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Cited by 337Drug Transport and Resistance MechanismsPharmacogenetics and Drug MetabolismProtein Interaction Studies and Fluorescence Analysis

The DOI matches its Crossref record; 199 of the 199 references it cites were found in a registry or an index.

EVALUATION OF DRUG-DRUG INTERACTION IN THE HEPATOBILIARY AND RENAL TRANSPORT OF DRUGS

Shitara, Yoshihisa, Sato, Hitoshi, Sugiyama, Yuichi·2005·Annual Review of Pharmacology and Toxicology
DOI 10.1146/annurev.pharmtox.44.101802.121444
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Abstract

Recent studies have revealed the import role played by transporters in the renal and hepatobiliary excretion of many drugs. These transporters exhibit a broad substrate specificity with a degree of overlap, suggesting the possibility of transporter-mediated drug-drug interactions with other substrates. This review is an overview of the roles of transporters and the possibility of transporter-mediated drug-drug interactions. Among the large number of transporters, we compare the Ki values of inhibitors for organic anion transporting polypeptides (OATPs) and organic anion transporters (OATs) and their therapeutic unbound concentrations. Among them, cephalosporins and probenecid have the potential to produce clinically relevant OAT-mediated drug-drug interactions, whereas cyclosporin A and rifampicin may trigger OATP-mediated ones. These drugs have been reported to cause drug-drug interactions in vivo with OATs or OATP substrates, suggesting the possibility of transporter-mediated drug-drug interactions. To avoid adverse consequences of such transporter-mediated drug-drug interactions, we need to be more aware of the role played by drug transporters as well as those caused by drug metabolizing enzymes.

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Metadata

Authors
Shitara, Y., Sato, H., & Sugiyama, Y.
Affiliations
  • SHOWA Medical University (JP)
  • The University of Tokyo (JP)
ORCID
Venue
Annual Review of Pharmacology and Toxicology
Publisher
Annual Reviews
Published
2005-09-22
Volume
45
Issue
1
Pages
689-723
ISSN
  • 0362-1642 (ISSN-L)
  • 1545-4304
DOI
10.1146/annurev.pharmtox.44.101802.121444
OpenAlex
W2066382275
Cited by
336
References
199
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 11 · 2020: 8 · 2019: 7 · 2018: 9 · 2017: 14 · 2016: 15 · 2015: 12 · 2014: 14 · 2013: 23 · 2012: 25
FWCI
2.12
Type
journal article
Language
en
Open access
closed
Locations
  • The Annual Review of Pharmacology and Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
Keywords
drug-drug interactions, drug transporters, renal drug excretion, organic anion transporting polypeptides, organic anion transporters, transporter inhibitors, Ki values, substrate specificity, probenecid, cephalosporins, cyclosporine, rifampicin, drug-metabolizing enzymes
MeSH terms
Animals, Biliary Tract, Biological Transport, Drug Evaluation, Drug Interactions, Pharmaceutical Preparations, Humans, Kidney, Liver

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