iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics
Open accessAbstract
Tumours respond differently to immunotherapies compared with chemotherapeutic drugs, raising questions about the assessment of changes in tumour burden-a mainstay of evaluation of cancer therapeutics that provides key information about objective response and disease progression. A consensus guideline-iRECIST-was developed by the RECIST working group for the use of modified Response Evaluation Criteria in Solid Tumours (RECIST version 1.1) in cancer immunotherapy trials, to ensure consistent design and data collection, facilitate the ongoing collection of trial data, and ultimate validation of the guideline. This guideline describes a standard approach to solid tumour measurements and definitions for objective change in tumour size for use in trials in which an immunotherapy is used. Additionally, it defines the minimum datapoints required from future trials and those currently in development to facilitate the compilation of a data warehouse to use to later validate iRECIST. An unprecedented number of trials have been done, initiated, or are planned to test new immune modulators for cancer therapy using a variety of modified response criteria. This guideline will allow consistent conduct, interpretation, and analysis of trials of immunotherapies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Other studies using TβRI small molecule inhibitors confirmed attenuation of metastasis in various carcinoma types.
“Other studies using TβRI small molecule inhibitors confirmed attenuation of metastasis in various carcinoma types325.”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [325]
TGF-β inhibition as monotherapy, using neutralizing antibodies, ligand traps or receptor kinase inhibitors, has seen some success in mouse models of carcinomas, primarily in reducing metastatic spread rather than reducing growth of the primary tumor.
“TGF-β inhibition as monotherapy, using neutralizing antibodies, ligand traps or receptor kinase inhibitors, has seen some success in mouse models of carcinomas, primarily in reducing metastatic spread rather than reducing growth of the primary tumor325 (Table 1).”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [325]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989 · see citing works
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)
Eisenhauer, E. A., Therasse, P., Bogaerts, J., Schwartz, L. H., Sargent, D., Ford, R., Dancey, J., Arbuck, S., Gwyther, S., Mooney, M., et al. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2008.10.026 · Cited by 29,534 · see citing works
Self-citationNew Guidelines to Evaluate the Response to Treatment in Solid Tumors
Therasse, P., Arbuck, S. G., Eisenhauer, E. A., Wanders, J., Kaplan, R. S., Rubinstein, L., Verweij, J., Van Glabbeke, M., van Oosterom, A. T., Christian, M. C., et al. (2000) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/92.3.205 · Cited by 15,660 · see citing works
Self-citationAdverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review
Wanchoo, R., Karam, S., Uppal, N. N., Barta, V. S., Deray, G., Devoe, C., Launay‐Vacher, V., Jhaveri, K. D., & on behalf of Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors (2017) · American Journal of Nephrology · doi:10.1159/000455014 · Cited by 15,314 · see citing works
Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
Hodi, F. S., O'Day, S. J., McDermott, D. F., Weber, R. W., Sosman, J. A., Haanen, J. B., Gonzalez, R., Robert, C., Schadendorf, D., Hassel, J. C., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1003466 · Cited by 15,155 · see citing works
Self-citationThe blockade of immune checkpoints in cancer immunotherapy
Pardoll, D. M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3239 · Cited by 13,838 · see citing works
Safety, activity, and immune correlates of anti–PD-1 antibody in cancer
Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., Powderly, J. D., Carvajal, R. D., Sosman, J. A., Atkins, M. B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200690 · Cited by 12,628 · see citing works
Self-citationPembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer
Reck, M., Rodríguez-Abreu, D., Robinson, A. G., Hui, R., Csőszi, T., Fülöp, A., Gottfried, M., Peled, N., Tafreshi, A., Cuffe, S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1606774 · Cited by 10,089 · see citing works
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
Borghaei, H., Paz-Ares, L., Horn, L., Spigel, D. R., Steins, M., Ready, N. E., Chow, L. Q., Vokes, E. E., Felip, E., Holgado, E., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1507643 · Cited by 9,335 · see citing works
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer
Brahmer, J., Reckamp, K. L., Baas, P., Crinò, L., Eberhardt, W. E. E., Poddubskaya, E., Antonia, S., Pluzanski, A., Vokes, E. E., Holgado, E., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1504627 · Cited by 8,447 · see citing works
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma
Larkin, J., Chiarion-Sileni, V., Gonzalez, R., Grob, J. J., Cowey, C. L., Lao, C. D., Schadendorf, D., Dummer, R., Smylie, M., Rutkowski, P., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1504030 · Cited by 8,157 · see citing works
Self-citationPembrolizumab for the Treatment of Non–Small-Cell Lung Cancer
Garon, E. B., Rizvi, N. A., Hui, R., Leighl, N., Balmanoukian, A. S., Eder, J. P., Patnaik, A., Aggarwal, C., Gubens, M., Horn, L., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1501824 · Cited by 6,198 · see citing works
Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
Motzer, R. J., Escudier, B., McDermott, D. F., George, S., Hammers, H. J., Srinivas, S., Tykodi, S. S., Sosman, J. A., Procopio, G., Plimack, E. R., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1510665 · Cited by 5,807 · see citing works
Rosenberg, J. E., Hoffman-Censits, J., Powles, T., van der Heijden, M. S., Balar, A. V., Necchi, A., Dawson, N., O'Donnell, P. H., Balmanoukian, A., Loriot, Y., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00561-4 · Cited by 3,669 · see citing works
Wolchok, J. D., Hoos, A., O'Day, S. J., Weber, J. S., Hamid, O., Lebbé, C., Maio, M., Binder, M., Bohnsack, O., Nichol, G. M., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1624 · Cited by 3,214 · see citing works
Self-citationIwai, Y., Ishida, M., Tanaka, Y., Okazaki, T., Honjo, T., & Minato, N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192461099 · Cited by 3,204 · see citing works
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
Postow, M. A., Chesney, J., Pavlick, A. C., Robert, C., Grossmann, K., McDermott, D., Linette, G. P., Meyer, N., Giguere, J. K., Agarwala, S. S., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1414428 · Cited by 2,781 · see citing works
Self-citationRECIST 1.1—Update and clarification: From the RECIST committee
Schwartz, L. H., Litière, S., de Vries, E., Ford, R., Gwyther, S., Mandrekar, S., Shankar, L., Bogaerts, J., Chen, A., Dancey, J., et al. (2016) · European Journal of Cancer · doi:10.1016/j.ejca.2016.03.081 · Cited by 1,906 · see citing works
Self-citationControl of peripheral T‐cell tolerance and autoimmunity via the CTLA‐4 and PD‐1 pathways
Fife, B. T., & Bluestone, J. A. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00662.x · Cited by 1,052 · see citing works
Lynch, T. J., Bondarenko, I., Luft, A. V., Serwatowski, P., Barlési, F., Chacko, R. T., Sebastian, M., Neal, J. W., Lu, H., Cuillerot, J.-M., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.38.4032 · Cited by 999 · see citing works
Pseudoprogression and Immune-Related Response in Solid Tumors
Chiou, V. L., & Burotto, M. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.61.6870 · Cited by 898 · see citing works
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal
Fife, B. T., Pauken, K. E., Eagar, T. N., Kangas, T. O., Wu, J. Q., Tang, Q., Azuma, M., Krummel, M. F., & Bluestone, J. A. (2009) · Nature Immunology · doi:10.1038/ni.1790 · Cited by 759 · see citing works
Hodi, F. S., Hwu, W., Kefford, R. F., Weber, J. S., DAUD, A. I., Hamid, O., Patnaik, A., Ribas, A., Robert, C., Gangadhar, T. C., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.64.0391 · Cited by 735 · see citing works
Self-citationNovel cancer immunotherapy agents with survival benefit: recent successes and next steps
Sharma, P., Wagner, K., Wolchok, J. D., & Allison, J. P. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3153 · Cited by 639 · see citing works
Self-citationReck, M., Bondarenko, I., Luft, A. V., Serwatowski, P., Barlési, F., Chacko, R. T., Sebastian, M., Lü, H., Cuillerot, J.-M., & Lynch, T. J. (2012) · Annals of Oncology · doi:10.1093/annonc/mds213 · Cited by 608 · see citing works
Antonia, S., Goldberg, S. B., Balmanoukian, A., Chaft, J. E., Sanborn, R. E., Gupta, A., Narwal, R., Steele, K., Gu, Y., Karakunnel, J. J., et al. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(15)00544-6 · Cited by 602 · see citing works
Nishino, M., Giobbie-Hurder, A., Gargano, M., Suda, M., Ramaiya, N. H., & Hodi, F. S. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0895 · Cited by 522 · see citing works
Schwartz, L. H., Seymour, L., Litière, S., Ford, R., Gwyther, S. J., Mandrekar, S. J., Shankar, L. K., Bogaerts, J., Chen, A. P., Dancey, J. E., et al. (2016) · European Journal of Cancer · doi:10.1016/j.ejca.2016.03.082 · Cited by 383 · see citing works
Self-citationCancer Drugs Approved on the Basis of a Surrogate End Point and Subsequent Overall Survival
Kim, C., & Prasad, V. K. (2015) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.5868 · Cited by 355 · see citing works
A Clinical Development Paradigm for Cancer Vaccines and Related Biologics
Hoos, A., Parmiani, G., Hege, K. M., Sznol, M., Loibner, H., Eggermont, A. M. M., Urba, W. J., Blumenstein, B. A., Sacks, N., Keilholz, U., et al. (2006) · Journal of Immunotherapy · doi:10.1097/01.cji.0000211341.88835.ae · Cited by 270 · see citing works
DeVita, V. T. (1981) · Cancer · doi:10.1002/1097-0142(19810101)47:1 · Cited by 164 · see citing works
Adaptation of the Immune Related Response Criteria: Irrecist
Bohnsack, O., Hoos, A., & Ludajic, K. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu342.23 · Cited by 93 · see citing works
Pseudoprogression in cancer immunotherapy: Rates, time course and patient outcomes.
Kurra, V., Sullivan, R. J., Gainor, J. F., Hodi, F. S., Gandhi, L., Sadow, C. A., Harris, G. J., Flaherty, K. T., & Lee, S. I. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.34.15_suppl.6580 · Cited by 76 · see citing works
Self-citationTremelimumab: A Review of Development to Date in Solid Tumors
Tarhini, A. A. (2013) · Immunotherapy · doi:10.2217/imt.13.9 · Cited by 74 · see citing works
Immunotherapy as a strategy for the treatment of non-small-cell lung cancer
Holt, G. E., Podack, E. R., & Raez, L. E. (2010) · Therapy · doi:10.2217/thy.10.84 · Cited by 57 · see citing works
Liu, Y., Litière, S., de Vries, E. G. E., Sargent, D. J., Shankar, L. K., Bogaerts, J., & Seymour, L. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2013.10.011 · Cited by 35 · see citing works
Self-citationAtezolizumab effective against advanced-stage disease
Sidaway, P. (2016) · Nature Reviews Urology · doi:10.1038/nrurol.2016.60 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Top 10 Challenges in Cancer Immunotherapy
Hegde, P. S., & Chen, D. S. (2020) · Immunity · doi:10.1016/j.immuni.2019.12.011 · Cited by 2,238 · see citing works
Planchard, D., Popat, S., Kerr, K., Novello, S., Smit, E. F., Faivre-Finn, C., Mok, T. S., Reck, M., Van Schil, P. E., Hellmann, M. D., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy275 · Cited by 2,274 · see citing works
Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients
Baruch, E. N., Youngster, I., Ben-Betzalel, G., Ortenberg, R., Lahat, A., Katz, L., Adler, K., Dick-Necula, D., Raskin, S., Bloch, N., et al. (2021) · Science · doi:10.1126/science.abb5920 · Cited by 1,757 · see citing works
A decade of immune-checkpoint inhibitors in cancer therapy
Robert, C. (2020) · Nature Communications · doi:10.1038/s41467-020-17670-y · Cited by 1,608 · see citing works
Gong, J., Chehrazi‐Raffle, A., Reddi, S., & Salgia, R. (2018) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-018-0316-z · Cited by 1,279 · see citing works
Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Vogel, A., Cervantes, A. M. R., Chau, I., Daniele, B., Llovet, J. M., Meyer, T., Nault, J., Neumann, U. P., Ricke, J., Sangro, B., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy308 · Cited by 1,047 · see citing works
Monitoring immune-checkpoint blockade: response evaluation and biomarker development
Nishino, M., Ramaiya, N. H., Hatabu, H., & Hodi, F. S. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.88 · Cited by 1,023 · see citing works
Self-citationEASL Clinical Practice Guidelines on the management of hepatocellular carcinoma
Sangro, B., Argemi, J., Ronot, M., Paradis, V., Meyer, T., Mazzaferro, V., Jepsen, P., Golfieri, R., Galle, P., Dawson, L., et al. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2024.08.028 · Cited by 985 · see citing works
TGFβ biology in cancer progression and immunotherapy
Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944 · see citing works
Voorwerk, L., Slagter, M., Horlings, H. M., Sikorska, K., de Vijver, K. K. V., de Maaker, M., Nederlof, I., Kluin, R. J. C., Warren, S., Ong, S., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0432-4 · Cited by 912 · see citing works
Wang, F., Shen, L., Li, J., Zhou, Z., Liang, H., Zhang, X., Tang, L., Xin, Y., Jin, J., Zhang, Y., et al. (2019) · 癌症:英文版 · doi:10.1186/s40880-019-0349-9 · Cited by 814 · see citing works
Guidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2019 Edition)
Zhou, J., Sun, H., Wang, Z., Cong, W., Wang, J., Zeng, M., Zhou, W., Bie, P., Liu, L., Wen, T., et al. (2020) · Liver Cancer · doi:10.1159/000509424 · Cited by 804 · see citing works
The Next Decade of Immune Checkpoint Therapy
Sharma, P., Siddiqui, B. A., Anandhan, S., Yadav, S. S., Subudhi, S. K., Gao, J., Goswami, S., & Allison, J. P. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1680 · Cited by 750 · see citing works
Ferrara, R., Mezquita, L., Texier, M., Lahmar, J., Audigier-Valette, C., Tessonnier, L., Mazieres, J., Zalcman, G., Brosseau, S., Le Moulec, S., et al. (2018) · JAMA Oncology · doi:10.1001/jamaoncol.2018.3676 · Cited by 720 · see citing works
Self-citationCohen, E. E. W., Bell, R. B., Bifulco, C. B., Burtness, B. A., Gillison, M. L., Harrington, K. J., Le, Q., Lee, N. Y., Leidner, R. S., Lewis, R. L., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0662-5 · Cited by 719 · see citing works
The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer
Janjigian, Y. Y., Kawazoe, A., Yanez, P. E., Li, N., Lonardi, S., Kolesnik, O., Barajas, O., Bai, Y., Shen, L., Tang, Y., et al. (2021) · Nature · doi:10.1038/s41586-021-04161-3 · Cited by 722 · see citing works
mRECIST for HCC: Performance and novel refinements
Llovet, J. M., & Lencioni, R. A. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2019.09.026 · Cited by 689 · see citing works
Hendriks, L. E. L., Kerr, K. M., Menis, J., Mok, T. S. K., Nestle, U., Passaro, A., Peters, S., Planchard, D., Smit, E. F., Solomon, B., et al. (2023) · Annals of Oncology · doi:10.1016/j.annonc.2022.12.013 · Cited by 645 · see citing works
Wang, F., Zhang, X., Li, Y., Tang, L., Qu, X., Ying, J., Zhang, J., Sun, L., Lin, R., Qiu, H., et al. (2021) · 癌症:英文版 · doi:10.1002/cac2.12193 · Cited by 614 · see citing works
Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends
Sun, Q., Hong, Z., Zhang, C., Wang, L., Han, Z., & Ma, D. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01522-4 · Cited by 598 · see citing works
Janjigian, Y. Y., Kawazoe, A., Bai, Y., Xu, J., Lonardi, S., Metges, J. P., Yanez, P. E., Wyrwicz, L. S., Shen, L., Ostapenko, Y., et al. (2023) · The Lancet · doi:10.1016/s0140-6736(23)02033-0 · Cited by 544 · see citing works
Clinical Challenges of Immune Checkpoint Inhibitors
Miguel, M. J. D., & Calvo, E. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.07.004 · Cited by 542 · see citing works
Tumor Immunology and Tumor Evolution: Intertwined Histories
Galon, J., & Bruni, D. (2020) · Immunity · doi:10.1016/j.immuni.2019.12.018 · Cited by 541 · see citing works
Lenvatinib plus pembrolizumab in patients with advanced endometrial cancer
Makker, V., Taylor, M. H., Aghajanian, C., Oaknin, A., Mier, J., Cohn, A. L., Romeo, M., Bratos, R., Brose, M. S., DiSimone, C., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.19.02627 · Cited by 522 · see citing works
Novel patterns of response under immunotherapy
Borcoman, É., Kanjanapan, Y., Champiat, S., Kato, S., Servois, V., Kurzrock, R., Goel, S., Bedard, P. L., & Tourneau, C. L. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz003 · Cited by 519 · see citing works
Guidelines for the Diagnosis and Treatment of Primary Liver Cancer (2022 Edition)
Zhou, J., Sun, H., Wang, Z., Cong, W., Zeng, M., Zhou, W., Bie, P., Liu, L., Wen, T., Kuang, M., et al. (2023) · Liver Cancer · doi:10.1159/000530495 · Cited by 505 · see citing works
Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy
Herrera, F. G., Ronet, C., Ochoa-de-Olza, M., Barras, D., Crespo, I., Andreatta, M., Corria-Osorio, J., Spill, A., Benedetti, F., Genolet, R., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0003 · Cited by 466 · see citing works
Kim, R. D., Chung, V. M., Alese, O. B., El‐Rayes, B. F., Li, D., Al‐Toubah, T., Schell, M. J., Zhou, J.-M., Mahipal, A., Kim, B., et al. (2020) · JAMA Oncology · doi:10.1001/jamaoncol.2020.0930 · Cited by 451 · see citing works
Wang, F., Zhang, X., Tang, L., Wu, Q., Cai, M., Li, Y., Qu, X., Qiu, H., Zhang, Y., Ying, J., et al. (2023) · 癌症:英文版 · doi:10.1002/cac2.12516 · Cited by 437 · see citing works
Trial Design and Endpoints in Hepatocellular Carcinoma: AASLD Consensus Conference
Llovet, J. M., Villanueva, A., Marrero, J. A., Schwartz, M., Meyer, T., Galle, P. R., Lencioni, R., Greten, T. F., Kudo, M., Mandrekar, S. J., et al. (2021) · Hepatology · doi:10.1002/hep.31327 · Cited by 413 · see citing works
Self-citationCurrent Landscape of Immunotherapy in Breast Cancer: A Review
Adams, S., Gatti-Mays, M. E., Kalinsky, K., Korde, L. A., Sharon, E., Amiri-Kordestani, L., Bear, H., McArthur, H. L., Frank, E., Perlmutter, J., et al. (2019) · JAMA Oncology · doi:10.1001/jamaoncol.2018.7147 · Cited by 384 · see citing works
(2019) · Gut and Liver · doi:10.5009/gnl19024 · Cited by 389 · see citing works
Systemic treatment of hepatocellular carcinoma: An EASL position paper
Bruix, J., Chan, S. L., Galle, P. R., Rimassa, L., & Sangro, B. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.07.004 · Cited by 382 · see citing works
Ianiro, G., Punčochář, M., Karcher, N., Porcari, S., Armanini, F., Asnicar, F., Beghini, F., Blanco-Míguez, A., Cumbo, F., Manghi, P., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01964-3 · Cited by 366 · see citing works
Immunotherapy in breast cancer: an overview of current strategies and perspectives
Debien, V., Caluwé, A. D., Wang, X., Piccart, M. J., Tuohy, V. K., Romano, E., & Buisseret, L. (2023) · npj Breast Cancer · doi:10.1038/s41523-023-00508-3 · Cited by 387 · see citing works
Hodi, F. S., Ballinger, M., Lyons, B., Soria, J.-C., Nishino, M., Tabernero, J., Powles, T., Smith, D., Hoos, A., McKenna, C., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.75.1644 · Cited by 366 · see citing works
Self-citationHyperprogressive disease: recognizing a novel pattern to improve patient management
Champiat, S., Ferrara, R., Massard, C., Besse, B., Marabelle, A., Soria, J., & Ferté, C. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0111-2 · Cited by 360 · see citing works
Geoerger, B., Kang, H. J., Yalon-Oren, M., Marshall, L. V., Vezina, C., Pappo, A., Laetsch, T. W., Petrilli, A. S., Ebinger, M., Toporski, J., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30671-0 · Cited by 357 · see citing works
Migrastatics—Anti-metastatic and Anti-invasion Drugs: Promises and Challenges
Gandalovičová, A., Rösel, D., Fernandes, M., Veselý, P., Heneberg, P., Čermák, V., Petruzelka, L. B., Kumar, S., Sanz‐Moreno, V., & Brábek, J. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.04.008 · Cited by 350 · see citing works
Tazdait, M., Mezquita, L., Lahmar, J., Ferrara, R., Bidault, F., Ammari, S., Balleyguier, C., Planchard, D., Gazzah, A., Soria, J., et al. (2017) · European Journal of Cancer · doi:10.1016/j.ejca.2017.10.017 · Cited by 349 · see citing works
Self-citation2022 KLCA-NCC Korea practice guidelines for the management of hepatocellular carcinoma
Korean Liver Cancer Association (KLCA), & National Cancer Center (NCC) Korea (2022) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2022.0294 · Cited by 350 · see citing works
Taı̈eb, J., Svrcek, M., Cohen, R., Basile, D., Tougeron, D., & Phelip, J. (2022) · European Journal of Cancer · doi:10.1016/j.ejca.2022.07.020 · Cited by 342 · see citing works
Necchi, A., Joseph, R. W., Loriot, Y., Hoffman-Censits, J. H., Perez‐Gracia, J. L., Petrylak, D. P., Derleth, C. L., Tayama, D., Zhu, Q., Ding, B., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx518 · Cited by 301 · see citing works
Neoadjuvant PD-1 Blockade in Resectable Lung Cancer
(2018) · New England Journal of Medicine · doi:10.1056/nejmc1808251 · Cited by 277 · see citing works
Delanoy, N., Michot, J., Comont, T., Kramkimel, N., Lazarovici, J., Dupont, R., Champiat, S., Chahine, C., Robert, C., Herbaux, C., et al. (2018) · The Lancet Haematology · doi:10.1016/s2352-3026(18)30175-3 · Cited by 296 · see citing works
Kluger, H. M., Tawbi, H. A., Ascierto, M. L., Bowden, M., Callahan, M. K., Cha, E., Chen, H. X., Drake, C. G., Feltquate, D., Ferris, R. L., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000398 · Cited by 301 · see citing works
Zerdes, I., Matikas, A., Bergh, J. C. S., Rassidakis, G. Z., & Foukakis, T. (2018) · Oncogene · doi:10.1038/s41388-018-0303-3 · Cited by 295 · see citing works
Wu, Y.-L., Planchard, D., Lü, S., Sun, H., Yamamoto, N., Kim, D., Tan, D. S.-W., Yang, J. C., Azrif, M., Mitsudomi, T., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy554 · Cited by 292 · see citing works
Kemp, R., & Prasad, V. K. (2017) · BMC Medicine · doi:10.1186/s12916-017-0902-9 · Cited by 289 · see citing works
Immunotherapy of Melanoma: Facts and Hopes
Weiss, S. A., Wolchok, J. D., & Sznol, M. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1550 · Cited by 279 · see citing works
Self-citationAntoniotti, C., Rossini, D., Pietrantonio, F., Catteau, A., Salvatore, L., Lonardi, S., Boquet, I., Tamberi, S., Marmorino, F., Moretto, R., et al. (2022) · The Lancet Oncology · doi:10.1016/s1470-2045(22)00274-1 · Cited by 280 · see citing works
Han, J., Duan, J., Bai, H., Wang, Y., Wan, R., Wang, X., Chen, S., Tian, Y., Wang, D., Fei, K., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-19-0398 · Cited by 260 · see citing works
Patterns of Response and Progression to Immunotherapy
Borcoman, É., Nandikolla, A. G., Long, G. V., Goel, S., & Tourneau, C. L. (2018) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_200643 · Cited by 262 · see citing works
FDG PET/CT for assessing tumour response to immunotherapy
Aide, N., Hicks, R. J., Tourneau, C. L., Lheureux, S., Fanti, S., & Lopci, E. (2018) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-018-4171-4 · Cited by 263 · see citing works
Hammerl, D., Martens, J. W. M., Timmermans, M., Smid, M., Trapman-Jansen, A. M., Foekens, R., Isaeva, O. I., Voorwerk, L., Balcioglu, H. E., Wijers, R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25962-0 · Cited by 262 · see citing works
Circulating tumor DNA to monitor treatment response in solid tumors and advance precision oncology
Bartolomucci, A., de Nóbrega, M., Ferrier, S. T., Dickinson, K., Kaorey, N., Nadeau, A., Castillo, A., & Burnier, J. V. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-00876-y · Cited by 287 · see citing works
Rogado, J., Sánchez-Torres, J. M., Romero-Laorden, N., Ballesteros, A. I., Pacheco-Barcia, V., Ramos-Leví, A., Arranz, R., Lorenzo, A., Gullón, P., Donnay, O., et al. (2019) · European Journal of Cancer · doi:10.1016/j.ejca.2018.10.014 · Cited by 255 · see citing works
Rini, B. I., Battle, D. J., Figlin, R. A., George, D. J., Hammers, H. J., Hutson, T., Jonasch, E. W., Joseph, R. W., McDermott, D. F., Motzer, R. J., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0813-8 · Cited by 254 · see citing works
Boyer, M. J., Şendur, M. A. N., Rodríguez‐Abreu, D., Park, K., Lee, D. H., Çiçin, İ., Yumuk, P. F., Orlandi, F., Leal, T. A. B., Molinier, O., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.20.03579 · Cited by 253 · see citing works
Progress and challenges of immunotherapy in triple-negative breast cancer
Zhu, Y., Zhu, X., Tang, C., Guan, X., & Zhang, W. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188593 · Cited by 237 · see citing works
Prognostic and predictive biomarkers for immunotherapy in advanced renal cell carcinoma
Rosellini, M., Marchetti, A., Mollica, V., Rizzo, A., Santoni, M., & Massari, F. (2022) · Nature Reviews Urology · doi:10.1038/s41585-022-00676-0 · Cited by 240 · see citing works
Chen, L.-T., Martinelli, E., Cheng, A., Pentheroudakis, G. E., Qin, S., Bhattacharyya, G. S., Ikeda, M., Lim, H. Y., Ho, G. F., Choo, S. P., et al. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2019.12.001 · Cited by 238 · see citing works
Randomized trials and endpoints in advanced HCC: Role of PFS as a surrogate of survival
Llovet, J. M., Montal, R., & Villanueva, A. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.01.028 · Cited by 233 · see citing works
(2019) · Korean Journal of Radiology · doi:10.3348/kjr.2019.0140 · Cited by 229 · see citing works
Moik, F., Chan, W.-S. E., Wiedemann, S., Höeller, C., Tuchmann, F., Aretin, M., Fuereder, T., Zöchbauer‐Müller, S., Preusser, M., Pabinger, I., et al. (2020) · Blood · doi:10.1182/blood.2020007878 · Cited by 235 · see citing works
BCLC strategy for prognosis prediction and treatment recommendations: The 2026 update
Reig, M., Sanduzzi‐Zamparelli, M., Forner, A., Rimola, J., Ferrer, J., Burrel, M., García‐Criado, Á., Díaz, A., Llarch, N., Iserte, G., et al. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.10.020 · Cited by 253 · see citing works
Zhang, S., Mao, Y., Zhang, Z.-Y., Li, Z., Kong, C., Chen, H., Cai, P., Han, B., Ye, T., & Wang, L. (2021) · Theranostics · doi:10.7150/thno.54476 · Cited by 231 · see citing works
Overcoming Immune Evasion in Melanoma
Eddy, K., & Chen, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238984 · Cited by 230 · see citing works
Elsholtz, F. H. J., Asbach, P., Haas, M., Becker, M., Beets‐Tan, R. G. H., Thoeny, H. C., Padhani, A. R., & Hamm, B. (2021) · European Radiology · doi:10.1007/s00330-020-07572-4 · Cited by 224 · see citing works
Amaria, R. N., Menzies, A. M., Burton, E. M., Scolyer, R. A., Tetzlaff, M. T., Antdbacka, R., Ariyan, C. E., Bassett, R. L., Carter, B., DAUD, A. I., et al. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30332-8 · Cited by 219 · see citing works
Marabelle, A., Andtbacka, R. H. I., Harrington, K. J., Melero, I., Leidner, R. S., de Baère, T., Robert, C., Ascierto, P. A., Baurain, J. F., Imperiale, M. J., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy423 · Cited by 216 · see citing works
Blomberg, O. S., Spagnuolo, L., Garner, H., Voorwerk, L., Isaeva, O. I., van Dyk, E., Bakker, N. A. M., Chalabi, M., Klaver, C., Duijst, M., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.11.014 · Cited by 217 · see citing works
Mittendorf, E. A., Lu, B., Melisko, M., Hiller, J. A. P., Bondarenko, I., Brunt, A. M., Sergii, G., Petráková, K., & Peoples, G. E. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-2867 · Cited by 214 · see citing works
Thyroid Immune-related Adverse Events Following Immune Checkpoint Inhibitor Treatment
Muir, C. A., Clifton-Bligh, R. J., Long, G. V., Scolyer, R. A., Lo, S., Carlino, M. S., Tsang, V., & Menzies, A. M. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab263 · Cited by 217 · see citing works
Imaging of Cancer Immunotherapy: Current Approaches and Future Directions
Nishino, M., Hatabu, H., & Hodi, F. S. (2018) · Radiology · doi:10.1148/radiol.2018181349 · Cited by 215 · see citing works
Self-citationChen, Y., Wang, D., Li, Y., Lu, Q., Si, W., Bo, Y., Chen, X., Ye, Z., Fan, H., Liu, B., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.06.009 · Cited by 215 · see citing works
Future cancer research priorities in the USA: a Lancet Oncology Commission
Jaffee, E. M., Dang, C. V., Agus, D. B., Alexander, B. M., Anderson, K. C., Ashworth, A., Barker, A. D., Bastani, R., Bhatia, S. N., Bluestone, J. A., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30698-8 · Cited by 211 · see citing works
Self-citationImmune Checkpoint Inhibitor Therapy in Oncology
Tan, S., Day, D., Nicholls, S. J., & Segelov, E. (2022) · JACC CardioOncology · doi:10.1016/j.jaccao.2022.09.004 · Cited by 215 · see citing works
Treatment after progression in the era of immunotherapy
Billan, S., Kaidar‐Person, O., & Gil, Z. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30328-4 · Cited by 203 · see citing works
Straathof, K. C. M., Flutter, B. R., Wallace, R., Jain, N., Loka, T., Depani, S., Wright, G., Thomas, S., Cheung, G. W.-K., Gileadi, T. E., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abd6169 · Cited by 202 · see citing works
Resumption of Immune Checkpoint Inhibitor Therapy After Immune-Mediated Colitis
Abu‐Sbeih, H., Ali, F. S., Naqash, A. R., Owen, D. H., Patel, S. H., Otterson, G. A., Kendra, K. L., Ricciuti, B., Chiari, R., Giglio, A. D., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.19.00320 · Cited by 199 · see citing works
Anwar, H., Sachpekidis, C., Winkler, J. K., Kopp‐Schneider, A., Haberkorn, U., Hassel, J. C., & Dimitrakopoulou‐Strauss, A. (2017) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-017-3870-6 · Cited by 198 · see citing works
Jia, W., Gao, Q., Han, A., Zhu, H., & Yu, J. (2019) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2019.0144 · Cited by 194 · see citing works
Abu-Sbeih, H., Ali, F. S., Wang, X., Mallepally, N., Chen, E., Altan, M., Bresalier, R. S., Charabaty, A., Dadu, R., Jazaeri, A., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0577-1 · Cited by 191 · see citing works
Lee, C., Shah, A. Y., Rasco, D. W., Rao, A., Taylor, M. H., Simone, C. D., Hsieh, J. J.-D., Pinto, Á., Shaffer, D. R., Sarrió, R. G., et al. (2021) · The Lancet Oncology · doi:10.1016/s1470-2045(21)00241-2 · Cited by 191 · see citing works
Goldfarb, L., Duchemann, B., Chouahnia, K., Zelek, L. H., & Soussan, M. (2019) · EJNMMI Research · doi:10.1186/s13550-019-0473-1 · Cited by 187 · see citing works
Cai, J., Song, L., Zhang, F., Wu, S., Zhu, G., Zhang, P., Chen, S., Du, J.-X., Wang, B., Cai, Y., et al. (2024) · 癌症:英文版 · doi:10.1002/cac2.12607 · Cited by 193 · see citing works
Hinterleitner, C., Strähle, J., Malenke, E., Hinterleitner, M., Henning, M., Seehawer, M., Bilich, T., Heitmann, J., Lutz, M., Mattern, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27303-7 · Cited by 175 · see citing works
Song, Y., Zhang, B., Xin, D., Kou, X., Tan, Z., Zhang, S., Sun, M., Zhou, J., Fan, M., Zhang, M., et al. (2023) · Nature Medicine · doi:10.1038/s41591-022-02179-2 · Cited by 178 · see citing works
Park, H. J., Kim, K. W., Pyo, J., Suh, C. H., Yoon, S., Hatabu, H., & Nishino, M. (2020) · Radiology · doi:10.1148/radiol.2020200443 · Cited by 162 · see citing works
Yamauchi, T., Hoki, T., Oba, T., Jain, V., Chen, H., Attwood, K. M., Battaglia, S., George, S., Chatta, G. S., Puzanov, I. J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21619-0 · Cited by 168 · see citing works
18F-FDG PET/CT for Monitoring of Ipilimumab Therapy in Patients with Metastatic Melanoma
Ito, K., Teng, R. S. Y., Schöder, H. M., Humm, J. L., Ni, A., Michaud, L., Nakajima, R., Yamashita, R., Wolchok, J. D., & Weber, W. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.213652 · Cited by 174 · see citing works
Self-citationEfficacy of Nivolumab and AVD in Early-Stage Unfavorable Classic Hodgkin Lymphoma
Bröckelmann, P. J., Goergen, H., Keller, U. B., Meißner, J., Ordemann, R., Halbsguth, T. V., Sasse, S., Sökler, M., Kerkhoff, A., Mathas, S., et al. (2020) · JAMA Oncology · doi:10.1001/jamaoncol.2020.0750 · Cited by 175 · see citing works
Identification of non-small cell lung cancer sensitive to systemic cancer therapies using radiomics
Dercle, L., Fronheiser, M., Lu, L., Du, S., Hayes, W., Leung, D. K., Roy, A., Wilkerson, J., Guo, P., Fojo, A. T., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-2942 · Cited by 173 · see citing works
Self-citationPractical recommendations for using ctDNA in clinical decision making
Cohen, S. A., Liu, M. C., & Aleshin, A. A. (2023) · Nature · doi:10.1038/s41586-023-06225-y · Cited by 177 · see citing works
ctDNA response after pembrolizumab in non-small cell lung cancer: phase 2 adaptive trial results
Anagnostou, V., Ho, C., Nicholas, G. A., Juergens, R. A., Sacher, A. G., Fung, A. S., Wheatley‐Price, P., Laurie, S. A., Levy, B. P., Brahmer, J. R., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02598-9 · Cited by 171 · see citing works
Self-citationBeaver, J. A., Hazarika, M., Mulkey, F. A., Mushti, S. L., Chen, H., He, K., Sridhara, R., Goldberg, K. B., Chuk, M. K., Chi, D.-C., et al. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30846-x · Cited by 167 · see citing works
Atezolizumab for Advanced Alveolar Soft Part Sarcoma
Chen, A. P., Sharon, E., Coyne, G. O., Moore, N., Foster, J. C., Hu, J. S., Tine, B. A. V., Conley, A. P., Read, W. L., Riedel, R. F., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2303383 · Cited by 170 · see citing works
Self-citationNowak, A. K., Lesterhuis, W. J., Kok, P., Brown, C. S. B., Hughes, B. G. M., Karikios, D. J., John, T., Kao, S. C.-H., Leslie, C., Cook, A., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30462-9 · Cited by 167 · see citing works
Yang, J. C., Lee, D. H., Lee, J., Fan, Y., de Marinis, F., Iwama, E., Inoue, T., Rodríguez‐Cid, J. R., Zhang, L., Yang, C., et al. (2024) · Journal of Clinical Oncology · doi:10.1200/jco.23.02747 · Cited by 165 · see citing works
- Authors
- Seymour, L., Bogaerts, J., Perrone, A., Ford, R., Schwartz, L. H., Mandrekar, S., Lin, N. U., Litière, S., Dancey, J., Chen, A., Hodi, F. S., Therasse, P., Hoekstra, O. S., Shankar, L. K., Wolchok, J. D., Ballinger, M., Caramella, C., & de Vries, E. G. E.
- Affiliations
- Queen's University (CA)
- European Organisation for Research and Treatment of Cancer (BE)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- NewYork–Presbyterian Hospital (US)
- Mayo Clinic (US)
- National Institutes of Health (US)
- Harvard University (US)
- Institut de Recherches Internationales Servier (France) (FR)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Memorial Sloan Kettering Cancer Center (US)
- Genentech (US)
- Institut Gustave Roussy (FR)
- Corresponding author
- Seymour, Lesley
- ORCID
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 18
- Issue
- 3
- Pages
- e143-e152
- ISSN
- 1470-2045 (ISSN-L)
- PMC
- PMC5648544
- OpenAlex
- W2592144107
- Cited by
- 2,472
- References
- 37
- Citations by year
- 2026: 264 · 2025: 267 · 2024: 319 · 2023: 305 · 2022: 270 · 2021: 308 · 2020: 304 · 2019: 223 · 2018: 146 · 2017: 62 · 2015: 1 · 2012: 1
- FWCI
- 21.17
- Type
- journal article
- Language
- en
- Update notices
- erratum (2019-05-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet Oncology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Pure Amsterdam UMC (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Cancer Institute (U10CA011488, P30CA008748)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Keywords
- iRECIST, cancer immunotherapy, response evaluation criteria, disease progression, immunomodulators, clinical trial data collection, data warehouse
- MeSH terms
- Humans, Immunotherapy, Neoplasms, Practice Guidelines as Topic, Disease Progression, Tumor Burden, Response Evaluation Criteria in Solid Tumors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review