The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Resting Brain Connectivity: Changes during the Progress of Alzheimer Disease
Abstract
PURPOSE: To investigate alterations in functional connectivity in the resting brain networks in healthy elderly volunteers and patients with mild, moderate, or severe Alzheimer Disease (AD). MATERIALS AND METHODS: This study was approved by the institutional ethics committee, and informed consent was obtained. Forty-six patients with AD and 16 healthy elderly volunteers were prospectively examined. Resting-state functional magnetic resonance imaging was used to detect alterations in posterior cingulate cortex (PCC) functional connectivity through a comparison of the healthy control group with three separate AD groups-mild, moderate, and severe AD. A temporal correlation method was used to obtain PCC connectivity maps. RESULTS: Dissociated functional connectivity between the PCC and a set of regions, including the visual cortices bilaterally, the inferior temporal cortex, the hippocampus, and especially the medial prefrontal cortex and the precuneus and/or cuneus, was observed in all AD groups. The disruption of connectivity intensified as the stage of AD progression increased. There were also regions that exhibited increased connectivity; these regions extended from left lateralized frontoparietal regions and spread to bilateral frontoparietal regions along with AD progression. CONCLUSION: Changes in PCC functional connectivity comprised bidirectional alterations in the resting networks in AD-affected brains, and the impaired resting functional connectivity seemed to change with AD progression. Therefore, alterations in functional connectivity in the default mode network might play a role in the progression of AD.
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“Furthermore, abnormalities in the default mode network, which is regulated in part by PV-INs [27], have been observed in AD patients [28][29][30][31][32].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [29]
Citations
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Resting state fMRI in Alzheimer's disease: beyond the default mode network
Agosta, F., Pievani, M., Geroldi, C., Copetti, M., Frisoni, G. B., & Filippi, M. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.06.007 · Cited by 599
Functional connectivity tracks clinical deterioration in Alzheimer's disease
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A cross-disorder connectome landscape of brain dysconnectivity
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Metadata
- Authors
- Zhang, H.-Y., Wang, S.-J., Liu, B., Ma, Z.-L., Yang, M., Zhang, Z.-J., & Teng, G.-J.
- Affiliations
- Southeast University (CN)
- Zhongda Hospital Southeast University (CN)
- Venue
- Radiology
- Published
- 2010-08
- Volume
- 256
- Issue
- 2
- Pages
- 598-606
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2011502145
- Cited by
- 320
- References
- 34
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 13 · 2023: 17 · 2022: 12 · 2021: 31 · 2020: 25 · 2019: 21 · 2018: 22 · 2017: 27 · 2016: 12 · 2015: 15 · 2014: 28 · 2013: 25 · 2012: 26
- FWCI
- 15.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, resting-state functional connectivity, posterior cingulate cortex, default mode network, disease progression, medial prefrontal cortex, precuneus, cuneus, hippocampus, visual cortex, frontoparietal connectivity
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Neural Pathways
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