The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
FROM MICE TO MEN: Insights into the Insulin Resistance Syndromes
Abstract
▪ Abstract The insulin resistance syndrome refers to a constellation of findings, including glucose intolerance, obesity, dyslipidemia, and hypertension, that promote the development of type 2 diabetes, cardiovascular disease, cancer, and other disorders. Defining the pathophysiological links between insulin resistance, the insulin resistance syndrome, and its sequelae is critical to understanding and treating these disorders. Over the past decade, two approaches have provided important insights into how changes in insulin signaling produce the spectrum of phenotypes associated with insulin resistance. First, studies using tissue-specific knockouts or tissue-specific reconstitution of the insulin receptor in vivo in mice have enabled us to deconstruct the insulin resistance syndromes by dissecting the contributions of different tissues to the insulin-resistant state. Second, in vivo and in vitro studies of the complex network of insulin signaling have provided insight into how insulin resistance can develop in some pathways whereas insulin sensitivity is maintained in others. These data, taken together, give us a framework for understanding the relationship between insulin resistance and the insulin resistance syndromes.
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Cited by
Mechanisms of Diabetic Complications
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“It also underlies risk factors—including hyperglycaemia, dyslipidaemia and hypertension—for the clustering of type 2 diabetes with cardiovascular disease, non-alcoholic fatty liver disease and related maladies (metabolic syndrome) [2].”
BackgroundSelective versus Total Insulin Resistance: A Pathogenic Paradox
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Metadata
- Authors
- Biddinger, S. B., & Kahn, C. R.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2006-01-01
- Volume
- 68
- Issue
- 1
- Pages
- 123-158
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2171290692
- Cited by
- 706
- References
- 29
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- closed
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