The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
CARDIAC REGENERATION: Repopulating the Heart
Abstract
▪ Abstract Many forms of pediatric and adult heart disease result from a deficiency in cardiomyocyte number. Through repopulation of the heart with new cardiomyocytes (that is, induction of regenerative cardiac growth), cardiac disease potentially can be reversed, provided that the newly formed myocytes structurally and functionally integrate in the preexisting myocardium. A number of approaches have been utilized to effect regenerative growth of the myocardium in experimental animals. These include interventions aimed at enhancing the ability of cardiomyocytes to proliferate in response to cardiac injury, as well as transplantation of cardiomyocytes or myogenic stem cells into diseased hearts. Here we review efforts to induce myocardial regeneration. We also provide a critical review of techniques currently used to assess cardiac regeneration and functional integration of de novo cardiomyocytes.
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Gnecchi, M., He, H., Liang, O. D., Melo, L. G., Morello, F., Mu, H., Noiseux, N., Zhang, L., Pratt, R. E., Ingwall, J. S., et al. (2005) · Nature Medicine · doi:10.1038/nm0405-367 · Cited by 1,677
Cited by
Evidence for Cardiomyocyte Renewal in Humans
Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., et al. (2009) · Science · doi:10.1126/science.1164680 · Cited by 3,130
Moretti, A., Caron, L., Nakano, A., Lam, J. T., Bernshausen, A., Chen, Y., Qyang, Y., Bu, L., Sasaki, M., Martin-Puig, S., et al. (2006) · Cell · doi:10.1016/j.cell.2006.10.029 · Cited by 1,038
Lepilina, A., Coon, A. N., Kikuchi, K., Holdway, J. E., Roberts, R. W., Burns, C. G., & Poss, K. D. (2006) · Cell · doi:10.1016/j.cell.2006.08.052 · Cited by 833
Cardiac Myocyte Cell Cycle Control in Development, Disease, and Regeneration
Ahuja, P., Sdek, P., & MacLellan, W. R. (2007) · Physiological Reviews · doi:10.1152/physrev.00032.2006 · Cited by 568
Prevascularization of cardiac patch on the omentum improves its therapeutic outcome
Dvir, T., Kedem, A., Ruvinov, E., Levy, O., Freeman, I., Landa, N., Holbova, R., Feinberg, M. S., Dror, S., Etzion, Y., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812242106 · Cited by 345
Metadata
- Authors
- Rubart, M., & Field, L. J.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2006-01-01
- Volume
- 68
- Issue
- 1
- Pages
- 29-49
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2146511487
- Cited by
- 235
- References
- 1
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rubart, M., & Field, L. J. (2006). CARDIAC REGENERATION: Repopulating the Heart. Annual Review of Physiology. https://doi.org/10.1146/annurev.physiol.68.040104.124530
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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