through EP4 receptor
Li, L., Guan, K., Zhou, Y. J., Wu, J., Wang, Y., & Wang, W. (2019) · World Allergy Organization Journal · doi:10.1016/j.waojou.2019.100090 · Cited by 12
Sacchathridine A, a Prostaglandin Release Inhibitor from Saccharothrix sp.
Nakae, K., Kurata, I., Kojima, F., Igarashi, M., Hatano, M., Sawa, R., Kubota, Y., Adachi, H., & Nomoto, A. (2013) · Journal of Natural Products · doi:10.1021/np3006327 · Cited by 12
Phosphodiesterase-4 Inhibition Augments Human Lung Fibroblast Vascular Endothelial Growth Factor Production Induced by Prostaglandin E2
Ikari, J., Michalski, J., Iwasawa, S., Gunji, Y., Nogel, S., Park, J. H., Nelson, A. J., Farid, M., Wang, X., Schulte, N. A., et al. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0004oc · Cited by 12
Increased lethality and defective pulmonary clearance ofStreptococcus pneumoniaein microsomal prostaglandin E synthase-1-knockout mice
Dolan, J. M., Weinberg, J. B., O’Brien, E., Abashian, A., Procario, M. C., Aronoff, D. M., Crofford, L. J., Peters-Golden, M. L., Ward, L. A., & Mancuso, P. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00220.2015 · Cited by 12
Edition of Prostaglandin E2 Receptors EP2 and EP4 by CRISPR/Cas9 Technology in Equine Adipose Mesenchymal Stem Cells
Mançanares, A. C. F., Cabezas, J. G., Manríquez, J., Souza, V. C. D. O., Wong, Y. S., Rojas, D. M., Navarrete, F., Rodriguez-Alvarez, L., & Castro, F. O. (2020) · Animals · doi:10.3390/ani10061078 · Cited by 12
Total Synthesis of Thromboxane B2 via a Key Bicyclic Enal Intermediate
Jing, C., & Aggarwal, V. K. (2020) · Organic Letters · doi:10.1021/acs.orglett.0c02299 · Cited by 12
Targeting the eicosanoid pathway in hepatocellular carcinoma.
Razdan, A., Main, N., Chiu, V., Shackel, N. A., SOUZA, P. D., Bryant, K., & Scott, K. F. (2021) · PubMed Central · Cited by 13
Effects of gestational age on prostaglandin EP receptor expression and functional involvement during in vitro contraction of the guinea pig uterus
Terry, K. K., Lebel, W. S., Riccardi, K. A., GRASSER, W. A., Thompson, D. D., & Paralkar, V. M. (2007) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2007.10.003 · Cited by 12
Differential modulation of prostaglandin receptor mRNA abundance by prostaglandins in primary cultured rat hepatocytes
Pérez, S., Maldonado, E. N., Aspichueta, P., Ochoa, B., & Chico, Y. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000049159.09349.02 · Cited by 12
15d-PGJ 2 Upregulates Synthesis of IL-8 in Endothelial Cells Through Induction of Oxidative Stress
Józkowicz, A., Waś, H., Taha, H., Kotlinowski, J., Mleczko‐Sanecka, K., Cisowski, J., Weigel, G., & Dulak, J. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2032 · Cited by 12
Eicosanoids: an emerging role in dendritic cell biology.
Harizi, H., & Gualde, N. (2004) · PubMed · Cited by 12
15-Deoxy-Δ12,14-prostaglandin-J2 inhibits expression of eNOS in human endothelial cells
Józkowicz, A., Nigisch, A., Winter, B., Weigel, G., Huk, I., & Dulak, J. (2004) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2004.05.001 · Cited by 12
1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists: Structure–activity relationships of 4- and 5-substituted benzoic acid derivatives
Hall, A., Brown, S. H., Chessell, I. P., Chowdhury, A., Clayton, N. M., Coleman, T., Giblin, G. M. P., Hammond, B., Healy, M. P., Johnson, M. R., et al. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.10.078 · Cited by 12
Analysis of polyunsaturated fatty acids and the omega-6 inflammatory pathway in hepatic ischemia/re-perfusion injury
Kıraç, E., Özcan, F., Tuzcu, H., Elpek, G. Ö., & Aslan, M. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3908 · Cited by 12
The expression of prostaglandin receptors EP 3 and EP 4 in human cervix in post‐term pregnancy differs between failed and successful labor induction
Roos, N., Blesson, C. S., Stephansson, O., Masironi, B., Stjernholm, Y. V., Ekman-Ordeberg, G. E., & Sahlin, L. (2013) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.12300 · Cited by 12
Characterization of the molecular mechanisms of the coupling between intracellular loops of prostacyclin receptor with the C-terminal domain of the Gαs protein in human coronary artery smooth muscle cells
Zhang, L., Bastepe, M., Jüppner, H., & Ruan, K. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.06.023 · Cited by 12
Induction of Cyclooxygenase‐2 and Peroxisome Proliferator‐Activated Receptor‐γ during Nitric Oxide‐Induced Apoptotic PC12 Cell Death
LIM, S., Jang, J.-H., & Surh, Y. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1299.119 · Cited by 12
Design of Dual EP2/EP4 Antagonists through Scaffold Merging of Selective Inhibitors
Corminboeuf, O., Diethelm, S., Zumbrunn, C., Lyothier, I., Niggli, N., Gnerre, C., Jeay, S., Lehembre, F., & Boss, C. (2023) · ChemMedChem · doi:10.1002/cmdc.202300606 · Cited by 11
Epigenetic regulation of progesterone receptors and the onset of labour
Ilicic, M., Zakár, T., & Paúl, J. (2019) · Reproduction Fertility and Development · doi:10.1071/rd18392 · Cited by 11
Protective Effect of Prostaglandin E2 Receptors EP2 and EP4 in Alloimmune Response In Vivo
Nomi, T., Sho, M., Akahori, T., Kanehiro, H., & Nakajima, Y. (2006) · Transplantation Proceedings · doi:10.1016/j.transproceed.2006.10.118 · Cited by 11
Estrogen Biosynthesis and Its Regulation in Endometriosis
Qi, Q.-M., Guo, S., & Liu, X. (2017) · Reproductive and Developmental Medicine · doi:10.4103/2096-2924.210698 · Cited by 11
Attenuation of Inhibitory Prostaglandin E2 Signaling in Human Lung Fibroblasts Is Mediated by Phosphodiesterase 4
Michalski, J., Kanaji, N., Liu, X., Nogel, S., Wang, X., Basma, H., Nakanishi, M., Sato, T., Gunji, Y., Fahrid, M., et al. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0057oc · Cited by 11
Crosstalk between possible cytostatic and antiinflammatory potential of ketoprofen in the treatment of culture of colon and cervix cancer cell lines
Damnjanović, I., Najman, S. J., Stojanović, S., Stojanovic, D., Veljković, A., Kocić, H., Langerholc, T., Damnjanović, Z., & Pesic, S. (2015) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2015_044 · Cited by 11
The EP3-agonist sulprostone, but not prosta glandin E2 potentiates platelet aggregation in human blood
Schober, L. J., Khandoga, A. L., Penz, S. M., & Siess, W. (2010) · Thrombosis and Haemostasis · doi:10.1160/th09-12-0815 · Cited by 11
Cellular density‐dependent down‐regulation of EP 4 prostanoid receptors via the up‐regulation of hypoxia‐inducible factor‐1α in HCA ‐7 human colon cancer cells
Otake, S., Yoshida, K., Seira, N., Sanchez, C. M., Regan, J. W., Fujino, H., & Murayama, T. (2014) · Pharmacology Research & Perspectives · doi:10.1002/prp2.83 · Cited by 11
Loss of EP2 Receptor Subtype in Colonic Cells Compromise Epithelial Barrier Integrity by Altering Claudin-4
Lejeune, M., Moreau, F., & Chadee, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113270 · Cited by 11
Stimulation of Prostaglandin EP2 Receptors on RGC-5 Cells in Culture Blunts the Negative Effect of Serum Withdrawal
Kang, K. D., da Costa, B. L. S. A., & Osborne, N. N. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0140-4 · Cited by 11
Role of the ER stress in prostaglandin E2/E-prostanoid 2 receptor involved TGF-β1-induced mice mesangial cell injury
Xu, Y., Wang, J., Pan, T., Chen, X., Xu, X., Jiang, D., & Yin, J. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2567-z · Cited by 11
NAD(P)H Quinone Oxidoreductase 1 (NQO1)-Bioactivated Pronqodine A Regulates Prostaglandin Release from Human Synovial Sarcoma Cells
Nakae, K., Adachi, H., Sawa, R., Hosokawa, N., Hatano, M., Igarashi, M., Nishimura, Y., Akamatsu, Y., & Nomoto, A. (2013) · Journal of Natural Products · doi:10.1021/np300643f · Cited by 11
NSAID treatment with meloxicam enhances peripheral stem cell mobilization in myeloma
Jeker, B., Novak, U., Taleghani, B. M., Baerlocher, G. M., Seipel, K., Mueller, B. U., Bigler, M., Betticher, D. C., Luethi, J.-M., Farese, S., et al. (2017) · Bone Marrow Transplantation · doi:10.1038/bmt.2017.234 · Cited by 11
Protection of 6-OHDA neurotoxicity by PGF2α through FP-ERK-Nrf2 signaling in SH-SY5Y cells
Sano, A., Maehara, T., & Fujimori, K. (2021) · Toxicology · doi:10.1016/j.tox.2021.152686 · Cited by 11
Prostaglandin E2 Selectively Antagonizes Prostaglandin F2α-stimulated T-cell Factor/β-Catenin Signaling Pathway by the FPB Prostanoid Receptor
Fujino, H., Vielhauer, G. A., & Regan, J. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408276200 · Cited by 11
Activation of the EP4 prostanoid receptor induces prostaglandin E2 and pro-inflammatory cytokine production in human airway epithelial cells
Li, T., Qi, J., & Cowley, E. A. (2010) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2010.10.009 · Cited by 10
Activation of cytosolic phospholipase A2 in human T-lymphocytes involves inhibitor-κB and mitogen-activated protein kinases
Burgermeister, E., Endl, J., & Scheuer, W. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01492-4 · Cited by 10

Authors: Breyer, R. M., Bagdassarian, C. K., Myers, S. A., & Breyer, M. D.
Affiliations: United States Department of Veterans Affairs (US)
ORCID: Breyer, Richard M
Breyer, Matthew D
Venue: Annual Review of Pharmacology and Toxicology
Publisher: Annual Reviews
Published: 2001-04
Volume: 41
Issue: 1
Pages: 661-690
ISSN: 0362-1642 (ISSN-L)
1545-4304
DOI: 10.1146/annurev.pharmtox.41.1.661
OpenAlex: W2129746956
Cited by: 1,011
References: 152
Citations by year: 2026: 7 · 2025: 17 · 2024: 11 · 2023: 22 · 2022: 17 · 2021: 27 · 2020: 37 · 2019: 22 · 2018: 24 · 2017: 32 · 2016: 38 · 2015: 43 · 2014: 50 · 2013: 40 · 2012: 51
FWCI: 5.37
Type: journal article
Language: en
Open access: closed
Locations: The Annual Review of Pharmacology and Toxicology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM 15431)
National Institute of Diabetes and Digestive and Kidney Diseases (DK37097, DK46205, R01DK037097, R01DK046205)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: prostanoid receptors, G protein-coupled receptors, prostaglandins, cyclooxygenase, arachidonic acid metabolism, prostaglandin E2, prostaglandin F2alpha, prostacyclin, thromboxane A2, prostaglandin D2, receptor subtypes, ligand selectivity, splice variants, receptor desensitization, receptor phosphorylation, constitutive receptor activity, signal transduction
MeSH terms: Amino Acid Sequence, Animals, Humans, Molecular Sequence Data, Prostaglandins, Receptors, Prostaglandin, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Prostanoid Receptors: Subtypes and Signaling

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks