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Cited by 495

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

ATP-SENSITIVE POTASSIUM CHANNELS: A Model of Heteromultimeric Potassium Channel/Receptor Assemblies

Seino, Susumu·1999·Annual Review of Physiology

Abstract

▪ Abstract ATP-sensitive K+ channels (K ATP channels) play important roles in many cellular functions by coupling cell metabolism to electrical activity. By cloning members of the novel inwardly rectifying K+ channel subfamily Kir6.0 (Kir6.1 and Kir6.2) and the receptors for sulfonylureas (SUR1 and SUR2), researchers have clarified the molecular structure of K ATP channels. K ATP channels comprise two subunits: a Kir6.0 subfamily subunit, which is a member of the inwardly rectifying K+ channel family; and a SUR subunit, which is a member of the ATP-binding cassette (ABC) protein superfamily. K ATP channels are the first example of a heteromultimeric complex assembled with a K+ channel and a receptor that are structurally unrelated to each other. Since 1995, molecular biological and molecular genetic studies of K ATP channels have provided insights into the structure-function relationships, molecular regulation, and pathophysiological roles of K ATP channels.

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Crossref · 10.1146/annurev.physiol.61.1.337

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Metadata

Authors
Seino, S.
Venue
Annual Review of Physiology
Published
1999-03
Volume
61
Issue
1
Pages
337-362
ISSN
  • 0066-4278 (ISSN-L)
  • 1545-1585
OpenAlex
W2160723322
Cited by
495
References
7
FWCI
2.25
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: ATP-SENSITIVE POTASSIUM CHANNELS: A Model of Heteromultimeric Potassium Channel/Receptor Assemblies. https://app.cochat.ai/papers/10.1146/annurev.physiol.61.1.337
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Seino, S. (1999). ATP-SENSITIVE POTASSIUM CHANNELS: A Model of Heteromultimeric Potassium Channel/Receptor Assemblies. Annual Review of Physiology. https://doi.org/10.1146/annurev.physiol.61.1.337

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.