KdmB, a Jumonji Histone H3 Demethylase, Regulates Genome-Wide H3K4 Trimethylation and Is Required for Normal Induction of Secondary Metabolism in Aspergillus nidulans
Open accessAbstract
Histone posttranslational modifications (HPTMs) are involved in chromatin-based regulation of fungal secondary metabolite biosynthesis (SMB) in which the corresponding genes-usually physically linked in co-regulated clusters-are silenced under optimal physiological conditions (nutrient-rich) but are activated when nutrients are limiting. The exact molecular mechanisms by which HPTMs influence silencing and activation, however, are still to be better understood. Here we show by a combined approach of quantitative mass spectrometry (LC-MS/MS), genome-wide chromatin immunoprecipitation (ChIP-seq) and transcriptional network analysis (RNA-seq) that the core regions of silent A. nidulans SM clusters generally carry low levels of all tested chromatin modifications and that heterochromatic marks flank most of these SM clusters. During secondary metabolism, histone marks typically associated with transcriptional activity such as H3 trimethylated at lysine-4 (H3K4me3) are established in some, but not all gene clusters even upon full activation. KdmB, a Jarid1-family histone H3 lysine demethylase predicted to comprise a BRIGHT domain, a zinc-finger and two PHD domains in addition to the catalytic Jumonji domain, targets and demethylates H3K4me3 in vivo and mediates transcriptional downregulation. Deletion of kdmB leads to increased transcription of about ~1750 genes across nutrient-rich (primary metabolism) and nutrient-limiting (secondary metabolism) conditions. Unexpectedly, an equally high number of genes exhibited reduced expression in the kdmB deletion strain and notably, this group was significantly enriched for genes with known or predicted functions in secondary metabolite biosynthesis. Taken together, this study extends our general knowledge about multi-domain KDM5 histone demethylases and provides new details on the chromatin-level regulation of fungal secondary metabolite production.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several genes were assigned to clusters enriched for gene sets consistent with their known functions, including KDM1B, BRSK2, and ITSN1, consistent with published functional evidence.
“Several genes were assigned to clusters that showed enrichment for gene sets consistent with their known functions, including KDM1B,41 BRSK2,42 and ITSN143 consistent with published functional evidence”
From Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes (2019) · cites this paper as [41]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
BEDTools: a flexible suite of utilities for comparing genomic features
Quinlan, A. R., & Hall, I. M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq033 · Cited by 27,437 · see citing works
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464 · see citing works
Robinson, J. T., Thorvaldsdóttir, H., Winckler, W., Guttman, M., Lander, E. S., Getz, G., & Mesirov, J. P. (2011) · Nature Biotechnology · doi:10.1038/nbt.1754 · Cited by 15,390 · see citing works
ggplot2: Elegant Graphics for Data Analysis
Wickham, H. (2009) · doi:10.1007/978-0-387-98141-3 · Cited by 14,447 · see citing works
Bioconductor: open software development for computational biology and bioinformatics
Gentleman, R., Carey, V., Bates, D., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome Biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 13,133 · see citing works
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883 · see citing works
Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
Thorvaldsdottir, H., Robinson, J. T., & Mesirov, J. P. (2013) · Briefings in Bioinformatics · doi:10.1093/bib/bbs017 · Cited by 9,049 · see citing works
Regulation of chromatin by histone modifications
Bannister, A. J., & Kouzarides, T. (2011) · Cell Research · doi:10.1038/cr.2011.22 · Cited by 6,012 · see citing works
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,759 · see citing works
The Role of Chromatin during Transcription
Li, B., Carey, M., & Workman, J. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.015 · Cited by 3,503 · see citing works
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
Bannister, A. J., Zegerman, P., Partridge, J. F., Miska, E. A., Thomas, J. O., Allshire, R. C., & Kouzarides, T. (2001) · Nature · doi:10.1038/35065138 · Cited by 2,903 · see citing works
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., & Jenuwein, T. (2001) · Nature · doi:10.1038/35065132 · Cited by 2,868 · see citing works
Active Genes Are Tri-Methylated at K4 of Histone H3
Santos-Rosa, H., Schneider, R., Bannister, A. J., Sherriff, J., Bernstein, B. E., Emre, N. C. T., Schreiber, S. L., Mellor, J., & Kouzarides, T. (2002) · Nature · doi:10.1038/nature01080 · Cited by 2,138 · see citing works
Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact
Black, J. C., Rechem, C. V., & Whetstine, J. R. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.11.006 · Cited by 1,318 · see citing works
Carrozza, M. J., Li, B., Florens, L. A., Suganuma, T., Swanson, S. K., Lee, K. K., Shia, W.-J., Anderson, S., Yates, J. R., Washburn, M. P., et al. (2005) · Cell · doi:10.1016/j.cell.2005.10.023 · Cited by 1,297 · see citing works
JmjC-domain-containing proteins and histone demethylation
Klose, R. J., Kallin, E. M., & Zhang, Y. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1945 · Cited by 1,290 · see citing works
Double-joint PCR: a PCR-based molecular tool for gene manipulations in filamentous fungi
Yu, J., Hamari, Z., Han, K., Seo, J.-A., Reyes-Domínguez, Y., & Scazzocchio, C. (2004) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2004.08.001 · Cited by 1,190 · see citing works
Regulation of fungal secondary metabolism
Brakhage, A. A. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2916 · Cited by 1,151 · see citing works
Shilatifard, A. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142422 · Cited by 1,099 · see citing works
Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases
Whetstine, J. R., Nottke, A. C., Lan, F., Huarte, M., Smolikov, S., Chen, Z., Spooner, E., Li, E., Zhang, G., Colaiácovo, M. P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.03.028 · Cited by 1,046 · see citing works
A histone H3 methyltransferase controls DNA methylation in Neurospora crassa
Tamaru, H., & Selker, E. U. (2001) · Nature · doi:10.1038/35104508 · Cited by 1,038 · see citing works
New nomenclature for chromatin-modifying enzymes
Allis, C. D., Berger, S. L., Cote, J., Dent, S., Jenuwien, T., Kouzarides, T., Pillus, L., Reinberg, D., Shi, Y., Shiekhattar, R., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.039 · Cited by 957 · see citing works
Molecular mechanisms and potential functions of histone demethylases
Kooistra, S. M., & Helin, K. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3327 · Cited by 882 · see citing works
Cotranscriptional Set2 Methylation of Histone H3 Lysine 36 Recruits a Repressive Rpd3 Complex
Keogh, M., Kurdistani, S. K., Morris, S. A., Ahn, S., Podolny, V., Collins, S. R., Schuldiner, M., Chin, K., Punna, T., Thompson, N. J., et al. (2005) · Cell · doi:10.1016/j.cell.2005.10.025 · Cited by 780 · see citing works
Dynamic Regulation of Histone Lysine Methylation by Demethylases
Shi, Y., & Whetstine, J. R. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.12.010 · Cited by 710 · see citing works
Schroeckh, V., Scherlach, K., Nützmann, H., Shelest, E., Schmidt‐Heck, W., Schuemann, J., Martin, K., Hertweck, C., & Brakhage, A. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901870106 · Cited by 662 · see citing works
Transformation by integration in Aspergillus nidulans
Tilburn, J., Scazzocchio, C., Taylor, G. G., Zabicky-Zissman, J. H., Lockington, R. A., & Davies, R. W. (1983) · Gene · doi:10.1016/0378-1119(83)90191-9 · Cited by 662 · see citing works
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36
Klose, R. J., Yamane, K., Bae, Y., Zhang, D., Erdjument‐Bromage, H., Tempst, P., Wong, J., & Zhang, Y. (2006) · Nature · doi:10.1038/nature04853 · Cited by 630 · see citing works
Nicol, J. W., Helt, G. A., Blanchard, S. G., Raja, A. N., & Loraine, A. E. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp472 · Cited by 623 · see citing works
A Versatile and Efficient Gene-Targeting System for Aspergillus nidulans
Nayak, T., Szewczyk, E., Oakley, C. E., Osmani, A. H., Ukil, L., Murray, S., Hynes, M. J., Osmani, S. A., & Oakley, B. R. (2005) · Genetics · doi:10.1534/genetics.105.052563 · Cited by 615 · see citing works
Reversal of Histone Methylation: Biochemical and Molecular Mechanisms of Histone Demethylases
Mosammaparast, N., & Shi, Y. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.070907.103946 · Cited by 585 · see citing works
Regulation of Secondary Metabolism in Filamentous Fungi
Yu, J., & Keller, N. P. (2005) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.43.040204.140214 · Cited by 562 · see citing works
RBP2 Belongs to a Family of Demethylases, Specific for Tri-and Dimethylated Lysine 4 on Histone 3
Christensen, J. F., Agger, K., Cloos, P. A., Pasini, D., Rose, S., Sennels, L., Rappsilber, J., Hansen, K. H., Salcini, A. E., & Helin, K. (2007) · Cell · doi:10.1016/j.cell.2007.02.003 · Cited by 554 · see citing works
Bayram, Ö., & Braus, G. H. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00285.x · Cited by 551 · see citing works
Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans.
Brown, D. W., Yu, J., Kelkar, H., Fernandes, M., Nesbitt, T. C., Keller, N. P., Adams, T. H., & Leonard, T. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1418 · Cited by 508 · see citing works
Wiemann, P., Sieber, C. M. K., von Bargen, K. W., Studt, L., Niehaus, E., Espino, J. J., Huß, K., Michielse, C. B., Albermann, S., Wagner, D., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003475 · Cited by 457 · see citing works
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
Klose, R. J., Yan, Q., Tóthová, Z., Yamane, K., Erdjument‐Bromage, H., Tempst, P., Gilliland, D. G., Zhang, Y., & Kaelin, W. G. (2007) · Cell · doi:10.1016/j.cell.2007.02.013 · Cited by 446 · see citing works
Recognition of Histone H3 Lysine-4 Methylation by the Double Tudor Domain of JMJD2A
Huang, Y., Fang, J., Bedford, M. T., Zhang, Y., & Xu, R.-M. (2006) · Science · doi:10.1126/science.1125162 · Cited by 446 · see citing works
Sims, R. J., Chen, C.-F., Santos-Rosa, H., Kouzarides, T., Patel, S. S., & Reinberg, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500395200 · Cited by 423 · see citing works
Histone Deacetylase Activity Regulates Chemical Diversity in Aspergillus
Shwab, E. K., Bok, J. W., Tribus, M., Galehr, J., Graessle, S., & Keller, N. P. (2007) · Eukaryotic Cell · doi:10.1128/ec.00186-07 · Cited by 414 · see citing works
Structural Insights into Histone Demethylation by JMJD2 Family Members
Chen, Z., Zang, J., Whetstine, J. R., Hong, X., Davrazou, F., Kutateladze, T. G., Simpson, M., Mao, Q., Pan, C., Dai, S., et al. (2006) · Cell · doi:10.1016/j.cell.2006.04.024 · Cited by 396 · see citing works
Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa
Tamaru, H., Zhang, X., McMillen, D. A., Singh, P. B., Nakayama, J., Grewal, S. I. S., Allis, C. D., Cheng, X., & Selker, E. U. (2003) · Nature Genetics · doi:10.1038/ng1143 · Cited by 385 · see citing works
Chromatin-level regulation of biosynthetic gene clusters
Bok, J. W., Chiang, Y., Szewczyk, E., Reyes-Domínguez, Y., Davidson, A. D., Sanchez, J. F., Lo, H.-C., Watanabe, K., Strauss, J., Oakley, B. R., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.177 · Cited by 381 · see citing works
Self-citationOPERating ON Chromatin, a Colorful Language where Context Matters
Gardner, K. E., Allis, C. D., & Strahl, B. D. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.01.040 · Cited by 362 · see citing works
Nützmann, H., Reyes-Domínguez, Y., Scherlach, K., Schroeckh, V., Horn, F., Gacek‐Matthews, A., Schümann, J., Hertweck, C., Strauss, J., & Brakhage, A. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103523108 · Cited by 340 · see citing works
Self-citationReyes-Domínguez, Y., Bok, J. W., Berger, H., Shwab, E. K., Basheer, A., Gallmetzer, A., Scazzocchio, C., Keller, N. P., & Strauss, J. (2010) · Molecular Microbiology · doi:10.1111/j.1365-2958.2010.07051.x · Cited by 319 · see citing works
Self-citationConnolly, L., Smith, K., & Freitag, M. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003916 · Cited by 319 · see citing works
Molecular Regulation of Histone H3 Trimethylation by COMPASS and the Regulation of Gene Expression
Schneider, J., Wood, A., Lee, J., Schuster, R. M., Dueker, J., Maguire, C., Swanson, S. K., Florens, L. A., Washburn, M. P., & Shilatifard, A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.07.024 · Cited by 302 · see citing works
Inglis, D. O., Binkley, J., Skrzypek, M. S., Arnaud, M. B., Cerqueira, G. C., Shah, P., Wymore, F., Wortman, J. R., & Sherlock, G. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-91 · Cited by 293 · see citing works
SUMO: A Multifaceted Modifier of Chromatin Structure and Function
Cubeñas-Potts, C., & Matunis, M. J. (2013) · Developmental Cell · doi:10.1016/j.devcel.2012.11.020 · Cited by 281 · see citing works
Secombe, J., Li, L., Carlos, L. S., & Eisenman, R. N. (2007) · Genes & Development · doi:10.1101/gad.1523007 · Cited by 277 · see citing works
Epigenetic Control of Effector Gene Expression in the Plant Pathogenic Fungus Leptosphaeria maculans
Soyer, J. L., Ghalid, M. E., Glaser, N., Ollivier, B., Linglin, J., Grandaubert, J., Balesdent, M., Connolly, L., Freitag, M., Rouxel, T., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004227 · Cited by 265 · see citing works
Genetic regulation of aflatoxin biosynthesis: From gene to genome
Georgianna, D. R., & Payne, G. A. (2008) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2008.10.011 · Cited by 264 · see citing works
Cerqueira, G., Arnaud, M. B., Inglis, D. O., Skrzypek, M. S., Binkley, G., Simison, M., Miyasato, S. R., Binkley, J., Orvis, J., Shah, P., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1029 · Cited by 253 · see citing works
Lo, H.-C., Entwistle, R., Guo, C., Ahuja, M., Szewczyk, E., Hung, J., Chiang, Y., Oakley, B. R., & Wang, C. C. C. (2012) · Journal of the American Chemical Society · doi:10.1021/ja209809t · Cited by 250 · see citing works
Dereplication of Microbial Natural Products by LC-DAD-TOFMS
Nielsen, K. F., Månsson, M., Rank, C., Frisvad, J. C., & Larsen, T. O. (2011) · Journal of Natural Products · doi:10.1021/np200254t · Cited by 246 · see citing works
Histone Lysine Demethylase JARID1a Activates CLOCK-BMAL1 and Influences the Circadian Clock
DiTacchio, L., Le, H. D., Vollmers, C., Hatori, M., Witcher, M., Secombe, J., & Panda, S. (2011) · Science · doi:10.1126/science.1206022 · Cited by 244 · see citing works
HP1 Is Essential for DNA Methylation in Neurospora
Freitag, M., Hickey, P. C., Khlafallah, T. K., Read, N. D., & Selker, E. U. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00024-3 · Cited by 236 · see citing works
The chromatin code of fungal secondary metabolite gene clusters
Gacek‐Matthews, A., & Strauss, J. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4208-8 · Cited by 218 · see citing works
Self-citationDNA methylation inhibits elongation but not initiation of transcription in Neurospora crassaPreprint
Rountree, M. R., & Selker, E. U. (1997) · Genes & Development · doi:10.1101/gad.11.18.2383 · Cited by 207 · see citing works
Chiang, Y., Szewczyk, E., Nayak, T., Davidson, A. D., Sanchez, J. F., Lo, H.-C., Ho, W., Simityan, H., Kuo, E. C., Praseuth, A. P., et al. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.05.010 · Cited by 204 · see citing works
Hung, T., Binda, O., Glass, K. C., Kuo, A. J., Johnson, K., Chang, H. Y., Simon, M. D., Kutateladze, T. G., & Gozani, O. (2009) · Molecular Cell · doi:10.1016/j.molcel.2008.12.016 · Cited by 201 · see citing works
Characterization of the Aspergillus nidulans Monodictyphenone Gene Cluster
Chiang, Y., Szewczyk, E., Davidson, A. D., Entwistle, R., Keller, N. P., Wang, C. C. C., & Oakley, B. R. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.02187-09 · Cited by 199 · see citing works
Regional control of histone H3 lysine 27 methylation in Neurospora
Jamieson, K., Rountree, M. R., Lewis, Z., Stajich, J., & Selker, E. U. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303750110 · Cited by 196 · see citing works
Self-citationChujo, T., & Scott, B. (2014) · Molecular Microbiology · doi:10.1111/mmi.12567 · Cited by 186 · see citing works
Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins
Seward, D. J., Cubberley, G., Kim, S., Schonewald, M., Zhang, L., Tripet, B., & Bentley, D. L. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1200 · Cited by 185 · see citing works
KDM5B regulates embryonic stem cell self‐renewal and represses cryptic intragenic transcription
Xie, L., Pelz, C., Wang, W., Bashar, A., Varlamova, O., Shadle, S. C., & Impey, S. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.91 · Cited by 180 · see citing works
Identification and Characterization of the Asperthecin Gene Cluster of Aspergillus nidulans
Szewczyk, E., Chiang, Y., Oakley, C. E., Davidson, A. D., Wang, C. C. C., & Oakley, B. R. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.01743-08 · Cited by 172 · see citing works
Varga, E., Glauner, T., Berthiller, F., Krska, R., Schuhmacher, R., & Sulyok, M. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-6831-3 · Cited by 160 · see citing works
Neurospora crassa, a Model System for Epigenetics ResearchPreprint
Aramayo, R., & Selker, E. U. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a017921 · Cited by 156 · see citing works
Essential Functions of the Histone Demethylase Lid
Li, L., Greer, C., Eisenman, R. N., & Secombe, J. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001221 · Cited by 150 · see citing works
Molecular genetic analysis of the orsellinic acid/F9775 genecluster of Aspergillus nidulans
Sanchez, J. F., Chiang, Y., Szewczyk, E., Davidson, A. D., Ahuja, M., Oakley, C. E., Bok, J. W., Keller, N. P., Oakley, B. R., & Wang, C. C. C. (2009) · Molecular BioSystems · doi:10.1039/b904541d · Cited by 150 · see citing works
Todd, R. B., Davis, M. A., & Hynes, M. J. (2007) · Nature Protocols · doi:10.1038/nprot.2007.112 · Cited by 147 · see citing works
Honda, S., & Selker, E. U. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00823-08 · Cited by 147 · see citing works
MacCabe, A., Riach, M. B. R., Unkles, S. E., & Kinghorn, J. R. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08106.x · Cited by 140 · see citing works
Structure, dynamics, and evolution of centromeric nucleosomes
Dalal, Y., Furuyama, T., Vermaak, D., & Henikoff, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707648104 · Cited by 135 · see citing works
Genome-wide redistribution of H3K27me3 is linked to genotoxic stress and defective growth
Basenko, E. Y., Sasaki, T., Ji, L., Prybol, C. J., Burckhardt, R. M., Schmitz, R. J., & Lewis, Z. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511377112 · Cited by 133 · see citing works
Self-citationJamieson, K., Wiles, E. T., McNaught, K. J., Sidoli, S., Leggett, N. A., Shao, Y., Garcia, B. A., & Selker, E. U. (2015) · Genome Research · doi:10.1101/gr.194555.115 · Cited by 128 · see citing works
The Budding Yeast NucleusPreprint
Taddei, A., Schober, H., & Gasser, S. M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000612 · Cited by 126 · see citing works
Bouhired, S. M., Weber, M., Kempf-Sontag, A., Keller, N. P., & Hoffmeister, D. (2007) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2006.12.010 · Cited by 114 · see citing works
Soukup, A. A., Chiang, Y., Bok, J. W., Reyes-Domínguez, Y., Oakley, B. R., Wang, C. C. C., Strauss, J., & Keller, N. P. (2012) · Molecular Microbiology · doi:10.1111/j.1365-2958.2012.08195.x · Cited by 112 · see citing works
Self-citationRoze, L. V., Arthur, A. E., Hong, S., Chanda, A., & Linz, J. E. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05952.x · Cited by 109 · see citing works
Liu, Y., Liu, N., Yin, Y., Chen, Y., Jiang, J., & Ma, Z. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.12993 · Cited by 106 · see citing works
Reyes-Domínguez, Y., Boedi, S., Sulyok, M., Wiesenberger, G., Stoppacher, N., Krska, R., & Strauss, J. (2011) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2011.11.002 · Cited by 104 · see citing works
Self-citationKlose, R. J., Gardner, K. E., Liang, G., Erdjument‐Bromage, H., Tempst, P., & Zhang, Y. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02180-06 · Cited by 96 · see citing works
Chd1 chromatin remodelers maintain nucleosome organization and repress cryptic transcription
Hennig, B. P., Bendrin, K., Zhou, Y., & Fischer, T. (2012) · EMBO Reports · doi:10.1038/embor.2012.146 · Cited by 94 · see citing works
Secombe, J., & Eisenman, R. N. (2007) · Cell Cycle · doi:10.4161/cc.6.11.4269 · Cited by 88 · see citing works
Structural Insight Into Histone Recognition by the ING PHD Fingers
Glass, K. C., & Kutateladze, T. G. (2009) · Current Drug Targets · doi:10.2174/138945009788185040 · Cited by 85 · see citing works
Epigenetics of β-globin gene regulation
Kiefer, C. M., Hou, C., Little, J. A., & Dean, A. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.07.014 · Cited by 81 · see citing works
Rodríguez-Urra, A. B., Jiménez, C., Nieto, M. I., Rodrı́guez, J., Hayashi, H., & Ugalde, U. (2012) · ACS Chemical Biology · doi:10.1021/cb200455u · Cited by 80 · see citing works
Palmer, J. M., Bok, J. W., Lee, S., Dagenais, T. R. T., Andes, D. R., Kontoyiannis, D. P., & Keller, N. P. (2013) · PeerJ · doi:10.7717/peerj.4 · Cited by 76 · see citing works
Gerke, J., Bayram, Ö., Feussner, K., Landesfeind, M., Shelest, E., Feußner, I., & Braus, G. H. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.01808-12 · Cited by 76 · see citing works
Halecker, S., Surup, F., Kuhnert, E., Mohr, K. I., Brock, N. L., Dickschat, J. S., Junker, C., Schulz, B., & Stadler, M. (2014) · Phytochemistry · doi:10.1016/j.phytochem.2014.01.018 · Cited by 68 · see citing works
Perez‐Esteban, B., Orejas, M., Gómez‐Pardo, E., & Peñalva, M. A. (1993) · Molecular Microbiology · doi:10.1111/j.1365-2958.1993.tb01746.x · Cited by 68 · see citing works
Reyes-Domínguez, Y., Narendja, F. M., Berger, H., Gallmetzer, A., Fernández-Martín, R., Garcia, I., Scazzocchio, C., & Strauss, J. (2008) · Eukaryotic Cell · doi:10.1128/ec.00184-07 · Cited by 64 · see citing works
Self-citationA Cytosine Methyltransferase Homologue Is Essential for Sexual Development in Aspergillus nidulans
Lee, D. W., Freitag, M., Selker, E. U., & Aramayo, R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002531 · Cited by 63 · see citing works
Identification of non-histone substrates for JMJD2A–C histone demethylases
Ponnaluri, V. K. C., Vavilala, D. T., Putty, S., Gutheil, W. G., & Mukherji, M. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.09.107 · Cited by 57 · see citing works
Gacek‐Matthews, A., Noble, L. M., Grünwald‐Gruber, C., Berger, H., Sulyok, M., Marcos, A. T., Strauss, J., & Andrianopoulos, A. (2015) · Molecular Microbiology · doi:10.1111/mmi.12977 · Cited by 53 · see citing works
Self-citationTakeda, I., Umemura, M., Koike, H., Asai, K., & Machida, M. (2014) · DNA Research · doi:10.1093/dnares/dsu010 · Cited by 51 · see citing works
Characterization of two putative histone deacetylase genes from Aspergillus nidulans
Graessle, S., Dangl, M., Haas, H., Mair, K., Trojer, P., Brandtner, E., Walton, J. D., Loidl, P., & Brosch, G. (2000) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00093-2 · Cited by 48 · see citing works
Shinohara, Y., Kawatani, M., Futamura, Y., Osada, H., & Koyama, Y. (2015) · The Journal of Antibiotics · doi:10.1038/ja.2015.73 · Cited by 44 · see citing works
Shi, Y., Sun, C., Gao, B., & Sun, A. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.08.038 · Cited by 43 · see citing works
Song, R., Xu, F., Zhang, Z., Liu, Y., Dong, H., & Tian, Y. (2008) · Biomedical Chromatography · doi:10.1002/bmc.1050 · Cited by 33 · see citing works
Pfeiffer, E., Fleck, S. C., & Metzler, M. (2014) · Chemical Research in Toxicology · doi:10.1021/tx500308k · Cited by 32 · see citing works
Stadler, M., Hellwig, V., Mayer‐Bartschmid, A., Denzer, D. J., Wiese, B., & Burkhardt, N. (2005) · The Journal of Antibiotics · doi:10.1038/ja.2005.105 · Cited by 31 · see citing works
Lorenz, D. R., Meyer, L. F., Grady, P. J. R., Meyer, M. M., & Cam, H. P. (2014) · eLife · doi:10.7554/elife.04506 · Cited by 30 · see citing works
Chang, Y., Wu, J., Tong, X.-J., Zhou, J., & Ding, J. (2010) · Biochemical Journal · doi:10.1042/bj20101418 · Cited by 23 · see citing works
Bayram, Ö., & Braus, G. H. (2012) · Maynooth University ePrints and eTheses Archive (Maynooth University) · Cited by 21 · see citing works
Govindaraghavan, M., Anglin, S. L., Osmani, A. H., & Osmani, S. A. (2014) · Genetics · doi:10.1534/genetics.114.165647 · Cited by 20 · see citing works
Erratum: Corrigendum: Chromatin-level regulation of biosynthetic gene clusters
Bok, J. W., Chiang, Y., Szewczyk, E., Reyes-Domínguez, Y., Davidson, A. D., Sanchez, J. F., Lo, H.-C., Watanabe, K., Strauss, J., Oakley, B. R., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio0909-696a · Cited by 3 · see citing works
Self-citation
Flagged first, then by citations
1 of the 111 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- [39]Gacek-Matthews A., Noble L.M., Gruber C., Berger H., Sulyok M., Marcos A.T, et al KdmA, a histone H3 demethylase with bipartite function, differentially regulates primary and secondary metabolism in Aspergillus nidulans. Molecular microbiology. accepted with minor revision. PMC4949671 25712266
- [40]Gacek-Matthews A, Noble LM, Gruber C, Berger H, Sulyok M, Marcos AT, et al KdmA, a histone H3 demethylase with bipartite function, differentially regulates primary and secondary metabolism in Aspergillus nidulans. Mol Microbiol. 2015. PMC4949671 25712266
Cited by
Sorted by citations
Fungal secondary metabolism: regulation, function and drug discovery
Keller, N. P. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0121-1 · Cited by 1,410 · see citing works
Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes
Feliciano, P., Zhou, X., Astrovskaya, I., Turner, T. N., Wang, T., Brueggeman, L., Barnard, R., Hsieh, A., Snyder, L. G., Muzny, D. M., et al. (2019) · npj Genomic Medicine · doi:10.1038/s41525-019-0093-8 · Cited by 247 · see citing works
Pfannenstiel, B. T., & Keller, N. P. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.02.001 · Cited by 168 · see citing works
Histone Methylation by SET Domain Proteins in Fungi
Freitag, M. (2017) · Annual Review of Microbiology · doi:10.1146/annurev-micro-102215-095757 · Cited by 161 · see citing works
Collemare, J., & Seidl, M. F. (2019) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuz018 · Cited by 101 · see citing works
Pillay, L. C., Nekati, L., Makhwitine, J. P., & Ndlovu, S. I. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.815008 · Cited by 82 · see citing works
Fischer, J., Müller, S., Netzker, T., Jäger, N., Gacek‐Matthews, A., Scherlach, K., Stroe, M. C., García‐Altares, M., Pezzini, F., Schoeler, H., et al. (2018) · eLife · doi:10.7554/elife.40969 · Cited by 67 · see citing works
Self-citationPost‐translational modifications drive secondary metabolite biosynthesis in Aspergillus : a review
Yang, K., Tian, J., & Keller, N. P. (2022) · Environmental Microbiology · doi:10.1111/1462-2920.16034 · Cited by 61 · see citing works
Biosynthesis of Saxitoxin in Marine Dinoflagellates: An Omics Perspective
Akbar, M. A., Yusof, N. Y. M., Tahir, N. I., Ahmad, A., Usup, G., Sahrani, F. K., & Bunawan, H. (2020) · Marine Drugs · doi:10.3390/md18020103 · Cited by 60 · see citing works
Studt, L., Janevska, S., Arndt, B., Boedi, S., Sulyok, M., Humpf, H., Tudzynski, B., & Strauss, J. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02144 · Cited by 60 · see citing works
Self-citationEmerging mechanistic insights into the regulation of specialized metabolism in plants
Méteignier, L., Nützmann, H., Papon, N., Osbourn, A., & Courdavault, V. (2022) · Nature Plants · doi:10.1038/s41477-022-01288-7 · Cited by 59 · see citing works
Hou, J., Feng, H., Chang, H., Liu, Y., Li, G., Yang, S., Sun, C., Zhang, M., Yuan, Y., Sun, J., et al. (2019) · New Phytologist · doi:10.1111/nph.16200 · Cited by 57 · see citing works
Janevska, S., Güldener, U., Sulyok, M., Tudzynski, B., & Studt, L. (2018) · Environmental Microbiology · doi:10.1111/1462-2920.14339 · Cited by 54 · see citing works
Karahoda, B., Pardeshi, L. A., Ulaş, M., Dong, Z., Shirgaonkar, N., Guo, S., Wang, F., Tan, K., Bayram, Ö. S., Bauer, I., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac744 · Cited by 53 · see citing works
Self-citationMolecular regulation of fungal secondary metabolism
Yu, W., Pei, R., Zhou, J., Zeng, B., Tu, Y., & He, B. (2023) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-023-03649-6 · Cited by 52 · see citing works
Soyer, J. L., Clairet, C., Gay, E. J., Lapalu, N., Rouxel, T., Stukenbrock, E. H., & Fudal, I. (2021) · Chromosome Research · doi:10.1007/s10577-021-09658-1 · Cited by 48 · see citing works
Insight into the global regulation of laeA in Aspergillus flavus based on proteomic profiling
Lv, Y., Lv, A., Zhai, H.-C., Zhang, S., Li, L., Cai, J.-P., & Hu, Y. (2018) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2018.06.024 · Cited by 38 · see citing works
Verma, A. K., Tiwari, H., Singh, S., Gupta, P., Rai, N., Singh, S. K., Singh, B. P., Rao, S., & Gautam, V. (2023) · Mycology: An International Journal on Fungal Biology · doi:10.1080/21501203.2023.2241486 · Cited by 36 · see citing works
High-throughput format for the phenotyping of fungi on solid substrates
Cánovas, D., Studt, L., Marcos, A. T., & Strauss, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-03598-9 · Cited by 35 · see citing works
Self-citationEtxebeste, O., & Espeso, E. A. (2019) · International Microbiology · doi:10.1007/s10123-019-00064-6 · Cited by 30 · see citing works
Zhou, S., Sun, W., Zhao, X., Xu, Y., Zhang, M., Yin, Y., Pan, S., Shen, M., Shen, M., Yang, J., et al. (2021) · Molecular Plant Pathology · doi:10.1111/mpp.13035 · Cited by 29 · see citing works
Liang, L., Liu, Y., Yang, K., Lin, G., Xu, Z., Lan, H., Wang, X., & Wang, S. (2017) · Toxins · doi:10.3390/toxins9070232 · Cited by 29 · see citing works
Secondary Metabolite Gene Regulation in Mycotoxigenic Fusarium Species: A Focus on Chromatin
Atanasoff-Kardjalieff, A. K., & Studt, L. (2022) · Toxins · doi:10.3390/toxins14020096 · Cited by 27 · see citing works
Etier, A., Dumetz, F., Chéreau, S., & Ponts, N. (2022) · Toxins · doi:10.3390/toxins14050317 · Cited by 27 · see citing works
Bachleitner, S., Sørensen, J. L., Gacek‐Matthews, A., Sulyok, M., Studt, L., & Strauss, J. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01759 · Cited by 26 · see citing works
Self-citationDeveloping filamentous fungal chassis for natural product production
Fan, J., Wei, P., Li, Y., Zhang, S., Ren, Z., Li, W., & Yin, W. (2024) · Bioresource Technology · doi:10.1016/j.biortech.2024.131703 · Cited by 26 · see citing works
Shostak, K., Bonner, C., Sproule, A., Thapa, I., Shields, S. W. J., Blackwell, B. A., Vierula, J., Overy, D. P., & Subramaniam, R. (2020) · Molecular Microbiology · doi:10.1111/mmi.14575 · Cited by 26 · see citing works
Huang, D., Xiao, F., Hao, H., Hua, F., Luo, Z., Huang, Z., Li, Q., Chen, S., Cheng, X., Zhang, X., et al. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00660-4 · Cited by 26 · see citing works
How to Completely Squeeze a Fungus—Advanced Genome Mining Tools for Novel Bioactive Substances
Schüller, A., Studt, L., & Strauss, J. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14091837 · Cited by 26 · see citing works
Self-citationBiosynthesis of Fusapyrone Depends on the H3K9 Methyltransferase, FmKmt1, in Fusarium mangiferae
Atanasoff-Kardjalieff, A. K., Lünne, F., Kalinina, S. A., Strauss, J., Humpf, H., & Studt, L. (2021) · Frontiers in Fungal Biology · doi:10.3389/ffunb.2021.671796 · Cited by 25 · see citing works
Self-citationA Matter of Scale and Dimensions: Chromatin of Chromosome Landmarks in the Fungi
Erlendson, A. A., Friedman, S., & Freitag, M. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0054-2017 · Cited by 24 · see citing works
Wang, B., Li, X., Yu, D., Chen, X., Tabudravu, J. N., Deng, H., & Pan, L. (2018) · Microbiological Research · doi:10.1016/j.micres.2018.10.004 · Cited by 24 · see citing works
Soyer, J. L., Grandaubert, J., Haueisen, J., Schotanus, K., & Stukenbrock, E. H. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/544627 · Cited by 20 · see citing works
Schüller, A., Wolansky, L., Berger, H., Studt, L., Gacek‐Matthews, A., Sulyok, M., & Strauss, J. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10900-9 · Cited by 22 · see citing works
Self-citationFerraro, A. R., Ameri, A. J., Lu, Z., Kamei, M., Schmitz, R. J., & Lewis, Z. (2021) · BMC Genomics · doi:10.1186/s12864-021-07774-0 · Cited by 21 · see citing works
Self-citationEpigenetic and Posttranslational Modifications in Regulating the Biology of Aspergillus Species
Nie, X., Li, B., & Wang, S. (2018) · Advances in applied microbiology · doi:10.1016/bs.aambs.2018.05.004 · Cited by 21 · see citing works
Regulation of subtelomeric fungal secondary metabolite genes by H3K4me3 regulators CclA and KdmB
Lukito, Y., Chujo, T., Hale, T. K., Mace, W. J., Johnson, L. J., & Scott, B. (2019) · Molecular Microbiology · doi:10.1111/mmi.14320 · Cited by 20 · see citing works
Karahoda, B., Pfannenstiel, B. T., Bayram, Ö. S., Dong, Z., Wong, K. H., Fleming, A. B., Keller, N. P., & Bayram, Ö. (2023) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2023.103836 · Cited by 19 · see citing works
Chettri, P., Dupont, P., & Bradshaw, R. E. (2017) · Molecular Microbiology · doi:10.1111/mmi.13898 · Cited by 19 · see citing works
Colabardini, A. C., Wang, F., Miao, Z., Pardeshi, L. A., Valero, C., de Castro, P. A., Akiyama, D. Y., Tan, K., Nora, L. C., Silva‐Rocha, R., et al. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010001 · Cited by 19 · see citing works
Schumacher, J., Studt, L., & Tudzynski, P. (2018) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2018.11.003 · Cited by 18 · see citing works
Huang, L., Li, X., Dong, L., Wang, B., & Pan, L. (2021) · BMC Biology · doi:10.1186/s12915-021-01114-0 · Cited by 18 · see citing works
Nowrousian, M. (2022) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00104-22 · Cited by 17 · see citing works
Effect of H2A.Z deletion is rescued by compensatory mutations in Fusarium graminearum
Chen, Z., Zehraoui, E., Atanasoff-Kardjalieff, A. K., Strauss, J., Studt, L., & Ponts, N. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1009125 · Cited by 17 · see citing works
Self-citationPRABHUKARTHIKEYAN, S. R., Parameswaran, C., Sawant, S. B., Naveenkumar, R., Mahanty, A., Keerthana, U., Yadav, M. K., Anandan, A., Panneerselvam, P., Bag, M. K., et al. (2022) · Journal of Fungi · doi:10.3390/jof8040370 · Cited by 14 · see citing works
Identification and Characterization of Pyrimidine Nucleoside 2′-Hydroxylase
Genz, F., Friedrich, F., Loenarz, C., Einsle, O., Jung, M., Müller, M., & Fessner, N. D. (2025) · ACS Catalysis · doi:10.1021/acscatal.4c07764 · Cited by 10 · see citing works
On the role of the global regulator RlcA in red-light sensing in Aspergillus nidulans
Yu, Z., Hübner, J., Herrero, S., Gourain, V., & Fischer, R. (2020) · Fungal Biology · doi:10.1016/j.funbio.2019.12.009 · Cited by 10 · see citing works
8 Coordination of Fungal Secondary Metabolism and Development
Gerke, J., Köhler, A. M., Meister, C., Thieme, K. G., Amoedo, H., & Braus, G. H. (2020) · Springer eBooks · doi:10.1007/978-3-030-49924-2_8 · Cited by 9 · see citing works
Kim, W., Jeong, M., Yun, S., & Hur, J. (2021) · Journal of Fungi · doi:10.3390/jof7050398 · Cited by 10 · see citing works
Fungal Lysine Deacetylases in Virulence, Resistance, and Production of Small Bioactive Compounds
Bauer, I., & Graessle, S. (2021) · Genes · doi:10.3390/genes12101470 · Cited by 10 · see citing works
Palos-Fernández, R., Pontes, M. V. A., Puebla-Planas, G., Berger, H., Studt, L., Strauss, J., Pietro, A. D., & López‐Berges, M. S. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012671 · Cited by 8 · see citing works
Self-citationRai, M. N., & Rai, R. (2024) · Pathogens · doi:10.3390/pathogens13121080 · Cited by 8 · see citing works
Choi, Y.-H., Lee, M.-W., & Shin, K.-S. (2022) · Journal of Fungi · doi:10.3390/jof8060590 · Cited by 8 · see citing works
Zehetbauer, F., Seidl, A., Berger, H., Sulyok, M., Kastner, F., & Strauss, J. (2022) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2022.103726 · Cited by 8 · see citing works
Self-citationBerger, H., Bacher, M., Labuda, R., Eppel, I. M., Bayer, F., Sulyok, M., Gasparotto, E., Zehetbauer, F., Doppler, M., Gratzl, H., et al. (2022) · Environmental Microbiology · doi:10.1111/1462-2920.16118 · Cited by 8 · see citing works
Self-citationUse of epigenetic regulation for the discovery of fungi derived cryptic natural product
Wang, Y., Guo, J., Zhong, J., & Xiao, H. (2024) · Process Biochemistry · doi:10.1016/j.procbio.2024.06.015 · Cited by 7 · see citing works
Li, Y., Song, Z., Wang, E., Dong, L., Bai, J., Wang, D., Zhu, J., & Zhang, C. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.980615 · Cited by 7 · see citing works
Zhang, X., Leahy, I., Collemare, J., & Seidl, M. F. (2024) · Genome Biology and Evolution · doi:10.1093/gbe/evae228 · Cited by 6 · see citing works
Luciano‐Rosario, D., Barda, O., Tannous, J., Frawley, D., Bayram, Ö., Prusky, D., Sionov, E., & Keller, N. P. (2023) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2023.103837 · Cited by 6 · see citing works
Fischer, J., Müller, S., Netzker, T., Jäger, N., Gacek‐Matthews, A., Scherlach, K., Stroe, M. C., García‐Altares, M., Pezzini, F., Schoeler, H., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/211979 · Cited by 5 · see citing works
Self-citationDetection and quantification of the histone code in the fungal genus Aspergillus
Zhang, X., Noberini, R., Vai, A., Bonaldi, T., Seidl, M. F., & Collemare, J. (2023) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2023.103800 · Cited by 4 · see citing works
Zhang, X., Yang, Y., Wang, L., & Qin, Y. (2024) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-024-03978-0 · Cited by 4 · see citing works
Soyer, J. L., Clairet, C., Gay, E. J., Lapalu, N., Rouxel, T., Stukenbrock, E. H., & Fudal, I. (2020) · Research Square · doi:10.21203/rs.3.rs-73550/v1 · Cited by 4 · see citing works
Epigenetic regulation of pathogenicity in fungi
Hardin, A. M., Hardin, C. M., Isaacs, G. D., & Price, M. S. (2025) · Current Genetics · doi:10.1007/s00294-025-01329-6 · Cited by 3 · see citing works
Weinstock, L. D., Schambach, J., Lara, A., Kunstadt, C., Lee, D. E., Koning, E. R., Morrell, W., Mays, W., Davis, W., IV, & Krishnakumar, R. (2026) · iScience · doi:10.1016/j.isci.2026.117280 · Cited by 3 · see citing works
1 Chromatin Structure and Function in Neurospora crassa
Courtney, A. J., Ferraro, A. R., Klocko, A. D., & Lewis, Z. (2020) · Springer eBooks · doi:10.1007/978-3-030-49924-2_1 · Cited by 3 · see citing works
Self-citationSchüller, A., Studt, L., Berger, H., Silvestrini, L., Labuda, R., Güldener, U., Gorfer, M., Bacher, M., Doppler, M., Gasparotto, E., et al. (2023) · Fungal Biology and Biotechnology · doi:10.1186/s40694-023-00158-x · Cited by 3 · see citing works
Self-citationCross-kingdom microRNA transfer for the control of the anthracnose disease in cassava
Pinweha, N., Netrphan, S., Sojikul, P., Viboonjun, U., Sae-Lim, P., & Narangajavana, J. (2022) · Tropical Plant Pathology · doi:10.1007/s40858-022-00503-2 · Cited by 3 · see citing works
Agnusdei, A., González-García, A., Gerin, D., Pollastro, S., Faretra, F., González-Candelas, L., & Ballester, A. (2025) · Toxins · doi:10.3390/toxins17040196 · Cited by 2 · see citing works
Unconventional approaches for the induction of microbial natural products
Thissera, B., Soldatou, S., Belbahri, L., Ebel, R., Jaspars, M., & Rateb, M. E. (2025) · Journal of Applied Microbiology · doi:10.1093/jambio/lxaf014 · Cited by 2 · see citing works
Fischer, J., Müller, S., Gacek‐Matthews, A., Netzker, T., Jäger, N., Scherlach, K., Stroe, M. C., García‐Altares, M., Pezzini, F., Schoeler, H., et al. (2017) · MPG.PuRe (Max Planck Society) · Cited by 2 · see citing works
Self-citationA Matter of Scale and Dimensions: Chromatin of Chromosome Landmarks in the Fungi
Erlendson, A. A., Friedman, S., & Freitag, M. (2017) · ASM Press eBooks · doi:10.1128/9781555819583.ch27 · Cited by 2 · see citing works
Studt, L. (2022) · The mycota · doi:10.1007/978-3-031-16503-0_12 · Cited by 2 · see citing works
Annotation of the 12th Chromosome of the Forest Pathogen Fusarium circinatum
Malewski, T., Matić, S., Okorski, A., Borowik, P., & Oszako, T. (2023) · Agronomy · doi:10.3390/agronomy13030773 · Cited by 2 · see citing works
Schüller, A., Wolansky, L., Berger, H., Studt, L., Gacek‐Matthews, A., Sulyok, M., & Strauss, J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.02.022053 · Cited by 2 · see citing works
Self-citationThe study of iron‐ and copper‐binding proteome of Fusarium oxysporum and its effector candidates
Kushwah, A. S., Dixit, H., UPADHYAY, V. K., Verma, S. K., & Prasad, R. (2024) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.26696 · Cited by 1 · see citing works
Locus-specific chromatin proteomics using dCas-guided proximity labelling in Aspergillus nidulans
Svoboda, T., Niederdöckl-Loibl, D., Schüller, A., Hummel, K., Schlosser, S., Razzazi‐Fazeli, E., & Strauss, J. (2025) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2025.103973 · Cited by 1 · see citing works
Self-citationWulandari, A. P., Lestari, E. N., Wandira, A., Pitaloka, R. P., Nurjannah, L., & Azhari, A. (2026) · Mycology: An International Journal on Fungal Biology · doi:10.1080/21501203.2026.2646460 · Cited by 1 · see citing works
Zehetbauer, F., Berger, H., Kastner, F., & Strauss, J. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127981 · Cited by 1 · see citing works
Self-citationDetection and quantification of the histone code in the fungal genus AspergillusPreprint
Zhang, X., Noberini, R., Vai, A., Bonaldi, T., Seidl, M. F., & Collemare, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.31.526455
Schüller, A., Studt, L., Berger, H., Silvestrini, L., Labuda, R., Güldener, U., Gorfer, M., Bacher, M., Doppler, M., Gasparotto, E., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23575476
Self-citationHuang, L., Li, X., Dong, L., Wang, B., & Pan, L. (2021) · Figshare · doi:10.6084/m9.figshare.16576050
Schüller, A., Studt, L., Berger, H., Silvestrini, L., Labuda, R., Güldener, U., Gorfer, M., Bacher, M., Doppler, M., Gasparotto, E., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23575467
Self-citationSchüller, A., Studt, L., Berger, H., Silvestrini, L., Labuda, R., Güldener, U., Gorfer, M., Bacher, M., Doppler, M., Gasparotto, E., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23575461
Self-citationHuang, L., Li, X., Dong, L., Wang, B., & Pan, L. (2021) · Figshare · doi:10.6084/m9.figshare.16576059
Huang, L., Li, X., Dong, L., Wang, B., & Pan, L. (2021) · Figshare · doi:10.6084/m9.figshare.16576062
Huang, L., Li, X., Dong, L., Wang, B., & Pan, L. (2021) · Figshare · doi:10.6084/m9.figshare.16576068
Schüller, A., Studt, L., Berger, H., Silvestrini, L., Labuda, R., Güldener, U., Gorfer, M., Bacher, M., Doppler, M., Gasparotto, E., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23575470
Self-citationSchüller, A., Studt, L., Berger, H., Silvestrini, L., Labuda, R., Güldener, U., Gorfer, M., Bacher, M., Doppler, M., Gasparotto, E., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23575473
Self-citationHuang, L., Li, X., Dong, L., Wang, B., & Pan, L. (2021) · Figshare · doi:10.6084/m9.figshare.16576065
Huang, L., Li, X., Dong, L., Wang, B., & Pan, L. (2021) · Figshare · doi:10.6084/m9.figshare.16576038
Huang, L., Li, X., Dong, L., Wang, B., & Pan, L. (2021) · Figshare · doi:10.6084/m9.figshare.16576047
Schüller, A., Studt, L., Berger, H., Silvestrini, L., Labuda, R., Güldener, U., Gorfer, M., Bacher, M., Doppler, M., Gasparotto, E., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23575479
Self-citationHuang, L., Li, X., Dong, L., Wang, B., & Pan, L. (2021) · Figshare · doi:10.6084/m9.figshare.16576077
Huang, L., Li, X., Dong, L., Wang, B., & Pan, L. (2021) · Figshare · doi:10.6084/m9.figshare.16576056
Huang, L., Li, X., Dong, L., Wang, B., & Pan, L. (2021) · Figshare · doi:10.6084/m9.figshare.16576071
Huang, L., Li, X., Dong, L., Wang, B., & Pan, L. (2021) · Figshare · doi:10.6084/m9.figshare.16576074
Locus-specific chromatin proteomics using dCas-guided proximity labelling in Aspergillus nidulansPreprint
Svoboda, T., Niederdöckl-Loibl, D., Schüller, A., Hummel, K., Schlosser, S., Razzazi‐Fazeli, E., & Strauss, J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.15.618449
Self-citationLocus-Specific Chromatin Proteomics Using Dcas-Guided Proximity Labelling in Aspergillus NidulansPreprint
Svoboda, T., Niederdöckl-Loibl, D., Schüller, A., Hummel, K., Schlosser, S., Razzazi‐Fazeli, E., & Strauss, J. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.5036922
Self-citationFerraro, A. R., Ameri, A. J., Lu, Z., Kamei, M., Schmitz, R. J., & Lewis, Z. A. (2021) · Figshare · doi:10.6084/m9.figshare.14812398
Self-citation
- Authors
- Gacek-Matthews, A., Berger, H., Sasaki, T., Wittstein, K., Gruber, C., Lewis, Z. A., & Strauss, J.
- Affiliations
- AIT Austrian Institute of Technology GmbH (AT)
- University of Georgia (US)
- Helmholtz Centre for Infection Research (DE)
- Corresponding author
- Strauss, Joseph
- Venue
- PLOS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2016-08-22
- Volume
- 12
- Issue
- 8
- Pages
- e1006222
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- PMC
- PMC4993369
- OpenAlex
- W2512239244
- Cited by
- 105
- References
- 111
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 10 · 2023: 9 · 2022: 16 · 2021: 19 · 2020: 15 · 2019: 9 · 2018: 7 · 2017: 9
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS Genetics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HZI (Helmholtz Centre for Infection Research) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Austrian Science Fund (F3703)
- Lower Austria Science Fund NFB (LS12-009)
- American Cancer Society (RSG-14-184-01-DMC.)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- H3K4 trimethylation, histone demethylation, Aspergillus nidulans, fungal secondary metabolism, secondary metabolite gene clusters, chromatin regulation, nutrient limitation, transcriptional downregulation, heterochromatin, gene silencing
- MeSH terms
- Aspergillus nidulans, Chromatin, Histones, Humans, Gene Expression Regulation, Fungal, Genome, DNA Methylation, Tandem Mass Spectrometry, Histone Demethylases, Jumonji Domain-Containing Histone Demethylases, Secondary Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review