The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hepatic Fat Fraction: MR Imaging for Quantitative Measurement and Display—Early Experience
Abstract
UNLABELLED: The institutional review board approved this HIPAA-compliant study. After all five patients with nonalcoholic fatty liver disease signed a consent, they underwent magnetic resonance (MR) imaging for hepatic fat quantification. The purpose of this study was to develop a fast and accurate method to acquire and display quantitative maps of the percentage of hepatic fat. In-phase and out-of-phase gradient-echo MR imaging was performed with dual flip angles (70 degrees, 20 degrees) to resolve ambiguity of the dominant constituent. T2* corrections were also estimated and applied to generate color-coded maps of the estimated percentage of hepatic fat. MR imaging results were compared with biopsy results in two of five patients, and the technique was validated qualitatively and quantitatively with a water-oil phantom. Results of the phantom study confirmed that the dual-flip angle algorithm can be used to correctly identify the dominant constituent, allowing depiction of 0%-100% of fat content. The estimated liver fat fraction was comparable to quantitative fat measurements at biopsy in both patients (MR imaging, 18.3% +/- 2.8 [standard deviation] and 28.6% +/- 2.4, vs quantitative histopathologic analysis, 11.2% and 28.5%, respectively). SUPPLEMENTAL MATERIAL: radiology.rsnajnls.org/cgi/content/full/2373041639/DC1
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Cites
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
MATTEONI, C., YOUNOSSI, Z., GRAMLICH, T., BOPARAI, N., LIU, Y., & MCCULLOUGH, A. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70506-8 · Cited by 3,345
Cited by
Klöting, N., Fasshauer, M., Dietrich, A., Kovacs, P., Schön, M. R., Kern, M., Stumvoll, M., & Blüher, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00586.2009 · Cited by 856
Schwimmer, J. B., Dunn, W., Norman, G. J., Pardee, P. E., Middleton, M. S., Kerkar, N., & Sirlin, C. B. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.052 · Cited by 498
Fat quantification with IDEAL gradient echo imaging: Correction of bias from T1 and noise
Liu, C., McKenzie, C. A., Yu, H., Brittain, J. H., & Reeder, S. B. (2007) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21301 · Cited by 477
Heritability of Nonalcoholic Fatty Liver Disease
Schwimmer, J. B., Celedon, M. A., Lavine, J. E., Salem, R., Campbell, N., Schork, N. J., Shiehmorteza, M., Yokoo, T., Chavez, A., Middleton, M. S., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.050 · Cited by 466
Estimation of Hepatic Proton-Density Fat Fraction by Using MR Imaging at 3.0 T
Yokoo, T., Shiehmorteza, M., Hamilton, G., Wolfson, T., Schroeder, M. E., Middleton, M. S., Bydder, M., Gamst, A. C., Kono, Y., Kuo, A., et al. (2011) · Radiology · doi:10.1148/radiol.10100659 · Cited by 290
Metadata
- Authors
- Hussain, H. K., Chenevert, T. L., Londy, F. J., Gulani, V., Swanson, S. D., McKenna, B. J., Appelman, H. D., Adusumilli, S., Greenson, J. K., & Conjeevaram, H. S.
- Venue
- Radiology
- Published
- 2005-12
- Volume
- 237
- Issue
- 3
- Pages
- 1048-1055
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2133671942
- Cited by
- 277
- References
- 1
- FWCI
- 8.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hussain, H. K., Chenevert, T. L., Londy, F. J., Gulani, V., Swanson, S. D., McKenna, B. J., Appelman, H. D., Adusumilli, S., Greenson, J. K., & Conjeevaram, H. S. (2005). Hepatic Fat Fraction: MR Imaging for Quantitative Measurement and Display—Early Experience. Radiology. https://doi.org/10.1148/radiol.2373041639
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