CoChat
Sign Up
Cited by 574Epigenetics and DNA MethylationMemory and Neural MechanismsBirth, Development, and Health

The DOI matches its Crossref record; 179 of the 181 references it cites were found in a registry or an index.

Epigenetics and the Environmental Regulation of the Genome and Its Function

Zhang, Tie-Yuan, Meaney, Michael J.·2010·Annual Review of Psychology
DOI 10.1146/annurev.psych.60.110707.163625
Open this paper in CoChat — free account

Abstract

There are numerous examples in psychology and other disciplines of the enduring effects of early experience on neural function. In this article, we review the emerging evidence for epigenetics as a candidate mechanism for these effects. Epigenetics refers to functionally relevant modifications to the genome that do not involve a change in nucleotide sequence. Such modifications include chemical marks that regulate the transcription of the genome. There is now evidence that environmental events can directly modify the epigenetic state of the genome. Thus studies with rodent models suggest that during both early development and in adult life, environmental signals can activate intracellular pathways that directly remodel the "epigenome," leading to changes in gene expression and neural function. These studies define a biological basis for the interplay between environmental signals and the genome in the regulation of individual differences in behavior, cognition, and physiology.

Overview

Integrity signals

Registry

Crossref · 10.1146/annurev.psych.60.110707.163625

Cites

179 of 179 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 181 references

Research works printed but not linked: 6

  1. 10.1037//0033-295X.105.4.792-802 · DOI · Paper page
  2. Lewontin RC, 1974, Am. J. Hum. Genet., 26, 400
  3. 10.1210/me.14.4.506 · DOI
  4. Meaney MJ, 2009, Child Dev.
  5. Reik WJ, 2001, Nature, 2, 21
  6. 10.1037//0033-2909.128.2.230 · DOI · Paper page

Cited by

Sorted by citations

Items 501–574 of 574

Related

See all

Metadata

Authors
Zhang, T.-Y., & Meaney, M. J.
Affiliations
  • Sackler Program for Epigenetics and Psychobiology of McGill University, Douglas Mental Health University Institute and the Singapore Institute for Clinical Sciences, Montreal, Quebec, H4H 1R3 Canada;
  • Douglas Mental Health University Institute (CA)
ORCID
Meaney, Michael J.
Venue
Annual Review of Psychology
Publisher
Annual Reviews
Published
2010-01-01
Volume
61
Issue
1
Pages
439-466
ISSN
  • 0066-4308 (ISSN-L)
  • 1545-2085
DOI
10.1146/annurev.psych.60.110707.163625
OpenAlex
W2172126177
Cited by
565
References
181
Citations by year
2026: 18 · 2025: 10 · 2024: 20 · 2023: 12 · 2022: 11 · 2021: 37 · 2020: 36 · 2019: 23 · 2018: 26 · 2017: 42 · 2016: 45 · 2015: 47 · 2014: 43 · 2013: 53 · 2012: 58
FWCI
3.54
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Psychology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
epigenetics, early life experience, gene expression, transcriptional regulation, neural function, individual differences in behavior, cognition, rodent models, environmental cues
MeSH terms
Animals, Environment, Humans, Maternal Behavior, Genome, Genomic Imprinting, Gene Expression Regulation, Developmental, DNA Methylation, Epigenesis, Genetic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review