CoChat
Sign Up
Cited by 144Atomic and Subatomic Physics ResearchEEG and Brain-Computer InterfacesEpilepsy research and treatment

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

On-Scalp Optically Pumped Magnetometers versus Cryogenic Magnetoencephalography for Diagnostic Evaluation of Epilepsy in School-aged Children

Open access
Feys, Odile, Corvilain, Pierre, Aeby, Alec, Sculier, Claudine, Holmes, Niall, Brookes, Matthew, Goldman, Serge, Wens, Vincent, De Tiège, Xavier·2022·Radiology
DOI 10.1148/radiol.212453

Published version of a preprint

Open this paper in CoChat — free accountOpen PDF

Abstract

Abstract Magnetoencephalography (MEG) is an established method to investigate epilepsy. Current MEG systems house hundreds of cryogenic sensors in a rigid, one-size-fits-all helmet, which results in several limitations, particularly in children. On-scalp MEG based on optically-pumped magnetometers (OPMs) may alleviate these limitations. We report on five children (5–11 years old) with self-limited focal (n=3) or structural (n=2) epilepsy who underwent cryogenic (102 magnetometers) and on-scalp (32 OPMs) MEG. We compared the two modalities for the detection and localization of interictal epileptiform discharges (IEDs). We identified IEDs in all children with comparable sensor topographies for both MEG devices. IED amplitudes were 2.3-4.8 times higher with on-scalp MEG and signal-to-noise ratio (SNR) was also 27-60% higher with on-scalp MEG in all but one patient with large head movement artifacts. The neural source of averaged IEDs was located at about 5 mm (n=3) or higher (8.3 mm, n=1; 15.6 mm, n=1) between on-scalp and cryogenic MEG. Despite limited number of sensors and scalp coverage, on-scalp MEG detects IEDs in epileptic children with higher SNR than cryogenic MEG. This technology, which is in constant development, should become a reference in the diagnostic workup of epilepsy and replace cryogenic MEG in the near future.

Overview

Integrity signals

Registry

Crossref · 10.1148/radiol.212453

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 16

  1. 10.1016/j.clinph.2019.01.009 · DOI
  2. 10.1016/j.nic.2020.02.004 · DOI
  3. 10.1093/brain/awz231 · DOI
  4. 10.1055/s-0035-1563726 · DOI
  5. 10.1002/acn3.50995 · DOI
  6. 10.1016/j.neuroimage.2021.117815 · DOI
  7. 10.1016/j.seizure.2011.01.015 · DOI
  8. 10.1088/0031-9155/51/7/008 · DOI
  9. 10.3389/fnins.2013.00267 · DOI
  10. 10.1016/j.seizure.2020.11.008 · DOI
  11. 10.1162/jocn.1993.5.2.162 · DOI · Paper page
  12. 10.1002/hbm.22943 · DOI
  13. 10.1111/epi.13709 · DOI · Paper page
  14. 10.1088/0031-9155/58/22/8153 · DOI · Paper page
  15. 10.1016/j.neuroimage.2021.118401 · DOI
  16. 10.1109/TBME.2021.3100770 · DOI

Cited by

Sorted by citations

Metadata

Authors
Feys, O., Corvilain, P., Aeby, A., Sculier, C., Holmes, N., Brookes, M., Goldman, S., Wens, V., & De Tiège, X.
Affiliations
Université Libre de Bruxelles (BE)
Corresponding author
Feys, Odile
ORCID
Venue
Radiology
Publisher
Radiological Society of North America (RSNA)
Published
2022-08
Volume
304
Issue
2
Pages
429-434
ISSN
  • 0033-8419 (ISSN-L)
  • 1527-1315
DOI
10.1148/radiol.212453
OpenAlex
W4225307071
Cited by
144
References
2
Citations by year
2026: 28 · 2025: 36 · 2024: 39 · 2023: 30 · 2022: 9
FWCI
11.69
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Radiology (publishedVersion)
  • medRxiv (acceptedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
  • Repository@Nottingham (University of Nottingham) (submittedVersion)
Funders
Fonds De La Recherche Scientifique (U.N013.21Fv)
Topics
  • Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Atomic and Subatomic Physics Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
  • Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Keywords
optically pumped magnetometers, interictal epileptiform discharges, focal epilepsy, pediatric epilepsy, signal-to-noise ratio, epileptogenic zone localization, motion artifacts, drug-resistant epilepsy, idiopathic epilepsy, school-aged children
MeSH terms
Brain, Child, Electroencephalography, Epilepsy, Epilepsies, Partial, Female, Humans, Prospective Studies, Scalp, Magnetoencephalography

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review