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COVID-19 on Chest Radiographs: A Multireader Evaluation of an Artificial Intelligence System

Open access
Murphy, Keelin, Smits, Henk, Knoops, Arnoud J. G., Korst, Michael B. J. M., Samson, Tijs, Scholten, Ernst T., Schalekamp, Steven, Schaefer-Prokop, Cornelia M., Philipsen, Rick H. H. M., Meijers, Annet, Melendez, Jaime, van Ginneken, Bram, Rutten, Matthieu·2020·Radiology

Abstract

Background Chest radiography may play an important role in triage for coronavirus disease 2019 (COVID-19), particularly in low-resource settings. Purpose To evaluate the performance of an artificial intelligence (AI) system for detection of COVID-19 pneumonia on chest radiographs. Materials and Methods An AI system (CAD4COVID-XRay) was trained on 24 678 chest radiographs, including 1540 used only for validation while training. The test set consisted of a set of continuously acquired chest radiographs (n = 454) obtained in patients suspected of having COVID-19 pneumonia between March 4 and April 6, 2020, at one center (223 patients with positive reverse transcription polymerase chain reaction [RT-PCR] results, 231 with negative RT-PCR results). Radiographs were independently analyzed by six readers and by the AI system. Diagnostic performance was analyzed with the receiver operating characteristic curve. Results For the test set, the mean age of patients was 67 years ± 14.4 (standard deviation) (56% male). With RT-PCR test results as the reference standard, the AI system correctly classified chest radiographs as COVID-19 pneumonia with an area under the receiver operating characteristic curve of 0.81. The system significantly outperformed each reader (P < .001 using the McNemar test) at their highest possible sensitivities. At their lowest sensitivities, only one reader significantly outperformed the AI system (P = .04). Conclusion The performance of an artificial intelligence system in the detection of coronavirus disease 2019 on chest radiographs was comparable with that of six independent readers. © RSNA, 2020

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Metadata

Authors
Murphy, K., Smits, H., Knoops, A. J. G., Korst, M. B. J. M., Samson, T., Scholten, E. T., Schalekamp, S., Schaefer-Prokop, C. M., Philipsen, R. H. H. M., Meijers, A., Melendez, J., van Ginneken, B., & Rutten, M.
Venue
Radiology
Published
2020-09
Volume
296
Issue
3
Pages
E166-E172
ISSN
  • 0033-8419 (ISSN-L)
  • 1527-1315
OpenAlex
W3021214012
Cited by
214
References
5
FWCI
20.28
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: COVID-19 on Chest Radiographs: A Multireader Evaluation of an Artificial Intelligence System. https://app.cochat.ai/papers/10.1148/radiol.2020201874
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Murphy, K., Smits, H., Knoops, A. J. G., Korst, M. B. J. M., Samson, T., Scholten, E. T., Schalekamp, S., Schaefer-Prokop, C. M., Philipsen, R. H. H. M., Meijers, A., Melendez, J., van Ginneken, B., & Rutten, M. (2020). COVID-19 on Chest Radiographs: A Multireader Evaluation of an Artificial Intelligence System. Radiology. https://doi.org/10.1148/radiol.2020201874

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