The DOI matches its Crossref record; 159 of the 159 references it cites were found in a registry or an index.
THE MANY ROLES OF c-Myc IN APOPTOSIS
Abstract
▪ Abstract The proto-oncogene c-myc encodes a transcription factor c-Myc, which is of great importance in controlling cell growth and vitality. The quantity of c-Myc is carefully controlled by many mechanisms, and its actions to induce and repress genes are modulated by interactions with other regulatory proteins. Understanding the kinetic and quantitative relationships that determine how and what genes c-Myc regulates is essential to understanding how Myc is involved in apoptosis. Reduction of c-myc expression and its inappropriate expression can be associated with cellular apoptosis. This review outlines the nature and regulation of the c-myc gene and of c-Myc and presents the systems and conditions in which Myc-related apoptotic events occur. Hypotheses of the mechanisms by which expression and repression of c-myc lead to apoptosis are discussed.
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“Research indicates that approximately 70% of human cancers involve dysregulated MYC expression.”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [515]
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“However, c-myc cannot transform cells on its own and requires survival cues to prevent cells from undergoing apoptosis (reviewed in Steiner, 1996; Thompson, 1998).”
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“This role was confirmed in different cell types under a wide variety of physiological conditions and both under- and overexpression of c-Myc can lead to cell death (reviewed in Conzen et al. 2000 and Thompson 1998).”
BackgroundThe myc Oncogene: arvelouslomplex
Oster, S. K., Ho, C. S. W., Soucie, E. L., & Penn, L. Z. (2002) · Advances in cancer research · doi:10.1016/s0065-230x(02)84004-0 · Cited by 465
Metadata
- Authors
- Thompson, E. B.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Thompson, E. Brad
- ORCID
- Thompson, E. Brad
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1998-10
- Volume
- 60
- Issue
- 1
- Pages
- 575-600
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2104373533
- Cited by
- 328
- References
- 159
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 24 · 2023: 31 · 2022: 17 · 2021: 10 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 6 · 2015: 10 · 2014: 3 · 2013: 6 · 2012: 3
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- c-Myc, c-myc proto-oncogene, apoptosis, transcription factor regulation, gene expression regulation, gene repression, cell growth regulation, transcriptional regulation
- MeSH terms
- Proto-Oncogene Mas, Animals, Humans, Genes, myc, Proto-Oncogene Proteins c-myc, Apoptosis
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