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Acute Pancreatitis: Assessment of Severity with Clinical and CT Evaluation
Abstract
Treatment of patients with acute pancreatitis is based on the initial assessment of disease severity. Severe pancreatitis occurs in 20%-30% of all patients with acute pancreatitis and is characterized by a protracted clinical course, multiorgan failure, and pancreatic necrosis. Early staging is based on the presence and degree of systemic failure (cardiovascular, pulmonary, renal) and on the presence and extent of pancreatic necrosis. Individual laboratory indexes (markers of pancreatic injury, markers of inflammatory response), while promising, have not yet gained clinical acceptance. Numeric grading systems with sensitivities of about 70% are commonly used today as indicators of organ failure and disease severity. Contrast material-enhanced computed tomography is used in addition to help evaluate local pancreatic morphology and the presence and extent of pancreatic necrosis. Advantages and limitations of the clinical, laboratory, and imaging prognostic indexes are analyzed and discussed.
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Cited by
American College of Gastroenterology guideline: management of acute pancreatitis
Tenner, S., Baillie, J., DeWitt, J., & Vege, S. S. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.218 · Cited by 2,327
Practice guidelines in acute pancreatitis
Banks, P. A., Freeman, M. L., & the Practice Parameters Committee of the American College of Gastroenterology (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00856.x · Cited by 2,050
UK guidelines for the management of acute pancreatitis
(2005) · Gut · doi:10.1136/gut.2004.057026 · Cited by 940
Thoeni, R. F. (2012) · Radiology · doi:10.1148/radiol.11110947 · Cited by 470
Clinical practice guideline: management of acute pancreatitis
Greenberg, J. A., Hsu, J., Bawazeer, M., Marshall, J., Friedrich, J. O., Nathens, A., Coburn, N., May, G. R., Pearsall, E., & McLeod, R. S. (2016) · Canadian Journal of Surgery · doi:10.1503/cjs.015015 · Cited by 429
Metadata
- Authors
- Balthazar, E. J.
- Venue
- Radiology
- Published
- 2002-06
- Volume
- 223
- Issue
- 3
- Pages
- 603-613
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2139810136
- Cited by
- 859
- References
- 0
- FWCI
- 11.19
- Type
- journal article
- Language
- en
- Open access
- closed
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