The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
The Na-K-Cl Cotransporter of Secretory Epithelia
Abstract
▪ Abstract The Na-K-Cl cotransporters are a class of ion transport proteins that transport Na, K, and Cl ions into and out of cells in an electrically neutral manner, in most cases with a stoichiometry of 1Na:1K:2Cl. To date, two Na-K-Cl cotransporter isoforms have been identified: NKCC1, which is present in a wide variety of secretory epithelia and non-epithelial cells; and NKCC2, which is present exclusively in the kidney, in the epithelial cells of the thick ascending limb of Henle’s loop and of the macula densa. Both NKCC isoforms represent part of a diverse family of cationchloride cotransport proteins that share a common predicted membrane topology; this family also includes Na-Cl cotransporters and multiple K-Cl cotransporter isoforms. In secretory epithelia, the regulation of NKCC1, which is typically present on the basolateral membrane, is tightly coordinated with that of other transporters, including apical Cl channels, to maintain cell volume and integrity during active salt and fluid secretion. Changes in intracellular [Cl] ([Cl]i) appear to be involved in this regulation of NKCC1, which is directly phosphorylated by an unknown protein kinase in response to various secretagogues as well as reductions in [Cl]i and cell volume. This review focuses on structure-function relationships within NKCC1 and on recent developments pertaining to NKCC1 regulation at cellular and molecular levels.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ion transport mechanisms in thick ascending limb of Henle's loop of mammalian nephron.
Greger, R. (1985) · Physiological Reviews · doi:10.1152/physrev.1985.65.3.760 · Cited by 714
Gamba, G., Miyanoshita, A., Lombardi, M., Lytton, J., Lee, W. S., Hediger, M. A., & Hebert, S. C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32499-7 · Cited by 598
Molecular Characterization of a Putative K-Cl Cotransporter in Rat Brain
Payne, J. A., Stevenson, T. J., & Donaldson, L. F. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.27.16245 · Cited by 570
Molecular cloning and functional expression of the bumetanide-sensitive Na-K-Cl cotransporter.
Xu, J. C., Lytle, C., Zhu, T. T., Payne, J. A., Benz, E., & Forbush, B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2201 · Cited by 424
Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter
Delpire, E., Lu, J., England, R., Dull, C., & Thorne, T. (1999) · Nature Genetics · doi:10.1038/9713 · Cited by 411
Payne, J. A. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.5.c1516 · Cited by 405
Flagella, M., Clarke, L. L., Miller, M. L., Erway, L. C., Giannella, R. A., Andringa, A., Gawenis, L. R., Kramer, J., Duffy, J. J., Doetschman, T., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.38.26946 · Cited by 400
Molecular Cloning and Functional Expression of the K-Cl Cotransporter from Rabbit, Rat, and Human
Gillen, C. M., Brill, S., Payne, J. A., & Forbush, B. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.27.16237 · Cited by 390
Gamba, G., Saltzberg, S. N., Lombardi, M., Miyanoshita, A., Lytton, J., Hediger, M. A., Brenner, B. M., & Hebert, S. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.7.2749 · Cited by 390
Distribution and diversity of Na-K-Cl cotransport proteins: a study with monoclonal antibodies
Lytle, C., Xu, J. C., Biemesderfer, D., & Forbush, B. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.269.6.c1496 · Cited by 367
Cited by
Physiology of cell volume regulation in vertebrates
Hoffmann, E. K., Lambert, I. H., & Pedersen, S. F. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2007 · Cited by 1,441
Electrolyte transport in the mammalian colon: mechanisms and implications for disease
Kunzelmann, K., & Mall, M. (2002) · Physiological Reviews · doi:10.1152/physrev.00026.2001 · Cited by 655
Moriguchi, T., Urushiyama, S., Hisamoto, N., Iemura, S.-I., Uchida, S., Natsume, T., Matsumoto, K., & Shibuya, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510042200 · Cited by 477
Chloride sensing by WNK1 involves inhibition of autophosphorylation
Piala, A. T., Moon, T. M., Akella, R., He, H., Cobb, M. H., & Goldsmith, E. J. (2014) · Science Signaling · doi:10.1126/scisignal.2005050 · Cited by 418
Cytotoxic edema: mechanisms of pathological cell swelling
Liang, D., Bhatta, S., Gerzanich, V., & Simard, J. M. (2007) · Neurosurgical Focus · doi:10.3171/foc.2007.22.5.3 · Cited by 398
Metadata
- Authors
- Haas, M., & Forbush III, B.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2000-03
- Volume
- 62
- Issue
- 1
- Pages
- 515-534
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2149085480
- Cited by
- 398
- References
- 64
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Na-K-Cl Cotransporter of Secretory Epithelia. https://app.cochat.ai/papers/10.1146/annurev.physiol.62.1.515
- The paper
- Haas, M., & Forbush III, B. (2000). The Na-K-Cl Cotransporter of Secretory Epithelia. Annual Review of Physiology. https://doi.org/10.1146/annurev.physiol.62.1.515
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
