A CT-based Radiomics Signature is Associated with Response to Immune Checkpoint Inhibitors in Advanced Solid Tumors
Abstract
Background Reliable predictive imaging markers of response to immune checkpoint inhibitors are needed. Purpose To develop and validate a pretreatment CT-based radiomics signature to predict response to immune checkpoint inhibitors in advanced solid tumors. Materials and Methods In this retrospective study, a radiomics signature was developed in patients with advanced solid tumors (including breast, cervix, gastrointestinal) treated with anti–programmed cell death–1 or programmed cell death ligand–1 monotherapy from August 2012 to May 2018 (cohort 1). This was tested in patients with bladder and lung cancer (cohorts 2 and 3). Radiomics variables were extracted from all metastases delineated at pretreatment CT and selected by using an elastic-net model. A regression model combined radiomics and clinical variables with response as the end point. Biologic validation of the radiomics score with RNA profiling of cytotoxic cells (cohort 4) was assessed with Mann-Whitney analysis. Results The radiomics signature was developed in 85 patients (cohort 1: mean age, 58 years ± 13 [standard deviation]; 43 men) and tested on 46 patients (cohort 2: mean age, 70 years ± 12; 37 men) and 47 patients (cohort 3: mean age, 64 years ± 11; 40 men). Biologic validation was performed in a further cohort of 20 patients (cohort 4: mean age, 60 years ± 13; 14 men). The radiomics signature was associated with clinical response to immune checkpoint inhibitors (area under the curve [AUC], 0.70; 95% CI: 0.64, 0.77; P < .001). In cohorts 2 and 3, the AUC was 0.67 (95% CI: 0.58, 0.76) and 0.67 (95% CI: 0.56, 0.77; P < .001), respectively. A radiomics-clinical signature (including baseline albumin level and lymphocyte count) improved on radiomics-only performance (AUC, 0.74 [95% CI: 0.63, 0.84; P < .001]; Akaike information criterion, 107.00 and 109.90, respectively). Conclusion A pretreatment CT-based radiomics signature is associated with response to immune checkpoint inhibitors, likely reflecting the tumor immunophenotype. © RSNA, 2021 Online supplemental material is available for this article. See also the editorial by Summers in this issue.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Radiology is one step ahead and shows what is possible with the emerging field of radiomics-the extraction of data from radiograms to diagnose cancer, predict outcomes or guide therapy.
“Radiology is one step ahead and shows what is possible with the emerging field of radiomics—the extraction of data from radiograms to diagnose cancer, predict outcomes or guide therapy (54–56).”
From Artificial Intelligence: Present and Future Potential for Solid Organ Transplantation (2022) · cites this paper as [55]
Cites
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)
Eisenhauer, E. A., Therasse, P., Bogaerts, J., Schwartz, L. H., Sargent, D., Ford, R., Dancey, J., Arbuck, S., Gwyther, S., Mooney, M., et al. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2008.10.026 · Cited by 29,534 · see citing works
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
Borghaei, H., Paz-Ares, L., Horn, L., Spigel, D. R., Steins, M., Ready, N. E., Chow, L. Q., Vokes, E. E., Felip, E., Holgado, E., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1507643 · Cited by 9,335 · see citing works
Self-citation3D Slicer as an image computing platform for the Quantitative Imaging Network
Fedorov, A., Beichel, R., Kalpathy–Cramer, J., Finet, J., Fillion‐Robin, J., Pujol, S., Bauer, C., Jennings, D. L., Fennessy, F., Milan Sonka, A., et al. (2012) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2012.05.001 · Cited by 9,095 · see citing works
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer
Brahmer, J., Reckamp, K. L., Baas, P., Crinò, L., Eberhardt, W. E. E., Poddubskaya, E., Antonia, S., Pluzanski, A., Vokes, E. E., Holgado, E., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1504627 · Cited by 8,447 · see citing works
Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
Gerlinger, M., Rowan, A. J., Horswell, S., Larkin, J., Endesfelder, D., Gronroos, E., Martinez, P., Matthews, N., Stewart, A., Tarpey, P., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1113205 · Cited by 7,774 · see citing works
Computational Radiomics System to Decode the Radiographic Phenotype
(2017) · doi:10.1158/0008-5472.can-17-0339 · Cited by 6,593 · see citing works
Herbst, R. S., Baas, P., Kim, D.-W., Felip, E., Pérez-Gracia, J. L., Han, J.-Y., Molina, J., Kim, J.-H., Arvis, C. D., Ahn, M.-J., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01281-7 · Cited by 6,449 · see citing works
Self-citationNivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
Motzer, R. J., Escudier, B., McDermott, D. F., George, S., Hammers, H. J., Srinivas, S., Tykodi, S. S., Sosman, J. A., Procopio, G., Plimack, E. R., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1510665 · Cited by 5,807 · see citing works
Radiomics: the bridge between medical imaging and personalized medicine
Lambin, P., Leijenaar, R. T. H., Deist, T. M., Peerlings, J., de Jong, E. E. C., van Timmeren, J., Sanduleanu, S., Larue, R. T. H. M., Even, A. J. G., Jochems, A., et al. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.141 · Cited by 5,688 · see citing works
Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach
Aerts, H. J. W. L., Velazquez, E. R., Leijenaar, R. T. H., Parmar, C., Grossmann, P., Carvalho, S., Bussink, J., Monshouwer, R., Haibe-Kains, B., Rietveld, D., et al. (2014) · Nature Communications · doi:10.1038/ncomms5006 · Cited by 5,132 · see citing works
Charoentong, P., Finotello, F., Angelova, M., Mayer, C., Efremova, M., Rieder, D., Hackl, H., & Trajanoski, Z. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.019 · Cited by 5,041 · see citing works
Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma
Motzer, R. J., Tannir, N. M., McDermott, D. F., Arén Frontera, O., Melichar, B., Choueiri, T. K., Plimack, E. R., Barthélémy, P., Porta, C., George, S., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1712126 · Cited by 4,656 · see citing works
Zwanenburg, A., Vallières, M., Abdalah, M. A., Aerts, H. J. W. L., Andrearczyk, V., Apte, A., Ashrafinia, S., Bakas, S., Beukinga, R. J., Boellaard, R., et al. (2020) · Radiology · doi:10.1148/radiol.2020191145 · Cited by 4,177 · see citing works
Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma
Bellmunt, J., de Wit, R., Vaughn, D. J., Fradet, Y., Lee, J.-L., Fong, L., Vogelzang, N. J., Climent, M. A., Petrylak, D. P., Choueiri, T. K., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1613683 · Cited by 3,395 · see citing works
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
Postow, M. A., Chesney, J., Pavlick, A. C., Robert, C., Grossmann, K., McDermott, D., Linette, G. P., Meyer, N., Giguere, J. K., Agarwala, S. S., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1414428 · Cited by 2,781 · see citing works
iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics
Seymour, L., Bogaerts, J., Perrone, A., Ford, R., Schwartz, L. H., Mandrekar, S., Lin, N. U., Litière, S., Dancey, J., Chen, A., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30074-8 · Cited by 2,472 · see citing works
Predictive biomarkers for checkpoint inhibitor-based immunotherapy
Gibney, G. T., Weiner, L. M., & Atkins, M. B. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30406-5 · Cited by 1,635 · see citing works
Ribas, A., Puzanov, I. J., Dummer, R., Schadendorf, D., Hamid, O., Robert, C., Hodi, F. S., Schachter, J., Pavlick, A. C., Lewis, K. D., et al. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(15)00083-2 · Cited by 1,580 · see citing works
Powles, T., Durán, I., van der Heijden, M. S., Loriot, Y., Vogelzang, N. J., De Giorgi, U., Oudard, S., Retz, M. M., Castellano, D., Bamias, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)33297-x · Cited by 1,408 · see citing works
Sun, R., Limkin, E. J., Vakalopoulou, M., Dercle, L., Champiat, S., Han, S. R., Verlingue, L., Brandao, D., Lancia, A., Ammari, S., et al. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30413-3 · Cited by 1,236 · see citing works
Predicting response to cancer immunotherapy using noninvasive radiomic biomarkers
Trebeschi, S., Drago, S. G., Birkbak, N. J., Kurilova, I., Calin, A., Pizzi, A. D., Lalezari, F., Lambregts, D. M. J., Rohaan, M. W., Parmar, C., et al. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz108 · Cited by 567 · see citing works
Angelova, M., Charoentong, P., Hackl, H., Fischer, M. L., Snajder, R., Krogsdam, A., Waldner, M. J., Bindea, G., Mlecnik, B., Galon, J., et al. (2015) · Genome biology · doi:10.1186/s13059-015-0620-6 · Cited by 521 · see citing works
Comprehensive analysis of the clinical immuno-oncology landscape
Tang, J., Shalabi, A., & Hubbard-Lucey, V. M. (2018) · Annals of Oncology · doi:10.1093/annonc/mdx755 · Cited by 508 · see citing works
Reproducibility and Prognosis of Quantitative Features Extracted from CT Images
Balagurunathan, Y., Gu, Y., Wang, H., Kumar, V., Grove, O., Hawkins, S. K., Kim, J., Goldgof, D. B., Hall, L., Gatenby, R. A., et al. (2014) · Translational Oncology · doi:10.1593/tlo.13844 · Cited by 305 · see citing works
Pascual-García, M., Bonfill-Teixidor, E., Planas-Rigol, E., Rubio-Perez, C., Iurlaro, R., Arias, A., Cuartas, I., Sala-Hojman, A., Escudero, L., Martínez-Ricarte, F., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10369-9 · Cited by 262 · see citing works
Self-citationCaswell, D. R., & Swanton, C. (2017) · BMC Medicine · doi:10.1186/s12916-017-0900-y · Cited by 219 · see citing works
Imaging of Cancer Immunotherapy: Current Approaches and Future Directions
Nishino, M., Hatabu, H., & Hodi, F. S. (2018) · Radiology · doi:10.1148/radiol.2018181349 · Cited by 215 · see citing works
Buder‐Bakhaya, K., & Hassel, J. C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01474 · Cited by 214 · see citing works
Nivolumab for Patients With Advanced Melanoma Treated Beyond Progression
Long, G. V., Weber, J. S., Larkin, J., Atkinson, V. G., Grob, J., Schadendorf, D., Dummer, R., Robert, C., Márquez‐Rodas, I., McNeil, C. M., et al. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2017.1588 · Cited by 176 · see citing works
Data Analysis Strategies in Medical Imaging
Parmar, C., Barry, J. D., Hosny, A., Quackenbush, J. F., & Aerts, H. J. W. L. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0385 · Cited by 161 · see citing works
Development of an Immune-Pathology Informed Radiomics Model for Non-Small Cell Lung Cancer
Tang, C., Hobbs, B., Amer, A., Li, X., Behrens, C., Canales, J. R., Cuentas, E. P., Villalobos, P., Fried, D., Chang, J. Y., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-20471-5 · Cited by 154 · see citing works
Tray, N., Weber, J. S., & Adams, S. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0214 · Cited by 101 · see citing works
Analysis of Drug Development Paradigms for Immune Checkpoint Inhibitors
Jardim, D. L. F., Gagliato, D. D. M., Giles, F. J., & Kurzrock, R. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-1970 · Cited by 54 · see citing works
Clinical benefit in oncology trials: Is this a patient-centred or tumour-centred end-point?
Ohorodnyk, P., Eisenhauer, E. A., & Booth, C. M. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2009.05.033 · Cited by 45 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Artificial Intelligence for Predictive Biomarker Discovery in Immuno-Oncology: A Systematic Review
Prelaj, A., Miskovic, V., Zanitti, M., Trovo, F., Genova, C., Viscardi, G., Rebuzzi, S. E., Mazzeo, L., Provenzano, L., Kosta, S., et al. (2024) · Annals of Oncology · doi:10.1016/j.annonc.2023.10.125 · Cited by 340 · see citing works
Deep Learning With Radiomics for Disease Diagnosis and Treatment: Challenges and Potential
Zhang, X., Zhang, Y., Zhang, G., Qiu, X., Tan, W., Yin, X., & Liao, L. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.773840 · Cited by 189 · see citing works
Saad, M. B., Hong, L., Aminu, M., Vokes, N. I., Chen, P., Salehjahromi, M., Qin, K., Sujit, S. J., Lu, X., Young, E., et al. (2023) · The Lancet Digital Health · doi:10.1016/s2589-7500(23)00082-1 · Cited by 121 · see citing works
An overview and a roadmap for artificial intelligence in hematology and oncology
Rösler, W., Altenbuchinger, M., Baeßler, B., Beißbarth, T., Beutel, G., Bock, R., von Bubnoff, N. C. C., Eckardt, J., Foersch, S., Loeffler, C. M. L., et al. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-04667-5 · Cited by 91 · see citing works
Chen, M., Lu, H., Copley, S. J., Han, Y., Logan, A., Viola, P., Cortellini, A., Pinato, D. J., Power, D., & Aboagye, E. O. (2023) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2023.01.089 · Cited by 77 · see citing works
Artificial Intelligence: Present and Future Potential for Solid Organ Transplantation
Peloso, A., Moeckli, B., Delaune, V., Oldani, G., Andres, A., & Compagnon, P. (2022) · Transplant International · doi:10.3389/ti.2022.10640 · Cited by 67 · see citing works
Artificial intelligence-based biomarkers for treatment decisions in oncology
Ligero, M., Nahhas, O. S. M. E., Aldea, M. D., & Kather, J. N. (2025) · Trends in cancer · doi:10.1016/j.trecan.2024.12.001 · Cited by 70 · see citing works
Self-citationCousin, F., Louis, T., Dheur, S., Aboubakar, F., Ghaye, B., Occhipinti, M., Vos, W., Bottari, F., Paulus, A., Sibille, A., et al. (2023) · Cancers · doi:10.3390/cancers15071968 · Cited by 51 · see citing works
Laleh, N. G., Ligero, M., Pérez-López, R., & Kather, J. N. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-0390 · Cited by 59 · see citing works
Self-citationXu, B., Dong, S.-Y., Bai, X., Song, T., Zhang, B., Zhou, L., Chen, Y., Zeng, Z., Wang, K., Zhao, H., et al. (2022) · Liver Cancer · doi:10.1159/000528034 · Cited by 56 · see citing works
Brendlin, A., Peisen, F., Almansour, H., Afat, S., Eigentler, T., Amaral, T., Faby, S., Calvarons, A., Nikolaou, K., & Othman, A. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003261 · Cited by 43 · see citing works
Tharmaseelan, H., Rotkopf, L. T., Ayx, I., Hertel, A., Nörenberg, D., Schoenberg, S. O., & Froelich, M. F. (2022) · Scientific Reports · doi:10.1038/s41598-022-22877-8 · Cited by 45 · see citing works
Bernatowicz, K., Amat, R., Prior, O., Frigola, J., Ligero, M., Grussu, F., Zatse, C., Serna, G., Nuciforo, P. G., Toledo, R. A., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009140 · Cited by 43 · see citing works
Self-citationRadiomics-guided deep neural networks stratify lung adenocarcinoma prognosis from CT scans
Cho, H.-H., Lee, H. Y., Kim, E., Lee, G., Kim, J., Kwon, J., & Park, H. (2021) · Communications Biology · doi:10.1038/s42003-021-02814-7 · Cited by 40 · see citing works
Robust imaging habitat computation using voxel-wise radiomics features
Bernatowicz, K., Grussu, F., Ligero, M., García-Ruiz, A., Delgado, E., & Pérez-López, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-99701-2 · Cited by 38 · see citing works
Self-citationImmunotherapy and Cancer: The Multi-Omics Perspective
Donisi, C., Pretta, A., Pusceddu, V., Ziranu, P., Lai, E., Puzzoni, M., Mariani, S., Massa, E., Madeddu, C., & Scartozzi, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063563 · Cited by 37 · see citing works
Peng, J., Zou, D., Zhang, X., Ma, H., Han, L.-J., & Yao, B. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04904-6 · Cited by 38 · see citing works
Tumor Microenvironment, Radiology, and Artificial Intelligence: Should We Consider Tumor Periphery?
Mohammadi, A., Mirza-Aghazadeh-Attari, M., Faeghi, F., Homayoun, H., Abolghasemi, J., Vogl, T., Bureau, N., Bakhshandeh, M., Acharya, R., & Ardakani, A. A. (2022) · Journal of ultrasound in medicine · doi:10.1002/jum.16086 · Cited by 26 · see citing works
Bevilacqua, R., Barbarossa, F., Fantechi, L., Fornarelli, D., Paci, E., Bolognini, S., Giammarchi, C., Lattanzio, F., Paciaroni, L., Riccardi, G. R., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12165432 · Cited by 26 · see citing works
Ligero, M., Gielen, B., Navarro, V., Morgado, P. C., Prior, O., Dienstmann, R., Nuciforo, P. G., Trebeschi, S., Beets‐Tan, R. G. H., Sala, E., et al. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00534-9 · Cited by 30 · see citing works
Self-citationYolchuyeva, S., Giacomazzi, E., Tonneau, M., Lamaze, F. C., Orain, M., Coulombe, F., Malo, J., Belkaid, W., Routy, B., Joubert, P., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-38076-y · Cited by 28 · see citing works
Tong, Y., Sun, P., Yong, J., Zhang, H., Huang, Y., Guo, Y., Yu, J., Zhou, S., Wang, Y., Wang, Y., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.682998 · Cited by 24 · see citing works
Kim, N., Lee, E. S., Won, S. E., Yang, M., Lee, A. J., Shin, Y., Ko, Y., Pyo, J., Park, H. J., & Kim, K. W. (2022) · Korean Journal of Radiology · doi:10.3348/kjr.2022.0225 · Cited by 25 · see citing works
Wang, Y., Zhang, L., Jiang, Y., Cheng, X., He, W., Yu, H., Li, X., Yang, J., Yao, G., Lu, Z., et al. (2024) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-24-7 · Cited by 24 · see citing works
Hellwig, K., Ellmann, S., Eckstein, M., Wiesmueller, M., Rutzner, S., Semrau, S., Frey, B., Gaipl, U. S., Gostian, A., Hartmann, A., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.734872 · Cited by 24 · see citing works
Imaging to predict checkpoint inhibitor outcomes in cancer. A systematic review
ter Maat, L. S., van Duin, I. A. J., Elias, S. G., van Diest, P. J., Pluim, J. P. W., Verhoeff, J. J. C., de Jong, P. A., Leiner, T., Veta, M., & Suijkerbuijk, K. P. M. (2022) · European Journal of Cancer · doi:10.1016/j.ejca.2022.07.034 · Cited by 21 · see citing works
Liu, Y., Zhang, H., Wang, L., Lin, S., Lu, H., Liang, H., Liang, P., Li, J., Lv, P., & Gao, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.740732 · Cited by 19 · see citing works
Radiomics Biomarkers to Predict Checkpoint Inhibitor Pneumonitis in Non-small Cell Lung Cancer.
Du, Y.-H., Zhang, S., Jia, X.-H., Zhang, X., Li, X.-Q., Pan, L.-B., Li, Z.-H., Niu, G., Liang, T., & Guo, H. (2024) · Academic Radiology · doi:10.1016/j.acra.2024.09.053 · Cited by 22 · see citing works
Chao Hui, Z. H. O. U., Hou, L., Tang, X., Liu, C., Meng, Y., Jia, H., Yang, H., & Zhou, S. (2023) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2023.109637 · Cited by 18 · see citing works
Qian, L.-J., Wu, T., Kong, S., Lou, X., Jiang, Y., Tan, Z., Wu, L., & Gao, C. (2024) · European Journal of Radiology · doi:10.1016/j.ejrad.2024.111314 · Cited by 18 · see citing works
Qian, L., Shen, Y., Zhang, S., Qin, H., Wang, W., Kan, Y., Liu, L., Li, J., Zhang, H., & Yang, J. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.840777 · Cited by 17 · see citing works
Qu, H., Zhai, H., Zhang, S., Chen, W., Zhong, H., & Cui, X.-Y. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.992096 · Cited by 18 · see citing works
Cheng, S., Hu, G., Jin, Z., Wang, Z., & Xue, H. (2023) · European Radiology · doi:10.1007/s00330-023-09830-7 · Cited by 16 · see citing works
Ramlee, S., Hulse, D., Bernatowicz, K., Pérez-López, R., Sala, E., & Aloj, L. (2022) · Cancers · doi:10.3390/cancers14153656 · Cited by 15 · see citing works
Cui, H., Zeng, L., Li, R., Li, Q., Hong, C., Zhu, H., Chen, L., Liu, L., Zou, X., & Xiao, L. (2022) · Clinical Radiology · doi:10.1016/j.crad.2022.09.113 · Cited by 14 · see citing works
Chen, Z., Yi, L., Peng, Z., Zhou, J., Zhang, Z., Tao, Y., Lin, Z., He, A., Jin, M., & Zuo, M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.949111 · Cited by 13 · see citing works
Predictive biomarkers for immune checkpoint inhibitors therapy in lung cancer
Yao, J., Lin, X., Zhang, X., Xie, M., Ma, X., Bao, X., Song, J., Liang, Y., Wang, Q., & Xue, X. (2024) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2024.2406063 · Cited by 12 · see citing works
Zhu, Z., Chen, M., Hu, G., Pan, Z., Han, W., Tan, W., Zhou, Z., Wang, M., Li, M., Li, X., et al. (2022) · European Radiology · doi:10.1007/s00330-022-09337-7 · Cited by 12 · see citing works
Wu, A., Wu, C., Zeng, Q.-X., Cao, Y., Shu, X.-F., Luo, L.-H., Feng, Z.-F., Tu, Y., Jie, Z.-G., Zhu, Y.-Y., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-35155-y · Cited by 13 · see citing works
Liu, Z., Yao, Y., Zhao, M., Zhao, Q., Xue, J., Huang, Y., & Qin, S. (2024) · Academic Radiology · doi:10.1016/j.acra.2024.07.028 · Cited by 12 · see citing works
Predicting response to immunotherapy in oral squamous cell carcinoma via a CT-based radiomics model
Ma, Q., Ren, J.-L., Wang, R., Yuan, Y., & Tao, X.-F. (2024) · BMC Medical Imaging · doi:10.1186/s12880-024-01444-9 · Cited by 11 · see citing works
Kuwano, A., Yada, M., Miyazaki, Y., TANAKA, K., KOGA, Y., Ohishi, Y., Masumoto, A., & Motomura, K. (2023) · Cancer Diagnosis & Prognosis · doi:10.21873/cdp.10241 · Cited by 9 · see citing works
Yolchuyeva, S., Giacomazzi, E., Tonneau, M., Lamaze, F. C., Orain, M., Coulombe, F., Malo, J., Belkaid, W., Routy, B., Joubert, P., et al. (2023) · JTO Clinical and Research Reports · doi:10.1016/j.jtocrr.2023.100602 · Cited by 9 · see citing works
Tur, C., Grussu, F., Angelis, F. D., Prados, F., Kanber, B., Calvi, A., Eshaghi, A., Charalambous, T., Cortese, R., Chard, D., et al. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102904 · Cited by 9 · see citing works
Han, X.-Y., Wang, Y.-J., Jia, X., Zheng, Y.-T., Ding, C., Zhang, X., Zhang, K., Cao, Y.-K., Li, Y.-M., Xia, L., et al. (2023) · Translational Lung Cancer Research · doi:10.21037/tlcr-24-7 · Cited by 7 · see citing works
Wang, C., Leng, B., You, R., Yu, Z., Ya, L., Diao, L., Jiang, H., Cheng, Y., Yin, G., & Xu, Q. (2024) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s480540 · Cited by 8 · see citing works
Leung, W., Ng, C. K. C., Lam, S., Wong, P.-T., Ng, K.-Y., Tam, C. H., Lee, T.-C., Chow, K. C., Chow, Y. K., Tam, V. C. W., et al. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13121643 · Cited by 8 · see citing works
Lin, S., Ma, Z., Yao, Y., Huang, H., Chen, W., Tang, D., & Gao, W. (2025) · Diagnostic and Interventional Radiology · doi:10.4274/dir.2024.242972 · Cited by 9 · see citing works
Artificial Intelligence for Drug Discovery: An Update and Future Prospects.
Howell, H. J., McGale, J. P., Choucair, A., Shirini, D., Aide, N., Postow, M., Wang, L., Tordjman, M., Lopci, E., Lecler, A., et al. (2025) · Seminars in nuclear medicine · doi:10.1053/j.semnuclmed.2025.01.004 · Cited by 3 · see citing works
Wang, C., Li, T., Jia, Z., Qiu, K., Jiang, R., Hang, Y., Ni, H., Cao, Y., Zhao, L., Li, M., et al. (2023) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2023.107358 · Cited by 7 · see citing works
Radio-immunomics in hepatocellular carcinoma: Unraveling the tumor immune microenvironment
Liu, Q., Zhu, W., Song, F., Lou, T., He, L., Zhou, W., & Feng, Z. (2024) · Meta-Radiology · doi:10.1016/j.metrad.2024.100098 · Cited by 7 · see citing works
Zheng, S.-J., Zheng, C.-P., Zhai, T., Xu, X., Zheng, Y.-Q., Li, Z., Li, E., Liu, W., & Xu, L. (2022) · Annals of Surgical Oncology · doi:10.1245/s10434-022-13026-6 · Cited by 7 · see citing works
Zhang, Y., Tan, W., Zheng, Z., Wang, J., Xing, L., & Sun, X. (2023) · Journal of Computer Assisted Tomography · doi:10.1097/rct.0000000000001496 · Cited by 7 · see citing works
Priya, S., Reutzel, A., Pria, O. A. F. D., Goetz, S., Pham, H. T., Alatoum, A., Aher, P. Y., Narayanasamy, S., Nagpal, P., & Carter, K. D. (2024) · European Journal of Radiology · doi:10.1016/j.ejrad.2024.111891 · Cited by 6 · see citing works
Nakajima, E. C., Simpson, A. L., Bogaerts, J., de Vries, E. G. E., Do, R., Garralda, E., Goldmacher, G., Kinahan, P. E., Lambin, P., LeStage, B., et al. (2024) · JCO Precision Oncology · doi:10.1200/po.23.00687 · Cited by 6 · see citing works
Self-citationHou, L., Chen, K., Chao Hui, Z. H. O. U., Tang, X., Yu, C., Jia, H., Xu, Q., Zhou, S., & Yang, H. (2024) · Clinical and Translational Radiation Oncology · doi:10.1016/j.ctro.2024.100828 · Cited by 6 · see citing works
Monette, A., Aguilar‐Mahecha, A., Altınmakas, E., Angelos, M. G., Assad, N., Batist, G., Bommareddy, P. K., Bonilla, D. L., Borchers, C. H., Church, S., et al. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-3791 · Cited by 5 · see citing works
Wang, T., Wang, L., Zhong, H., Zong, Y., Hou, F., Wang, H., Zhou, R., Gao, S., Shi, X., Yang, J., et al. (2025) · Insights into Imaging · doi:10.1186/s13244-025-02086-3 · Cited by 5 · see citing works
Wang, J., Kang, B., Sun, C., Du, F., Lin, J., Ding, F., Dai, Z., Zhang, Y., Yang, C., Shang, L., et al. (2023) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2023.2166490 · Cited by 5 · see citing works
Huang, R., Geng, H., Zhu, L., Yan, J. Y., Li, C., & Li, Y. (2023) · Clinical Radiology · doi:10.1016/j.crad.2023.05.022 · Cited by 5 · see citing works
Yu, Y., Bai, Y.-P., Zheng, P., Wang, N., Deng, X., Ma, H.-H., Yu, R., Ma, C., Liu, P., Xie, Y., et al. (2022) · BMC Cancer · doi:10.1186/s12885-022-10344-6 · Cited by 5 · see citing works
O'Malley, R. B., Cox, D., Soloff, E. V., Zečević, M., GREEN, S. M., Coveler, A. L., Busey, J. M., & Wang, C. L. (2022) · Abdominal Radiology · doi:10.1007/s00261-022-03638-7 · Cited by 4 · see citing works
Yang, W., Wu, W., Wang, L., Zhang, S., Zhao, J.-J., & Qiang, Y. (2023) · Comput. Biol. Medicine · doi:10.1016/j.compbiomed.2023.107371 · Cited by 4 · see citing works
Zhang, X., Zhang, X., Luo, Q., Fu, Q., Liu, P., Pan, C., Liu, C., Zhang, H., & Qin, T. (2025) · World Journal of Clinical Oncology · doi:10.5306/wjco.v16.i4.102735 · Cited by 3 · see citing works
Liang, M., Wu, S., Ou, B., Wu, J., Qiu, H., Zhao, X., & Luo, B. (2025) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2025.05.006 · Cited by 3 · see citing works
Zhu, J.-B., & Ning, Y.-D. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1586130 · Cited by 4 · see citing works
Yu, X., Kang, B., Nie, P., Deng, Y., Liu, Z., Mao, N., An, Y., Xu, J., Huang, C., Huang, Y., et al. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002671 · Cited by 3 · see citing works
Lu, Z., Li, Y., Hu, W., Cao, Y., Lv, X., Jia, X., Shen, S., Zhao, J., & Xu, C. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1347650 · Cited by 3 · see citing works
He, W., Wang, K., Wang, Y., Liu, Z., Zhang, L., Jia, S., He, K., Zhang, X., & Wu, H. (2025) · Bioengineering · doi:10.3390/bioengineering12060666 · Cited by 3 · see citing works
Radiomics in Gynaecological Imaging: A State-of-the-Art Review
Franco, P. N., Vernuccio, F., Maino, C., Cannella, R., Otero-García, M., & Ippolito, D. (2023) · Applied Sciences · doi:10.3390/app132111839 · Cited by 2 · see citing works
Ma, W.-L., Hou, C.-L., Yang, M.-X., Wei, Y.-G., Mao, J., Guan, L., & Zhao, Z.-H. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1509207 · Cited by 2 · see citing works
Yang, H., Zhao, J., Wang, Y., Zhu, D., Junpeng, G., & Ren, W. (2025) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s535606 · Cited by 2 · see citing works
Contrast Agent Dynamics Determine Radiomics Profiles in Oncologic Imaging
Watzenboeck, M. L., Beer, L., Kifjak, D., Röhrich, S., Heidinger, B. H., Prayer, F., Milos, R., Apfaltrer, P., Langs, G., Baltzer, P., et al. (2024) · Cancers · doi:10.3390/cancers16081519 · Cited by 2 · see citing works
Wang, C., Li, Y.-X., Ji, Y., Yu, K., Qin, C., Liu, L., Shuai, Y.-J., Chen, J.-H., Li, A., & Zhang, T. (2025) · Academic Radiology · doi:10.1016/j.acra.2025.09.037 · Cited by 3 · see citing works
Chen, J., Meng, T., Xu, J., Ooi, J. D., Eggenhuizen, P. J., Liu, W., Li, F., Wu, X., Sun, J., Zhang, H., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1084299 · Cited by 2 · see citing works
Tanahashi, Y., Ikeda, T., Kubota, K., Kutsuna, M., Kobayashi, T., Funayama, S., Ozaki, K., Ichikawa, S., & Goshima, S. (2025) · Magnetic Resonance in Medical Sciences · doi:10.2463/mrms.mp.2025-0055 · Cited by 1 · see citing works
Zou, X. C., Wang, B., Yu, Z., Chao, H., Xu, X. D., & Zeng, T. (2025) · Clinical & Experimental Metastasis · doi:10.1007/s10585-025-10383-w · Cited by 1 · see citing works
Xiao, L., Wang, J., Cui, H., Zhu, H., He, J., Deng, H., Zhang, W., Dong, H., Zhou, Y., JIANG, P. C., et al. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.02.003 · Cited by 1 · see citing works
Yin, M., Yu, C., Su, Q., Song, X., Zhao, Q., & Zhang, J. (2026) · BMC Medical Imaging · doi:10.1186/s12880-026-02203-8 · Cited by 1 · see citing works
Chang, S., Swicklik, J. R., Zhou, Z., Kharat, S., Wellinghoff, J., Gong, H., Williamson, E. E., Foley, T. A., McCollough, C. H., & Leng, S. (2026) · Medical Physics · doi:10.1002/mp.70403 · Cited by 1 · see citing works
Independent Testing of Published CT Models for PD-L1 Status in Non–Small Cell Lung Cancer
O’Shea, R., Horst, C., Manickavasagar, T., Josephides, E., Hunter, S. J., Taniere, P., Nonaka, D., Hemelrijck, M. V., Spicer, J. F., Hughes, D. J., et al. (2026) · Radiology · doi:10.1148/radiol.241962 · Cited by 2 · see citing works
Huang, S.-W., Jia, K.-P., Liang, S., Ma, B., Chen, H.-T., Zhang, Z., Kang, N., Wu, Z.-L., Lin, Y.-D., Li, P., et al. (2026) · Cancer · doi:10.1002/cncr.70498 · Cited by 1 · see citing works
Imaging the hallmarks of cancer
Grimm, J., Kiessling, F. M., Brindle, K. M., Hanahan, D., Jain, S. K., Lambin, P., Lammers, T., Li, K. C., de Vries, I. J., Weber, W., et al. (2026) · Nature reviews. Cancer · doi:10.1038/s41568-026-00950-y · Cited by 1 · see citing works
Radiomics for the Detection and Prediction of Cancer Therapy-Related Cardiotoxicity
Kandala, A., Rai, A., Penumaka, R. R., Wilcox, N. S., Lefebvre, B., Bravo, P. E., & Fradley, M. G. (2026) · JACC Advances · doi:10.1016/j.jacadv.2026.102942 · Cited by 1 · see citing works
Behmanesh, B., Saray, A. A., Deevband, M. R., Amoui, M., & Haghighatkhah, H. (2023) · Journal of Biomedical Physics and Engineering · doi:10.31661/jbpe.v0i0.2112-1444 · Cited by 1 · see citing works
AI-Assisted Immunology for Precision Cancer Medicine
Sah, A. K., Verma, M., Mishra, P. S., Rahaman, S. A., Gupta, T., & Mishra, R. (2025) · Advances in computational intelligence and robotics book series · doi:10.4018/979-8-3693-9725-1.ch010 · Cited by 1 · see citing works
Erasmus, J. J., & Vlahos, I. (2023) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2023.02.012 · Cited by 1 · see citing works
The Role of CT-Based Radiomics in Precise Imaging of Renal Cancer
Ligero, M., Bernatowicz, K., & Pérez-López, R. (2021) · Journal of Nephrological Science · doi:10.29245/2767-5149/2021/2.1111
Self-citationViswanathan, V. S., Khorrami, M., Jazieh, K., Fu, P., Pennell, N. A., & Madabhushi, A. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-005086
Saad, M. B., Hong, L., Aminu, M., Vokes, N. I., Chen, P., Salehjahromi, M., Qin, K., Sujit, S. J., Wu, C. C., Carter, B. W., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4135321
The Utility of Radiomics in Predicting Response to Cancer Immunotherapy
Khalili, N., & Rezaei, N. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_136-1
Zhou, X., Yang, L., Dai, Q., Han, D., Leng, S., & Zhang, J. (2023) · Research Square · doi:10.21203/rs.3.rs-3323194/v1
Yin, M., Yu, C., Zhang, J., Su, Q., & Song, X. (2024) · Research Square · doi:10.21203/rs.3.rs-4063556/v1
KI in der Medizin: Begrifflichkeiten, Chancen und Risiken
Widmer, C. (2024) · InFo Hämatologie + Onkologie · doi:10.1007/s15004-024-0567-4
Ma, W., Hou, C., Yang, M., Wei, Y., Mao, J., Guan, L., & Zhao, Z. (2024) · Research Square · doi:10.21203/rs.3.rs-4622526/v1
Bodenmann, T. R., Gil, N., Dorfner, F. J., Cleveland, M. C., Patel, J., Brahmavar, S. B., Guelen, M. S., Pulido-Arias, D., Kalpathy–Cramer, J., Thiran, J., et al. (2024) · Lecture notes in computer science · doi:10.1007/978-3-031-73376-5_4
Xue, H., Liang, M.-L., Xu, H.-Z., Wang, C.-Y., Xu, T., & Zhao, A. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1476340
Multicenter Radiomic Feature-Based Prediction of PD-L1 Status in Lung Cancer Using Multimodal PET/CT
Da‐ano, R., Tankyevych, O., Lemée, N., Stamouli, I., Kagadis, G. C., Kalathas, T., Shi, K., Hu, J., Wang, H., Rest, C. C. L., et al. (2025) · IEEE International Symposium on Biomedical Imaging (ISBI) · doi:10.1109/isbi60581.2025.10981025
Song, J., Kim, J., Lee, H., Min, R., & Chae, Y. K. (2025) · medRxiv · doi:10.64898/2025.12.03.25341593
- Authors
- Ligero, M., Garcia-Ruiz, A., Viaplana, C., Villacampa, G., Raciti, M. V., Landa, J., Matos, I., Martin-Liberal, J., Ochoa-de-Olza, M., Hierro, C., Mateo, J., Gonzalez, M., Morales-Barrera, R., Suarez, C., Rodon, J., Elez, E., Braña, I., Muñoz-Couselo, E., Oaknin, A., Fasani, R., Nuciforo, P., Gil, D., Rubio-Perez, C., Seoane, J., Felip, E., Escobar, M., Tabernero, J., Carles, J., Dienstmann, R., Garralda, E., & Perez-Lopez, R.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- ORCID
- Ligero, Marta
- Garcia-Ruiz, Alonso
- Viaplana, Cristina
- Villacampa, Guillermo
- Raciti, Maria V.
- Matos, Ignacio
- Ochoa-de-Olza, Maria
- Hierro, Cinta
- Mateo, Joaquin
- Morales-Barrera, Rafael
- Suarez, Cristina
- Rodon, Jordi
- Braña, Irene
- Muñoz-Couselo, Eva
- Oaknin, Ana
- Fasani, Roberta
- Nuciforo, Paolo
- Gil, Debora
- Rubio-Perez, Carlota
- Seoane, Joan
- Felip, Enriqueta
- Escobar, Manuel
- Tabernero, Josep
- Carles, Joan
- Dienstmann, Rodrigo
- Garralda, Elena
- Perez-Lopez, Raquel
- Venue
- Radiology
- Published
- 2021-04
- Volume
- 299
- Issue
- 1
- Pages
- 109-119
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W3124556679
- Cited by
- 107
- References
- 34
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 22 · 2023: 26 · 2022: 18 · 2021: 10 · 2020: 2 · 2019: 1
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Banco Bilbao Vizcaya Argentaria (RTI2018-095209-B-C21, FIS-G64384969)
- Generalitat de Catalunya (2017-SGR-1624)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- radiomics signature, immune checkpoint inhibitors, predictive imaging biomarkers, treatment response prediction, advanced solid tumors, PD-1/PD-L1 inhibitors, metastasis, computed tomography, elastic net feature selection, albumin, lymphocyte count, bladder cancer, lung cancer, breast cancer, cervical cancer, gastrointestinal cancer, biomarker validation
- MeSH terms
- Immune Checkpoint Inhibitors, Aged, Female, Humans, Male, Middle Aged, Neoplasms, Retrospective Studies, Tomography, X-Ray Computed, Biomarkers, Tumor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review