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The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Relationship between Apparent Diffusion Coefficients at 3.0-T MR Imaging and Gleason Grade in Peripheral Zone Prostate Cancer

Open access
Hambrock, Thomas, Somford, Diederik M., Huisman, Henkjan J., van Oort, Inge M., Witjes, J. Alfred, Hulsbergen-van de Kaa, Christina A., Scheenen, Thomas, Barentsz, Jelle O.·2011·Radiology
DOI 10.1148/radiol.11091409
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Abstract

PURPOSE: To retrospectively determine the relationship between apparent diffusion coefficients (ADCs) obtained with 3.0-T diffusion-weighted (DW) magnetic resonance (MR) imaging and Gleason grades in peripheral zone prostate cancer. MATERIALS AND METHODS: The requirement to obtain institutional review board approval was waived. Fifty-one patients with prostate cancer underwent MR imaging before prostatectomy, including DW MR imaging with b values of 0, 50, 500, and 800 sec/mm(2). In prostatectomy specimens, separate slice-by-slice determinations of Gleason grade groups were performed according to primary, secondary, and tertiary Gleason grades. In addition, tumors were classified into qualitative grade groups (low-, intermediate-, or high-grade tumors). ADC maps were aligned to step-sections and regions of interest annotated for each tumor slice. The median ADC of tumors was related to qualitative grade groups with linear mixed-model regression analysis. The accuracy of the median ADC in the most aggressive tumor component in the differentiation of low- from combined intermediate- and high-grade tumors was summarized by using the area under the receiver operating characteristic (ROC) curve (A(z)). RESULTS: In 51 prostatectomy specimens, 62 different tumors and 251 step-section tumor lesions were identified. The median ADC in the tumors showed a negative relationship with Gleason grade group, and differences among the three qualitative grade groups were statistically significant (P < .001). Overall, with an increase of one qualitative grade group, the median ADC (±standard deviation) decreased 0.18 × 10(-3) mm(2)/sec ± 0.02. Low-, intermediate-, and high-grade tumors had a median ADC of 1.30 × 10(-3) mm(2)/sec ± 0.30, 1.07 × 10(-3) mm(2)/sec ± 0.30, and 0.94 × 10(-3) mm(2)/sec ± 0.30, respectively. ROC analysis showed a discriminatory performance of A(z) = 0.90 in discerning low-grade from combined intermediate- and high-grade lesions. CONCLUSION: ADCs at 3.0 T showed an inverse relationship to Gleason grades in peripheral zone prostate cancer. A high discriminatory performance was achieved in the differentiation of low-, intermediate-, and high-grade cancer.

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Metadata

Authors
Hambrock, T., Somford, D. M., Huisman, H. J., van Oort, I. M., Witjes, J. A., Hulsbergen-van de Kaa, C. A., Scheenen, T., & Barentsz, J. O.
Venue
Radiology
Publisher
Radiological Society of North America (RSNA)
Published
2011-05
Volume
259
Issue
2
Pages
453-461
ISSN
  • 0033-8419 (ISSN-L)
  • 1527-1315
DOI
10.1148/radiol.11091409
OpenAlex
W2109923019
Cited by
572
References
22
FWCI
39.76
Type
journal article
Language
en
Open access
green

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Hambrock, T., Somford, D. M., Huisman, H. J., van Oort, I. M., Witjes, J. A., Hulsbergen-van de Kaa, C. A., Scheenen, T., & Barentsz, J. O. (2011). Relationship between Apparent Diffusion Coefficients at 3.0-T MR Imaging and Gleason Grade in Peripheral Zone Prostate Cancer. Radiology. https://doi.org/10.1148/radiol.11091409

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