A cross-disorder connectome landscape of brain dysconnectivity

van den Heuvel, Martijn P.; Sporns, Olaf

doi:10.1038/s41583-019-0177-6

Cited by 462Functional Brain Connectivity StudiesAdvanced Neuroimaging Techniques and ApplicationsMental Health Research Topics

A cross-disorder connectome landscape of brain dysconnectivity

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van den Heuvel, Martijn P., Sporns, Olaf·2019·Nature Reviews Neuroscience

DOI 10.1038/s41583-019-0177-6PMC PMC8864539

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Abstract

Many human brain disorders are associated with characteristic alterations in the structural and functional connectivity of the brain. In this article, we explore how commonalities and differences in connectome alterations can reveal relationships across disorders. We survey recent literature on connectivity changes in neurological and psychiatric disorders in the context of key organizational principles of the human connectome and observe that several disturbances to network properties of the human brain have a common role in a wide range of brain disorders and point towards potentially shared network mechanisms underpinning disorders. We hypothesize that the distinct dimensions along which connectome networks are organized (for example, 'modularity' and 'integration') provide a general coordinate system that allows description and categorization of relationships between seemingly disparate disorders. We outline a cross-disorder 'connectome landscape of dysconnectivity' along these principal dimensions of network organization that may place shared connectome alterations between brain disorders in a common framework.

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[111]Wolf DA & Mash EJ (eds) Behavioral and Emotional Disorders in Adolescents: Nature, Assessment, and Treatment (Guilford Press, 2008).

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Authors: van den Heuvel, M. P., & Sporns, O.
Affiliations: Indiana University Bloomington (US)
ORCID: Sporns, Olaf
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2019-05-24
Volume: 20
Issue: 7
Pages: 435-446
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/s41583-019-0177-6
PMC: PMC8864539
OpenAlex: W2945032471
Cited by: 462
References: 207
Citations by year: 2026: 58 · 2025: 73 · 2024: 60 · 2023: 55 · 2022: 75 · 2021: 76 · 2020: 56 · 2019: 9
FWCI: 6.84
Type: journal article
Language: en
Open access: green
pure.amsterdamumc.nl
Licence: other-oa
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion, other-oa)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
VU Research Portal (publishedVersion, other-oa)
PubMed Central (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Nederlandse Organisatie voor Wetenschappelijk Onderzoek (452-16-015, VIDI-452-16-015, ALWOP.179)
National Institutes of Health
National Center for Complementary and Integrative Health (R01AT009036)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords: brain dysconnectivity, connectome, cross-disorder analysis, structural connectivity, functional connectivity, network modularity, network integration, neurological disorders, mental illness
MeSH terms: Animals, Brain, Brain Diseases, Humans, Nerve Net, Connectome

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A cross-disorder connectome landscape of brain dysconnectivity

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