The DOI matches its Crossref record; 214 of the 214 references it cites were found in a registry or an index.
Molecular Basis of Ethnic Differences in Drug Disposition and Response
Abstract
Ethnicity is an important demographic variable contributing to interindividual variability in drug metabolism and response. In this rapidly expanding research area many genetic factors that account for the effects of ethnicity on pharmacokinetics, pharmacodynamics, and drug safety have been identified. This review focuses on recent developments that have improved understanding of the molecular mechanisms responsible for such interethnic differences. Genetic variations that may provide a molecular basis for ethnic differences in drug metabolizing enzymes (CYP 2C9, 2C19, 2D6, and 3A4), drug transporter (P-glycoprotein), drug receptors (adrenoceptors), and other functionally important proteins (eNOS and G proteins) are discussed. A better understanding of the molecular basis underlying ethnic differences in drug metabolism, transport, and response will contribute to improved individualization of drug therapy.
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Cited by
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Metadata
- Authors
- Xie, H.-G., Kim, R. B., Wood, A. J., & Stein, C. M.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2001-04
- Volume
- 41
- Issue
- 1
- Pages
- 815-850
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2114346603
- Cited by
- 600
- References
- 214
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xie, H.-G., Kim, R. B., Wood, A. J., & Stein, C. M. (2001). Molecular Basis of Ethnic Differences in Drug Disposition and Response. Annual Review of Pharmacology and Toxicology. https://doi.org/10.1146/annurev.pharmtox.41.1.815
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
