The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Regulation of Secondary Metabolism in Filamentous Fungi
Open accessAbstract
Fungal secondary metabolites are of intense interest to humankind due to their pharmaceutical (antibiotics) and/or toxic (mycotoxins) properties. In the past decade, tremendous progress has been made in understanding the genes that are associated with production of various fungal secondary metabolites. Moreover, the regulatory mechanisms controlling biosynthesis of diverse groups of secondary metabolites have been unveiled. In this review, we present the current understanding of the genetic regulation of secondary metabolism from clustering of biosynthetic genes to global regulators balancing growth, sporulation, and secondary metabolite production in selected fungi with emphasis on regulation of metabolites of agricultural concern. Particularly, the roles of G protein signaling components and developmental regulators in the mycotoxin sterigmatocystin biosynthesis in the model fungus Aspergillus nidulans are discussed in depth.
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Cites
Signal Transduction Cascades Regulating Fungal Development and Virulence
Lengeler, K. B., Davidson, R. C., D'souza, C., Harashima, T., Shen, W.-C., Wang, P., Pan, X., Waugh, M., & Heitman, J. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.4.746-785.2000 · Cited by 915
LaeA, a Regulator of Secondary Metabolism in Aspergillus spp
Bok, J. W., & Keller, N. P. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.2.527-535.2004 · Cited by 902
Self-citation
Cited by
Genome sequence of the model medicinal mushroom Ganoderma lucidum
Chen, S., Xu, J., Liu, C., Zhu, Y., Nelson, D. R., Zhou, S., Li, C., Wang, L., Guo, X., Sun, Y., et al. (2012) · Nature Communications · doi:10.1038/ncomms1923 · Cited by 579
Nützmann, H.-W., Reyes-Dominguez, Y., Scherlach, K., Schroeckh, V., Horn, F., Gacek, A., Schümann, J., Hertweck, C., Strauss, J., & Brakhage, A. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103523108 · Cited by 337
The VeA regulatory system and its role in morphological and chemical development in fungi
Calvo, A. M. (2008) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2008.03.014 · Cited by 272
Schumacher, J. (2016) · Molecular Microbiology · doi:10.1111/mmi.13262 · Cited by 157
Gacek-Matthews, A., Berger, H., Sasaki, T., Wittstein, K., Gruber, C., Lewis, Z. A., & Strauss, J. (2016) · PLOS Genetics · doi:10.1371/journal.pgen.1006222 · Cited by 105
Metadata
- Authors
- Yu, J.-H., & Keller, N.
- Venue
- Annual Review of Phytopathology
- Publisher
- Annual Reviews
- Published
- 2005-09-01
- Volume
- 43
- Issue
- 1
- Pages
- 437-458
- ISSN
- 0066-4286 (ISSN-L)
- 1545-2107
- OpenAlex
- W2140942626
- Cited by
- 562
- References
- 2
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Yu, J.-H., & Keller, N. (2005). Regulation of Secondary Metabolism in Filamentous Fungi. Annual Review of Phytopathology. https://doi.org/10.1146/annurev.phyto.43.040204.140214
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