Supratentorial cerebrospinal fluid production rate in healthy adults: quantification with two-dimensional cine phase-contrast MR imaging with high temporal and spatial resolution
Abstract
A method for objectively determining supratentorial cerebrospinal fluid (CSF) production rate is described. The method employs cine phase-contrast magnetic resonance imaging with high temporal and spatial resolution at the level of the aqueduct of Sylvius. Automatic encircling of the aqueduct was accomplished by using a pulsatility-based segmentation approach. Results in 23 healthy adults (18 men, five women; age range, 21-39 years) yielded an average CSF production rate of 305 microL/min +/- 145 (standard deviation); this rate is in good agreement with literature-reported values obtained with invasive ventriculolumbar perfusion measurements. Average operator imprecision was 23.1% if automatic segmentation was not used. The proposed method is potentially an effective means for measuring supratentorial CSF production rate in humans.
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Cites
Pratt, W. K. (2002) · Wiley eBooks · doi:10.1002/0471221325 · Cited by 4,348 · see citing works
Normal-pressure hydrocephalus: evaluation with cerebrospinal fluid flow measurements at MR imaging.
Bradley, W. G., Scalzo, D. C., Queralt, J. A., Nitz, W., Atkinson, D. J., & Wong, P. (1996) · Radiology · doi:10.1148/radiology.198.2.8596861 · Cited by 391 · see citing works
Human brain motion and cerebrospinal fluid circulation demonstrated with MR velocity imaging.
Feinberg, D. A., & Mark, A. S. (1987) · Radiology · doi:10.1148/radiology.163.3.3575734 · Cited by 378 · see citing works
Cerebrospinal fluid production is reduced in healthy aging
May, C., Kaye, J. A., Atack, J. R., Schapiro, M. B., Friedland, R. P., & Рапопорт, С. И. (1990) · Neurology · doi:10.1212/wnl.40.3_part_1.500 · Cited by 317 · see citing works
The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer’s type
Silverberg, G. D., Heit, G., Huhn, S. L., Jaffe, R., Chang, S. D., Bronte-Stewart, H. M., Rubenstein, E., Possin, K. L., & Saul, T. (2001) · Neurology · doi:10.1212/wnl.57.10.1763 · Cited by 274 · see citing works
Nitz, W. R., Bradley, W. G., Watanabe, A. S., Lee, R. R., Burgoyne, B., O’Sullivan, R., & Herbst, M. D. (1992) · Radiology · doi:10.1148/radiology.183.2.1561340 · Cited by 272 · see citing works
Circadian variation in human cerebrospinal fluid production measured by magnetic resonance imaging
Nilsson, C., Ståhlberg, F., Thomsen, C., Henriksen, O. M., Herning, M., & Owman, C. (1992) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1992.262.1.r20 · Cited by 234 · see citing works
Effects of Proteins, Blood Cells and Glucose on the Viscosity of Cerebrospinal Fluid
Bloomfield, I. G. S., Johnston, I. H., & Bilston, L. E. (1998) · Pediatric Neurosurgery · doi:10.1159/000028659 · Cited by 233 · see citing works
Gideon, P., St�hlberg, F., Thomsen, C., Gjerris, F., S�rensen, P. S., & Henriksen, O. M. (1994) · Neuroradiology · doi:10.1007/bf00588133 · Cited by 125 · see citing works
PUBS: Pulsatility‐based segmentation of lumens conducting non‐steady flow
Alperin, N. J., & Lee, S. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10455 · Cited by 117 · see citing works
Cerebrospinal fluid perfusion for central nervous system neoplasms
Rubin, R. C., Ommaya, A. K., Henderson, E. S., et al. (1966) · Neurology · doi:10.1212/wnl.16.7.680 · Cited by 98 · see citing works
Thomsen, C., Ståhlberg, F., Stubgaard, M., et al. (1990) · Radiology · doi:10.1148/radiology.177.3.2243965 · Cited by 97 · see citing works
Cerebrospinal fluid production and dynamics in normal aging: a MRI phase-mapping study
Gideon, P., Thomsen, C., Ståhlberg, F., et al. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1994.tb02647.x · Cited by 84 · see citing works
Yasuda, T., Tomita, T., McLone, D. G., & Donovan, M. (2002) · Pediatric Neurosurgery · doi:10.1159/000048344 · Cited by 69 · see citing works
Gideon, P., S�rensen, P. S., Thomsen, C., St�hlberg, F., Gjerris, F., & Henriksen, O. M. (1994) · Neuroradiology · doi:10.1007/bf00612116 · Cited by 68 · see citing works
Nilsson, C., Ståhlberg, F., Gideon, P., Thomsen, C., & Henriksen, O. M. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.267.6.r1445 · Cited by 41 · see citing works
MR prediction of shunt response in NPH: CSF morphology versus physiology.
Bradley, W. G. (1998) · PubMed · Cited by 21 · see citing works
General physics with bioscience essays
Marion, J. B. (1972) · Cited by 15 · see citing works
Javaheri, S., & Corbett, W. S. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00949-4 · Cited by 5 · see citing works
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Brinker, T., Stopa, E., Morrison, J., & Klinge, P. (2014) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-11-10 · Cited by 819 · see citing works
McGill, F., Heyderman, R. S., Michael, B. D., Defres, S., Beeching, N. J., Borrow, R., Glennie, L., Gaillemin, O., Wyncoll, D., Kaczmarski, E., et al. (2016) · Journal of Infection · doi:10.1016/j.jinf.2016.01.007 · Cited by 254 · see citing works
Coles, J. A., Myburgh, E., Brewer, J. M., & McMenamin, P. G. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.05.002 · Cited by 123 · see citing works
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- Authors
- Huang, T.-Y., Chung, H.-W., Chen, M.-Y., Giiang, L.-H., Chin, S.-C., Lee, C.-S., Chen, C.-Y., & Liu, Y.-J.
- Affiliations
- National Taiwan University of Science and Technology (TW)
- National Defense Medical Center (TW)
- Feng Chia University (TW)
- Venue
- Radiology
- Published
- 2004-11
- Volume
- 233
- Issue
- 2
- Pages
- 603-608
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W1972444337
- Cited by
- 91
- References
- 19
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 8 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 7
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
- Keywords
- aqueduct of Sylvius, phase-contrast cine MRI, automatic segmentation, healthy adults
- MeSH terms
- Adult, Cerebral Aqueduct, Cerebrospinal Fluid, Humans, Male, Magnetic Resonance Imaging, Cine
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