Cited by 384AI in cancer detectionRadiomics and Machine Learning in Medical ImagingBreast Lesions and Carcinomas

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Lymph Node Metastasis Prediction from Primary Breast Cancer US Images Using Deep Learning

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Zhou, Li-Qiang, Wu, Xing-Long, Huang, Shu-Yan, Wu, Ge-Ge, Ye, Hua-Rong, Wei, Qi, Bao, Ling-Yun, Deng, You-Bin, Li, Xing-Rui, Cui, Xin-Wu, Dietrich, Christoph F.·2020·Radiology

DOI 10.1148/radiol.2019190372

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Abstract

Background Deep learning (DL) algorithms are gaining extensive attention for their excellent performance in image recognition tasks. DL models can automatically make a quantitative assessment of complex medical image characteristics and achieve increased accuracy in diagnosis with higher efficiency. Purpose To determine the feasibility of using a DL approach to predict clinically negative axillary lymph node metastasis from US images in patients with primary breast cancer. Materials and Methods A data set of US images in patients with primary breast cancer with clinically negative axillary lymph nodes from Tongji Hospital (974 imaging studies from 2016 to 2018, 756 patients) and an independent test set from Hubei Cancer Hospital (81 imaging studies from 2018 to 2019, 78 patients) were collected. Axillary lymph node status was confirmed with pathologic examination. Three different convolutional neural networks (CNNs) of Inception V3, Inception-ResNet V2, and ResNet-101 architectures were trained on 90% of the Tongji Hospital data set and tested on the remaining 10%, as well as on the independent test set. The performance of the models was compared with that of five radiologists. The models’ performance was analyzed in terms of accuracy, sensitivity, specificity, receiver operating characteristic curves, areas under the receiver operating characteristic curve (AUCs), and heat maps. Results The best-performing CNN model, Inception V3, achieved an AUC of 0.89 (95% confidence interval [CI]: 0.83, 0.95) in the prediction of the final clinical diagnosis of axillary lymph node metastasis in the independent test set. The model achieved 85% sensitivity (35 of 41 images; 95% CI: 70%, 94%) and 73% specificity (29 of 40 images; 95% CI: 56%, 85%), and the radiologists achieved 73% sensitivity (30 of 41 images; 95% CI: 57%, 85%; P = .17) and 63% specificity (25 of 40 images; 95% CI: 46%, 77%; P = .34). Conclusion Using US images from patients with primary breast cancer, deep learning models can effectively predict clinically negative axillary lymph node metastasis. Artificial intelligence may provide an early diagnostic strategy for lymph node metastasis in patients with breast cancer with clinically negative lymph nodes. Published under a CC BY 4.0 license. Online supplemental material is available for this article. See also the editorial by Bae in this issue.

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Self-citation
Intra- and Peritumoral Radiomics of Contrast-Enhanced Mammography Predicts Axillary Lymph Node Metastasis in Patients With Breast Cancer: A Multicenter Study
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Authors: Zhou, L.-Q., Wu, X.-L., Huang, S.-Y., Wu, G.-G., Ye, H.-R., Wei, Q., Bao, L.-Y., Deng, Y.-B., Li, X.-R., Cui, X.-W., & Dietrich, C. F.
Affiliations: Wuhan Textile University (CN)
China Resources (China) (CN)
ORCID: Zhou, Li-Qiang
Wu, Xing-Long
Huang, Shu-Yan
Ye, Hua-Rong
Bao, Ling-Yun
Deng, You-Bin
Li, Xing-Rui
Cui, Xin-Wu
Dietrich, Christoph F.
Venue: Radiology
Publisher: Radiological Society of North America (RSNA)
Published: 2020-01
Volume: 294
Issue: 1
Pages: 19-28
ISSN: 0033-8419 (ISSN-L)
1527-1315
DOI: 10.1148/radiol.2019190372
OpenAlex: W2989693433
Cited by: 384
References: 24
Citations by year: 2026: 36 · 2025: 61 · 2024: 66 · 2023: 88 · 2022: 69 · 2021: 41 · 2020: 20
FWCI: 15.06
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: Radiology (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
Keywords: breast cancer, axillary lymph node metastasis, ultrasonography, convolutional neural networks, InceptionV3, lymph node metastasis prediction, radiologist comparison, breast cancer early detection, lymph node echogenicity
MeSH terms: Deep Learning, Adult, Aged, Aged, 80 and over, Algorithms, Breast Neoplasms, Feasibility Studies, Female, Humans, Image Interpretation, Computer-Assisted, Lymph Nodes, Lymphatic Metastasis, Middle Aged, Predictive Value of Tests, Retrospective Studies, Sensitivity and Specificity, Cohort Studies, Ultrasonography, Mammary, Neural Networks, Computer, Young Adult

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Lymph Node Metastasis Prediction from Primary Breast Cancer US Images Using Deep Learning

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