Cited by 334Cancer-related Molecular PathwaysCell death mechanisms and regulationSignaling Pathways in Disease

The DOI matches its Crossref record; 159 of the 159 references it cites were found in a registry or an index.

THE MANY ROLES OF c-Myc IN APOPTOSIS

Thompson, E. Brad·1998·Annual Review of Physiology

Open this paper in CoChat — free account

Abstract

▪ Abstract The proto-oncogene c-myc encodes a transcription factor c-Myc, which is of great importance in controlling cell growth and vitality. The quantity of c-Myc is carefully controlled by many mechanisms, and its actions to induce and repress genes are modulated by interactions with other regulatory proteins. Understanding the kinetic and quantitative relationships that determine how and what genes c-Myc regulates is essential to understanding how Myc is involved in apoptosis. Reduction of c-myc expression and its inappropriate expression can be associated with cellular apoptosis. This review outlines the nature and regulation of the c-myc gene and of c-Myc and presents the systems and conditions in which Myc-related apoptotic events occur. Hypotheses of the mechanisms by which expression and repression of c-myc lead to apoptosis are discussed.

Integrity signals

Registry

Crossref · 10.1146/annurev.physiol.60.1.575

Cites

159 of 159 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Induction of apoptosis in fibroblasts by c-myc protein
Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M. W., Waters, C. M., Penn, L. Z., & Hancock, D. C. (1992) · Cell · doi:10.1016/0092-8674(92)90123-t · Cited by 2,941
Thymocyte apoptosis induced by p53-dependent and independent pathways
Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., & Wyllie, A. H. (1993) · Nature · doi:10.1038/362849a0 · Cited by 2,271
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
Yonish-Rouach, E., Resnftzky, D., Lotem, J., Sachs, L., Kimchi, A., & Oren, M. (1991) · Nature · doi:10.1038/352345a0 · Cited by 2,079
c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth
Shim, H., Dolde, C., Lewis, B. C., Wu, C.-S., Dang, G., Jungmann, R. A., Dalla-Favera, R., & Dang, C. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6658 · Cited by 1,092
Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.
Askew, D. S., Ashmun, R. A., Simmons, B. C., & Cleveland, J. L. (1991) · PubMed · Cited by 867
Myc Function and Regulation
Marcu, K. B., Bossone, S., & Patel, A. J. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.004113 · Cited by 802
A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death
Ham, J., Babij, C., Whitfield, J. R., Pfarr, C. M., Lallemand, D., Yaniv, M., & Rubin, L. L. (1995) · Neuron · doi:10.1016/0896-6273(95)90331-3 · Cited by 795
Proteins of the Myc Network: Essential Regulators of Cell Growth and Differentiation
Arsenian‐Henriksson, M., & Lüscher, B. (1996) · Advances in cancer research · doi:10.1016/s0065-230x(08)60353-x · Cited by 781
A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
Littlewood, T. D., Hancock, D. C., Danielian, P. S., Parker, M. G., & Evan, G. I. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.10.1686 · Cited by 780
Reactive oxygen species and programmed cell death
Jacobson, M. D. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)20008-8 · Cited by 754
Gene inhibition using antisense oligodeoxynucleotides
Wagner, R. W. (1994) · Nature · doi:10.1038/372333a0 · Cited by 747
Mediation of c-Myc-Induced Apoptosis by p53
Hermeking, H., & Eick, D. (1994) · Science · doi:10.1126/science.8091232 · Cited by 741
c‐Myc‐induced apoptosis in fibroblasts is inhibited by specific cytokines.
Harrington, E. A., Bennett, M. R., Fanidi, A., & Evan, G. I. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06630.x · Cited by 737
Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas
Shi, Y., Glynn, J. M., Guilbert, L. J., Cotter, T. G., Bissonnette, R. P., & Green, D. R. (1992) · Science · doi:10.1126/science.1378649 · Cited by 689
Control of c-myc Regulation in Normal and Neoplastic Cells
Spencer, C. A., & Groudine, M. T. (1991) · Advances in cancer research · doi:10.1016/s0065-230x(08)60476-5 · Cited by 616
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.Preprint
Wagner, A. J., Kokontis, J. M., & Hay, N. (1994) · Genes & Development · doi:10.1101/gad.8.23.2817 · Cited by 541
Deregulated Expression of E2F-1 Induces S-Phase Entry and Leads to Apoptosis
Shan, B., & Lee, W. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8166 · Cited by 529
BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]
McGahon, A. J., Bissonnette, R. P., Schmitt, M., Cotter, K., Green, D. R., & Cotter, T. G. (1994) · Blood · doi:10.1182/blood.v83.5.1179.bloodjournal8351179 · Cited by 484
P53, cell cycle control and apoptosis: Implications for cancer
Kastan, M. B., Canman, C. E., & Leonard, C. J. (1995) · Cancer and Metastasis Reviews · doi:10.1007/bf00690207 · Cited by 482
Induction of apoptosis by the transcription factor c‐Jun
Bossy‐Wetzel, E., Bakiri, L., & Yaniv, M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.7.1695 · Cited by 432
The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells.
Harris, A. W., Pinkert, C. A., Crawford, M., Langdon, W. Y., Brinster, R. L., & Adams, J. M. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.2.353 · Cited by 432
The c‐Myc protein induces cell cycle progression and apoptosis through dimerization with Max.
Amati, B. B., Littlewood, T. D., Evan, G. I., & Land, H. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06202.x · Cited by 384
The role of c-myc in cell growth
Evan, G. I., & Littlewood, T. D. (1993) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(05)80339-9 · Cited by 364
Apoptosis and the cell cycle
Evan, G. I., Brown, L., Whyte, M. K. B., & Harrington, E. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80066-2 · Cited by 338
Control of programmed cell death in normal and leukemic cells: new implications for therapy
Sachs, L., & Lotem, J. (1993) · Blood · doi:10.1182/blood.v82.1.15.bloodjournal82115 · Cited by 282
Oncogenes and cell death
Harrington, E. A., Fanidi, A., & Evan, G. I. (1994) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(94)90100-7 · Cited by 264
The block to transcriptional elongation within the human c-myc gene is determined in the promoter-proximal region.Preprint
Krumm, A., Meulia, T., Brunvand, M. W., & Groudine, M. T. (1992) · Genes & Development · doi:10.1101/gad.6.11.2201 · Cited by 263
Glucocorticoid‐induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor.
Helmberg, A., Auphan‐Anezin, N., Caelles, C., & Karin, M. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07021.x · Cited by 262
c-Myc and apoptosis
Packham, G., & Cleveland, J. L. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(94)00015-t · Cited by 250
Ornithine Decarboxylase Is a Mediator of c-Myc-Induced Apoptosis
Packham, G., & Cleveland, J. L. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5741-5747.1994 · Cited by 245
Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells.
Reynolds, J. E., Yang, T., Lü, Q., Jenkinson, J. D., Zhou, P., Eastman, A. R., & Craig, R. W. (1994) · PubMed · Cited by 240
Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis
Desaintes, C., Demeret, C., Goyat, S., Yaniv, M., & Thierry, F. (1997) · The EMBO Journal · doi:10.1093/emboj/16.3.504 · Cited by 215
Participation of cyclin A in Myc-induced apoptosis.
Hoang, A. T., Cohen, K. J., Barrett, J. F., Bergstrom, D. A., & Dang, C. V. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.6875 · Cited by 206
Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation.
Ohta, H., Sweeney, E. A., Masamune, A., Yatomi, Y., Hakomori, S., & Igarashi, Y. (1995) · PubMed · Cited by 195
Requirement of AP-1 for Ceramide-induced Apoptosis in Human Leukemia HL-60 Cells
Sawai, H., Okazaki, T., Yamamoto, H., OKANO, H., Takeda, Y., Tashima, M., Sawada, H., Okuma, M., Ishikura, H., Umehara, H., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27326 · Cited by 185
Hold back of RNA polymerase II at the transcription start site mediates down‐regulation of c‐myc in vivo.
Strobl, L. J., & Eick, D. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05409.x · Cited by 184
Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment.
Lebowitz, P. F., Sakamuro, D., & Prendergast, G. C. (1997) · PubMed · Cited by 183
Hypoxia impairs cell fusion and differentiation process in human cytotrophoblast, in vitro
Alsat, E., Wyplosz, P., Malassiné, A., Guibourdenche, J., Porquet, D., Nessmann, C., & Evain‐Brion, D. (1996) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199608)168:2 · Cited by 182
Myc oncogenes: the enigmatic family
Ryan, K. M., & Birnie, G. D. (1996) · Biochemical Journal · doi:10.1042/bj3140713 · Cited by 179
Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide identifies a critical role for c-myc in the growth of human breast cancer.
Watson, P. H., Pon, R. T., & Shiu, R. P. C. (1991) · PubMed · Cited by 177
Translational Control of Programmed Cell Death: Eukaryotic Translation Initiation Factor 4E Blocks Apoptosis in Growth-Factor-Restricted Fibroblasts with Physiologically Expressed or Deregulated Myc
Polunovsky, V. A., Rosenwald, I. B., Tan, A., White, J. G., Chiang, L., Sonenberg, N., & Bitterman, P. B. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6573 · Cited by 165
Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling
Roussel, M. F., Cleveland, J. L., Shurtleff, S. A., & Sherr, C. J. (1991) · Nature · doi:10.1038/353361a0 · Cited by 164
c-fos proto-oncogene regulation and function
Piechaczyk, M., & Blanchard, J. (1994) · Critical Reviews in Oncology/Hematology · doi:10.1016/1040-8428(94)90021-3 · Cited by 151
Tumour-specific inhibition of lymphoma growth by an antisense oligodeoxynucleotide
McManaway, M. E., Alnasser, A., Shiramizu, B. T., Goldschmidts, W., Bhatia, K. G., MAGRATH, I. T., Neckers, L., Loke, S. L., Redner, R. L., & Huber, B. E. (1990) · The Lancet · doi:10.1016/0140-6736(90)90934-w · Cited by 150
Integrated control of cell proliferation and cell death by the c- myc oncogene
Evan, G. I., Harrington, E. O., Fanidi, A., Land, H., Amati, B. B., & Bennett, M. R. (1994) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1994.0105 · Cited by 147
Induction of apoptosis during normal and neoplastic B-cell development in the bursa of Fabricius.
Neiman, P. E., Thomas, S. J., & Loring, G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5857 · Cited by 147
Identification of Putative c-Myc-Responsive Genes: Characterization of rcl , a Novel Growth-Related Gene†
Lewis, B. C., Shim, H., Li, Q., Wu, C. S., Lee, L. A., Maity, A. M., & Dang, C. V. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.4967 · Cited by 147
c-Myc induces apoptosis in epithelial cells by both p53-dependent and p53-independent mechanisms.
Sakamuro, D., Eviner, V. T., Elliott, K. J., Showe, L. C., White, E., & Prendergast, G. C. (1995) · PubMed · Cited by 145
Phenylacetate: a novel nontoxic inducer of tumor cell differentiation.
Samid, D., Shack, S., & Sherman, L. T. (1992) · PubMed · Cited by 144
How p53 Suppresses Cell Growth
Marx, J. L. (1993) · Science · doi:10.1126/science.8259506 · Cited by 142
Apoptosis and steroid hormones.
Thompson, E. B. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.6.7935482 · Cited by 141
Self-citation
Inhibition of c-myc Expression Induces Apoptosis of WEHI 231 Murine B Cells
Wu, M., Arsura, M., Bellas, R. E., Fitzgerald, M. J., Lee, H., Schauer, S. L., Sherr, D. H., & Sonenshein, G. E. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.5015 · Cited by 136
p53 Tumor Suppressor Gene: At the Crossroads of Molecular Carcinogenesis, Molecular Epidemiology, and Cancer Risk Assessment
Harris, C. C. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104s3435 · Cited by 135
Inducible overproduction of the mouse c-myc protein in mammalian cells.
Wurm, F. M., Gwinn, K. A., & Kingston, R. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.15.5414 · Cited by 130
Suppression of c-myc is a critical step in glucocorticoid-induced human leukemic cell lysis.
Thulasi, R., Harbour, D. V., & Thompson, E. B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46845-1 · Cited by 122
Self-citation
Antitumor Effect of c-myc Antisense Phosphorothioate Oligodeoxynucleotides on Human Melanoma Cells In Vitro and in Mice
Leonetti, C., D’Agnano, I., Lozupone, F., Valentini, A., Geiser, T., Zon, G., Calabretta, B., Citro, G., & Zupi, G. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.7.419 · Cited by 121
Specific inhibition of c- myc protein biosynthesis using an antisense synthetic deoxy-oligonucleotide in human T lymphocytes.
Harel‐Bellan, A., Ferris, D. K., Vinocour, M., Holt, J. T., & Farrar, W. L. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.7.2431 · Cited by 118
The Cellular Effects of E2F Overexpression
Adams, P. D., & Kaelin, W. G. (1996) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-79910-5_4 · Cited by 113
Delivery of c-myc Antisense Phosphorothioate Oligodeoxynucleotides to Hematopoietic Cells in Culture by Liposome Fusion: Specific Reduction in c-myc Protein Expression Correlates with Inhibition of Cell Growth and DNA Synthesis
Loke, S. L., Stein, C. A., Zhang, X., Avigan, M., Cohen, J. S., & Neckers, L. (1988) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-74006-0_38 · Cited by 103
Lymphoma models for B cell activation and tolerance. X. Anti-mu-mediated growth arrest and apoptosis of murine B cell lymphomas is prevented by the stabilization of myc.
Fischer, G., Kent, S. C., Joseph, L. J., Green, D. R., & Scott, D. W. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.1.221 · Cited by 100
Specific regulation of c-myc oncogene expression in a murine B-cell lymphoma.
McCormack, J. E., Pepe, V. H., Kent, R. B., Dean, M. C., Marshak‐Rothstein, A., & Sonenshein, G. E. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.17.5546 · Cited by 99
Glucocorticoid Effect on Oncogene/Growth Gene Expression in Human T Lymphoblastic Leukemic Cell Line CCRF-CEM
Yuh, Y. S., & Thompson, E. B. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81706-9 · Cited by 97
Self-citation
Increased Tumor Proliferation and Genomic Instability without Decreased Apoptosis in MMTV-ras Mice Deficient in p53
Hundley, J. E., Koester, S. K., Troyer, D. A., Hilsenbeck, S. G., Subler, M. A., & Windle, J. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.2.723 · Cited by 92
Role of myc amplification and overexpression in cell growth, differentiation and death.
Koskinen, P. J., & Alitalo, K. K. (1993) · PubMed · Cited by 89
Overexpression of PU.1 Induces Growth and Differentiation Inhibition and Apoptotic Cell Death in Murine Erythroleukemia Cells
Yamada, T., Kondoh, N., Matsumoto, M., Yoshida, M., Maekawa, A., & Oikawa, T. (1997) · Blood · doi:10.1182/blood.v89.4.1383 · Cited by 87
Control of apoptosis in hematopoiesis and leukemia by cytokines, tumor suppressor and oncogenes.
Lotem, J., & Sachs, L. (1996) · PubMed · Cited by 86
Alterations of c-myc expression by antisense oligodeoxynucleotides enhance the induction of apoptosis in HL-60 cells.
Kimura, S., Maekawa, T., Hirakawa, K., Murakami, A., & Abé, T. (1995) · PubMed · Cited by 84
Induction of differentiation and growth arrest associated with nascent (nonoligosomal) DNA fragmentation and reduced c-myc expression in MCF-7 human breast tumor cells after continuous exposure to a sublethal concentration of doxorubicin.
Fornari, F. A., Jarvis, W. D., Grant, S., Orr, M. S., Randolph, J. K., White, F. K. H., Mumaw, V. R., Lovings, E. T., Freeman, R. H., & Gewirtz, D. A. (1994) · PubMed · Cited by 84
Cooperation of TGF alpha and c-Myc in mouse mammary tumorigenesis: coordinated stimulation of growth and suppression of apoptosis.
Amundadottir, L. T., Nass, S. J., Berchem, G., Johnson, M. D., & Dickson, R. B. (1996) · PubMed · Cited by 83
Evidence that c-myc mediated apoptosis does not require wild-type p53 during lymphomagenesis.
Hsu, B., Marín, M. C., El‐Naggar, A. K., Stephens, L. C., Brisbay, S. M., & McDonnell, T. J. (1995) · PubMed · Cited by 83
Glucocorticoid inhibition of c-myc, c-myb, and c-Ki-ras expression in a mouse lymphoma cell line.
Eastman‐Reks, S. B., & Vedeckis, W. V. (1986) · PubMed · Cited by 82
Cell cycle: On target with Myc
Zörnig, M., & Evan, G. I. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70769-0 · Cited by 80
Doxorubicin sensitizes human bladder carcinoma cells to Fas-mediated cytotoxicity
Mizutani, Y., Okada, Y., Yoshida, O., Fukumoto, M., & Bonavida, B. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19970315)79:6 · Cited by 80
Cell Cycle Regulation of the c-Myc Transcriptional Activation Domain
Seth, A., Gupta, S., & Davis, R. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.4125 · Cited by 79
DNA Fragmentation and Prolonged Expression of c- fos , c- jun , and hsp 70 in Kainic Acid-Induced Neuronal Cell Death in Transgenic Mice Overexpressing Human CuZn-Superoxide Dismutase
Kondo, T., Sharp, F. R., Honkaniemi, J., Mikawa, S., Epstein, C. J., & Chan, P. H. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199703000-00001 · Cited by 79
c-Myc in the Controlm of Cell Proliferation and Embryonic Development
Lemaı̂tre, J.-M., Buckle, R. S., & Méchali, M. (1996) · Advances in cancer research · doi:10.1016/s0065-230x(08)60873-8 · Cited by 76
Naturally Occurring (Programmed) and Radiation‐induced Apoptosis are Associated with Selective c‐Jun Expression in the Developing Rat Brain
Ferrer, I., Olivé, M., Ribera, J., & Planas, A. M. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01297.x · Cited by 75
Induction of apoptosis in NIH3T3 cells after serum deprivation by overexpression of rho-p21, a GTPase protein of the ras superfamily.
Jiménez, B., Arends, M. J., Esteve, P., Perona, R., Sánchez, R. J. B., y Cajal, S. R., Wyllie, A. H., & Lacal, J. C. (1995) · PubMed · Cited by 71
c-myc-dependent hepatoma cell apoptosis results from oxidative stress and not a deficiency of growth factors
Xu, Y., Nguyen, Q., Lo, D. C., & Czaja, M. J. (1997) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199702)170:2 · Cited by 70
c-Myc and cyclin D3 (CcnD3) genes are independent targets for glucocorticoid inhibition of lymphoid cell proliferation.
Rhee, K., Bresnahan, W. A., Hirai, A. M., Hirai, M., & Thompson, E. A. (1995) · PubMed · Cited by 69
Self-citation
Glucocorticoid Regulation of Transcription of the c-mycCellular Protooncogene in P1798 Cells
Forsthoefel, A. M., & Thompson, E. A. (1987) · Molecular Endocrinology · doi:10.1210/mend-1-12-899 · Cited by 68
Self-citation
Activation of apoptosis associated with enforced myc expression in myeloid progenitor cells is dominant to the suppression of apoptosis by interleukin-3 or erythropoietin
Askew, D. S., Ihle, J., & Cleveland, J. (1993) · Blood · doi:10.1182/blood.v82.7.2079.2079 · Cited by 68
Use of transgenic mice to study myc family gene function in normal mammalian development and in cancer.
Morgenbesser, S. D., & DePinho, R. A. (1994) · PubMed · Cited by 68
Activated N-ras contributes to the chemoresistance of human melanoma in severe combined immunodeficiency (SCID) mice by blocking apoptosis.
Jansen, B., Schlagbauer‐Wadl, H., Eichler, H. G., Wolff, K., van Elsas, A., Schrier, P. I., & Pehamberger, H. (1997) · PubMed · Cited by 64
Apoptosis and steroid hormones
Thompson, E. B. (1994) · Molecular Endocrinology · doi:10.1210/me.8.6.665 · Cited by 64
Self-citation
Electroporation of synthetic oligodeoxynucleotides: a novel technique for ex vivo bone marrow purging
Bergan, R. C., Hakim, F. T., Schwartz, G., Kyle, E., Cepada, R., Szabo, J., Fowler, D. H., Gress, R. E., & Neckers, L. (1996) · Blood · doi:10.1182/blood.v88.2.731.bloodjournal882731 · Cited by 61
Untitled work
(1998) · PubMed · Cited by 60
Self-citation
Antisense oligodeoxynucleotide combination therapy of primary chronic myelogenous leukemia blast crisis in SCID mice
Skórski, T., Nieborowska-Skorska, M., Wlodarski, P. K., Zon, G., Iozzo, R. V., & Calabretta, B. (1996) · Blood · doi:10.1182/blood.v88.3.1005.1005 · Cited by 60
Cyclin D3 Sensitizes Tumor Cells to Tumor Necrosis Factor-Induced, c-Myc-Dependent Apoptosis
Jänicke, R. U., Lin, X. Y., Lee, F. H. H., & Porter, A. G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5245 · Cited by 58
Anti-IgM-mediated Regulation of c-myc and Its Possible Relationship to Apoptosis
Kaptein, J. S., Lin, C.-K. E., Wang, C. L., Nguyen, T. T., Kalunta, C. I., Park, E., Chen, F.-S., & Lad, P. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.31.18875 · Cited by 56
The Max Transcription Factor Network: Involvement of Mad in Differentiation and an Approach to Identification of Target GenesPreprint
Hurlin, P. J., Ayer, D. E., Grandori, C., & Eisenman, R. N. (1994) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1994.059.01.014 · Cited by 56
Apoptosis and c-Jun in the thalamus of the rat following cortical infarction
Soriano, M. A., Ferrer, I., Rodrı́guez-Farré, E., & Planas, A. M. (1996) · Neuroreport · doi:10.1097/00001756-199601310-00012 · Cited by 56
Selective c-Jun overexpression is associated with ionizing radiation-induced apoptosis in the developing cerebellum of the rat
Ferrer, I., Olivé, M., Blanco, R. E., Cinós, C., & Planas, A. M. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00334-o · Cited by 56
Overexpression of cyclin A in the mammary glands of transgenic mice results in the induction of nuclear abnormalities and increased apoptosis.
Bortner, D. M., & Rosenberg, M. P. (1995) · PubMed · Cited by 56
Role of Three Cancer ≪Master Genes≫ P53, Bcl2 and C-Myc on the Apoptotic Process
Chiarugi, V. P., & Ruggiero, M. (1996) · Tumori Journal · doi:10.1177/030089169608200303 · Cited by 54
Block of c-myc expression by antisense oligonucleotides inhibits proliferation of human thyroid carcinoma cell lines.
Cerutti, J. M., Trapasso, F., Battaglia, C., Zhang, L., Martelli, M. L., Visconti, R., Berlingieri, M. T., Fagin, J. A., Santoro, M. M., & Fusco, A. (1996) · PubMed · Cited by 53
Functional Myc-Max heterodimer is required for activation-induced apoptosis in T cell hybridomas.
Bissonnette, R. P., McGahon, A. J., Mahboubi, A., & Green, D. R. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.6.2413 · Cited by 52
Promotion and Inhibition of Activation‐Induced Apoptosis in T‐Cell Hybridomas by Oncogenes and Related Signals
Green, D. R., Mahboubi, A., Nishioka, W. K., Oja, S., Echeverri, F., Shi, Y., Glynn, J., Yang, Y., Ashwell, J. D., & Bjssonnette, R. (1994) · Immunological Reviews · doi:10.1111/j.1600-065x.1994.tb00895.x · Cited by 51
Reconstitution of wild-type p53 expression triggers apoptosis in a p53-negative v-myc retrovirus-induced T-cell lymphoma line.
Wang, Y., Ramqvist, T., Székely, L., Axelson, H., Klein, G., & Wiman, K. G. (1993) · PubMed · Cited by 51
Activation-induced apoptosis in lymphoid systems.
Green, D. R., Bissonnette, R. P., Glynn, J. M., & Shi, Y. (1992) · PubMed · Cited by 50
Apoptosis and macrophage-mediated deletion of precursor B cells in the bone marrow of E mu-myc transgenic mice
Jacobsen, K. A., Prasad, V., Sidman, C., & Osmond, D. G. (1994) · Blood · doi:10.1182/blood.v84.8.2784.2784 · Cited by 49
DNA fragmentation and activation of c-Jun in the cerebellum of mutant mice (weaver, Purkinje cell degeneration)
Gillardon, F., Bäurle, J., Grüsser‐Cornehls, U., & Zimmermann, M. (1995) · Neuroreport · doi:10.1097/00001756-199509000-00014 · Cited by 45
Functional characterization of p53 molecules expressed in human squamous cell carcinomas of the head and neck
Yeudall, W. A., Jakus, J., Ensley, J. F., & Robbins, K. C. (1997) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199702)18:2 · Cited by 45
Inhibition of DLX-7 homeobox gene causes decreased expression of GATA-1 and c- myc genes and apoptosis
Shimamoto, T., Nakamura, S., Bollekens, J. A., Ruddle, F. H., & Takeshita, K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3245 · Cited by 44
Analysis of Events Associated with Serum Deprivation-Induced Apoptosis in C3H/Sol8 Muscle Satellite Cells
Mampuru, L. J., Chen, S., Kalenik, J. L., Bradley, M. E., & Lee, T. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0238 · Cited by 43
Myc: a single gene controls both proliferation and apoptosis in mammalian cells
Desbarats, L., Schneider, A., Müller, D., Bürgin, A., & Eilers, M. (1996) · Cellular and Molecular Life Sciences · doi:10.1007/bf01952111 · Cited by 42
Characteristics of 25-Hydroxycholesterol-Induced Apoptosis in the Human Leukemic Cell Line CEM
Ayala‐Torres, S., Möller, P. C., Johnson, B. H., & Thompson, E. B. (1997) · Experimental Cell Research · doi:10.1006/excr.1997.3630 · Cited by 42
Self-citation
The Role of Ornithine Decarboxylase in c-Myc-induced Apoptosis
Packham, G., & Cleveland, J. L. (1995) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-79275-5_33 · Cited by 42
Down-modulation of c-myc expression induces apoptosis of B lymphocyte models of tolerance via clonal deletion
Sonenshein, G. E. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.5.1994 · Cited by 40
Apoptosis Induced by c-Myc Overexpression Is Dependent on Growth Conditions
Gibson, A. W., Cheng, T., & Johnston, R. N. (1995) · Experimental Cell Research · doi:10.1006/excr.1995.1166 · Cited by 40
Role of c-jun induction in the glucocorticoid-evoked apoptotic pathway in human leukemic lymphoblasts
Zhou, F. L., & Thompson, E. B. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.3.8833659 · Cited by 40
Self-citation
Differential regulation of cell cycle characteristics and apoptosis in MMTV-myc and MMTV-ras mouse mammary tumors.
Hundley, J. E., Koester, S. K., Troyer, D. A., Hilsenbeck, S. G., Barrington, R. E., & Windle, J. J. (1997) · PubMed · Cited by 36
Induction of hepatoma cell apoptosis by c-myc requires zinc and occurs in the absence of DNA fragmentation
Xu, J., Xu, Y., Nguyen, Q., Novikoff, P. M., & Czaja, M. J. (1996) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1996.270.1.g60 · Cited by 34
Induction of apoptosis by rho in NIH 3T3 cells requires two complementary signals. Ceramides function as a progression factor for apoptosis.
Esteve, P., del Peso, L., & Lacal, J. C. (1995) · PubMed · Cited by 34
Murine c-myc retroviruses alter the growth requirements of myeloid cell lines.
Cory, S., Bernard, O., Bowtell, D. D. L., Schrader, S., & Schrader, J. (1987) · PubMed · Cited by 34
Serum Withdrawal Induces Apoptotic Cell Death in Ki-ras Transformed but Not in Normal Differentiated Thyroid Cells
Jeso, B. D., Ulianich, L., Racioppi, L., D'Armiento, F. N., Feliciello, A., Pacifico, F., Consiglio, E., & Formisano, S. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2360 · Cited by 33
Apoptosis Induced by Oxysterol in CEM Cells Is Associated with Negative Regulation of c-Myc
Ayala‐Torres, S., Zhou, F. L., & Thompson, E. B. (1999) · Experimental Cell Research · doi:10.1006/excr.1998.4308 · Cited by 33
Self-citation
Effects of c-myc oncogene modulation on drug resistance in human small cell lung carcinoma cell lines.
Waardenburg, R. C. V., Prins, J., Meijer, C., Uges, D. R., Vries, E. G. D., & Mulder, N. H. (1996) · PubMed · Cited by 33
Myc Protein: Partners and Antagonists
Västrik, I., Mäkelä, T. P., Koskinen, P. J., Klefström, J. T., & Alitalo, K. K. (1994) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.v5.i1.30 · Cited by 32
Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase C.
Freemerman, A. J., Turner, A., Birrer, M. J., Szabo, E. M., Valerie, K. C., & Grant, S. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09059-5 · Cited by 32
Changes in c-myc expression and the kinetics of dexamethasone-induced programmed cell death (apoptosis) in human lymphoid leukaemia cells
Wood, A., Waters, C. M., Garner, A., & Hickman, J. A. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.128 · Cited by 30
Overexpression of mos oncogene product in Swiss 3T3 cells induces apoptosis preferentially during S-phase.
Fukasawa, K., Rulong, S., Resau, J., Silva, P. P. D., & Woude, G. F. V. (1995) · PubMed · Cited by 30
Cytotoxic effect of sodium nitroprusside on cancer cells: involvement of apoptosis and suppression of c-myc and c-myb proto-oncogene expression.
Sumitani, K., Kamijo, R., & NAGUMO, M. (1997) · PubMed · Cited by 29
Embryonic development of the enteric nervous system of the grasshopperSchistocerca americana
Ganfornina, M. D., S�nchez, D., & Bastiani, M. J. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960902)372:4 · Cited by 28
Jun and JNK Kinase Are Activated in Thymocytes in Response to VM26 and Radiation but Not Glucocorticoids
Testolin, L., Carson, C., Wang, Y., Walker, P. R., Armato, U., & Sikorska, M. (1997) · Experimental Cell Research · doi:10.1006/excr.1996.3419 · Cited by 28
C-JUN/AP-1 as possible mediators of tumor necrosis factor-alpha-induced apoptotic response in mouse JB6 tumor cells.
Singh, N., Sun, Y., Nakamura, K., Smith, M. R., & Colburn, N. H. (1995) · PubMed · Cited by 28
Modulation of cytotoxicity of chemotherapeutic drugs by activated H-γas
Fan, J., Banerjee, D., Stambrook, P. J., & Bertino, J. R. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00101-9 · Cited by 26
Strong c-Jun immunoreactivity is associated with apoptotic cell death in human tumors of the central nervous system
Fewer, I., Seguı́, J., & Olivé, M. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12879-2 · Cited by 26
Strong c-Jun immunoreactivity is associated with apoptotic cell death in human tumors of the central nervous system
Ferrer, I. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)12879-2 · Cited by 26
Glucocorticoid Antagonist RU 486 Reverses Agonist‐Induced Apoptosis and C‐Myc Repression in Human Leukemic CEM‐C7 Cells
Thompson, E. B., Thulasi, R., SAEED, M. F., & Johnson, B. H. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb31383.x · Cited by 25
Self-citation
Overexpression of c-Fos induces apoptosis of CD43+ pro-B cells
Hu, L., Hatano, M., Rüther, U., & Tokuhisa, T. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.9.3804 · Cited by 24
Mutant H-ras overexpression inhibits drug and U.V. induced apoptosis.
Fernandes, R. S., McGowan, A. J., & Cotter, T. G. (1996) · PubMed · Cited by 23
p53 Tumor Suppressor Gene: At the Crossroads of Molecular Carcinogenesis, Molecular Epidemiology, and Cancer Risk Assessment
Harris, C. C. (1996) · Environmental Health Perspectives · doi:10.2307/3432799 · Cited by 23
Relationship of c‐myc gene copy number and gene expression: Cellular effects of elevated c‐myc protein
Pallavicini, M. G., Rosette, C., Reitsma, M. J., DeTeresa, P. S., & Gray, J. W. (1990) · Journal of Cellular Physiology · doi:10.1002/jcp.1041430223 · Cited by 22
Apoptosis and c-jun induction by cisplatin in a human melanoma cell line and a drug-resistant daughter cell line
Zhao, R., Rabo, Y. B., Egyházi, S., Andersson, A., Edgren, M., Linder, S., & Hansson, J. (1995) · Anti-Cancer Drugs · doi:10.1097/00001813-199510000-00005 · Cited by 22
Characterization of double transgenic mice expressing hepatocye growth factor and transforming growth factor alpha.
Shiota, G., Kawasaki, H., Nakamura, T., & Schmidt, E. V. (1995) · PubMed · Cited by 22
Cationic lipids reduce time and dose of c-myc antisense oligodeoxynucleotides required to specifically inhibit Burkitt's lymphoma cell growth.
Sa, W., Chang, L., Buzby, J. S., Suen, Y., & CAIRO, M. S. (1996) · PubMed · Cited by 21
Combination Anti-Gene Therapy Targeting c-myc and p53 in Ovarian Cancer Cell Lines
Janicek, M. F., Sevin, B. U., Nguyen, H. N., & Averette, H. E. (1995) · Gynecologic Oncology · doi:10.1006/gyno.1995.1272 · Cited by 19
Antitumor Effects of Antisense Phosphorothioate c-myc Oligodeoxynucleotides: a Question of Mechanism
Stein, C. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.7.391 · Cited by 18
Role of c-myc and CD45 in spontaneous and anti-receptor-induced apoptosis in adult murine B cells
Scott, D. W., Lamers, M. C., Köhler, G., Sidman, C. L., Maddox, B., Carsetti, R., & Haughton, G. (1996) · International Immunology · doi:10.1093/intimm/8.9.1375 · Cited by 17
Down Regulation of C-MYC and MAX Genes Is Associated to Inhibition of Protein Phosphatase 2A in K562 Human Leukemia Cells
Lerga, A., Belandia, B., Delgado, M. D., Cuadrado, M. A., Richard, C., Ortiz, J. M., Martı́n-Pérez, J., & León, J. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2547 · Cited by 16
Antiapoptotic effect of ras in the apoptosis induced by serum deprivation and exposure to actinomycin D
Chou, C. C., & Yung, B. Y. (1997) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/pl00004929 · Cited by 16
Glucocorticoid regulation of c-myc promoter utilization in P1798 T-lymphoma cells.
Ma, T., Mahajan, P. B., & Thompson, E. A. (1992) · Molecular Endocrinology · doi:10.1210/mend.6.6.1495494 · Cited by 16
Self-citation
Exogenous c-myc gene overexpression interferes with early events in F9 cell differentiation.
Onclercq, R., Babinet, C., & Crémisi, C. (1989) · PubMed · Cited by 16
Myc-Mediated Apoptosis
Kuchino, Y., Asai, A., & Kitanaka, C. (1996) · Progress in molecular and subcellular biology · doi:10.1007/978-3-642-79850-4_7 · Cited by 15
Glucocorticoid insensitivity of P1798 lymphoma cells is associated with production of a factor that attenuates the lytic response.
Thompson, E. A. (1991) · PubMed · Cited by 15
Self-citation
In vivo footprints between the murine c-myc P1 and P2 promoters.
Plet, A., Tourkine, N., Mechti, N., Jeanteur, P., & Blanchard, J. (1992) · PubMed · Cited by 13
Cell death regulation during multistep lymphomagenesis
Hsu, B., Marín, M. C., & McDonnell, T. J. (1995) · Cancer Letters · doi:10.1016/0304-3835(95)03836-l · Cited by 11
Differentiation of F9 cells is independent of c-myc expression.
Nishikura, K., Kim, U., & Jm, M. (1990) · PubMed · Cited by 11
Apoptosis Regulation by Raf, Bcl-2, and R-Ras
Troppmair, J., & Rapp, U. R. (1997) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-60393-8_17 · Cited by 10
Genetic Instability and Apoptotic Cell Death during Neoplastic Progression of v-myc-initiated B-cell Lymphomas in the Bursa of FabriciusPreprint
Neiman, P. E., Summers, J., Thomas, S. J., Xuereb, S., & Loring, G. (1994) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1994.059.01.056 · Cited by 10
Glucocorticoid regulation of c-myc promoter utilization in P1798 T- lymphoma cells
Ma, T. (1992) · Molecular Endocrinology · doi:10.1210/me.6.6.960 · Cited by 9
Modulation of cellular functions in retroorbital fibroblasts using antisense oligonucleotides targeting the c-myc protooncogene.
Heufelder, A. E., & Bahn, R. S. (1995) · PubMed · Cited by 8
Characterization of senescence- and apoptosis-dependent forms of terminin as derived from a precursor found in replicating and nonreplicating cells
Wang, E., & Liu, D. (1996) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19960101)60:1 · Cited by 8
C-myc expression is down-regulated in mafosfamide-treated HL-60 cells undergoing apoptosis.
Davidoff, A. N., & Bv, M. (1993) · PubMed · Cited by 8
Association with C-Myc: An Alternated Mechanism for c-Myc Function
Shrivastava, A., & Calame, K. L. (1995) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-79275-5_32 · Cited by 7
Abrupt reduction of c-myc expression by antisense RNA inducing terminal differentiation and apoptosis of a human esophageal cancer cell line.
Zhao, X., Wang, X., Zhou, C., Peng, R., Yan, S., & Wu, M. (1995) · PubMed · Cited by 7
Deregulation of the c-myc and N-myc Genes in Transformed Cells
Dean, M. C., Cleveland, J. L., Kim, H.-Y., Campisi, J., Levine, R. A., Ihle, J. N., & Rapp, U. R. (1988) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-74006-0_29 · Cited by 4
Effects of 4-hydroxynonenal and N-acetyl-L-cysteine on Myc-induced apoptosis
Yıldız, D., Ercala, N., Frank, R. L., & Matthews, R. H. (1996) · Toxicology Letters · doi:10.1016/s0378-4274(96)03816-7 · Cited by 4

Flagged first, then by citations

Research works printed but not linked: 55

Lemaitre JM, 1996, Adv. Cancer Res., 70, 96
Shrivastava A, 1995, Curr. Top. Microbiol. Immunol., 194, 273
Plet A, 1992, Oncogene, 7, 1847
Eastman-Reks SB, 1986, Cancer Res., 46, 2457
Rhee K, 1995, Cancer Res., 55, 4188
Thompson EA, 1991, Cancer Res., 51, 5551
Medh RD, 1997, Cancer Res.
Ayala-Torres S, 1997, Mol. Cell. Biol.
Dean M, 1988, Curr. Top. Microbiol. Immunol., 141, 216
Cory S, 1987, Oncogene Res., 1, 61
Askew DS, 1991, Oncogene, 6, 1915
Kimura S, 1995, Cancer Res., 55, 1379
Ohta H, 1995, Cancer Res., 55, 691
Davidoff AN, 1993, Anticancer Res., 13, 1167
Samid D, 1992, Cancer Res., 52, 1988
Sumitani K, 1997, Anticancer Res., 17, 865
Zhao X, 1995, Sci. China-Ser. B, 38, 580
Fornari FA, 1994, Cell Growth Differ., 5, 723
Van Waardenburg RC, 1996, Anticancer Res., 16, 1963
Cerutti J, 1996, Clin. Cancer Res., 2, 119
Heufelder AE, 1995, Invest. Ophthalmol. Visual Sci., 36, 1420
Williams SA, 1996, Leukemia, 10, 1980
Watson PH, 1991, Cancer Res., 51, 3996
Loke SL, 1988, Curr. Topics Microbiol. Immunol., 141, 282
Chiarugi V, 1996, Tumori, 82, 205
Lotem J, 1996, Leukemia, 10, 925
10.1016/S0065-230X(08)60353-X · DOI
Koskinen PJ, 1993, Semin. Cancer Biol., 4, 3
Onclercq R, 1989, Oncogene Res., 4, 293
Nishikura K, 1990, Oncogene, 5, 981
Shiota G, 1995, Res. Commun. Mol. Pathol. Pharmacol., 90, 17
Amundadottir LT, 1996, Oncogene, 13, 757
Hundley JE, 1997, Cancer Res., 57, 600
Morgenbesser SD, 1994, Semin. Cancer Biol., 5, 21
Green DR, 1992, Semin. Immunol., 4, 379
Wang Y, 1993, Cell Growth Differ., 4, 467
Sakamuro D, 1995, Oncogene, 11, 2411
Hsu B, 1995, Oncogene, 11, 175
Czaja MJ, 1996, Am. J. Physiol., 270, G60
Reynolds JE, 1994, Cancer Res., 54, 6348
Packham G, 1995, Curr. Topics Microbiol. Immunol., 194, 283
Packham G, 1994, Mol. Cell. Biol., 14, 41
10.1016/0968-0004(96)20008-8 · DOI
10.1182/blood.V83.5.1179.1179 · DOI
10.1210/me.10.3.306 · DOI
Singh N, 1995, Oncol. Res., 7, 353
Freemerman AJ, 1996, Mol. Pharmacol., 49, 788
Bortner DM, 1995, Cell Growth Differ., 6, 1579
Adams PD, 1996, Curr. Top. Microbiol. Immunol., 208, 79
Lebowitz PF, 1997, Cancer Res., 57, 708
Esteve P, 1995, Oncogene, 11, 2657
Jimenez B, 1995, Oncogene, 10, 811
Fukasawa K, 1995, Oncogene, 10, 1
Jansen B, 1997, Cancer Res., 57, 362
Fernandes RS, 1996, Anticancer Res., 16, 1691

Sorted by citations

Controls of Hair Follicle Cycling
Stenn, K. S., & Paus, R. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.449 · Cited by 1,543
The c-Myc target gene network
Dang, C. V., O’Donnell, K. A., Zeller, K. I., Nguyen, T., Osthus, R. C., & Li, F. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.07.014 · Cited by 1,188
Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways
Miller, J. R., Hocking, A. M., Brown, J. D., & Moon, R. T. (1999) · Oncogene · doi:10.1038/sj.onc.1203245 · Cited by 689
“However, c-myc cannot transform cells on its own and requires survival cues to prevent cells from undergoing apoptosis (reviewed in Steiner, 1996; Thompson, 1998).”
Background
Cell cycle and apoptosis
Vermeulen, K., Berneman, Z. N., & Bockstaele, D. R. V. (2003) · Cell Proliferation · doi:10.1046/j.1365-2184.2003.00267.x · Cited by 474
“This role was confirmed in different cell types under a wide variety of physiological conditions and both under- and overexpression of c-Myc can lead to cell death (reviewed in Conzen et al. 2000 and Thompson 1998).”
Background
The myc Oncogene: arvelouslomplex
Oster, S. K., Ho, C. S. W., Soucie, E. L., & Penn, L. Z. (2002) · Advances in cancer research · doi:10.1016/s0065-230x(02)84004-0 · Cited by 465

See all 334

Authors: Thompson, E. B.
Affiliations: The University of Texas Medical Branch at Galveston (US)
Corresponding author: Thompson, E. Brad
ORCID: Thompson, E. Brad
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 1998-10
Volume: 60
Issue: 1
Pages: 575-600
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev.physiol.60.1.575
OpenAlex: W2104373533
Cited by: 328
References: 159
Citations by year: 2026: 6 · 2025: 8 · 2024: 24 · 2023: 31 · 2022: 17 · 2021: 10 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 6 · 2015: 10 · 2014: 3 · 2013: 6 · 2012: 3
FWCI: 3.50
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: c-Myc, c-myc proto-oncogene, apoptosis, transcription factor regulation, gene expression regulation, gene repression, cell growth regulation, transcriptional regulation
MeSH terms: Proto-Oncogene Mas, Animals, Humans, Genes, myc, Proto-Oncogene Proteins c-myc, Apoptosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

THE MANY ROLES OF c-Myc IN APOPTOSIS

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks