Cited by 574Epigenetics and DNA MethylationMemory and Neural MechanismsBirth, Development, and Health

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Epigenetics and the Environmental Regulation of the Genome and Its Function

Zhang, Tie-Yuan, Meaney, Michael J.·2010·Annual Review of Psychology

DOI 10.1146/annurev.psych.60.110707.163625

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Abstract

There are numerous examples in psychology and other disciplines of the enduring effects of early experience on neural function. In this article, we review the emerging evidence for epigenetics as a candidate mechanism for these effects. Epigenetics refers to functionally relevant modifications to the genome that do not involve a change in nucleotide sequence. Such modifications include chemical marks that regulate the transcription of the genome. There is now evidence that environmental events can directly modify the epigenetic state of the genome. Thus studies with rodent models suggest that during both early development and in adult life, environmental signals can activate intracellular pathways that directly remodel the "epigenome," leading to changes in gene expression and neural function. These studies define a biological basis for the interplay between environmental signals and the genome in the regulation of individual differences in behavior, cognition, and physiology.

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Authors: Zhang, T.-Y., & Meaney, M. J.
Affiliations: Sackler Program for Epigenetics and Psychobiology of McGill University, Douglas Mental Health University Institute and the Singapore Institute for Clinical Sciences, Montreal, Quebec, H4H 1R3 Canada;
Douglas Mental Health University Institute (CA)
ORCID: Meaney, Michael J.
Venue: Annual Review of Psychology
Publisher: Annual Reviews
Published: 2010-01-01
Volume: 61
Issue: 1
Pages: 439-466
ISSN: 0066-4308 (ISSN-L)
1545-2085
DOI: 10.1146/annurev.psych.60.110707.163625
OpenAlex: W2172126177
Cited by: 565
References: 181
Citations by year: 2026: 18 · 2025: 10 · 2024: 20 · 2023: 12 · 2022: 11 · 2021: 37 · 2020: 36 · 2019: 23 · 2018: 26 · 2017: 42 · 2016: 45 · 2015: 47 · 2014: 43 · 2013: 53 · 2012: 58
FWCI: 3.54
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Psychology (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords: epigenetics, early life experience, gene expression, transcriptional regulation, neural function, individual differences in behavior, cognition, rodent models, environmental cues
MeSH terms: Animals, Environment, Humans, Maternal Behavior, Genome, Genomic Imprinting, Gene Expression Regulation, Developmental, DNA Methylation, Epigenesis, Genetic

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Epigenetics and the Environmental Regulation of the Genome and Its Function

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