Cited by 1,011Inflammatory mediators and NSAID effectsReceptor Mechanisms and SignalingEicosanoids and Hypertension Pharmacology

The DOI matches its Crossref record; 154 of the 154 references it cites were found in a registry or an index.

Prostanoid Receptors: Subtypes and Signaling

Breyer, Richard M, Bagdassarian, Carey K, Myers, Scott A, Breyer, Matthew D·2001·Annual Review of Pharmacology and Toxicology

DOI 10.1146/annurev.pharmtox.41.1.661

Open this paper in CoChat — free account

Abstract

Cyclooxygenases metabolize arachidonate to five primary prostanoids: PGE 2, PGF 2α, PGI 2, TxA 2, and PGD 2. These autacrine lipid mediators interact with specific members of a family of distinct G-protein-coupled prostanoid receptors, designated EP, FP, IP, TP, and DP, respectively. Each of these receptors has been cloned, expressed, and characterized. This family of eight prostanoid receptor complementary DNAs encodes seven transmembrane proteins which are typical of G-protein-coupled receptors and these receptors are distinguished by their ligand-binding profiles and the signal transduction pathways activated on ligand binding. Ligand-binding selectivity of these receptors is determined by both the transmembrane sequences and amino acid residues in the putative extracellular-loop regions. The selectivity of interaction between the receptors and G proteins appears to be mediated at least in part by the C-terminal tail region. Each of the EP 1, EP 3, FP, and TP receptors has alternative splice variants described that alter the coding sequence in the C-terminal intracellular tail region. The C-terminal variants modulate signal transduction, phosphorylation, and desensitization of these receptors, as well as altering agonist-independent constitutive activity.

Integrity signals

Registry

Crossref · 10.1146/annurev.pharmtox.41.1.661

Cites

154 of 154 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
Moncada, S., Gryglewski, R. J., Bunting, S., & Vane, J. R. (1976) · Nature · doi:10.1038/263663a0 · Cited by 3,593
Prostanoid Receptors: Structures, Properties, and Functions
Narumiya, S., Sugimoto, Y., & Ushikubi, F. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1193 · Cited by 2,417
International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.
Coleman, R. A., Smith, W. L., & Narumiya, S. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06784-5 · Cited by 1,747
G Protein-coupled Receptors
Ji, T. H., Grossmann, M., & Ji, I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17299 · Cited by 1,281
G-protein-coupled receptor heterodimerization modulates receptor function
Jordan, B. A., & Devi, L. A. (1999) · Nature · doi:10.1038/21441 · Cited by 1,169
The probable arrangement of the helices in G protein‐coupled receptors.
Baldwin, J. M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05814.x · Cited by 968
Prostacyclin Synthase Expression Is Decreased in Lungs from Patients with Severe Pulmonary Hypertension
Tuder, R. M., Cool, C. D., Geraci, M. W., Wang, J., Abman, S. H., Wright, L. A., Badesch, D. B., & Voelkel, N. F. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.6.9804054 · Cited by 804
Altered pain perception and inflammatory response in mice lacking prostacyclin receptor
Murata, T., Ushikubi, F., Matsuoka, T., Hirata, M., Yamasaki, A., Sugimoto, Y., Ichikawa, A., Aze, Y., Tanaka, T., Yoshida, N., et al. (1997) · Nature · doi:10.1038/41780 · Cited by 773
Cloning and expression of cDNA for a human thromboxane A2 receptor
Hirata, M., Hayashi, Y., Ushikubi, F., Yokota, Y., Kageyama, R., Nakanishi, S., & Narumiya, S. (1991) · Nature · doi:10.1038/349617a0 · Cited by 679
Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3
Ushikubi, F., Segi, E., Sugimoto, Y., Murata, T., Matsuoka, T., Kobayashi, T., Hizaki, H., Tuboi, K., Katsuyama, M., Ichikawa, A., et al. (1998) · Nature · doi:10.1038/26233 · Cited by 677

Show all 152 references

Research works printed but not linked: 18

Coleman RA, 1994, Pharmacol. Rev., 46, 205
Leach AR. 1996.Molecular Modelling. Essex, England: Longman Ltd.pp. 25–90
Kolakowski L, 1994, Mol. Pharmacol. Recept. Channels, 2, 1
Morinelli TA, 1989, J. Pharmacol. Exp. Ther., 251, 557
Kinsella BT, 1997, J. Pharmacol. Exp. Ther., 281, 957
Funk CD, 1993, Mol. Pharmacol., 44, 934
Sakamoto K, 1994, J. Biol. Chem., 5, 3381
Fujino H, 2000, Mol. Pharmacol., 57, 353
Coleman RA, Kennedy I, Humphrey PPA, Bunce K, Lumley P. 1990.Prostanoids and their receptors.InComprehensive Medicinal Chemistry, ed. JC Emmet, pp. 643–714. Oxford, UK: Pergamon
Abramovitz M, 1995, Adv. Prostaglandin Thromboxane Leukot. Res., 23, 499
Regan JW, 1994, Mol. Pharmacol., 46, 213
Guan Y, 1996, J. Am. Soc. Nephrol, 7, 1646
Nishigaki N, 1996, Mol. Pharmacol., 50, 1031
Perkins W, 1991, J. Pharmacol. Exp. Ther., 259, 1004
10.1042/0264-6021:3400365 · DOI
Audoly L, 1999, J. Pharmacol. Exp. Ther., 289, 140
Edwards RM, 1985, Am. J. Physiol., 248, F779
Kotani M, 1995, Mol. Pharmacol., 48, 869

Sorted by citations

Prostaglandins and Inflammation
Ricciotti, E., & FitzGerald, G. A. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.207449 · Cited by 4,035
Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective
Bindu, S., Mazumder, S., & Bandyopadhyay, U. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114147 · Cited by 2,075
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
Wang, B., Wu, L., Chen, J., Dong, L., Chen, C., Zheng, W., Hu, J., Fleming, I., & Wang, D. W. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00443-w · Cited by 1,538
Prostaglandins as modulators of immunity
Harris, S. G., Padilla, J., Koumas, L., Ray, D. M., & Phipps, R. P. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(01)02154-8 · Cited by 1,168
Selexipag for the Treatment of Pulmonary Arterial Hypertension
Sitbon, O., Channick, R. N., Chin, K., Frey, A., Gaine, S., Galiè, N., Ghofrani, H. A., Hoeper, M. M., Lang, I. M., Preiss, R., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1503184 · Cited by 1,062
Urinary Bladder Contraction and Relaxation: Physiology and Pathophysiology
Andersson, K., & Arner, A. (2004) · Physiological Reviews · doi:10.1152/physrev.00038.2003 · Cited by 948
Pharmacology and signaling of prostaglandin receptors: Multiple roles in inflammation and immune modulation
Hata, A. N., & BREYER, R. M. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.06.003 · Cited by 839
Self-citation
Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects
Bringmann, A., Iandiev, I., Pannicke, T., Wurm, A., Hollborn, M., Wiedemann, P., Osborne, N. N., & Reichenbach, A. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.07.001 · Cited by 761
Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases
Imig, J. D., & Hammock, B. D. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2875 · Cited by 616
Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function
Kristiansen, K. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.05.002 · Cited by 631
Multifaceted roles of PGE2 in inflammation and cancer
Nakanishi, M., & Rosenberg, D. W. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0342-8 · Cited by 611
Sensitization of TRPV1 by EP1 and IP Reveals Peripheral Nociceptive Mechanism of Prostaglandins
Moriyama, T., Higashi, T., Togashi, K., Iida, T., Segi‐Nishida, E., Sugimoto, Y., Tominaga, T., Narumiya, S., & Tominaga, M. (2005) · Molecular Pain · doi:10.1186/1744-8069-1-3 · Cited by 551
Restoring metabolism of myeloid cells reverses cognitive decline in ageing
Minhas, P. S., Latif-Hernandez, A., McReynolds, M. R., Durairaj, A. S., Wang, Q., Rubin, A., Joshi, A. U., He, J. Q., Gauba, E., Liu, L., et al. (2021) · Nature · doi:10.1038/s41586-020-03160-0 · Cited by 526
Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells
Scandella, E., Men, Y., Gillessen, S., Förster, R., & Groettrup, M. (2002) · Blood · doi:10.1182/blood-2001-11-0017 · Cited by 498
Mechanical Strain Opens Connexin 43 Hemichannels in Osteocytes: A Novel Mechanism for the Release of Prostaglandin
Cherian, P. P., Siller-Jackson, A. J., Gu, S., Wang, X., Bonewald, L. F., Sprague, E., & Jiang, J. X. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-10-0912 · Cited by 481
Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence
Andersson, K., & Wein, A. J. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.4.4 · Cited by 479
The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies
Sobolewski, C., Cerella, C., Dicato, M. A., Ghibelli, L., & Diederich, M. F. (2010) · International Journal of Cell Biology · doi:10.1155/2010/215158 · Cited by 493
Many actions of cyclooxygenase‐2 in cellular dynamics and in cancer
Cao, Y., & Prescott, S. M. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10068 · Cited by 463
Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: Their role and involvement in neurological disorders
Phillis, J. W., Horrocks, L. A., & Farooqui, A. A. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.02.002 · Cited by 470
Organization and Ca2+Regulation of Adenylyl Cyclases in cAMP Microdomains
Willoughby, D., & Cooper, D. M. F. (2007) · Physiological Reviews · doi:10.1152/physrev.00049.2006 · Cited by 466
Cyclic AMP and progesterone receptor cross-talk in human endometrium: a decidualizing affair
Gellersen, B., & Brosens, J. J. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1780357 · Cited by 442
Arachidonic Acid Metabolism and Kidney Inflammation
Wang, T., Fu, X., Chen, Q., Patra, J. K., Wang, D., Wang, Z., & Gai, Z. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153683 · Cited by 435
Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation
Hoggatt, J., Singh, P., Sampath, J., & Pelus, L. M. (2009) · Blood · doi:10.1182/blood-2009-01-201335 · Cited by 422
Prostanoids and prostanoid receptors in signal transduction
Bos, C. L., Richel, D. J., Ritsema, T., Peppelenbosch, M. P., & Versteeg, H. H. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2003.08.006 · Cited by 396
Targeting arachidonic acid pathway by natural products for cancer prevention and therapy
Yarla, N. S., Bishayee, A., Sethi, G., Reddanna, P., Kalle, A. M., Dhananjaya, B. L., Kaladhar, D. S. V. G. K., Chintala, R., & Duddukuri, G. R. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.02.001 · Cited by 368
Epoxides and Soluble Epoxide Hydrolase in Cardiovascular Physiology
Imig, J. D. (2012) · Physiological Reviews · doi:10.1152/physrev.00021.2011 · Cited by 363
Neuroprotective Function of the PGE 2 EP2 Receptor in Cerebral Ischemia
McCullough, L. D., Wu, L., Haughey, N. J., Liang, X., Hand, T. A., Wang, Q., BREYER, R. M., & Andreasson, K. I. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4485-03.2004 · Cited by 362
Self-citation
The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis
McCoy, J. M., Wicks, J. R., & Audoly, L. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15528 · Cited by 360
Prostaglandin E2 Inhibits Alveolar Macrophage Phagocytosis through an E-Prostanoid 2 Receptor-Mediated Increase in Intracellular Cyclic AMP
Aronoff, D. M., Canetti, C. D. A., & Peters-Golden, M. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.559 · Cited by 359
GPR109A (PUMA-G/HM74A) mediates nicotinic acid–induced flushing
Benyó, Z., Gille, A., Kero, J. T., Csiky, M., Suchánková, M. C., Nüsing, R. M., Moers, A., Pfeffer, K., & Offermanns, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23626 · Cited by 344
Cyclooxygenases, prostanoids, and tumor progression
Wang, M., Honn, K. V., & Nie, D. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9096-5 · Cited by 344
Pharmacology of the Lower Urinary Tract
de Groat, W. C., & Yoshimura, N. (2001) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.691 · Cited by 339
Cell signalling by reactive lipid species: new concepts and molecular mechanisms
Higdon, A. N., Diers, A. R., Oh, J. Y., Landar, A. L., & Darley-Usmar, V. M. (2012) · Biochemical Journal · doi:10.1042/bj20111752 · Cited by 327
The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis
McCoy, J. M., Wicks, J. R., & Audoly, L. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215528 · Cited by 320
Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma
Harmer, D., Falank, C., & Reagan, M. R. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00788 · Cited by 307
Role of nitric oxide and prostacyclin as vasoactive hormones released by the endothelium
Mitchell, J. A., Ali, F. Y., Bailey, L. K., Moreno, L., & Mackenzie, L. S. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2007.038588 · Cited by 291
Prostaglandins PGE2 and PGI2 promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation
Birukova, A. A., Zagranichnaya, T. K., Fu, P., Alekseeva, E. A., Chen, W., Jacobson, J. R., & Birukov, K. G. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.03.036 · Cited by 283
Alpha-Pinene Exhibits Anti-Inflammatory Activity Through the Suppression of MAPKs and the NF-κB Pathway in Mouse Peritoneal Macrophages
Kim, D., Lee, H.-J., Jeon, Y., Han, Y.-H., Kee, J., Kim, H.-J., Shin, H.-J., Kang, J., Lee, B. S., Kim, S., et al. (2015) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x15500457 · Cited by 281
Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception
Jang, Y., Kim, M., & Hwang, S. W. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1703-1 · Cited by 289
The Prostanoid EP4 Receptor and Its Signaling Pathway
Yokoyama, U., Iwatsubo, K., Umemura, M., Fujita, T., & Ishikawa, Y. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007195 · Cited by 272
Role of β-arrestin 1 in the metastatic progression of colorectal cancer
Buchanan, F. G., Gorden, D. L., Matta, P., Shi, Q., Matrisian, L. M., & DuBois, R. N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510562103 · Cited by 264
Prostaglandin E2receptor distribution and function in the gastrointestinal tract
Dey, I., Lejeune, M., & Chadee, K. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706923 · Cited by 252
Forming a Multinucleated Cell: Molecules That Regulate Myoblast Fusion
Horsley, V., & Pavlath, G. K. (2004) · Cells Tissues Organs · doi:10.1159/000075028 · Cited by 247
Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor
Yang, H. H., Yamagata, N., Yadav, R., Brandon, S., Courtney, R., Morrow, J. D., Shyr, Y., Boothby, M. R., Joyce, S., Carbone, D. P., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16492 · Cited by 246
Self-citation
FOXP3+CD4+CD25+ Adaptive Regulatory T Cells Express Cyclooxygenase-2 and Suppress Effector T Cells by a Prostaglandin E2-Dependent Mechanism
Mahic, M., Yaqub, S., Johansson, C. C., Taskén, K., & Aandahl, E. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.246 · Cited by 245
The Regulation of Chondrocyte Function by Proinflammatory Mediators
Goldring, M. B., & Berenbaum, F. (2004) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000144484.69656.e4 · Cited by 245
Cyclooxygenase inhibitors: From pharmacology to clinical read-outs
Patrignani, P., & Patrono, C. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.09.016 · Cited by 244
Physiology and pathophysiology of cyclooxygenase-2 and prostaglandin E2 in the kidney
Nørregaard, R., Kwon, T., & Frøkiær, J. (2015) · Kidney Research and Clinical Practice · doi:10.1016/j.krcp.2015.10.004 · Cited by 229
Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets
Samad, T. A., Sapirstein, A., & Woolf, C. J. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02383-3 · Cited by 229
Deletion of the Prostaglandin E2EP2 Receptor Reduces Oxidative Damage and Amyloid Burden in a Model of Alzheimer's Disease
Liang, X., Wang, Q., Hand, T. A., Wu, L., BREYER, R. M., Montine, T. J., & Andreasson, K. I. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3591-05.2005 · Cited by 232
Self-citation
Prostaglandin D2 induces nuclear import of the sex‐determining factor SOX9 via its cAMP‐PKA phosphorylation
Malki, S., Nef, S., Notarnicola, C., Thevenet, L., Gasca, S., Méjean, C., Berta, P., Poulat, F., & Boizet‐Bonhoure, B. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600660 · Cited by 224
Emerging roles of PGE2 receptors in models of neurological disease
Andreasson, K. I. (2009) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2009.04.003 · Cited by 225
Emerging roles of DP and CRTH2 in allergic inflammation
Kostenis, E., & Ulven, T. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.02.005 · Cited by 215
Cyclooxygenase-2 and its role in ovulation: a 2004 account
Sirois, J., Sayasith, K., Brown, K. A., Stock, A. E., Bouchard, N., & Doré, M. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh032 · Cited by 212
Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP 3 receptors
Tunaru, S., Althoff, T. F., Nüsing, R. M., Diener, M., & Offermanns, S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201627109 · Cited by 211
Prostaglandin E2and T cells: friends or foes?
Sreeramkumar, V., Fresno, M., & Cuesta, N. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2011.75 · Cited by 210
Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development
Robichaux, W. G., & Cheng, X. (2018) · Physiological Reviews · doi:10.1152/physrev.00025.2017 · Cited by 222
Cyclooxygenase-2 in synaptic signaling
Yang, H., & Chen, C. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784480144 · Cited by 195
Effects of Mechanical Strain on the Function of Gap Junctions in Osteocytes Are Mediated through the Prostaglandin EP2 Receptor
Cherian, P. P., Cheng, B., Gu, S., Sprague, E. A., Bonewald, L. F., & Jiang, J. X. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302993200 · Cited by 195
PGE 2 ‐EP 2 signalling in endothelium is activated by haemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF‐κB
Aoki, T., Nishimura, M., Matsuoka, T., Yamamoto, K., Furuyashiki, T., Kataoka, H., Kitaoka, S., Ishibashi, R., Ishibazawa, A., Miyamoto, S., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01358.x · Cited by 193
Lipid signaling: Sleep, synaptic plasticity, and neuroprotection
Chen, C., & Bazan, N. G. (2005) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2005.07.001 · Cited by 193
TGF-β Effects on Prostate Cancer Cell Migration and Invasion Are Mediated by PGE2 through Activation of PI3K/AKT/mTOR Pathway
Vo, B. T., Morton, D. J., Komaragiri, S. K., Millena, A. C., Leath, C., & Khan, S. A. (2013) · Endocrinology · doi:10.1210/en.2012-2074 · Cited by 192
Role of G protein-coupled receptors in inflammation
Sun, L., & Ye, R. D. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.200 · Cited by 192
Brugada syndrome: 1992–2002
Antzelevitch, C. N., Brugada, P., Brugada, J., Brugada, R., Towbin, J. A., & Nademanee, K. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00310-3 · Cited by 193
Postsynaptically Synthesized Prostaglandin E2 (PGE2) Modulates Hippocampal Synaptic Transmission via a Presynaptic PGE2 EP2 Receptor
Sang, N., Zhang, J., Marcheselli, V., Bazan, N. G., & Chen, C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2392-05.2005 · Cited by 197
Interplay between inflammation and cancer
Piotrowski, I., Kulcenty, K. I., & Suchorska, W. M. (2020) · Reports of Practical Oncology & Radiotherapy · doi:10.1016/j.rpor.2020.04.004 · Cited by 192
The Role of Prostaglandins and Other Eicosanoids in the Gastrointestinal Tract
Wang, D., Mann, J. R., & DuBois, R. N. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.09.080 · Cited by 185
An EP2 receptor-selective prostaglandin E 2 agonist induces bone healing
Paralkar, V. M., Borovečki, F., Ke, H. Z., Cameron, K. O., Lefker, B. A., GRASSER, W. A., Owen, T. A., Li, M., DaSilva-Jardine, P. A., Zhou, M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1037343100 · Cited by 182
Cannabinoid Mechanisms of Pain Suppression
Walker, J. M., & Hohmann, A. G. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-26573-2_17 · Cited by 177
Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells
Salcedo, R., Zhang, X., Young, H. A., Michael, N. L., Wasserman, K., Ma, W.-H., Martins‐Green, M. M., Murphy, W. J., & Oppenheim, J. J. (2003) · Blood · doi:10.1182/blood-2002-11-3400 · Cited by 174
GPCR-I-TASSER: A Hybrid Approach to G Protein-Coupled Receptor Structure Modeling and the Application to the Human Genome
Zhang, J., Yang, J., Jang, R., & Zhang, Y. (2015) · Structure · doi:10.1016/j.str.2015.06.007 · Cited by 173
Cyclooxygenase-2: a potential target in breast cancer
Wang, D., & DuBois, R. N. (2004) · Seminars in Oncology · doi:10.1053/j.seminoncol.2004.01.008 · Cited by 170
Prostaglandins as inflammatory messengers across the blood-brain barrier
Engblom, D., Ek, M., Saha, S., Ericsson‐Dahlstrand, A., Jakobsson, P., & Blomqvist, A. G. (2002) · Journal of Molecular Medicine · doi:10.1007/s00109-001-0289-z · Cited by 167
Prostaglandin E2 Induces Degranulation-Independent Production of Vascular Endothelial Growth Factor by Human Mast Cells
Abdel-Majid, R. M., & Marshall, J. S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.2.1227 · Cited by 165
2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), an Orally Available and Long-Acting Prostacyclin Receptor Agonist Prodrug
Kuwano, K., Hashino, A., Asaki, T., Hamamoto, T., Yamada, T., Okubo, K., & Kuwabara, K. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.124248 · Cited by 164
Prostaglandin E2 Suppresses Bacterial Killing in Alveolar Macrophages by Inhibiting NADPH Oxidase
Serezani, C. H., Chung, J., Ballinger, M. N., Moore, B. B., Aronoff, D. M., & Peters-Golden, M. L. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0153oc · Cited by 164
Prostaglandin E2 involvement in mammalian female fertility: ovulation, fertilization, embryo development and early implantation
Niringiyumukiza, J. D., Cai, H., & Xiang, W. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0359-5 · Cited by 163
COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer
Timoshenko, A. V., Chakraborty, C., Wagner, G. F., & Lala, P. K. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603067 · Cited by 159
Cyclooxygenases and lipoxygenases in cancer
Schneider, C. G., & Pozzi, A. (2011) · Cancer and Metastasis Reviews · doi:10.1007/s10555-011-9310-3 · Cited by 158
Structural features of subtype-selective EP receptor modulators
Markovič, T., Jakopin, Ž., Dolenc, M. S., & Mlinarič‐Raščan, I. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.08.003 · Cited by 158
Production of PGE2 increases in tendons subjected to repetitive mechanical loading and induces differentiation of tendon stem cells into non‐tenocytes
Zhang, J., & Wang, J. H. (2009) · Journal of Orthopaedic Research® · doi:10.1002/jor.20962 · Cited by 155
The Prostaglandin E2 E-Prostanoid 4 Receptor Exerts Anti-Inflammatory Effects in Brain Innate Immunity
Shi, J., Johansson, J. U., Woodling, N. S., Wang, Q., Montine, T. J., & Andreasson, K. I. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903487 · Cited by 157
Physiology and Pharmacology of the Bladder and Urethra
Yoshimura, N., & Chancellor, M. B. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4160-6911-9.00060-8 · Cited by 154
Colon Carcinoma Cell Growth Is Associated with Prostaglandin E2/EP4 Receptor-evoked ERK Activation
Pozzi, A., Yan, X. S., Macias‐Perez, I., Wei, S. D., Hata, A. N., BREYER, R. M., Morrow, J. D., & Capdevila, J. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313989200 · Cited by 154
Self-citation
Prostaglandin F2α stimulates growth of skeletal muscle cells via an NFATC2-dependent pathway
Horsley, V., & Pavlath, G. K. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200208085 · Cited by 152
Cyclooxygenase-2 Inhibitor Induces Apoptosis in Breast Cancer Cells in an In vivo Model of Spontaneous Metastatic Breast Cancer
Basu, G. D., Pathangey, L. B., Tinder, T. L., LaGioia, M., Gendler, S. J., & Mukherjee, P. (2004) · Molecular Cancer Research · doi:10.1158/1541-7786.632.2.11 · Cited by 151
Localization of Adenylyl Cyclase Isoforms and G Protein-Coupled Receptors in Vascular Smooth Muscle Cells: Expression in Caveolin-Rich and Noncaveolin Domains
Ostrom, R. S., Liu, X., Head, B. P., Gregorian, C., Seasholtz, T. M., & Insel, P. A. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.5.983 · Cited by 151
Role of prostaglandin E2 receptors in migration of murine and human breast cancer cells
Timoshenko, A. V., Xu, G., Chakrabarti, S., Lala, P. K., & Chakraborty, C. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00269-6 · Cited by 151
Prostaglandin E2 EP receptors as therapeutic targets in breast cancer
Reader, J. C., Holt, D. M., & Fulton, A. M. (2011) · Cancer and Metastasis Reviews · doi:10.1007/s10555-011-9303-2 · Cited by 152
COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis
Majumder, M., Xin, X., Liu, L., Tutunea-Fatan, E., Rodriguez-Torres, M., Vincent, K. M., Postovit, L.-M. M., Hess, D. A., & Lala, P. K. (2016) · Stem Cells · doi:10.1002/stem.2426 · Cited by 147
Differential stem- and progenitor-cell trafficking by prostaglandin E2
Hoggatt, J., Mohammad, K. S., Singh, P., Hoggatt, A. F., Chitteti, B. R., Speth, J. M., Hu, P., Poteat, B. A., Stilger, K. N., Ferraro, F., et al. (2013) · Nature · doi:10.1038/nature11929 · Cited by 150
Self-citation
Endogenous PGE2Regulates Membrane Excitability and Synaptic Transmission in Hippocampal CA1 Pyramidal Neurons
Chen, C., & Bazan, N. G. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00696.2004 · Cited by 149
Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts
Akune, T., Ogata, N., Hoshi, K., Kubota, N., Terauchi, Y., Tobe, K., Takagi, H., Azuma, Y., Kadowaki, T., Nakamura, K., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200204046 · Cited by 141
Cyclooxygenase-2-derived Prostaglandin E2 Promotes Human Cholangiocarcinoma Cell Growth and Invasion through EP1 Receptor-mediated Activation of the Epidermal Growth Factor Receptor and Akt
Han, C. L., & Wu, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500562200 · Cited by 138
Retracted
Prostanoid Receptors
Hirata, T., & Narumiya, S. (2011) · Chemical Reviews · doi:10.1021/cr200010h · Cited by 137
COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice.
Vardeh, D., Wang, D.-R., Costigan, M., Lazarus, M., Saper, C., Woolf, C., FitzGerald, G., & Samad, T. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37098 · Cited by 146
The second PGD2 receptor CRTH2: structure, properties, and functions in leukocytes
Nagata, K., & Hirai, H. (2003) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(03)00078-4 · Cited by 137
Molecular pathways mediating the anti-inflammatory effects of calcitriol: implications for prostate cancer chemoprevention and treatment
Krishnan, A. V., & Feldman, D. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0139 · Cited by 139
Molecular Mechanisms of Mouse Skin Tumor Promotion
Rundhaug, J. E., & Fischer, S. M. (2010) · Cancers · doi:10.3390/cancers2020436 · Cited by 140
Prostaglandin E 2 : the master of endometriosis?
Wu, M., Lu, C.-W., Chuang, P., & Tsai, S. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.009321 · Cited by 139

Authors: Breyer, R. M., Bagdassarian, C. K., Myers, S. A., & Breyer, M. D.
Affiliations: United States Department of Veterans Affairs (US)
ORCID: Breyer, Richard M
Breyer, Matthew D
Venue: Annual Review of Pharmacology and Toxicology
Publisher: Annual Reviews
Published: 2001-04
Volume: 41
Issue: 1
Pages: 661-690
ISSN: 0362-1642 (ISSN-L)
1545-4304
DOI: 10.1146/annurev.pharmtox.41.1.661
OpenAlex: W2129746956
Cited by: 1,011
References: 152
Citations by year: 2026: 7 · 2025: 17 · 2024: 11 · 2023: 22 · 2022: 17 · 2021: 27 · 2020: 37 · 2019: 22 · 2018: 24 · 2017: 32 · 2016: 38 · 2015: 43 · 2014: 50 · 2013: 40 · 2012: 51
FWCI: 5.37
Type: journal article
Language: en
Open access: closed
Locations: The Annual Review of Pharmacology and Toxicology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM 15431)
National Institute of Diabetes and Digestive and Kidney Diseases (DK37097, DK46205, R01DK037097, R01DK046205)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: prostanoid receptors, G protein-coupled receptors, prostaglandins, cyclooxygenase, arachidonic acid metabolism, prostaglandin E2, prostaglandin F2alpha, prostacyclin, thromboxane A2, prostaglandin D2, receptor subtypes, ligand selectivity, splice variants, receptor desensitization, receptor phosphorylation, constitutive receptor activity, signal transduction
MeSH terms: Amino Acid Sequence, Animals, Humans, Molecular Sequence Data, Prostaglandins, Receptors, Prostaglandin, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Prostanoid Receptors: Subtypes and Signaling

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks