The DOI matches its Crossref record; 199 of the 199 references it cites were found in a registry or an index.
REGULATION OF SIGNAL TRANSDUCTION PATHWAYS BY ESTROGEN AND PROGESTERONE
Abstract
▪ Abstract The female sex steroid hormones 17β-estradiol and progesterone mediate their biological effects on development, differentiation, and maintenance of reproductive tract and other target tissues through gene regulation by nuclear steroid receptors that function as ligand-dependent transcription factors. However, not all effects of 17β-estradiol and progesterone are mediated by direct control of gene expression. These hormones also have rapid stimulatory effects on the activities of a variety of signal transduction molecules and pathways and, in many cases, these effects appear to be initiated from the plasma cell membrane. There is growing evidence that a subpopulation of the conventional nuclear steroid receptor localized at the cell membrane mediates many of the rapid signaling actions of steroid hormones; however, novel membrane receptors unrelated to conventional steroid receptors have also been implicated. This chapter reviews the nature of the receptors that mediate rapid signaling actions of estrogen and progesterone and describes the signaling molecules and pathways involved, the mechanisms by which receptors couple with components of signaling complexes and trigger responses, and the target tissues and cell functions regulated by this mode of steroid hormone action.
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1 retracted
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CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
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Cited by
The G-protein-coupled estrogen receptor GPER in health and disease
Prossnitz, E. R., & Barton, M. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.122 · Cited by 925
“Our understanding of the widespread physiological effects of 17β-estradiol is complicated by the existence of several types of estrogen receptors (ERs) and multiple modes of cellular signaling mechanisms that span time frames from seconds to hours, or even days”
BackgroundBernardo, B. C., Weeks, K. L., Pretorius, L., & McMullen, J. R. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.04.005 · Cited by 894
Vascular Actions of Estrogens: Functional Implications
Miller, V. M., & Duckles, S. P. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.08002 · Cited by 593
Physiological and molecular determinants of embryo implantation
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The impact of the gut microbiota on the reproductive and metabolic endocrine system
Qi, X., Yun, C., Pang, Y., & Qiao, J. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1894070 · Cited by 554
Metadata
- Authors
- Edwards, D. P.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2005-03-17
- Volume
- 67
- Issue
- 1
- Pages
- 335-376
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2167644938
- Cited by
- 502
- References
- 199
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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