The DOI matches its Crossref record; 146 of the 146 references it cites were found in a registry or an index.
Mechanisms of Sperm Chemotaxis
Abstract
Sperm are attracted by chemical factors that are released by the egg-a process called chemotaxis. Most of our knowledge on sperm chemotaxis originates from the study of marine invertebrates. In recent years, the main features of the chemotactic signaling pathway and the swimming behavior evoked by chemoattractants have been elucidated in sea urchins. In contrast, our understanding of mammalian sperm chemotaxis is still rudimentary and subject to an ongoing debate. In this review, we raise new questions and discuss current concepts of sperm chemotaxis. Finally, we highlight commonalities and differences of sensory signaling in sperm, photoreceptors, and olfactory neurons.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Various single-celled eukaryotes (protists) and the ciliated larvae of sponges devoid of neurons can display sophisticated behaviours, including phototaxis, gravitaxis or chemotaxis.”
From Origin and early evolution of neural circuits for the control of ciliary locomotion (2011) · cites this paper as [31]
Citations
Cites
Molecular Physiology of Low-Voltage-Activated T-type Calcium Channels
Perez‐Reyes, E. (2003) · Physiological Reviews · doi:10.1152/physrev.00018.2002 · Cited by 1,655
Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES
Schall, T. J., Bacon, K. B., Toy, K. J., & Goeddel, D. V. (1990) · Nature · doi:10.1038/347669a0 · Cited by 1,378
Hyperpolarization-Activated Cation Currents: From Molecules to Physiological Function
Robinson, R. B., & Siegelbaum, S. A. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142734 · Cited by 1,177
Queer Current and Pacemaker: The Hyperpolarization-Activated Cation Current in Neurons
Pape, H.-C. (1996) · Annual Review of Physiology · doi:10.1146/annurev.ph.58.030196.001503 · Cited by 1,152
A sperm ion channel required for sperm motility and male fertility
Ren, D., Navarro, B., Perez, G. I., Jackson, A. C., Battaglia-Hsu, S.-F., Shi, Q., Tilly, J. L., & Clapham, D. E. (2001) · Nature · doi:10.1038/35098027 · Cited by 957
Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium
Vassar, R. J., Ngai, J., & Axel, R. (1993) · Cell · doi:10.1016/0092-8674(93)90422-m · Cited by 874
Mutations in the K+ channel signature sequence
Heginbotham, L., Lü, Z., Abramson, T., & MacKinnon, R. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80887-2 · Cited by 853
Soluble Adenylyl Cyclase as an Evolutionarily Conserved Bicarbonate Sensor
Chen, Y., Cann, M. J., Litvin, T. N., Iourgenko, V., Sinclair, M. L., Levin, L. R., & Buck, J. (2000) · Science · doi:10.1126/science.289.5479.625 · Cited by 846
Identification of a Testicular Odorant Receptor Mediating Human Sperm Chemotaxis
Spehr, M., Gisselmann, G., Poplawski, A., Riffell, J. A., Wetzel, C. H., Zimmer, R. K., & Hatt, H. H. (2003) · Science · doi:10.1126/science.1080376 · Cited by 769
RANTES: a versatile and controversial chemokine
Appay, V., & Rowland‐Jones, S. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(00)01812-3 · Cited by 652
Cited by
Sorted by citations
Physics of microswimmers—single particle motion and collective behavior: a review
Elgeti, J., Winkler, R. G., & Gompper, G. (2015) · Reports on Progress in Physics · doi:10.1088/0034-4885/78/5/056601 · Cited by 1,472
“port of the genetic material to the egg. Here, chemotaxis is important to guide the spermotozoa to nd their target (Alvarez et al., 2014; Eisenbach and Giojalas, 2006; Friedrich and Julic her, 2007; Kaupp et al., 2008, 2003). Trypanosomes. Trypanosomes (T. brucei) are motile parasites responsible for sleeping sickness…”
BackgroundProgesterone activates the principal Ca2+ channel of human sperm
Lishko, P. V., Botchkina, I. L., & Kirichok, Y. (2011) · Nature · doi:10.1038/nature09767 · Cited by 617
Control of hyperactivation in sperm
Suárez, S. S. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn029 · Cited by 586
The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm
Strünker, T., Goodwin, N., Brenker, C., Kashikar, N. D., Weyand, I., Seifert, R., & Kaupp, U. B. (2011) · Nature · doi:10.1038/nature09769 · Cited by 573
Gibbs, G. M., Roelants, K., & O’Bryan, M. K. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0032 · Cited by 497
Metadata
- Authors
- Kaupp, U. B., Kashikar, N. D., & Weyand, I.
- Affiliations
- Forschungszentrum Jülich (DE)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2008-03-01
- Volume
- 70
- Issue
- 1
- Pages
- 93-117
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2155214806
- Cited by
- 284
- References
- 144
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 12 · 2023: 7 · 2022: 11 · 2021: 18 · 2020: 18 · 2019: 14 · 2018: 8 · 2017: 19 · 2016: 10 · 2015: 19 · 2014: 23 · 2013: 23 · 2012: 14
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- JuSER (Forschungszentrum Jülich) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- sperm chemotaxis, chemotactic signaling, chemoattractants, sea urchin sperm, mammalian sperm, sensory signaling, photoreceptors, olfactory sensory neurons
- MeSH terms
- Animals, Chemotaxis, Humans, Male, Sperm Motility, Spermatozoa, Signal Transduction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
