Cited by 284Sperm and Testicular FunctionReproductive biology and impacts on aquatic speciesReproductive Biology and Fertility

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Mechanisms of Sperm Chemotaxis

Kaupp, U. Benjamin, Kashikar, Nachiket D., Weyand, Ingo·2008·Annual Review of Physiology

DOI 10.1146/annurev.physiol.70.113006.100654

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Abstract

Sperm are attracted by chemical factors that are released by the egg-a process called chemotaxis. Most of our knowledge on sperm chemotaxis originates from the study of marine invertebrates. In recent years, the main features of the chemotactic signaling pathway and the swimming behavior evoked by chemoattractants have been elucidated in sea urchins. In contrast, our understanding of mammalian sperm chemotaxis is still rudimentary and subject to an ongoing debate. In this review, we raise new questions and discuss current concepts of sperm chemotaxis. Finally, we highlight commonalities and differences of sensory signaling in sperm, photoreceptors, and olfactory neurons.

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Perez‐Reyes, E. (2003) · Physiological Reviews · doi:10.1152/physrev.00018.2002 · Cited by 1,655
Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES
Schall, T. J., Bacon, K. B., Toy, K. J., & Goeddel, D. V. (1990) · Nature · doi:10.1038/347669a0 · Cited by 1,378
Hyperpolarization-Activated Cation Currents: From Molecules to Physiological Function
Robinson, R. B., & Siegelbaum, S. A. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142734 · Cited by 1,177
Queer Current and Pacemaker: The Hyperpolarization-Activated Cation Current in Neurons
Pape, H.-C. (1996) · Annual Review of Physiology · doi:10.1146/annurev.ph.58.030196.001503 · Cited by 1,152
A sperm ion channel required for sperm motility and male fertility
Ren, D., Navarro, B., Perez, G. I., Jackson, A. C., Battaglia-Hsu, S.-F., Shi, Q., Tilly, J. L., & Clapham, D. E. (2001) · Nature · doi:10.1038/35098027 · Cited by 957
Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium
Vassar, R. J., Ngai, J., & Axel, R. (1993) · Cell · doi:10.1016/0092-8674(93)90422-m · Cited by 874
Mutations in the K+ channel signature sequence
Heginbotham, L., Lü, Z., Abramson, T., & MacKinnon, R. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80887-2 · Cited by 853
Soluble Adenylyl Cyclase as an Evolutionarily Conserved Bicarbonate Sensor
Chen, Y., Cann, M. J., Litvin, T. N., Iourgenko, V., Sinclair, M. L., Levin, L. R., & Buck, J. (2000) · Science · doi:10.1126/science.289.5479.625 · Cited by 846
Identification of a Testicular Odorant Receptor Mediating Human Sperm Chemotaxis
Spehr, M., Gisselmann, G., Poplawski, A., Riffell, J. A., Wetzel, C. H., Zimmer, R. K., & Hatt, H. H. (2003) · Science · doi:10.1126/science.1080376 · Cited by 769
RANTES: a versatile and controversial chemokine
Appay, V., & Rowland‐Jones, S. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(00)01812-3 · Cited by 652
Untitled work
(1998) · Cited by 601
All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility
Qi, H., Moran, M. M., Navarro, B., Chong, J. A., Krapivinsky, G. B., Krapivinsky, L., Kirichok, Y., Ramsey, I. S., Quill, T. A., & Clapham, D. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610286104 · Cited by 523
General Anosmia Caused by a Targeted Disruption of the Mouse Olfactory Cyclic Nucleotide–Gated Cation Channel
Brunet, L. J., Gold, G. H., & Ngai, J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80200-7 · Cited by 519
Sperm guidance in mammals — an unpaved road to the egg
Eisenbach, M., & Giojalas, L. C. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1893 · Cited by 507
Molecular identification of a hyperpolarization-activated channel in sea urchin sperm
Gauss, R., Seifert, R., & Kaupp, U. B. (1998) · Nature · doi:10.1038/31248 · Cited by 468
Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel
Kirichok, Y., Navarro, B., & Clapham, D. E. (2006) · Nature · doi:10.1038/nature04417 · Cited by 462
Expression of members of the putative olfactory receptor gene family in mammalian germ cells
Parmentier, M., Libert, F., Schurmans, S., Schiffmann, S. N., Lefort, A., Eggerickx, D., Ledent, C. A., Mollereau, C., Gerard, C. M., Perret, J., et al. (1992) · Nature · doi:10.1038/355453a0 · Cited by 405
The “Soluble” Adenylyl Cyclase in Sperm Mediates Multiple Signaling Events Required for Fertilization
Hess, K. C., Jones, B. H., Marquez, B., Chen, Y., Ord, T. S., Kamenetsky, M., Miyamoto, C., Zippin, J. H., Kopf, G. S., Suárez, S. S., et al. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.06.007 · Cited by 405
Regulation of Mammalian Ciliary Beating
Salathe, M. A. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.040705.141253 · Cited by 404
Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect
Esposito, G., Jaiswal, B. S., Xie, F., Krajnc-Franken, M. A. M., Robben, T. J. A. A., Strik, A., Kuil, C. W., Philipsen, R. L. A., van Duin, M., Conti, M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400050101 · Cited by 390
Molecular Diversity of Pacemaker Ion Channels
Kaupp, U. B., & Seifert, R. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.235 · Cited by 355
RANTES is a chemotactic and activating factor for human eosinophils
Alam, R., Stafford, S. J., Forsythe, P., Harrison, R., Faubion, D., Lett-Brown, M. A., & Grant, J. A. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.8.3442 · Cited by 349
Chapter 5 Phototransduction in vertebrate rods and cones: Molecular mechanisms of amplification, recovery and light adaptation
Pugh, E. N., & Lamb, T. D. (2000) · Handbook of biological physics · doi:10.1016/s1383-8121(00)80008-1 · Cited by 325
Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells
Lowe, G., & Gold, G. H. (1993) · Nature · doi:10.1038/366283a0 · Cited by 323
Chemotaxis of Arbacia punctulata spermatozoa to resact, a peptide from the egg jelly layer.
Ward, G. E., Brokaw, C. J., Garbers, D. L., & Vacquier, V. D. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.6.2324 · Cited by 323
Ion Channels in Sperm Physiology
Darszon, A., Labarca, P. P., Nishigaki, T., & Espinosa, F. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.2.481 · Cited by 321
A voltage-gated ion channel expressed specifically in spermatozoa
Quill, T. A., Ren, D., Clapham, D. E., & Garbers, D. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221454998 · Cited by 317
[Ca2+]i signalling in sperm — making the most of what you've got
Publicover, S. J., Harper, C. V., & Barratt, C. L. R. (2007) · Nature Cell Biology · doi:10.1038/ncb0307-235 · Cited by 292
Chemotaxis of sperm cells
Friedrich, B. M., & Jülicher, F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703530104 · Cited by 280
Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3
Biel, M., Seeliger, M. W., Pfeifer, A., Köhler, K., Gerstner, A., Ludwig, A., Jaissle, G. B., Fauser, S., Zrenner, E., & Hofmann, F. B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7553 · Cited by 280
Non-random Distribution of Bull Spermatozoa in a Drop of Sperm Suspension
ROTHSCHILD (1963) · Nature · doi:10.1038/1981221a0 · Cited by 276
Calcium-induced asymmetrical beating of triton-demembranated sea urchin sperm flagella.
Brokaw, C. J. (1979) · The Journal of Cell Biology · doi:10.1083/jcb.82.2.401 · Cited by 274
A new sperm-specific Na+/H+ Exchanger required for sperm motility and fertility
Wang, D., King, S. M., Quill, T. A., Doolittle, L. K., & Garbers, D. L. (2003) · Nature Cell Biology · doi:10.1038/ncb1072 · Cited by 268
Thermotaxis of mammalian sperm cells: A potential navigation mechanism in the female genital tract
Bahat, A., Tur-Kaspa, I., Gakamsky, A., Giojalas, L. C., Breitbart, H., & Eisenbach, M. (2003) · Nature Medicine · doi:10.1038/nm0203-149 · Cited by 268
Membrane guanylate cyclase is a cell-surface receptor with homology to protein kinases
Singh, S., Lowe, D. G., Thorpe, D. S., Rodriguez, H., Kuang, W.-J., Dangott, L. J., Chinkers, M., Goeddel, D. V., & Garbers, D. L. (1988) · Nature · doi:10.1038/334708a0 · Cited by 259
Sperm-specific protein kinase A catalytic subunit Cα 2 orchestrates cAMP signaling for male fertility
Nolan, M. A., Babcock, D. F., Wennemuth, G., Brown, W., Burton, K. A., & McKnight, G. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405580101 · Cited by 259
Widespread ectopic expression of olfactory receptor genes
Feldmesser, E., Olender, T., Khen, M., Yanai, I., Ophir, R., & Lancet, D. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-121 · Cited by 252
Sperm capacitation in humans is transient and correlates with chemotactic responsiveness to follicular factors.
Cohen-Dayag, A., Tur-Kaspa, I., Dor, J., Mashiach, S., & Eisenbach, M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11039 · Cited by 244
Motility of spermatozoa at surfaces
Woolley, D. M. (2003) · Reproduction · doi:10.1530/rep.0.1260259 · Cited by 236
Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization
Xie, F., Garcia, M. A., Carlson, A. E., Schuh-Huerta, S. M., Babcock, D. F., Jaiswal, B. S., Gossen, J. A., Esposito, G., van Duin, M., & Conti, M. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.05.038 · Cited by 232
Functional characterization of a mouse testicular olfactory receptor and its role in chemosensing and in regulation of sperm motility
Fukuda, N., Yomogida, K., Okabe, M., & Touhara, K. (2004) · Journal of Cell Science · doi:10.1242/jcs.01507 · Cited by 223
Speract. Purification and characterization of a peptide associated with eggs that activates spermatozoa.
Hansbrough, J. R., & Garbers, D. L. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69983-7 · Cited by 219
Calcium ion regulation of flagellar beat symmetry in reactivated sea urchin spermatozoa
Brokaw, C. J., Josslin, R., & Bobrow, L. (1974) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(74)80487-0 · Cited by 213
Use of voltage-sensitive dyes and optical recordings in the central nervous system
Ebner, T. J., & Chen, G. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)00010-s · Cited by 210
The signal flow and motor response controling chemotaxis of sea urchin sperm
Kaupp, U. B., Solzin, J., Hildebrand, E., Brown, J. E., Helbig, A., Hagen, V., Beyermann, M., Pampaloni, F., & Weyand, I. (2003) · Nature Cell Biology · doi:10.1038/ncb915 · Cited by 203
Different Signaling Pathways in Bovine Sperm Regulate Capacitation and Hyperactivation1
Marquez, B., & Suárez, S. S. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.026476 · Cited by 202
Progesterone at the picomolar range is a chemoattractant for mammalian spermatozoa
Teves, M. E., Barbano, M. F., Guidobaldi, H. A., Sánchez, R., MISKA, W., & Giojalas, L. C. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.02.080 · Cited by 200
Identification of gene products present in Triton X‐100 soluble and insoluble fractions of human spermatozoa lysates using LC‐MS/MS analysis
Baker, M. A., Reeves, G., Hetherington, L., Müller, J., Baur, I., & Aitken, R. J. (2007) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200601013 · Cited by 196
Sperm attraction to a follicular factor(s) correlates with human egg fertilizability.
Ralt, D., Goldenberg, M., Fetterolf, P. M., Thompson, D., Dor, J., Mashiach, S., Garbers, D. L., & Eisenbach, M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2840 · Cited by 194
Sperm Chemo-Orientation in the Metazoa
Miller, R. L. (1985) · Elsevier eBooks · doi:10.1016/b978-0-12-492602-8.50015-2 · Cited by 193
Sperm channel diversity and functional multiplicity
Darszon, A., Acevedo‐Fernández, J. J., Galindo, B. E., Hernández-González, E. O., Nishigaki, T., Treviño, C. L., Wood, C. D., & Beltrán, C. (2006) · Reproduction · doi:10.1530/rep.1.00612 · Cited by 190
Olfactory receptors are displayed on dog mature sperm cells.
Vanderhaeghen, P., Schurmans, S., Vassart, G., & Parmentier, M. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.6.1441 · Cited by 185
A chemoattractant for ascidian spermatozoa is a sulfated steroid
Yoshida, M., Murata, M., Inaba, K., & Morisawa, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242470599 · Cited by 184
Ca2+ spikes in the flagellum control chemotactic behavior of sperm
Bohmër, M., Van, Q., Weyand, I., Hagen, V., Beyermann, M., Matsumoto, M., Hoshi, M., Hildebrand, E., & Kaupp, U. B. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600744 · Cited by 181
Ion Transport in Sperm Signaling
Darszon, A., Beltrán, C., Felix, R., Nishigaki, T., & Treviño, C. L. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0387 · Cited by 180
Elementary Response of Olfactory Receptor Neurons to Odorants
Bhandawat, V., Reisert, J., & Yau, K. (2005) · Science · doi:10.1126/science.1109886 · Cited by 180
Human spermatozoa contain multiple targets for protein S‐nitrosylation: An alternative mechanism of the modulation of sperm function by nitric oxide?
Lefièvre, L., Chen, Y., Conner, S. J., Scott, J. L., Publicover, S. J., Ford, W. C. L., & Barratt, C. L. R. (2007) · PROTEOMICS · doi:10.1002/pmic.200700254 · Cited by 166
Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo
Kubagawa, H. M., Watts, J. L., Corrigan, C., Edmonds, J. W., Sztul, E. S., Browse, J., & Miller, M. A. (2006) · Nature Cell Biology · doi:10.1038/ncb1476 · Cited by 162
Chemotaxis and Chemokinesis of Human Spermatozoa to Follicular Factors1
Ralt, D., Manor, M., Cohen-Dayag, A., Tur-Kaspa, I., Ben‐Shlomo, I., Makler, A., Yuli, I., Dor, J., Blumberg, S., Mashiach, S., et al. (1994) · Biology of Reproduction · doi:10.1095/biolreprod50.4.774 · Cited by 160
Human sperm chemotaxis: both the oocyte and its surrounding cumulus cells secrete sperm chemoattractants
Sun, F., Bahat, A., Gakamsky, A., Girsh, E., Katz, N., Giojalas, L. C., Tur-Kaspa, I., & Eisenbach, M. (2005) · Human Reproduction · doi:10.1093/humrep/deh657 · Cited by 156
Particulate Adenylate Cyclase Plays a Key Role in Human Sperm Olfactory Receptor-mediated Chemotaxis
Spehr, M., Schwane, K., Riffell, J. A., Barbour, J., Zimmer, R. K., Neuhaus, E. M., & Hatt, H. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403913200 · Cited by 156
Phosphorylation of the Kinase Homology Domain Is Essential for Activation of the A-Type Natriuretic Peptide Receptor
Potter, L. R., & Hunter, T. R. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.4.2164 · Cited by 154
Physiology: Sperm numbers and distribution within the human Fallopian tube around ovulation
Williams, M., Hill, C. J., Scudamore, I., Dunphy, B., Cooke, I. D., & Barratt, C. L. R. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137975 · Cited by 148
A New Look at Locomotion in Microorganisms: Rotating and Translating
Crenshaw, H. C. (1996) · American Zoologist · doi:10.1093/icb/36.6.608 · Cited by 143
Mechanisms of Disease: regulation of RANTES (CCL5) in renal disease
Krensky, A. M., & Ahn, Y.-T. (2007) · Nature Reviews Nephrology · doi:10.1038/ncpneph0418 · Cited by 142
Sperm Chemotaxis: Egg Peptides Control Cytosolic Calcium to Regulate Flagellar Responses
Cook, S. P., Brokaw, C. J., MULLER, C. H., & Babcock, D. F. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1229 · Cited by 137
A peptide associated with eggs causes a mobility shift in a major plasma membrane protein of spermatozoa.
Suzuki, N., Shimomura, H., Radany, E. W., Ramarao, C. S., Ward, G. E., Bentley, J. K., & Garbers, D. L. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42685-8 · Cited by 135
A molecular dissection of spatial patterning in the olfactory system
Ressler, K. J., Sullivan, S. L., & Buck, L. B. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90061-2 · Cited by 133
Specific Repertoire of Olfactory Receptor Genes in the Male Germ Cells of Several Mammalian Species
Vanderhaeghen, P., Schurmans, S., Vassart, G., & Parmentier, M. (1997) · Genomics · doi:10.1006/geno.1996.4490 · Cited by 128
Non-random Distribution of Bull Spermatozoa in a Drop of Sperm Suspension
MAUDE, A. D. (1963) · Nature · doi:10.1038/200381a0 · Cited by 128
The Guanylyl Cyclase Family at Y2K
Wedel, B. J., & Garbers, D. L. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.215 · Cited by 128
Identification and Characterization of the Major Phosphorylation Sites of the B-type Natriuretic Peptide Receptor
Potter, L. R., & Hunter, T. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15533 · Cited by 127
Multiple Phosphorylation Sites Confer Reproducibility of the Rod's Single-Photon Responses
Doan, T. A., Méndez, A., Detwiler, P. B., Chen, J., & Rieke, F. M. (2006) · Science · doi:10.1126/science.1126612 · Cited by 127
Real-time analysis of the role of Ca2+ in flagellar movement and motility in single sea urchin sperm
Wood, C. D., Nishigaki, T., Furuta, T., Baba, S. A., & Darszon, A. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200411001 · Cited by 125
Allurin, a 21-kDa sperm chemoattractant from Xenopus egg jelly, is related to mammalian sperm-binding proteins
Olson, J. H., Xiang, X., Ziegert, T., Kittelson, A., Rawls, A., Bieber, A. L., & Chandler, D. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211316798 · Cited by 123
A K+-selective cGMP-gated ion channel controls chemosensation of sperm
Strünker, T., Weyand, I., Bönigk, W., Van, Q., Loogen, A., Brown, J. E., Kashikar, N. D., Hagen, V., Krause, E., & Kaupp, U. B. (2006) · Nature Cell Biology · doi:10.1038/ncb1473 · Cited by 120
Covalent coupling of a resact analogue to guanylate cyclase.
Shimomura, H., Dangott, L. J., & Garbers, D. L. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66786-9 · Cited by 109
Inactivation in HCN Channels Results from Reclosure of the Activation Gate
Shin, K. S., Maertens, C., Proenza, C., Rothberg, B. S., & Yellen, G. (2004) · Neuron · doi:10.1016/s0896-6273(04)00083-2 · Cited by 108
Early persistent activation of sperm K+ channels by the egg peptide speract.
Babcock, D. F., Bosma, M. M., Battaglia, D. E., & Darszon, A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.6001 · Cited by 107
Regulatory modes of rod outer segment membrane guanylate cyclase differ in catalytic efficiency and Ca2+‐sensitivity
Hwang, J., Lange, C. M., Helten, A., Höppner‐Heitmann, D., Duda, T., Sharma, R. K., & Koch, K. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03770.x · Cited by 106
How spermatozoa come to be confined to surfaces
Cosson, J., Huitorel, P., & Gagnon, C. (2002) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.10085 · Cited by 105
Fertilization in the sea
Riffell, J. A., Krug, P. J., & Zimmer, R. K. (2002) · Journal of Experimental Biology · doi:10.1242/jeb.205.10.1439 · Cited by 103
Odorant Receptors and Desensitization Proteins Colocalize in Mammalian Sperm
Walensky, L. D., Roskams, A. J., Lefkowitz, R. J., Snyder, S. H., & Ronnett, G. V. (1995) · Molecular Medicine · doi:10.1007/bf03401561 · Cited by 101
Speract induces calcium oscillations in the sperm tail
Wood, C. D., Darszon, A., & Whitaker, M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212053 · Cited by 98
Chemotaxis of the spermatozoa of Ciona intestinalis
Miller, R. L. (1975) · Nature · doi:10.1038/254244a0 · Cited by 96
Receptor-mediated activation of spermatozoan guanylate cyclase.
Bentley, J. K., Tubb, D. J., & Garbers, D. L. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66793-6 · Cited by 95
Membrane Potential Regulates Sea Urchin Sperm Adenylylcyclase
Beltrán, C., Zapata, O., & Darszon, A. (1996) · Biochemistry · doi:10.1021/bi952806v · Cited by 90
Human Sperm Chemotaxis: Is Progesterone a Chemoattractant?1
Jaiswal, B. S., Tur-Kaspa, I., Dor, J., Mashiach, S., & Eisenbach, M. (1999) · Biology of Reproduction · doi:10.1095/biolreprod60.6.1314 · Cited by 88
The Membrane-Bound Spermatozoal Adenylyl Cyclase System Does not Share Coupling Characteristics with Somatic Cell Adenylyl Cyclases*
Hildebrandt, J. D., Codina, J., Tash, J. S., KIRCHICK, H. J., Lipschultz, L. I., Sekura, R. D., & Birnbaumer, L. (1985) · Endocrinology · doi:10.1210/endo-116-4-1357 · Cited by 86
Evidence for multiple distinctly localized adenylyl cyclase isoforms in mammalian spermatozoa
Baxendale, R. W., & Fraser, L. R. (2003) · Molecular Reproduction and Development · doi:10.1002/mrd.10344 · Cited by 85
A sperm-activating peptide controls a cGMP-signaling pathway in starfish sperm☆
Matsumoto, M., Solzin, J., Helbig, A., Hagen, V., Ueno, S.-I., Kawase, O., Maruyama, Y., Ogiso, M., Godde, M., Minakata, H., et al. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00236-7 · Cited by 84
Store-operated calcium channel regulates the chemotactic behavior of ascidian sperm
Yoshida, M., Ishikawa, M., Izumi, H., Santis, R. D., & Morisawa, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135565100 · Cited by 84
Chemotactic Turning Behaviour of Tubularia Spermatozoa
Miller, R. L., & Brokaw, C. J. (1970) · Journal of Experimental Biology · doi:10.1242/jeb.52.3.699 · Cited by 83
Sperm chemotaxis in marine invertebrates—molecules and mechanisms
Kaupp, U. B., Hildebrand, E., & Weyand, I. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20669 · Cited by 82
Progesterone induces human sperm Chemotaxis
Villanueva-Díaz, C., Arias-Martínez, J., Bermejo-Martínez, L., & Vadillo‐Ortega, F. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57982-5 · Cited by 77
Genomic Structure and Transcription of a Murine Odorant Receptor Gene: Differential Initiation of Transcription in the Olfactory and Testicular Cells
Asai, H., Kasai, H., Matsuda, Y., Yamazaki, N., Nagawa, F., Sakano, H., & Tsuboi, A. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0580 · Cited by 74
Activation of Ca2+ permeability by cAMP is coordinated through the pHi increase induced by speract.
Cook, S. P., & Babcock, D. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41544-x · Cited by 72
Orientation by helical motion—I. Kinematics of the helical motion of organisms with up to six degrees of freedom
Crenshaw, H. C. (1993) · Bulletin of Mathematical Biology · doi:10.1016/s0092-8240(05)80069-2 · Cited by 71
Dual capacity of a human olfactory receptor
Spehr, M., Schwane, K., Heilmann, S., Gisselmann, G., Hummel, T. R., & Hatt, H. H. (2004) · Current Biology · doi:10.1016/j.cub.2004.09.034 · Cited by 70
Orientation by helical motion—II. Changing the direction of the axis of motion
Crenshaw, H. C., & Leah Edelstein-keshet, A. (1993) · Bulletin of Mathematical Biology · doi:10.1016/s0092-8240(05)80070-9 · Cited by 70
Evidence that human follicular fluid contains a chemoattractant for spermatozoa
Villanueva-Díaz, C., Vadillo‐Ortega, F., Kably-Ambé, A., Díaz-Pérez, M. D. L. Á., & Krivitzky, S. K. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54027-8 · Cited by 69
Novel function of β-arrestin2 in the nucleus of mature spermatozoa
Neuhaus, E. M., Mashukova, A., Barbour, J., Wolters, D. A., & Hatt, H. H. (2006) · Journal of Cell Science · doi:10.1242/jcs.03046 · Cited by 68
Orientation by helical motion—III. Microorganisms can orient to stimuli by changing the direction of their rotational velocity
Crenshaw, H. C. (1993) · Bulletin of Mathematical Biology · doi:10.1016/s0092-8240(05)80071-0 · Cited by 67
Different Roles for the Cyclic Nucleotide Binding Domain and Amino Terminus in Assembly and Expression of Hyperpolarization-activated, Cyclic Nucleotide-gated Channels
Proenza, C., Tran, N., Angoli, D., Zahynacz, K., Balcar, P., & Accili, E. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200504200 · Cited by 66
Selective modulation by cGMP of the K+ channel activated by speract.
Cook, S. P., & Babcock, D. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41543-8 · Cited by 63
The Production of Sperm Iso-Agglutinins by Ova
Lillie, F. R. (1912) · Science · doi:10.1126/science.36.929.527 · Cited by 63
Encoding of progesterone stimulus intensity by intracellular [Ca2+] ([Ca2+]i) in human spermatozoa
Harper, C. V., Kirkman‐Brown, J., Barratt, C. L. R., & Publicover, S. J. (2003) · Biochemical Journal · doi:10.1042/bj20021560 · Cited by 63
Orientation by helical motion—III. Microorganisms can orient to stimuli by changing the direction of their rotational velocity
Crenshaw, H. C. (1993) · Bulletin of Mathematical Biology · doi:10.1007/bf02460304 · Cited by 63
Dephosphorylation of a major sperm membrane protein is induced by egg jelly during sea urchin fertilization
Ward, G. E., & Vacquier, V. D. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.18.5578 · Cited by 62
Altering the speract-induced ion permeability changes that generate flagellar Ca2+ spikes regulates their kinetics and sea urchin sperm motility
Wood, C. D., Nishigaki, T., Tatsu, Y., Yumoto, N., Baba, S. A., Whitaker, M., & Darszon, A. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.03.036 · Cited by 61
Patterns of [Ca2+]i mobilization and cell response in human spermatozoa exposed to progesterone
Bedu-Addo, K., Barratt, C. L. R., Kirkman‐Brown, J., & Publicover, S. J. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.09.040 · Cited by 61
Participation of a K+ Channel Modulated Directly by cGMP in the Speract-Induced Signaling Cascade of Strongylocentrotus purpuratus Sea Urchin Sperm
Galindo, B. E., Beltrán, C., Cragoe, E. J., & Darszon, A. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9678 · Cited by 60
Developmental expression patterns of testicular olfactory receptor genes during mouse spermatogenesis
Fukuda, N., & Touhara, K. (2005) · Genes to Cells · doi:10.1111/j.1365-2443.2005.00915.x · Cited by 57
Classic and Non-classic Progesterone Receptors are both Expressed in Human Spermatozoa
Lösel, R., Breiter, S., Seyfert, M., Wehling, M., & Falkenstein, E. (2005) · Hormone and Metabolic Research · doi:10.1055/s-2005-861023 · Cited by 56
The effect of RANTES on human sperm chemotaxis
Isobe, T., Minoura, H., Tanaka, K., Shibahara, T., Hayashi, N., & Toyoda, N. (2002) · Human Reproduction · doi:10.1093/humrep/17.6.1441 · Cited by 56
Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location
Linardopoulou, E. V. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.21.2373 · Cited by 56
Fast nongenomic effects of steroids on synaptic transmission and role of endogenous neurosteroids in spinal pain pathways
Schlichter, R., Keller, A., Roo, M. D., Breton, J.-D., Inquimbert, P., & Poisbeau, P. (2007) · Journal of Molecular Neuroscience · doi:10.1385/jmn:28:1:33 · Cited by 54
Sp-tetraKCNG: A novel cyclic nucleotide gated K+ channel
Galindo, B. E., de la Vega‐Beltrán, J. L., Labarca, P. P., Vacquier, V. D., & Darszon, A. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.035 · Cited by 52
Fertilization in Sepia officinalis: the first mollusk sperm-attracting peptide
Zatylny‐Gaudin, C., Marvin, L., Gagnon, J., & Henry, J. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02036-3 · Cited by 51
Stimulation of the nitric oxide/cyclic guanosine monophosphate signaling pathway elicits human sperm chemotaxis in vitro
Miraglia, E., Rullo, M. L., Bosìa, A., Massobrio, M., Revelli, A., & Ghigo, D. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.07.1540 · Cited by 47
Capacitation
Jaiswal, B. S., & Eisenbach, M. (2002) · Elsevier eBooks · doi:10.1016/b978-012311629-1/50005-x · Cited by 47
Identification of voltage‐dependent Ca2+ channels in sea urchin sperm
Granados‐González, G., Mendoza-Lujambio, I., Rodriguez, E., Galindo, B. E., Beltrán, C., & Darszon, A. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.10.035 · Cited by 46
Receptors in Spermatozoa: Are They Real?
Naz, R. K., & Sellamuthu, R. (2006) · Journal of Andrology · doi:10.2164/jandrol.106.000620 · Cited by 46
Lack of species-specificity in mammalian sperm chemotaxis
Sun, F., Giojalas, L. C., Rovasio, R. A., Tur-Kaspa, I., Sánchez, R., & Eisenbach, M. (2003) · Developmental Biology · doi:10.1016/s0012-1606(02)00090-8 · Cited by 44
Chemotactic behavior of the sperm of chitons (Mollusca: Polyplacophora)
Miller, R. L. (1977) · Journal of Experimental Zoology · doi:10.1002/jez.1402020209 · Cited by 44
Effects of follicular fluid and steroid hormones on chemotaxis and motility of human spermatozoa in vitro
Wang, Y., Storeng, R., Dale, P. O., Åbyholm, T., & Tanbo, T. G. (2001) · Gynecological Endocrinology · doi:10.1080/gye.15.4.286.292 · Cited by 42
Non-Genomic Steroid Actions in Human Spermatozoa
Correia, J., Conner, S. J., & Kirkman‐Brown, J. (2007) · Seminars in Reproductive Medicine · doi:10.1055/s-2007-973433 · Cited by 41
Signaling Pathways for Modulation of Mouse Sperm Motility by Adenosine and Catecholamine Agonists1
Schuh-Huerta, S. M., Carlson, A. E., McKnight, G. S., Conti, M., Hille, B., & Babcock, D. F. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.105.047837 · Cited by 39
Expression of the G-protein α-subunit gustducin in mammalian spermatozoa
Fehr, J., Meyer, D., Widmayer, P., Borth, H., Ackermann, F., Wilhelm, B., Gudermann, T. W., & Boekhoff, I. (2006) · Journal of Comparative Physiology A · doi:10.1007/s00359-006-0168-8 · Cited by 38
A new hyperpolarization-activated, cyclic nucleotide-gated channel from sea urchin sperm flagella
Galindo, B. E., Neill, A. T., & Vacquier, V. D. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.06.074 · Cited by 38
Beta‐chemokine receptors 5 and 3 are expressed on the head region of human spermatozoon
Muciaccia, B., Padula, F., Vicini, E., Gandini, L., Lenzi, A., & Stefanini, M. (2005) · The FASEB Journal · doi:10.1096/fj.05-3962fje · Cited by 32
Differential effects of resact analogs on sperm respiration rates and cyclic nucleotide concentrations
Shimomura, H., & Garbers, D. L. (1986) · Biochemistry · doi:10.1021/bi00359a046 · Cited by 32
An N-Terminal Partial Sequence of the 13 kDa Pycnopodia Helianthoides Sperm Chemoattractant ‘Startrak’ Possesses Sperm-Attracting Activity
Miller, R. L., & Vogt, R. G. (1996) · Journal of Experimental Biology · doi:10.1242/jeb.199.2.311 · Cited by 29
Sperm-Activating Peptide Induces Asymmetric Flagellar Bending in Sea Urchin Sperm
Shiba, K., Ohmuro, J., Mogami, Y., Nishigaki, T., Wood, C. D., Darszon, A., Tatsu, Y., Yumoto, N., & Baba, S. A. (2005) · ZOOLOGICAL SCIENCE · doi:10.2108/zsj.22.293 · Cited by 28
Revisiting the Role of H+ in Chemotactic Signaling of Sperm
Solzin, J., Helbig, A., Van, Q., Brown, J. E., Hildebrand, E., Weyand, I., & Kaupp, U. B. (2004) · The Journal of General Physiology · doi:10.1085/jgp.200409030 · Cited by 28
Molecular mechanisms during sperm capacitation
Brewis, I. A., Moore, H. D. M., Fraser, L. R., Holt, W. V., Baldi, E., Luconi, M., Gadella, B. M., Ford, W. C. L., & Harrison, R. A. P. (2005) · Human Fertility · doi:10.1080/14647270500420178 · Cited by 26
Allurin, a 21 kD sperm chemoattractant, is rapidly released from the outermost jelly layer of the Xenopus egg by diffusion and medium convection
Xiang, X., Kittelson, A., Olson, J. H., Bieber, A. L., & Chandler, D. E. (2004) · Molecular Reproduction and Development · doi:10.1002/mrd.20201 · Cited by 24
Adenylyl cyclase isoforms in rat testis and spermatozoa from the cauda epididymidis
Wade, M. A., Roman, S. D., Jones, R. C., & Aitken, R. J. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0801-6 · Cited by 19
My Favourite Cell: The sea urchin spermatozoon
Brokaw, C. J. (1990) · BioEssays · doi:10.1002/bies.950120910 · Cited by 18
Dephosphorylation of Sea Urchin Sperm Guanylate Cyclase During Fertilization
Ward, G. E., Moy, G. W., & Vacquier, V. D. (1986) · Springer eBooks · doi:10.1007/978-1-4613-2255-9_19 · Cited by 17
Effect of some sex steroid hormones on human spermatozoa migration in vitro
Sliwa, L. (1995) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(95)80019-o · Cited by 17
A novel group of sperm activating peptides from the sea urchin Glyptocidaris crenularis
Suzuki, N., Yoshino, K., Kurita, M., Nomura, K., & Yamaguchi, M. (1988) · Comparative Biochemistry and Physiology Part C Comparative Pharmacology · doi:10.1016/0742-8413(88)90003-5 · Cited by 15
Non-genomic Effects of Steroid Hormones on Membrane Channels
Herve, J. (2002) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557023405981 · Cited by 11
Effect of some sex steroid hormones on human spermatozoa migration in vitro
Sliwa, L. (1995) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(94)01972-x · Cited by 10
To be or not to be (a receptor)
Wehling, M., Schultz, A., & Lösel, R. (2007) · Steroids · doi:10.1016/j.steroids.2006.11.007 · Cited by 9
Sperm and cilia dynamics
Elgeti, J. (2006) · Kölner Universitäts PublikationsServer (Universität zu Köln) · Cited by 5

Research works printed but not linked: 3

Ward GE, 1986, Adv. Exp. Med. Biol., 207, 359
10.1007/BF02460302 · DOI
10.1080/713602886 · DOI

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“port of the genetic material to the egg. Here, chemotaxis is important to guide the spermotozoa to nd their target (Alvarez et al., 2014; Eisenbach and Giojalas, 2006; Friedrich and Julic her, 2007; Kaupp et al., 2008, 2003). Trypanosomes. Trypanosomes (T. brucei) are motile parasites responsible for sleeping sickness…”
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See all 284

Authors: Kaupp, U. B., Kashikar, N. D., & Weyand, I.
Affiliations: Forschungszentrum Jülich (DE)
ORCID: Kaupp, U. Benjamin
Kashikar, Nachiket D.
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 2008-03-01
Volume: 70
Issue: 1
Pages: 93-117
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev.physiol.70.113006.100654
OpenAlex: W2155214806
Cited by: 284
References: 144
Citations by year: 2026: 4 · 2025: 8 · 2024: 12 · 2023: 7 · 2022: 11 · 2021: 18 · 2020: 18 · 2019: 14 · 2018: 8 · 2017: 19 · 2016: 10 · 2015: 19 · 2014: 23 · 2013: 23 · 2012: 14
FWCI: 2.15
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
JuSER (Forschungszentrum Jülich) (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords: sperm chemotaxis, chemotactic signaling, chemoattractants, sea urchin sperm, mammalian sperm, sensory signaling, photoreceptors, olfactory sensory neurons
MeSH terms: Animals, Chemotaxis, Humans, Male, Sperm Motility, Spermatozoa, Signal Transduction

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Mechanisms of Sperm Chemotaxis

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