The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Molecular Approach to Adenosine Receptors: Receptor-Mediated Mechanisms of Tissue Protection
Abstract
Adenosine accumulation during ischemia and inflammation protects tissues from injury. In ischemic tissues adenosine accumulates due to inhibition of adenosine kinase, and in inflamed tissues adenosine is formed from adenine nucleotides that are released from many cells including platelets, mast cells, nerves, and endothelium. Nucleotides are rapidly converted to adenosine by a family of ecto-nucleotidases including CD39 and CD73. Activation of A 1 and possibly A 3 adenosine receptors (ARs) protects heart and other tissues by preconditioning through a pathway including protein kinase C and mitochondrial K ATP channels. Activation of A 2A receptors limits reperfusion injury by inhibiting inflammatory processes in neutrophils, platelets, macrophages and T cells. Adenosine produces proinflammatory responses mediated by receptors that vary among species; A 3 and A 2B receptors mediate degranulation of rodent and human or canine mast cells, respectively. Novel adenosine receptor subtype–selective ligands have recently been developed. These include MRS1754 (A 2B blocker), MRS1220 (A 3 blocker), MRE 3008F20 (human A 3 blocker), MRS1523 (rat A 3 blocker), and ATL146e (A 2A agonist). These new pharmacologic tools will help investigators to sort out how adenosine protects tissues from injury and to identify new therapeutic agents that hold promise for the treatment of inflammatory and ischemic diseases.
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Cites
A 2A -Adenosine Receptor Reserve for Coronary Vasodilation
Shryock, J. C., Snowdy, S., Baraldi, P. G., Cacciari, B., Spalluto, G., Monopoli, A., Ongini, E., Baker, S. P., & Belardinelli, L. (1998) · Circulation · doi:10.1161/01.cir.98.7.711 · Cited by 199
Cited by
International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors
Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Klotz, K.-N., & Linden, J. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01511-4 · Cited by 2,585
Self-citationSynnestvedt, K., Furuta, G. T., Comerford, K. M., Louis, N., Karhausen, J., Eltzschig, H. K., Hansen, K. R., Thompson, L. F., & Colgan, S. P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215337 · Cited by 660
Regulation of immune cells by local-tissue oxygen tension: HIF1α and adenosine receptors
Sitkovsky, M., & Lukashev, D. (2005) · Nature Reviews Immunology · doi:10.1038/nri1685 · Cited by 518
Coordinated Adenine Nucleotide Phosphohydrolysis and Nucleoside Signaling in Posthypoxic Endothelium
Eltzschig, H. K., Ibla, J. C., Furuta, G. T., Leonard, M. O., Jacobson, K. A., Enjyoji, K., Robson, S. C., & Colgan, S. P. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030891 · Cited by 499
Ferrante, C. J., Pinhal-Enfield, G., Elson, G., Cronstein, B. N., Hasko, G., Outram, S., & Leibovich, S. J. (2013) · Inflammation · doi:10.1007/s10753-013-9621-3 · Cited by 375
Regulation of Inflammation by Adenosine
Haskó, G., & Cronstein, B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00085 · Cited by 367
Samanta, D., Park, Y., Ni, X., Li, H., Zahnow, C. A., Gabrielson, E., Pan, F., & Semenza, G. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718197115 · Cited by 302
Sitkovsky, M. V., Kjaergaard, J., Lukashev, D., & Ohta, A. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0229 · Cited by 253
Acute adenosinergic cardioprotection in ischemic-reperfused hearts.
Headrick, J. P., Hack, B., & Ashton, K. J. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00407.2003 · Cited by 171
A nucleotidase with unique catalytic properties is secreted by Trichinella spiralis
Gounaris, K., Selkirk, M. E., & Sadeghi, S. J. (2004) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2004.04.008 · Cited by 31
Jo, S., Baek, A., Cho, Y., Kim, S. H., Baek, D., Hwang, J., Cho, S.-R., & Kim, H. J. (2023) · Scientific Reports · doi:10.1038/s41598-023-32744-9 · Cited by 19
Zhang, J., Walk, S. F., Ravichandran, K. S., & Garrison, J. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.016865 · Cited by 18
Metadata
- Authors
- Linden, J.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2001-04
- Volume
- 41
- Issue
- 1
- Pages
- 775-787
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2116238347
- Cited by
- 685
- References
- 1
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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